1S4V,1CQD,1YAL,1PPO,1PBH


Conserved Protein Domain Family
Pept_C1

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smart00645: Pept_C1 
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Papain family cysteine protease
Statistics
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PSSM-Id: 214761
Aligned: 274 rows
Threshold Bit Score: 96.1126
Threshold Setting Gi: 302840830
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1S4V_A          2 VPASVDWRKKG---AVTS--VKDQG---QCGSCWAFSTIVAVEGINQIKTNk-----LVSLSEQELVDCDTd--QNq--- 63   castor bean
Q9XZI2         67 LPIAFDWRNKDg--VNYAgvDRNQHiprYCGSCWAFGSTSALADRFNIKRKna--wpQVYLSVQEVIDCGGq--GS---- 136  dog roundworm
P91771         66 LPVAWDWRNINg--VNYAsvDRNQHipqYCGSCWAFGSTSALADRFNIKRKga--wpPAYLSVQEVIDCANa--GS---- 135  Onchocerca vo...
O28333        594 LPSRFDWRDYTg--LSa---VRDQGs---CGSCWAHSAVAALESALIVESGas---sSIDLSEQHLLSCEQd--CEvgig 660  Archaeoglobus...
XP_002951961  211 LYPVWDSRSVNg--SNYIspVKDQG---GCGSCVAFAVTGAAEAAVAAARKtt--vnSNDYSEQWLFFCNGmssa----- 278  Volvox carter...
2123443A      218 LPLEFDWTSPPdgsRSPVtpIRNQGi---CGSCYASPSAAALEARIRLVSNfs---eQPILSPQTVVDCSPy--SEg--- 286  Schistosoma m...
AAC32040      222 LPKEFDWVNRPeglRSPVtpVRNQKt---CGSCYAFASTAAIEARIRLASRfr---lQPILSPQDIIDCSPy--SEg--- 290  Schistosoma j...
NP_496805     223 TEPTVDWRP-------FLkpILDQS---TCGGCWAFSMISMIESFFAIQgy-----nTSSLSVQQLLTCDTkvdSTygl- 286  nematode
NP_506318     221 LPTGWDWRNVSg--VNYCspTRNQHipvYCGSCWVFGTTGALNDRFNVARKgrwpmtQLSPQEIIDCNGKg--------- 289  nematode
2118248A      231 LPTSWDWRNVHg--INFVspVRNQAs---CGSCYSFASMGMLEARIRILTNns-----qTPILSPQEVVSCsqy------ 294  human
Q9XZI2         67 LPIAFDWRNKDg--VNYAgvDRNQHiprYCGSCWAFGSTSALADRFNIKRKna--wpQVYLSVQEVIDCGGq--GS---- 136  dog roundworm
P91771         66 LPVAWDWRNINg--VNYAsvDRNQHipqYCGSCWAFGSTSALADRFNIKRKga--wpPAYLSVQEVIDCANa--GS---- 135  Onchocerca vo...
O28333        594 LPSRFDWRDYTg--LSa---VRDQGs---CGSCWAHSAVAALESALIVESGas---sSIDLSEQHLLSCEQd--CEvgig 660  Archaeoglobus...
XP_002951961  211 LYPVWDSRSVNg--SNYIspVKDQG---GCGSCVAFAVTGAAEAAVAAARKtt--vnSNDYSEQWLFFCNGmssa----- 278  Volvox carter...
2123443A      218 LPLEFDWTSPPdgsRSPVtpIRNQGi---CGSCYASPSAAALEARIRLVSNfs---eQPILSPQTVVDCSPy--SEg--- 286  Schistosoma m...
AAC32040      222 LPKEFDWVNRPeglRSPVtpVRNQKt---CGSCYAFASTAAIEARIRLASRfr---lQPILSPQDIIDCSPy--SEg--- 290  Schistosoma j...
NP_496805     223 TEPTVDWRP-------FLkpILDQS---TCGGCWAFSMISMIESFFAIQgy-----nTSSLSVQQLLTCDTkvdSTygl- 286  nematode
NP_506318     221 LPTGWDWRNVSg--VNYCspTRNQHipvYCGSCWVFGTTGALNDRFNVARKgrwpmtQLSPQEIIDCNGKg--------- 289  nematode
2118248A      231 LPTSWDWRNVHg--INFVspVRNQAs---CGSCYSFASMGMLEARIRILTNns-----qTPILSPQEVVSCsqy------ 294  human
1S4V_A         64 --------GCN-GGLMDYAF-EFIKQR-GG--ITteANYPYEAydgtcdvskenapavsidgh-------------envp 117  castor bean
Q9XZI2        137 ---------CE-GGEPGGVY-QFAHEKgIP--He--TCNNYQArdgkctaynkcgscwpddcfsinnytlykvgdfgrvs 201  dog roundworm
P91771        136 ---------CE-GGEPGPVY-KYAHEFgIP--He--TCNNYQArdgtcssynkcgscwpgscfsiknytiyrvknygavs 200  Onchocerca vo...
O28333        661 dwcwassgDCD-GGWPHKAL-NFIINNgVP--De--SCFPYTAtngncgskcgdwedrtegavyr----------gkvss 724  Archaeoglobus...
XP_002951961  279 -----afpNCDsGWFATAAAkVVVTKN-IP--YEl-NY-PYTGsrgcalgspperr------------------------ 324  Volvox carter...
2123443A      287 ---------CN-GGFPFLIAgKYGEDf-gL--PQk-IVIPYTGedtgkctvsknctryyttdysyig------gyygatn 346  Schistosoma m...
AAC32040      291 ---------CD-GGFPYLVAgKHGED---FgfVEe-KCNPYTGvksgtcnkllgctryyttdyhyig------gyygatn 350  Schistosoma j...
NP_496805     287 -----anvGCK-GGYFQIAG-SYLEVSaAR--Da--SLIPFDLedtscdssffppvvptillfddgyis--gnftaaqli 353  nematode
NP_506318     290 --------nCQ-GGEIGNVL-EHAKIQgLV--Ee--GCNVYRAtngecnpyhrcgscwpnecfsltnytryyvkdygqvq 355  nematode
2118248A      295 ------aqgCE-GGFPYLIAgKYAQDFgLV--Ee--ACFPYTGtdspckmkedcfryysseyhyvg--------gfyggc 355  human
Q9XZI2        137 ---------CE-GGEPGGVY-QFAHEKgIP--He--TCNNYQArdgkctaynkcgscwpddcfsinnytlykvgdfgrvs 201  dog roundworm
P91771        136 ---------CE-GGEPGPVY-KYAHEFgIP--He--TCNNYQArdgtcssynkcgscwpgscfsiknytiyrvknygavs 200  Onchocerca vo...
O28333        661 dwcwassgDCD-GGWPHKAL-NFIINNgVP--De--SCFPYTAtngncgskcgdwedrtegavyr----------gkvss 724  Archaeoglobus...
XP_002951961  279 -----afpNCDsGWFATAAAkVVVTKN-IP--YEl-NY-PYTGsrgcalgspperr------------------------ 324  Volvox carter...
2123443A      287 ---------CN-GGFPFLIAgKYGEDf-gL--PQk-IVIPYTGedtgkctvsknctryyttdysyig------gyygatn 346  Schistosoma m...
AAC32040      291 ---------CD-GGFPYLVAgKHGED---FgfVEe-KCNPYTGvksgtcnkllgctryyttdyhyig------gyygatn 350  Schistosoma j...
NP_496805     287 -----anvGCK-GGYFQIAG-SYLEVSaAR--Da--SLIPFDLedtscdssffppvvptillfddgyis--gnftaaqli 353  nematode
NP_506318     290 --------nCQ-GGEIGNVL-EHAKIQgLV--Ee--GCNVYRAtngecnpyhrcgscwpnecfsltnytryyvkdygqvq 355  nematode
2118248A      295 ------aqgCE-GGFPYLIAgKYAQDFgLV--Ee--ACFPYTGtdspckmkedcfryysseyhyvg--------gfyggc 355  human
1S4V_A        118 endenallkavanqpvSVAIDAggSD-----FQFYSEG----VFTG--SCGTE---------LDHGVAIVGYGTti---- 173  castor bean
Q9XZI2        202 gidkmkaeifhngpiaCGIAAT--KA-----FEMYSGG----IYTEe-TS-EE---------IDHIIAVYGWGVdhd--- 256  dog roundworm
P91771        201 glhkmkaeiyhhgpiaCGIAAT--KA-----FETYAGG----IYNEr-TN-ED---------IDHIISVHGWGVdse--- 255  Onchocerca vo...
O28333        725 nvealkralichgplsVASENW--EHa----LLLVG-------YDDl-ST----------------ICTQKYGKs----- 769  Archaeoglobus...
XP_002951961  325 ----aeggfkdtaytdITQAKQ--HIrmygaVTSYFAvygdfFRWRasSPPYAwd--------gISALAG-YHQvlvvgy 389  Volvox carter...
2123443A      347 eklmqlelisngpfpvG-FEVY--ED-----FQFYKEG----IYHHt-TVQTDhynfnpfelTNHAVLLVGYGVdk---- 409  Schistosoma m...
AAC32040      351 edlmklelvkngpfpvG-FEVY--GD-----FLQYKSG----VYSHt-DIINNhhpfnpfelTNHAVLLVGYGIdn---- 413  Schistosoma j...
NP_496805     354 tmeqniedkvrkgpiaVGMAAG--PD-----IYKYSEG----VYDG--DCGTI---------INHAVVIVGFT------- 404  nematode
NP_506318     356 grdkimseikkggpiaCAIGAT--KKf----EYEYVKG----VYSEk-SD-LE---------SNHIISLTGWGVde---- 410  nematode
2118248A      356 nealmklelvhhgpmaVAFEVY--DD-----FLHYKKG----IYHHt-GLRDPfnp---felTNHAVLLVGYGTdsa--- 417  human
Q9XZI2        202 gidkmkaeifhngpiaCGIAAT--KA-----FEMYSGG----IYTEe-TS-EE---------IDHIIAVYGWGVdhd--- 256  dog roundworm
P91771        201 glhkmkaeiyhhgpiaCGIAAT--KA-----FETYAGG----IYNEr-TN-ED---------IDHIISVHGWGVdse--- 255  Onchocerca vo...
O28333        725 nvealkralichgplsVASENW--EHa----LLLVG-------YDDl-ST----------------ICTQKYGKs----- 769  Archaeoglobus...
XP_002951961  325 ----aeggfkdtaytdITQAKQ--HIrmygaVTSYFAvygdfFRWRasSPPYAwd--------gISALAG-YHQvlvvgy 389  Volvox carter...
2123443A      347 eklmqlelisngpfpvG-FEVY--ED-----FQFYKEG----IYHHt-TVQTDhynfnpfelTNHAVLLVGYGVdk---- 409  Schistosoma m...
AAC32040      351 edlmklelvkngpfpvG-FEVY--GD-----FLQYKSG----VYSHt-DIINNhhpfnpfelTNHAVLLVGYGIdn---- 413  Schistosoma j...
NP_496805     354 tmeqniedkvrkgpiaVGMAAG--PD-----IYKYSEG----VYDG--DCGTI---------INHAVVIVGFT------- 404  nematode
NP_506318     356 grdkimseikkggpiaCAIGAT--KKf----EYEYVKG----VYSEk-SD-LE---------SNHIISLTGWGVde---- 410  nematode
2118248A      356 nealmklelvhhgpmaVAFEVY--DD-----FLHYKKG----IYHHt-GLRDPfnp---felTNHAVLLVGYGTdsa--- 417  human
1S4V_A        174 dGTK-YWTVKNSWGPE-------WGEKGYIRMERGisdKEGLCGI-AMEASYP 217  castor bean
Q9XZI2        257 ssVP-YWIGRNSWGTP-------WGESGWFRVVTS---EYKH-AGsRynlkie 297  dog roundworm
P91771        256 sgVP-YWIGRNSWGTP-------WGENGWFRIVTS---EYKN-SSsKYNLKIE 296  Onchocerca volvulus
O28333        770 ----gCWILKNSWGVFsgfshdvWHEYGYAYIPYS---GFKYSDIkNGAYYVI 815  Archaeoglobus fulgidus
XP_002951961  390 nDIGsYWIVKNSWGTR-------WGDNGFIRISYS---A-NVGFMsGYVGSIi 431  Volvox carteri f. nagariensis
2123443A      410 lSGEpYWKVKNSWGVE-------WGEQGYFRILRG---T-DECGVeSLGVRFD 451  Schistosoma mansoni
AAC32040      414 sSNLpYWKIKNSWGQY-------WGEEGYFRILRG---S-DECGVqSIAIKFD 455  Schistosoma japonicum
NP_496805     405 --DD-YWIIRNSWGAS-------WGEAGYFRVKRT---PGKDPCQfYKYWSQA 444  nematode
NP_506318     411 ngVE-YWIARNSWGEA-------WGELGWFRVVTS---KFKDGQGdQYNMGIE 452  nematode
2118248A      418 sgMD-YWIVKNSWGTG-------WGENGYFRIRRG---TD-ECAIeSIAVAAT 458  human
Q9XZI2        257 ssVP-YWIGRNSWGTP-------WGESGWFRVVTS---EYKH-AGsRynlkie 297  dog roundworm
P91771        256 sgVP-YWIGRNSWGTP-------WGENGWFRIVTS---EYKN-SSsKYNLKIE 296  Onchocerca volvulus
O28333        770 ----gCWILKNSWGVFsgfshdvWHEYGYAYIPYS---GFKYSDIkNGAYYVI 815  Archaeoglobus fulgidus
XP_002951961  390 nDIGsYWIVKNSWGTR-------WGDNGFIRISYS---A-NVGFMsGYVGSIi 431  Volvox carteri f. nagariensis
2123443A      410 lSGEpYWKVKNSWGVE-------WGEQGYFRILRG---T-DECGVeSLGVRFD 451  Schistosoma mansoni
AAC32040      414 sSNLpYWKIKNSWGQY-------WGEEGYFRILRG---S-DECGVqSIAIKFD 455  Schistosoma japonicum
NP_496805     405 --DD-YWIIRNSWGAS-------WGEAGYFRVKRT---PGKDPCQfYKYWSQA 444  nematode
NP_506318     411 ngVE-YWIARNSWGEA-------WGELGWFRVVTS---KFKDGQGdQYNMGIE 452  nematode
2118248A      418 sgMD-YWIVKNSWGTG-------WGENGYFRIRRG---TD-ECAIeSIAVAAT 458  human
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