1V7V,1V7X


Conserved Protein Domain Family
GH94N_ChBP_like
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cd11755: GH94N_ChBP_like 
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N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins
The glycoside hydrolase family 94 (previously known as glycosyltransferase family 36) includes chitobiose phosphorylase (EC:2.4.1.-). This N-terminal domain is involved in oligomerization and may play a role in catalysis, but it is separate from the catalytic domain [an (alpha/alpha)(6) barrel]. Chitobiose phosphorylase catalyzes the reversible phosphate dependent hydrolysis of chitobiose [(GlcNAc)2] into alpha-GlcNAc-1-phosphate and GlcNAc. In some organisms, ChBP may be involved in the production of GlcNac-6-phosphate in intracellular pathways.
Links
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Statistics
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PSSM-Id: 213071
Aligned: 29 rows
Threshold Bit Score: 415.865
Created: 15-May-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalyticputative
Conserved site includes 42 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic domain interface [polypeptide binding site]
Evidence:
  • Structure:1V7V: The N-terminal domain of Vibrio proteolyticus chitobiose phosphorylase contacts the C-terminal catalytic domain, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #### # #  ###       ####### ###### # #   ### # ####  #   # #     #              
1V7V_A         1 MKYGYFDNDNREYVITRPDVPAPWTNYLGTEKFCTVISHNAGGYSFYNSPEYNRVTKFRPNAt-FDRPGHYVYLRDDDSG 79  Vibrio proteoly...
YP_005845985   4 NKYGFFSKDGREFVITDPKTPRPWFNYMWNENYAGLISHTGGGFSYLETPRDNRLTRMRYNClpWDRPGRYVIVKDSESG 83  Ignavibacterium...
ZP_09551555    2 KRYGAFSEDKKEFVIKRPDTPLPWVNYISNGRYNGLISNTGGGFSFYLSPRDSRITRWRYNAlpVDRPGRYLYIRDEEDG 81  Caldithrix abys...
ADO77439       1 MKYGFFDDKNREYVIQRPDIPVSWTNYLGTKDFCTVISQNAGGYSFYKSAQHHRITKFRANSipLDRPGHYLYLRDQDDG 80  Halanaerobium p...
AEJ18457       1 MQYGYFDDERREYVITRPDIPVSWTNYLGVQDLCAVISHNAGGYLFYKNAQYHRITRFRPNGvpLDRPGHYVYIRDDDTG 80  Spirochaeta cal...
ADQ05847       1 MRYGYFDNQNREYVIERPDIPVSWTNYLGVKDMCTVISHNAGGYSFYKTPQYHRITRFRQNGvpLDRPGHYVYLRDDETG 80  Caldicellulosir...
AEF84583       1 MRYGHFDEQHREYVIDRVDVPVSWTNYIGLRDLCGVFNHTAGGYLFYKTPEYHRITRFRPNGvpMDRPGHYIYVRDDDTG 80  Treponema primi...
YP_003325642  11 TAYGRFDVDAHEYVVERPDVPVSWTNYLGTKDLCTVISHHGGGYSYYKSAQTGRITRFRQNGvpLDRPGKYVYLRDDDDA 90  Xylanimonas cel...
P77846         1 MRYGYFDEKAREYVITRPDTPTPWINYIGNGKYGGIVTNTGGGYSFHKDPQNRRITRYRYNNlpTDRPGRYIYVRDRLTG 80  Clostridium ste...
YP_002509718   1 MSYGYFDSENKEYVITNPRTPTPWINYIGGGNYGGIVSQTGGGYSFDGDPRFKRVLRYRYNSipEDQPGRYIYLRDIDNN 80  Halothermothrix...

Feature 1                                                     ####                               
1V7V_A        80 DYWSISWQPVAKSLDe-----------------------aQYQIRHGLSYSKFQCDYNGIHARKTLFVPKGEDAEIWDVV 136 Vibrio proteoly...
YP_005845985  84 KYWSLSWAPTIDKKYd------------------------LYECHHGQGYTTIITEKNKIRGEITYFVPTDLNGEIWKVK 139 Ignavibacterium...
ZP_09551555   82 HYWSPTWQPTETALD-------------------------FYECRHGVYYTTIQSEYRKLRHEITYFVPLDDDLEIWRVR 136 Caldithrix abys...
ADO77439      81 DYWSISWQPVAKNLNq-----------------------aNYEVRHGLSYSKFKCDYKDLKAEKTIFVPLADDLEIWDFK 137 Halanaerobium p...
AEJ18457      81 EYWTISWQPVGKDISv-----------------------aRYQVRHGLSYSVFSCDYQDIRAQQTLFIPLDDPVELWDVV 137 Spirochaeta cal...
ADQ05847      81 DYWSISWQPVGKSLSi-----------------------aKYVCRHGLSYSKFICDYNNIHAEQWLFIPLDDAVEIWDVR 137 Caldicellulosir...
AEF84583      81 EYWTLSWQPVGKKFAlplgdpsgdpseapstaavpgpdeaVYTCRHGLSYSTYQCQYQGISGEQTLFIPLDDPAELWDLR 160 Treponema primi...
YP_003325642  91 DFWSVSWQPVGKPFVgpddavp------------ldgsagRWTAAHGTGYTRFSSSYRGIDATQTVFVPLDDDAEVWDVR 158 Xylanimonas cel...
P77846        81 EYWNPGYQPVQRKLD-------------------------SYRCRHGMGYTVLEGEYKGIAADVTYFVPDDRDFEIWLVQ 135 Clostridium ste...
YP_002509718  81 NYWSATWQPVKADFD-------------------------EYVCRHGLGYTTIEQKKDDIVTSVTYFVPGNESLEIWQLN 135 Halothermothrix...

Feature 1                               ##                                                       
1V7V_A       137 IKNTSDQVRTISAFSFVEFSFsHIQSDNQ-NHQMSLYSAGTAYRP---GLIEYDLYYNTdd----------feGFYYLAS 202 Vibrio proteoly...
YP_005845985 140 LTNLSSRKRKLEVYSFTELLM-GNALNDIiNQPNDKHFTDIHFNKeheTLLCTRRYWVLnrkvtva-qpnidwRYNLLFT 217 Ignavibacterium...
ZP_09551555  137 LENKNDRTIKLNLFAFVELCL-GHALVDLiNQPNDQHFNEVFFNRqkqILFASKRYWVRyqgatvkqaneawdRYVFMAS 215 Caldithrix abys...
ADO77439     138 IKNEGALDRNLSLFSYLEFSF-HEIDIDNqNFQMSLYAAGSSYQD---GIIEYDFYYDPr-------------KYHYFTA 200 Halanaerobium p...
AEJ18457     138 LENTGSKVRNLSVFSYCEFSFnHIDIDNQ-NFQMSLYCSGSSYHE---GIIEIDQHYNPd-------------GFHFFTS 200 Spirochaeta cal...
ADQ05847     138 VKNTGISRRKLSIFTYAEFSY-HHIEIDNqNLQMSLYASGSSYKD---GIIEYDFFYIPd-------------MYHFFAS 200 Caldicellulosir...
AEF84583     161 LTNNSPRKRKLSIFGYAEFSF-HHIEFDNqNFQMSLYSSGSSYQD---GIIEVELFYEDg-------------GFQFFTL 223 Treponema primi...
YP_003325642 159 LTNTTDRTRSITVTGYVEFSF-HTITVDNqNLQMSLYSQGADYAD---GVVEVDAYYEPw-------------TFHYFTS 221 Xylanimonas cel...
P77846       136 IRNLCHVERNLQVFSYAEFCF-WDAIMDQqNVDWVQQINQGRYED---RLITWHPHHFKd-------------ACAFFAT 198 Clostridium ste...
YP_002509718 136 VKNLGEETRHLSLYTYAEFSF-FDAVKDQqNVDWTQQIQQGEFED---NILFWNAFMKNw-------------EYIFMTS 198 Halothermothrix...

Feature 1                                                                                        
1V7V_A       203 Tf------DPDSYDGQRDRFLGLYRDEANPlAVEQGRCSNSAQTCYNHCGSLHKQFTLQPGEEIRFAYILGIGk-----g 271 Vibrio proteoly...
YP_005845985 218 Tt-----lPVSGFDGSLDNFIGRWRSEANPiSVETGKMSNTEITAGDPIAALQSKITLDKKSEIEFAVIMFVVskdeknp 292 Ignavibacterium...
ZP_09551555  216 Sl------PVIGWDGSKNSFIGRWRSESNPlAVERGACANSEITAGDAVGVLQMNVNLAPGQSADFAVLLGVVarhnfeq 289 Caldithrix abys...
ADO77439     201 Df------QADSYDCLRDKFIGDYRSEANPiALVRGICSNSSKKGGNHCAALNKEFNLAAGEEKRFILILGVGkr----e 270 Halanaerobium p...
AEJ18457     201 Sv------EADGFDAVRDSFIGPYRTETNPlAVERGVCSGSTELGGNHCGVLYKRLQLSGGASARLVFLLGDGnr----q 270 Spirochaeta cal...
ADQ05847     201 Nf------EPDSFDCVRDIFIGNYRTETNPiAVEKGMCSNSEDLTGNHCASLHKRFILEPGEEKRFIFMLGVGdr----n 270 Caldicellulosir...
AEF84583     224 AdnaagsdEADSYDCLRDRFIGPYRSESNPlAVERGYCSGSSELGGNHCGALQRKITLEPGEAYRTIFILGEGsr----k 299 Treponema primi...
YP_003325642 222 Agpd--gaEADSFDTLRDAFIGSYRDESDPlAVSVGQGSGSQGTTQNHCGALAHRVTLAPGETVRLSFVLGYGsr---da 296 Xylanimonas cel...
P77846       199 Na------EINSFDTNLEAFIGRYRCESNPiAVETGACSNSVSYRMNGVGAFCIDVNLKPGEEREIIFILGFTe------ 266 Clostridium ste...
YP_002509718 199 Si------QVTSYETSRERFVGCYRDLSNPiAVEESNCSNYLAQRGNGVGCLNHEIKLEPGCEKEIIYILGTTps---kq 269 Halothermothrix...

Feature 1                             
1V7V_A       272 NGERLREHYQDVANIDAAFAA 292 Vibrio proteolyticus
YP_005845985 293 FKASQLKQLKEIKTIDKKFEA 313 Ignavibacterium album Mat9-16
ZP_09551555  290 DGVAIVQKYRDMEMVDAELKR 310 Caldithrix abyssi DSM 13497
ADO77439     271 KAQKMRKKYSDFNLVDKEFNK 291 Halanaerobium praevalens DSM 2228
AEJ18457     271 TGAALRKKYSNVSVVDQAFQA 291 Spirochaeta caldaria DSM 7334
ADQ05847     271 KGREIKEKYSKFENVDNSFYE 291 Caldicellulosiruptor hydrothermalis 108
AEF84583     300 TGAAIRKKYRDFKAVDAAFAA 320 Treponema primitia ZAS-2
YP_003325642 297 VGRAMRVKYADPDVVDREHAA 317 Xylanimonas cellulosilytica DSM 15894
P77846       267 NKSTIRDEIRDYLNVEYAKEA 287 Clostridium stercorarium
YP_002509718 270 TVKEKISSFLDPEQVEQEKEG 290 Halothermothrix orenii H 168

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