2HEK,3IBJ,1ZKL,3BJC,3GW7


Conserved Protein Domain Family
HDc

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smart00471: HDc 
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Metal dependent phosphohydrolases with conserved 'HD' motif.
Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
Statistics
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PSSM-Id: 214679
View PSSM: smart00471
Aligned: 135 rows
Threshold Bit Score: 30.7274
Threshold Setting Gi: 14601310
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HEK_A        47 AQHTRFEHSLGVYHI------TE------RICESLKv------kE------K---ELVKLAGLLHDLGHPPFSHTTEVLl 99
gi 71989276  419 vPYHNWSHAFAVTHF------CWltlrtdAIRRALSd------mE------R---LSLLIACLCHDIDHRGTTNSFQMQs 477
gi 6324936   262 nkfHNFRHAIDVMQA------TW------RLCTYLLk------dN------PvqtLLLCMAAIGHDVGHPGTNNQLLCNc 317
gi 193202333 482 VAYHNWAHGWSVAHA------MF------ATLMNSPdaf--tklE------A---LALYVSCLCHDLDHRGKNNAYMKTm 538
gi 119893544 376 VAYHNWRHAFNTAQC------MF------AALKAGKiqkrltdlE------I---LALLIAALSHDLDHRGVNNSYIQRs 434
gi 73988193  647 PPYHNWMHAFSVSHF------CY------LLYKNLEltnylediE------I---FALFISCMCHDLDHRGTNNSFQVAs 705
gi 66809777  484 NRYHNFTHAFDVTQT------VY------TFLTSFNaaqylthlD------I---FALLISCMCHDLNHPGFNNTFQVNa 542
3IBJ_A       440 pPYHNWMHAFSVSHF------CY------LLYKNLEl------tNyledieI---FALFISCMCHDLDHRGTNNSFQVAs 498
1ZKL_A        80 NPYHNAVHAADVTQA------MH------CYLKEPKlansvtpwD------I---LLSLIAAATHDLDHPGVNQPFLIKt 138
3BJC_A       613 vAYHNWRHAFNTAQCmfaalkAG------KIQNKLTd------lE------I---LALLIAALSHDLDHRGVNNSYIQRs 671
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HEK_A       100 p--------------rERShEDFTERVIKeTE--------------IYE-----------IL-----------KQdys-- 127
gi 71989276  478 lqktplsvlystegsvLERhHFAQTIKLLqQE--------------ECS-----------IL-----------ENlpaad 521
gi 6324936   318 esevaq---nfknvsiLENfHRELFQQLLsEH--------------WPQllsiskkkfdfIS-----------EAila-- 367
gi 193202333 539 stplas----iystsvMERhHFNQTVTILqqD--------------GHN-----------IL-----------KSlssed 578
gi 119893544 435 ehplaq----lychsiMEHhHFDQCLMILnsP--------------GNQ-----------IL-----------SGlsiee 474
gi 73988193  706 ksvlaal--yssegsvMERhHFAQAIAILntH--------------GCN-----------IF-----------DHfsrkd 747
gi 66809777  543 qtelsl---eyndisvLENhHAMLTFKILrnS--------------ECN-----------IL-----------EGlnedq 583
3IBJ_A       499 ksvlaal--yssegsvMERhHFAQAIAILnTH--------------GCN-----------IF-----------DHfsrkd 540
1ZKL_A       139 nhylat---lykntsvLENhHWRSAVGLLrESglfshlplesrqqmETQ-----------IG-----------ALilatd 193
3BJC_A       672 ehplaq----lychsiMEHhHFDQCLMILnSP--------------GNQ-----------ILsglsieeykttLKiik-- 720
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HEK_A       128 ---------------heDI--------ER---------LVritlgk-------pedeeE------------KLLSEIITG 156
gi 71989276  522 frtivntirevilatdiSA--------HLrkqeriktmISegyn----------pmsfD------------HRYLLMCLV 571
gi 6324936   368 --------------tdmAL--------HS---------QYedrlm---------henpM------------KQITLISLI 395
gi 193202333 579 ykktlslikhcilatdlAL--------FF---------SNkaklnvildnntfdinrqE------------HRLLTQAVM 629
gi 119893544 475 ykttlkiikqailatdlAL--------YI---------KRrgeffelimknqfnledpH------------QKELFLAML 525
gi 73988193  748 yqrmldlmrdiilatdlAH--------HL---------RIfkdlqkmae-------------vgydrtnkqHHSLLLCLL 797
gi 66809777  584 ykelrrsvvqlilatdmQN--------HF---------EHtnkfqhhlnnlpfdrnkkE------------DRQMILNFL 634
3IBJ_A       541 yqrmldlmrdiilatdlAH--------HL---------RIfkd-------------lqKmaevgydrnnkqHHRLLLCLL 590
1ZKL_A       194 isr------qneylslfRS--------HL---------DRgdl-------------clEdt---------rHRHLVLQMA 228
3BJC_A       721 --------------qaiLAtdlalyikRR---------GEffelirkn---qfnledpH------------QKELFLAML 762
                        250
                 ....*....|....*....
2HEK_A       157 EFGSDRMDYLRRDAYFCGV 175
gi 71989276  572 MTASDLSDQAKNFHNAKRI 590
gi 6324936   396 IKAADISNVTRTLSISARW 414
gi 193202333 630 MTGCDLVASAKPWNIQTET 648
gi 119893544 526 MTACDLSAITKPWPIQQRI 544
gi 73988193  798 MTSCDLSDQTKGWKTTRKI 816
gi 66809777  635 IKCGDISNIARPWHLNFEW 653
3IBJ_A       591 MTSCDLSDQTKGWkttrki 609
1ZKL_A       229 LKCADICNPCRTWELSKQW 247
3BJC_A       763 MTACDLSAITKPWPIQQRI 781
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