Conserved Protein Domain Family
CE4_NodB_like_5s_6s

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cd10918: CE4_NodB_like_5s_6s 
Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands
This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.
Statistics
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PSSM-Id: 213023
View PSSM: cd10918
Aligned: 315 rows
Threshold Bit Score: 65.6954
Threshold Setting Gi: 15597636
Created: 31-May-2011
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
putative activeputative metal
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on similarity to other CE4 superfamily members

cd10918 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd10918 is a member of the superfamily cl15692.
cd10585:CE4_SFcd10916:CE4_PuuE_HpPgdA_likecd10917:CE4_NodB_like_6s_7scd10918:CE4_NodB_like_5s_6scd10919:CE4_CDA_likecd10920:CE4_WbmScd10921:CE4_MJ0505_likecd10922:CE4_PelA_like_Ccd10923:CE4_COG5298cd10924:CE4_COG4878cd10925:CE4_u1cd10926:CE4_u2cd10927:CE4_u3cd10928:CE4_u4cd10929:CE4_u5cd10930:CE4_u6cd10931:CE4_u7cd10932:CE4_u8cd10933:CE4_u9cd10934:CE4_cadherin_MopE_like_Ncd10935:CE4_WalWcd10936:CE4_DAC2cd10938:CE4_HpPgdA_likecd10939:CE4_ArnDcd10940:CE4_PuuE_HpPgdA_like_1cd10941:CE4_PuuE_HpPgdA_like_2cd10942:CE4_u11cd10943:CE4_NodBcd10944:CE4_SmPgdA_likecd10946:CE4_Mll8295_likecd10947:CE4_SpPgdA_BsYjeA_likecd10948:CE4_BsPdaA_likecd10949:CE4_BsPdaB_likecd10950:CE4_BsYlxY_likecd10951:CE4_ClCDA_likecd10952:CE4_MrCDA_likecd10953:CE4_SlAXE_likecd10954:CE4_CtAXE_likecd10955:CE4_BH0857_likecd10956:CE4_BH1302_likecd10958:CE4_NodB_like_2cd10959:CE4_NodB_like_3cd10960:CE4_NodB_like_1cd10962:CE4_GT2-likecd10963:CE4_RC0012_likecd10964:CE4_PgaB_5scd10965:CE4_IcaB_5scd10966:CE4_yadE_5scd10967:CE4_GLA_like_6scd10968:CE4_Mlr8448_like_5scd10969:CE4_Ecf1_like_5scd10970:CE4_DAC_u1_6scd10971:CE4_DAC_u2_5scd10972:CE4_DAC_u3_5scd10973:CE4_DAC_u4_5scd10974:CE4_CDA_like_1cd10975:CE4_CDA_like_2cd10976:CE4_CDA_like_3cd10977:CE4_PuuE_SpCDA1cd10978:CE4_Sll1306_likecd10979:CE4_PuuE_likecd10980:CE4_SpCDA1cd11374:CE4_u10754235211266622062701581683251039553259548073007754752555355363205495153223711852895829203007097153007120203007112002841654462926537523007099403205491873353376983007114222841640182841635452895815662263125243259586493043779203299452263025548863011668372263576542838508352895829173223712832840157863007096943093897377072675514629973822091353921896171732596166510846258625865336581534933839455502737535416265082158878291961849712542943231463016551266635852821634421491776533247174420091170282163442336304641255037258753435109002032433266802411433557125429472718241372425444324533630417788859141262199408324774423362996593132044961106376453252875162614163622889212481242662542962688651624523772209142901199523102209142913108228721084670631590420172975268802960948983259685833197529813075946021609017182181328488153118628135760233629964822515591226136680486134431858594262813564312248037562813582652813575072813574938331054032472604313204794261368347332298851833091432301605028945097325682567428403952331320319432510364232739825422943493413404629214917439716388385429478336121853190122982782030266979033864974295132980299821794315931429218886938783582901266967731683335072585910101106397083428273693097928312809778553128873271491955875941041128135820533960876233612053481623326256395521325968603149923468302342150288817627159898119332701196311895046120554560192361787310820953861590641710597502983311322393551329716394628498903932888286233485785232500243581779637209550527220907146306982095288941242221369680332525275326385985223935528163748111331695719145294072170751006338739634331695731297569733307592142118471621212234263118946993201021452437608971146157315016525219679163311695010307721111783626526763333326222509814489763046201112118414953152991581149194778959295003273982649426417815736376831711420525560603530324861419623089018773610517191249025553377831189947912043635233774880585709072125972699295098986150389401310658764188585073269836362149279947226225857257056441284031753169335859159896613262196133257386954712779843422150343339757482915332021215333403252898372196696331885869897822323019321420712451472781547908890918981798788633596345300710061189218360223890744196228063221635506269839349334132928867402851583127093394826592376539072971648838674029222622852621853292325851620332739876612153584932053003929153412511986283690407054206601998294340203782232205380264439997056163801938120554555323277042218130532187922858288960432336296433197045771971386781545527197045791541495083235194092376544242196759322574613681872516542839521421872510351482643823020381671194780708879709714937518083645515116624495294338715335420743332701899283851873285808302332668596313122376254515067218960993298527767150006712343083433414070691493751691194780731624553019001980588797100333810780241203382399378433231386481885808893079452378177610425446973823983271515891101338821367328545529273814161707430833289478261962301863131437873201245792951121321452060433993582127380081146341155115524853222056035320352483251775927780436913043122101571639337745824292112375155976367804496828498901428378160117074149031711603114917847329612094533169571833389220725709303228385186771146691302344522319750304242146982535685833247466315000882726979709733270924622090714834308342128403734825553192312199833630248851239996841319945131163753820297569713262201059284046742336304326262198986162455568220935541299137777323141690912009433427326952943402001245159363340987972563976043405238463263338571166268342991377641500072182556925502698380432956975438163769130287352881533680335350351334882112815385903199936872982455622840416072821087781531140183093662820999681529910254519570815325502568221503291212753128978003339759553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cd10918 Sequence Cluster
cd10918 Sequence Cluster
Sub-family Hierarchy
 cd10918 Branch
 Whole Hierarchy
 [Download CDTree]
CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ##                                                                        
gi 81534933   42 MVSFSFDDAPatACEAGARALEArglRGTYYFAAgltgrd---------------------------------------- 81
gi 320352483  91 AVLLTFDDGLrnNYTVAWPILRArkiPATVFLTVdyigghrllwpdelyllvknahenaqalpepfaslclqtetvw--- 167
gi 320125561  74 LFSLTFDDGWkdNYANAFPVLLKhnvPALMFIATeavesgslfwtediatktqrrlselgcaavkdsliasfpeikglrm 153
gi 77458242   90 QVALTFDDGWrdNAANAFPLLQKhqvPASIFLSTdfigsrqrfwwesigetlwgshgekarthlieclraagqplpvl-- 167
gi 251775927  94 AALITFDDGIrnNFSVAFPHLVElglPASIFLTVdlvgsrdmlwfdelyllmqegmrlgiqldlmgeaangcyrnrdl-- 171
gi 75343728   62 SVMLTFDDGYldNWLRAWPVLKEynlHAHIFLITgligkgnvrsrqeqeys----------------------------- 112
gi 283781601 124 VFVVTFDDGYenNFTEAFPILCElevPATIFLATayldtqdpfpsddwe------------------------------- 172
gi 304312210  90 FACLTFDDGGqdNYLYAWPQLKSqkiPASIYLSAghirrdlpfwwlrlgdafaeaqnnaeaqarlkqalesitpn----- 164
gi 92112375   89 RIALTFDGGWrdTAEVALRQLERlalPASMFLTTgwvnrargdwwntlgdalwegiqparvrdclgdaglplpparpa-- 166
gi 15597636   82 RIALSVDGNPaeLAEQVYPLLERyemPASAFIGGdprswreavaetlwqadataagpllellegysgaalmavfer---- 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #    #        
gi 81534933   82 -----------------------------------------gpmgryATGEDARRLHEa-GHEIACHTYs-HLdcgq--- 115
gi 320352483 168 -----pryailvealkrmdddqrqqamdalrratplpdhahcedftlLNWQEVDTMHRdgLMDFGVHTAs-HIilsr--- 238
gi 320125561 154 gtdesvlaatqmwieklklvppldrkklvndyysrvgadpqplqgfiLDWGEMKEMLNh-KVSFGSHTHq-HViled--- 228
gi 77458242  168 ----lddidvdrrsltllhylqslkaldpkilerltdecpqesqpqaLDWHQVRAMESsgLVRFGPHGAs-HAiltg--- 239
gi 251775927 172 ----wqayqlcvesvkhagaatrdsfierlrsqvpldkgpwledfglLDWEEVDEMRRsgLISFGVHTAt-HRilse--- 243
gi 75343728  113 ------------------------------hrdcerliadnrsdevmLRWSEVREMRDsgLVEFHVHTHs-HKrwdrlsv 161
gi 283781601 173 ---------------------------------lagddaqpidswrpLSTDQCREMQRsgLIELAAHTHt-HAdfrg--- 215
gi 304312210 165 -------psdfdsidrfmdfiytlseeqrnnltqilsphlpgshsvsLKLSEIQEMSAsgLIRFGAQTAs-HLplpl--- 233
gi 92112375  167 ----hpgtayshalrayleglahhtdpltlarlgdalgdeldippqtLDPFSIRRLESsgLVRFGARGVsaTPldal--- 239
gi 15597636  158 ------tgddqrrsrnldlllrklerldpasqqalhaacpvpapysaGDWERVRRLENsgLLRFGLRGQepHPsa----- 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          ###                                           
gi 81534933  116 ---ssqtETLADVDRNAESLAawg-agdPVSFAYPYGDVa-------aPAKTALSGrfkTLRALHHGLItdga------- 177
gi 320352483 239 ---iapgDLKKEIVWPKKRLEekl-gheVEAFCYPNGRSgidf-heehKTGLHQAGy-aCAFTTDHGLHamgt------- 305
gi 320125561 229 ---lpadQTEQELLRSKAVILekl-qfeADSFCYPNGRYsg-----keGKLLALAGy-kYGFCLDNKPLserk------- 291
gi 77458242  240 ---lddvRLSEEISRSSDALNngc-nrpLPVYCYPNGDNde-----rvREQVANHDy-pFALGTGTGLYrgtg------- 302
gi 251775927 244 ---lqehELVAEVAQAREKMIsrt-gedVTSFCYPNGRPgedf-drrhQQFLRDCGy-rCAFTTKDELFdwrsg------ 311
gi 75343728  162 sraeqcrLMKEDILVGKQCLTekl-gfcSSHLCWPEGYYnr-----dyINLAGKLGf-sYLYTTERRMNcpengslrigr 234
gi 283781601 216 ----rpdALYEDLLINQQVLAerf-gitEATFAFPYGTRstgfsgpllAGAVKAAGl-sCALTTESELVfpts------- 282
gi 304312210 234 ---ldeaAAIADIRSGFAAVSalegvhfNRLFCYPNGAYdh-----rlMEQVESAGf-qGALTGFASYAsrqer------ 298
gi 92112375  240 ----ddaQVQWQIRQSRRQLGvlc-rdpLPGFAYPQAEAsp-----rvRLLAQRCGi-qEGLHGHAGWLshrd------- 301
gi 15597636  227 -----glCAEDCLGRAHRQLQqhc-aapLPVFCQARTTPaaq---pglRAALGRLGy-rFAFGARNGLVdtrc------- 289
                        250       260
                 ....*....|....*....|
Feature 1                            
gi 81534933  178 -------dlnqTPAVGIEGE 190
gi 320352483 306 -------dpfaIKRIAAGND 318
gi 320125561 292 -------skhyIPRVLVSEQ 304
gi 77458242  303 -------dplnLPRFGVSQR 315
gi 251775927 312 -------epmgIGRVPAGND 324
gi 75343728  235 istkerehsgwLKRRLFYYT 254
gi 283781601 283 -------dpfdWGRFTAEEH 295
gi 304312210 299 -------erfcLPRVNVSDS 311
gi 92112375  302 -------dplaLPRFPITLP 314
gi 15597636  290 -------dpldLPRIEVDAA 302

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