3ISM,1QL0,2XRG,3OWV


Conserved Protein Domain Family
Endonuclease_NS

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smart00892: Endonuclease_NS 
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DNA/RNA non-specific endonuclease
A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.
Statistics
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PSSM-Id: 214889
Aligned: 154 rows
Threshold Bit Score: 57.0325
Threshold Setting Gi: 15675815
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ISM_A        36 HSDYVLSYDRRNRVPHWVFEHLTAESVaKNDA----VDRSKCDFKQDe------------------S------------- 80  fruit fly
XP_315045    145 INYFQVCYDLTKSSALYSQHQILGKVI-SQAQ----INNNRPSFKLGglk-------------stvR------------- 193 Anopheles gambi...
XP_001653477 154 ITYIDSCFDADRSSVLYTRHILPGAAI-ANAV----VADAYQTWRTDgidakidpdalytqttqfeR------------- 215 yellow fever mo...
XP_001663220  82 IKYFQSCYNVDKSSVIYSEHDILGASI-EKAQ----INNDRPSFKIGg-----------------lK------------- 126 yellow fever mo...
XP_001653475 119 IPYIHSCMDMQRASVLWTRHILPGAAV-AGSM----VESSRPAWKVAg-----------------mPshvrpstsytqas 176 yellow fever mo...
XP_001663225 102 FDLYQICFDEPSATAIYTHHTLIGNEI-EHKC-----FSTRPDFKSAgfpqglavssaynqesqlnR------------- 162 yellow fever mo...
NP_996301    123 MELYRSCYDARTMKAYFSINTVYPT----NLK----SDRPPTVFDKDg-----------------iI------------- 164 fruit fly
NP_001034074 119 LELYRACFDTRAVRAIFVEHRVYGKP----FY----ITRPCVQFSSDgvisgad-----easytvrN------------- 172 fruit fly
NP_610558    128 lELYRTCFDCGQGRLVYSQSDVYYKT----FF----PKRPFVEFVADemfspqeaa-aymksniyfA------------- 185 fruit fly
XP_001653754 154 FILGEACYDVKRGQTLFVHTKIKSGSN-TVEAlalkTANNADYFRREhpt-------------sryK------------- 206 yellow fever mo...
3ISM_A        81 --------IHPF---FR---------------------S---Q-----NT-------D-----------------Y---- 92  fruit fly
XP_315045    194 --------LASV---YT---------------------Q---R-----HQ-------LehfstilgsaehaskfiD---- 222 Anopheles gambi...
XP_001653477 216 --------FEAL---LG---------------------S---K-----AQ-------A-----------------E---- 227 yellow fever mo...
XP_001663220 127 --------VKAR---LStvytqnsqrtrltnllgseelA---K-----QY-------I-----------------S---- 159 yellow fever mo...
XP_001653475 177 qlerlttlLGSA---EQ---------------------A---S-----RF-------V-----------------F---- 196 yellow fever mo...
XP_001663225 163 --------LVAL---FG---------------------A---D-----PNpwgsaevY-----------------Y---- 181 yellow fever mo...
NP_996301    165 --------TPADeatFQ---------------------M---NsiynrFE-------Y-----------------L---- 184 fruit fly
NP_001034074 173 --------IHGT---FR---------------------RlfgN-----NQ-------N-----------------Yipnn 191 fruit fly
NP_610558    186 --------FKCI---YG---------------------D---D-----QS-------Y-----------------L---- 197 fruit fly
XP_001653754 207 --------VELN---KA---------------------L---N-----IN-------D-----------------H---- 218 yellow fever mo...
3ISM_A        93 R-----RSG-----------Y---DRGHMAA-AGNHRLHQKHCDETFYLSNMAPQVgQ-GFNR-----DAWNTLEAHVR- 145 fruit fly
XP_315045    223 S-----TSY-----------L---AKGHLTP-DGD-AVLDSWAGATYFFINAVPEW-Q-VVNG-----GNWLRVENAARk 274 Anopheles gambi...
XP_001653477 228 KyiepgRTF-----------L---NRGHLTP-RG-DGIFQTWKHATFFYTNAIPQW-N-VINE-----GNWNNIEQRVRi 284 yellow fever mo...
XP_001663220 160 S-----SSF-----------F---AKGHLTP-DG-DAVLNSWAGATYFYINVAPEW-Q-IINT-----GNWIRIENAARk 211 yellow fever mo...
XP_001653475 197 T-----NSF-----------M---ARGHMSP-DA-DGIYRSWQFTTYFFTNAVPKW-Q-VVNN-----GNWVRVERVTRd 248 yellow fever mo...
XP_001663225 182 N-----LSY-----------L---QRGHLVP-DA-DQLFTTWQWSTYFYLNVVGMW-E-QINN-----GNWKYLESNVRt 233 yellow fever mo...
NP_996301    185 F-----GSGqtyvpssrslsF---DRGHLTP-VA-DYSFPKILRQTNKYLNVVPQY-Y-NINR-----SNWKIVENWVRg 247 fruit fly
NP_001034074 192 R-----DVI-----------I---NRGHLAA-SA-DFFFGDQLCATFKYVNAVPQF-K-SIND-----GNWETIERFVRn 243 fruit fly
NP_610558    198 Q-----NAN-----------YlviNRGHMVA-SA-DFLFTDQMGSTFRYLNVVPQF-K-SIND-----GNWEKIERWVRs 252 fruit fly
XP_001653754 219 Aerf--kgV-----------F---GNKNIPKiEARRYVNEDLLTHKQYQSVLKLAW-NyQIVKdlsilENFDNLVDDISd 281 yellow fever mo...
3ISM_A       146 RLTKTYSNVYVCT---GPL------------YLPHKE-----------DdgksyvkyevigaN------------T---- 183 fruit fly
XP_315045    275 VATQLNDTVDVYS---GVY------------DVLQLP-----------N-------------K------------Kgnlv 303 Anopheles gambi...
XP_001653477 285 VASLLQEDVLVIQgsfGVL------------SLPNDA-----------N-------------Q------------S---- 312 yellow fever mo...
XP_001663220 212 MAAQLNDTVKVFT---GVY------------DVLTLP-----------D-------------V------------Ngrpv 240 yellow fever mo...
XP_001653475 249 TAIALHEDLVIIQ---GTD------------GILTLP-----------H-------------E------------Dgrqi 277 yellow fever mo...
XP_001663225 234 LAQNAKKTLEIYT---GVYdtlslcslwdhcPEFTLS-----------N-------------G------------R---- 270 yellow fever mo...
NP_996301    248 ----QKDVLNVCT---GAL------------GVLDLL-----------N-------------R------------Sqksv 272 fruit fly
NP_001034074 244 SVTGN-NFVNVRT---GAR------------GVLSLPsgnrpknvflsG-------------N------------R---- 278 fruit fly
NP_610558    253 QIPKS-SYFRVKS---GGI------------GILTLP-----------D-------------T------------Rgflq 280 fruit fly
XP_001653754 282 LDAK---EVEIYT---GAH------------GVLSLK-----------D-------------KnnhnvdvylkdnR---- 315 yellow fever mo...
3ISM_A       184 ---------VA---------VPTHFYKVIVGESA-DHKL-HMESYVMP-NQV--ISNDTPIS-V-F-QVPPESVE-R--- 233 fruit fly
XP_315045    304 slslgddgvVP---------VPKWLWKAVVHR-PsNKGI-VLITLNNP-FAT--SAET--LC-EdI-CSRYGWNQ-K--- 361 Anopheles gambi...
XP_001653477 313 ---------IAislsaagldVPLWMWKILKSP-SkNAGI-AFVTLNNP-YET--KKPDELLCtN-V-CERYGWTE-Q--- 372 yellow fever mo...
XP_001663220 241 pitlaeddqVE---------APKWLWKILHHS-AsNSAI-AFATLNNP-FVT--SGDQ--LCnN-I-CNRYGWAQ-Q--- 298 yellow fever mo...
XP_001653475 278 pi-tledggIE---------APRWIWKIIKSPKl-DAGI-AFVTSNNP-FETa-IHPMDFICvD-V-CGETGWAQ-Defa 340 yellow fever mo...
XP_001663225 271 ---------IP---------VPKWLWKVVKSPDl-NAAI-ALVVSNNP-FVG--ENPICGLNgashgwnssivsnitygt 327 yellow fever mo...
NP_996301    273 si-ylapnkNP---------VPRWTYKIIRSLTTgIKYV-ILTSNNGW-ETQ--QPNPASVC-K-VtACPRTLNP-T--- 332 fruit fly
NP_001034074 279 ---------NP---------VPQWMYKIV--RNAnNQPIvAFLTLNNI-YARq-RPAAPNFC-QpV-NCPVALVNtA--- 331 fruit fly
NP_610558    281 sa-flagskIP---------VPEWTYKAVRD-ATgNGLY-VFLTYNSTfQME--KPPCLAIC-YpV-NCPIHLPN-Np-- 341 fruit fly
XP_001653754 316 ---------FP---------VPKFHWTVVRSEs---kAV-AFAVFNKA-QLTdaEREKDSFC-NsI-CDQLTWIS-T--- 366 yellow fever mo...
3ISM_A       234 --SA-----G----------LLFFDQINR 245 fruit fly
XP_315045    362 --EFqdlrkG----------FTYCCSVSE 378 Anopheles gambiae str. PEST
XP_001653477 373 --DYnnftaG----------FTYCCDPND 389 yellow fever mosquito
XP_001663220 299 --EFqdlrrG----------YTICCTVRD 315 yellow fever mosquito
XP_001653475 341 nfAR-----G----------YTYCCDPNE 354 yellow fever mosquito
XP_001663225 328 vsyctvqdlqtvvgnipqeamapsilsfv 356 yellow fever mosquito
NP_996301    333 --GT-----G----------YTFCCDPID 344 fruit fly
NP_001034074 332 --QA-----G----------FSFCCNPAT 343 fruit fly
NP_610558    342 --ND-----G----------YTFCCDPKR 353 fruit fly
XP_001653754 367 --LR-----EnssysnpqlgYVLCCELNE 388 yellow fever mosquito
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