Conserved Protein Domain Family
Yos9_DD

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cd11745: Yos9_DD 
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C-terminal dimerization domain (DD) of Saccharomyces cerevisiae Yos9 and related proteins
Yos9 participates in the ER-associated protein degradation pathway that targets misfolded proteins for proteolysis. Yos9 is a component of the reductase degradation (HRD) ubiquitin-ligase complex, specifically part of the luminal submodule of the ligase. Yos9 scans proteins for specific oligosaccharide modifications, which are critical determinants of degradation signal. It has been shown to be involved in the degradation of glycosylated proteins and various nonglycosylated proteins. Yos9 functions as a homodimer where this domain is responsible for the self-association; it has an alphabeta-roll domain architecture, and is found at the C-terminus of the protein. The N-terminal portion of Yos9 which includes an MRH domain is required for binding to Hrd3p, another component of the HRD complex. The DD domain does not appear to be directly binding Hrd3p.
Statistics
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PSSM-Id: 213372
View PSSM: cd11745
Aligned: 13 rows
Threshold Bit Score: 138.575
Threshold Setting Gi: 74605816
Created: 6-Sep-2012
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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homodimer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:2YMA: Saccharomyces cerevisiae Yos9 DD domain homodimer interface, contacts at 4A
    View structure with Cn3D

cd11745 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd11745 is the only member of the superfamily cl17090
cd11745:Yos9_DD74693484238935480746058161561151603575221923597498962389414382YMA A746236543724652587461051434229988134376671574693484238935480746058161561151603575221923597498962389414382YMA A7462365437246525874610514342299881343766715
cd11745 Sequence Cluster
cd11745 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2YMA_A        14 YEPIFLGsGIYFLRPfn--------tdERDKLMVtdnams------nwdeiTETYYQKFGNAINKMLSLRlvSLPNGHIl 79
gi 156115160 273 YNPLFLGyGFYLLNPkissys-hdqfpSRSVLMYsgisnie----qnvdaiYRELYQRAGKAMTRMMYLKflTLPDGNPy 347
gi 357522192 276 YDPTFLGySFYLLTPksavi--nseikNRNLLMYtgavsky----asldelYAVLYQKASNAVSRMMFMKylLLPDNKPf 349
gi 372465258 268 YSPKFLGhGVYLLEPar--------enEMWALMYsddinn-----edngkvSRHVYENFGNAINKLIAQGllKAPDGSPm 334
gi 359749896 254 YKPTFLGnEVYLLEPydki-----sshNRTALMFtgnmss------hgsllEQKLDIKLANAISRMVFQHllLLPDGLPy 322
gi 342299881 259 YDPIFLGrSIYLLRPnal------gnnKKYKLMYsgplpsg----eswelpSEHLYKTFNTIFGRMMDLHllKDSDGSIa 328
gi 74610514  260 YDVSFVAnQVYFLLPmnn------snvDRALLMYtgnated---glemdpfPMEIYKKFIDVMNKMLGLGllSPPDGKPf 330
gi 238941438 258 YEPIFVGsDFYLLDPqtgs-----tddQRKVLLYsgkhkvk----dgfvesDAELYENIGSAFSRMLYQQl-LMPPGEPa 327
gi 343766715 264 FDPIFLGqSIYLLAPngk------nheKKANLMYteqlndp----siwdspTEVLYKAFTIAFSRVITLGllHFPDGSKl 333
gi 74623654  277 YEPIFLGsGIYFLRPfn--------tdERDKLMVtdnams------nwdeiTETYYQKFGNAINKMLSLRlvSLPNGHIl 342
gi 74693484  254 YKPTFLGhGFYHLAPhanl----thkeTTAMLMYhqqpipgn--eeddgtmDSAFIKHSTMAYMQLLEMGllNGPDGLPf 327
gi 238935480 254 YSPTFLGsGFYFLQErsnpkftgmrnnAASKLLYieelklsg-edaeldpsEKLFFDRAANAFQEIILKNlfPKSQNLPl 332
gi 74605816  256 YSATVLDhGIYLLKPkns-------akDRRQLMYhaaepldsqttlfeltvEERFIGDFISSLKKLIGSDfiQSPTGKSi 328
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1               # #              # # #       # # #           ##### 
2YMA_A        80 q-pGDSCVWLAEVVDMKDRFQTTLSLNILNSq--RAEIFFNktftfnedngNFLSYKI 134
gi 156115160 348 m-hGDRFTWISDVVDLNGKFITRMIFTIDEKd--VAEIKLDytlef-knfgNFVSYQR 401
gi 357522192 350 k-eGDEFTWVADLVNMEGNRVYTLTFHINERl--LVDIQKTegvqf-peigNFISYKR 403
gi 372465258 335 q-sGDQYAWISDIFDLEGNRVQKLRFAIADSr--QGELVIRnnlts-pldsNFEYYHK 388
gi 359749896 323 n-vDDKFAWMSEVLDSKGNFVTMVQFNLSST---LADIDINssief-kgpgNFVFFER 375
gi 342299881 329 e-iGDAFEWIADIVDTDGKFLSRFKVKESPNd--TLELLLFkslhs-gvdgNFISFQK 382
gi 74610514  331 d-vHDSYQWIGDIVDMHGNYLNRLRLDVDVNm--EATLIIDksinf-tgpnNFQWYFR 384
gi 238941438 328 yetGDEISWISDVVDLRGNYLTRLQFNLSSNa--LADISLSsgief-pesgNLLYHRQ 382
gi 343766715 334 e-nGDTFSWIAEIVDITGKPLSKIKVSTKHDg--SMELLIYkdlpl-ldvgNFEYYSK 387
gi 74623654  343 q-pGDSCVWLAEVVDMKDRFQTTLSLNILNSq--RAEIFFNktftfnedngNFLSYKI 397
gi 74693484  328 s-eEGNFTVYAKVIGFDGGLITVTRFQISHGe-vIIDHVVPevled-meqgNSEDYEQ 382
gi 238935480 333 t-iEDAFVWFVEVVDKRGDHLCILRVGVESG---IASISFDqsge---sglNFRGNAF 383
gi 74605816  329 k-pGDLFLWRAPVVDETGNLLFLIDLELNSAseaIGKVNNDasllnelpihNMVYFDS 385

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