1I6P,2W3Q,1YM3,3EYX,3LAS,1G5C


Conserved Protein Domain Family
Pro_CA

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smart00947: Pro_CA 
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Carbonic anhydrase
Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.
Statistics
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PSSM-Id: 214929
View PSSM: smart00947
Aligned: 320 rows
Threshold Bit Score: 65.6042
Threshold Setting Gi: 146278365
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1I6P_A        30 AQAQKPRFLWIGCSDSRVPAERLTG--LEPGELFVHRNVANLVIHTDLNCLSVVQYAVDVLEVEH----------IIICG 97
gi 72162531   25 qpvaargLALVTCMDSRIEPLEMLG--LKPGDAKILRNAGARV---TDDTLRTLVLAVYLLGVNR----------VIVLP 89
gi 152964995  27 pgiagsgLAVLTCMDSRISPLEVLG--LEKGDAKILRNAGARV---TDDVLRTLVLAHHLLGVQR----------VLVLA 91
gi 117928879  38 lgiaARQLAVLTCMDCRIDPLRVLG--LAPGDAKILRNAGARVTP---DVLATLAVAVHLLNVRR----------IMVMA 102
gi 119717176  26 dgvaragVAIVTCMDSRIDPLGMVG--LQPGDAKIFRNPGGRV---TDQALEALVLGVHLLNVDR----------ILVIP 90
gi 134298323  40 kKYDHAEILIGMCMDNRKRLNIPEK--F----AYVIRTGAGNLRTSEFKVS----YAIAVGGVRA----------IALIG 99
gi 153940063  36 eKYDNAELLVGMCMDNRKQLNIPNN--F----AYILRTGGGNLRYSEFKIS----YAIAVGGVKA----------LALIG 95
gi 111222223  24 SISPSGNLMVVCCVDPRV--DPTRVlgLEQGEAAVIRNv---gGRITPATLRTMALLGEVGQADRdgrpa-gdwnLVILH 97
gi 94969794   23 QSLQTLKAVIIGCADMRV--DPAHVlgIKPGEAVVIRNi---gGRVTPGLLEEFGLLGRIGEVAGaipggggefhLIVLH 97
gi 94968629   24 SPHPRMALAVLTCMDTRI--SLP-AlgLKVGDAHMIRNa---gGIATDDAIRSLVVSHYLLGTNE----------IMVIN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1I6P_A        98 HYGCGGVQAAVEnPELGLINNWLLHIRDIWFKHSSLLGEMpqerrlDTL-CELNVMEQVYN-----LGHST-I-MQSAWK 169
gi 72162531   90 HTGCKMASVSGD-EEVH------------DTIAARYGVDT------RSL-EFHTDSDQIGA-----LHRDV-ErIRHHPL 143
gi 152964995  92 HTDCGMTKNTD---------------ADVHAKVLAQGVDS------RSI-EFRTIADQRAT-----LVHDVqR-IRSWPF 143
gi 117928879 103 HTRCRMASGTED-DLHQAIAH-------------AGGPDT------RSL-AFLTTTDQTAA-----VQRDVqR-IQSWPY 155
gi 119717176  91 HTRCAMASSTLD-Q--------------VREKVGASAGQD------VSWqTFSMVSDQRAA-----LADDVhK-VVSHPL 143
gi 134298323 100 HNNCGMANLKSK-KQK-FIDGLVE-VGWNRRAAEDHFENL------APM-FE--IGNEMDF-----LITET-N--RLRLR 159
gi 153940063  96 HNRCGMVN-LMN-KKERFIQGLVDNAGWDRNQAEEHFMSF------APM-FE------IENetsflLSETK-R-LREKY- 157
gi 111222223  98 HTDCGMTDLAAF-P---ALLADYFEIPARD------------------L-DAKAVGDPVAS-----VRVDV-GiIEREIR 148
gi 94969794   98 HTDCGSTRLVGD-P---AMLAHYFQIPERE------------------V-EAKSVRDPRKS-----VAVDV-AaLRAIPA 148
gi 94968629   88 HTDCGLMKAS-E-S---DLHHKISTEAGKPANA--------------SV-KFHAFHDVNAN-----VREQI-EqLYAHTW 141
                        170       180
                 ....*....|....*....|....*
1I6P_A       170 R-Gq-K-VTIHGWAYGIHDGLLRDL 191
gi 72162531  144 LpP--D-LPVMGAIYDVDTGRVTPV 165
gi 152964995 144 LpP--T-MPVAGGVYDVRTGAIEMV 165
gi 117928879 156 L-QgsG-VAVGGFLYDVDTGDVHVV 178
gi 119717176 144 V-P--DaVKVGGFIYDVDTGLLEQL 165
gi 134298323 160 Y-P--K-ILVAPMMYQLEDNRLYLL 180
gi 153940063 158 --P--K-ILIAPLFYNVDDNLLYLV 177
gi 111222223 149 A-R--G-FLVSGLVYDVATGLVDTV 169
gi 94969794  149 L-Pd-D-WLISGLVYDVATGLVEVV 170
gi 94968629  142 L-Kg-R-VKIRGFVFEVETGRLREV 163
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