3BXJ


Conserved Protein Domain Family
RasGAP_DAB2IP
?
cd05136: RasGAP_DAB2IP 
Click on image for an interactive view with Cn3D
Ras-GTPase Activating Domain of DAB2IP and similar proteins.
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP; also known as ASK-interacting protein 1 (AIP1)), is a member of the GTPase-activating proteins, down-regulates Ras-mediated signal pathways, and mediates TNF-induced activation of ASK1-JNK signaling pathways. The mechanism by which TNF signaling is coupled to DAB2IP is not known.
Links
?
Statistics
?
PSSM-Id: 213338
Aligned: 31 rows
Threshold Bit Score: 399.266
Created: 30-May-2007
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative RAS
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RAS interface [polypeptide binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #                                    # # 
3BXJ_A        154 RYQTMSILPMELYKEFAEYVTNHYrmLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRfmEREHLIF 233  Norway rat
33112297      525 RWQSVHILPLRAYDNLLETLCYNYlpLCEQLEPVLNVRDKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKl-DNDHLMF 603  Caenorhabditi...
XP_001945701  331 RFQSVDILPVQIYQEFLQYLRTDYktICEILEPVVGVKAKEDIATALVHVMQKENLAKEFLSDIVMMDIEKv-EDDRLTF 409  pea aphid
XP_002643464  144 RWQSVDVLPLRVYDRLSELLTYNYldLCQQLEPVLNVRDKEDFATSFVRVMYKQNCAVEYLADLVMAEIGKl-DNDNLMF 222  Caenorhabditi...
XP_002427120  308 RFQSVDILPLHVYQEFLDYICSDYrpLCELLEPVIGVKAKEDISTALVHIMQKQGLAKEFLSDVVMMDIDRi-DDERLMF 386  human body louse
ADY40192      381 RYQSVDILPMYMYDELLRFVRLRYlsLCLALEPLLGVRAKEDFATALVRIMHKQRMAKEFLCDLIMCEVDVl-DNEHLMF 459  pig roundworm
EGI71108      181 RFQSVDILPVQVYQEFLEYLKTDYasLCEKLEPVIGVKAKEDIATALVAVMQREKKAPQFLADLVMMDIHRi-DDERLTF 259  Panamanian le...
XP_003139493   32 RYQSVQILPMQAYTDLLTFMKQYYlsLCHVLEPTLSVKAKEDLATVLVRIMHKLHMAKYFLCDLIMSEVDVl-DNEHLMF 110  Loa loa
XP_002409009  271 RYQSMEVMPLASYDPFLQYLKQNFgeLCRLLEPVLGVRLKEEIATGLVSVMHRENMAREFLTELVMADLQEi-EDQHLTF 349  black-legged ...
CCD76009      875 HYQTVDILPIACYNQLKEFIKTKYldLIRNLEPKLSAKQKEELTSCFVNIFEKLPDLSVAEFLSVLLREDL--RKESMIF 952  Schistosoma m...

Feature 1         ## #  #   #                                                                     
3BXJ_A        234 RENTLATKAIEEYMRLIGQKYLKDAIGEFIRALyeseeNCEVDPIKCtas---------------slAEHQANLRMCCEL 298  Norway rat
33112297      604 RGNTLATKAMESFMKLVADDYLDSTLSDFIKTVlqcedSCEVDPQKLgnvs------------nsslEKNRALLMRYVEV 671  Caenorhabditi...
XP_001945701  410 RGNSLATKAMEAYLKLTGEKYLHETLSELVSNVmqtgfDCEVDPLKAgsa--------------snlAKQQANLRNAVET 475  pea aphid
XP_002643464  223 RGNTVATKSMESFMKLVASDYLEFTLRDFIMTVvacedSCEVDPQRLgnvp------------ssvlEKNRALLTRYVEV 290  Caenorhabditi...
XP_002427120  387 RGNSLATKAMEAYLKLTGDKYLQETLGGLVTHVlangqDCEVDADKMsns--------------aalQKQQQNLRSAVEM 452  human body louse
ADY40192      460 RGNSLATKAMEAYMKLVADEYLKETLGEFVKSIlesddNCEVDPLKMvann------------qatlERNRQHLTFNVEA 527  pig roundworm
EGI71108      260 RGNSLATKAMEAYLKLTGDRYLQETLGAVVRGAve-ggDCEVDPLKVasv--------------aalHKQQQNLRNAVEL 324  Panamanian le...
XP_003139493  111 RGNSLATKAMEAYMKLVADEYLQNTLGEFVKIMqqsdkDCEVDPLKManis------------vitlEKNRHQLVTNVKT 178  Loa loa
XP_002409009  350 RGNSLATKATEAYLKLLGDGYLHETLGGLVRDVlssseECEVGGWPS--------------------TGQWSTGTCSRYE 409  black-legged ...
CCD76009      953 RANSAGSKAMECYIKLVGTDYLRYVLGPVIDQLlvigdDFEIDPSRLgasndsstasnnrntlsvilERNRTALLKNVAM 1032 Schistosoma m...

Feature 1                                               #       ##  ##  #                     #  #
3BXJ_A        299 ALCKVVNSHCvfpRELKEVFASWRLRCAERGRe-DIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDE-QTSRTLTLIA 376  Norway rat
33112297      672 AWTKILNNVHqlpKNLRDVFSALRCRLEAQNRe-ALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP-TNARNLTLIA 749  Caenorhabditi...
XP_001945701  476 TWNRILSSHTsfpFELRECFTRFRERMNGSGRh-DISDNLISACIFLRFLCPAILSPSLFNITHEYPNE-KAARNLTLVA 553  pea aphid
XP_002643464  291 AWTKIINSVHmvpKILGKVFATLRLRLEAQNRg-EHAETIISSSIFLRFLCPAILSPSLFNLVAEFPSI-NNARNLTLIA 368  Caenorhabditi...
XP_002427120  453 AWSKIMSSHTyfpTELRECFATFKERLIEIGRe-DVSDNLISASIFLRFLCPAILSPNLFNITHEYPNE-KAARNLTLIA 530  human body louse
ADY40192      528 AWGKIVNSTSsfpLELRDIFDSLRRRLEQADRr-DLADTLISSSIFLRFLCPAILSPSLFNLVSEYPSG-SAARNLTLIA 605  pig roundworm
EGI71108      325 AWSRILSSHAhfpLELRECFRIFRERLADLGRe-DIADNLISASIFLRFLCPAILSPSLFNITHEYPNE-KAARNLTLVA 402  Panamanian le...
XP_003139493  179 AWSKILASTEifpIELREIFVTLRRRLEKVGRl-DLADTLISSSIFLRFLCPAILSPSLFNLISEYPSG-NAARNLTLIA 256  Loa loa
XP_002409009  410 HLKKSLLAILlcfRELRALFHAYRQRLSGGQReeELCDNLISGSIFLRFLCPAILSPSLFGLTPEYPDE-KAARSLTLIA 488  black-legged ...
CCD76009     1033 IWQRIESSQCklpKELRDVFTALALTIEETHGv-QSAAHLISSCLFLRFICPAIHGPVLFGLASSIPENnRISRNLTLIA 1111 Schistosoma m...

Feature 1         #  #   # #    ##                                                                
3BXJ_A        377 KVIQNLANFSKFtsKEDFLGFMNEFLELEWGSMQQFLYEISNLDtlt-------nssSFEGYIDLGRELSTLHALLwEVL 449  Norway rat
33112297      750 KTLQNLANFSKFggKEPHMEFMNEFVDREWHRMKDFLLRISSESksg-------pekNADAIVDAGKELSLIATYLeEAW 822  Caenorhabditi...
XP_001945701  554 KTLQTLANFTRFqgKENFMEFMNDFLEREAASMKSFLKIISSPVpngyst-pqdhstEFDGHIDLAKQLSILHTLLmECV 632  pea aphid
XP_002643464  369 KTLQNLANFSKFggKEPHMEFMNTFVDREWNRMHEFLLEISTESksvg------pdkSADAIVDAGKELSLIGSYLeEVW 442  Caenorhabditi...
XP_002427120  531 KTLQTLANFTRFqgKESFMEFLNDFLEKEALSMKNFLQLISSRVqkentshhnitstDFDGYIDLGKQLSILHTLLlECL 610  human body louse
ADY40192      606 KTLQTLANFTKFggKEHYMEFMNEFVTREWDNMHHYLMRISTAPprsdk---qsassEWDACVDLGKEISLLHSYLdEIW 682  pig roundworm
EGI71108      403 KTLQTLANFTRFqgKENFMEFMNDLLEREAPSMKNFLQLISSPLpkdap---tnnslEFDGYIDLGKQLSLLHALLrESV 479  Panamanian le...
XP_003139493  257 KTLQTLANFTKFggKEHYMNFMNEFVEHEWDNMHRYLMKISTPPannqr---nsgenDWNISVDIGKEVSLLHSYLdELW 333  Loa loa
XP_002409009  489 KTIQTLANFTRFggKEGFMEFMNDFVEKEWSTMKAFLKQISSPSpre-------smnRDTLCVDLGLELAQLQGLLrECL 561  black-legged ...
CCD76009     1112 KVLQNLANLTLFedKEIHMKALNSFIEPEIPTMYKFLRSVASNTdanyh---lstnsDCHEFIELGYEFAKLTQLLnHYV 1188 Schistosoma m...

Feature 1                                         
3BXJ_A        450 PQLSKEal----lkLGPLPRLLSDISTALRNP 477  Norway rat
33112297      823 TPLLQEkngn-khpLSNVKSVLSELAECKRRS 853  Caenorhabditis elegans
XP_001945701  633 EKISPVrl----qeVEKLHMILERIQLALAQP 660  pea aphid
XP_002643464  443 SPLLQEknl--nkpLGEVKQVLTELAEAKRRP 472  Caenorhabditis briggsae
XP_002427120  611 EKIAPVkl----akVEKLPRILERIRLSLTQP 638  human body louse
ADY40192      683 TEEVHEqavahdrsLEEVRKILSRLDMRRQGG 714  pig roundworm
EGI71108      480 ATVAPSsps---mpPSRLPEILDRISIALDQP 508  Panamanian leafcutter ant
XP_003139493  334 TPEIHEqaskygsqMAELRLILAKLRYIRMRS 365  Loa loa
XP_002409009  562 PQLEGKe------gEAALRGALDGAVPVRGRR 587  black-legged tick
CCD76009     1189 SKINITp------qIAELPDLLQNISELLNNQ 1214 Schistosoma mansoni

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap