2AL7,1ZD9


Conserved Protein Domain Family
Arl10_like

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cd04159: Arl10_like 
Click on image for an interactive view with Cn3D
Arf-like 9 (Arl9) and 10 (Arl10) GTPases
Arl10-like subfamily. Arl9/Arl10 was identified from a human cancer-derived EST dataset. No functional information about the subfamily is available at the current time, but crystal structures of human Arl10b and Arl10c have been solved.
Statistics
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PSSM-Id: 206724
Aligned: 18 rows
Threshold Bit Score: 213.719
Threshold Setting Gi: 50310361
Created: 23-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:2AL7: Human Arl10 binds GDP and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ######                                                                  
2AL7_A     24 ELTLVGLQYSGKTTFVNVIASg------------qFSEDMIPTVGFNMRKVTKGn-VTIKIWDIGGQPRFRSMWERYCRG 90  human
AAM48037   21 ELSLIGLQNAGKTSLVNVVATg------------gYSEDMIPTVGFNMRKVTKGn-VTIKLWDLGGQPRFRSMWERYCRA 87  thale cress
XP_455200  25 SIAVVGLQNSGKTTFTNLIAGe------------eFVVDTIPTLGVNIKDVKLPnhTNLKVYDLAGQTRFQKLWDRCFQQ 92  Kluyveromyces lact...
XP_503834  21 DITLLGLQNAGKTSLLKAICGs------------dFTPDSIPTVGFAMKRVKVGr-VTLKCWDLGGQPRFRSMWERYCRG 87  Yarrowia lipolytic...
AAW43884   22 EVTIVGLQASGKTSLVNVLGSd------------qWSEDVVPTVAFNLRQVRKGn-VTMKIWDVAGQPKFRGMWDRYCRG 88  Cryptococcus neofo...
XP_639087  21 ELTLVGLQGSGKTTLVNVISNg------------gFIEDTIPTIGFNMKKVTKGn-VTIKLWDIGGQPRFRSMWERYCRG 87  Dictyostelium disc...
EAL88680    2 DVTMIGLQNAGKSSLLRVLAGlattglslswfakpCIYSSIPTIGFNTKRVQKGh-VTLKCWDLGGQPRFRPMWERYCRG 80  Aspergillus fumiga...
XP_661538   1 MAGIFRTIYDWLLRMFWATEMd------------vTMIGLQNAGKSSLLRVLAGg-EFTIDWDLGGQPRFRPMWERYCRG 67  Aspergillus nidula...
XP_757689  28 EICVVGLQAAGKTSLVNLLSSg------------qFADEMVPTVGFNMRKVRSGn-TTIKVWDIGGQPRFRSMWERYCRG 94  Ustilago maydis 521
XP_810889  21 EVTLVGLQGAGKTTFLAAITDgte---------svRLHDTIPTIGLNTRKVTRGn-VCIKVWDIGGQPRFRGMWERYCRG 90  Trypanosoma cruzi
AAM48037   21 ELSLIGLQNAGKTSLVNVVATg------------gYSEDMIPTVGFNMRKVTKGn-VTIKLWDLGGQPRFRSMWERYCRA 87  thale cress
XP_455200  25 SIAVVGLQNSGKTTFTNLIAGe------------eFVVDTIPTLGVNIKDVKLPnhTNLKVYDLAGQTRFQKLWDRCFQQ 92  Kluyveromyces lact...
XP_503834  21 DITLLGLQNAGKTSLLKAICGs------------dFTPDSIPTVGFAMKRVKVGr-VTLKCWDLGGQPRFRSMWERYCRG 87  Yarrowia lipolytic...
AAW43884   22 EVTIVGLQASGKTSLVNVLGSd------------qWSEDVVPTVAFNLRQVRKGn-VTMKIWDVAGQPKFRGMWDRYCRG 88  Cryptococcus neofo...
XP_639087  21 ELTLVGLQGSGKTTLVNVISNg------------gFIEDTIPTIGFNMKKVTKGn-VTIKLWDIGGQPRFRSMWERYCRG 87  Dictyostelium disc...
EAL88680    2 DVTMIGLQNAGKSSLLRVLAGlattglslswfakpCIYSSIPTIGFNTKRVQKGh-VTLKCWDLGGQPRFRPMWERYCRG 80  Aspergillus fumiga...
XP_661538   1 MAGIFRTIYDWLLRMFWATEMd------------vTMIGLQNAGKSSLLRVLAGg-EFTIDWDLGGQPRFRPMWERYCRG 67  Aspergillus nidula...
XP_757689  28 EICVVGLQAAGKTSLVNLLSSg------------qFADEMVPTVGFNMRKVRSGn-TTIKVWDIGGQPRFRSMWERYCRG 94  Ustilago maydis 521
XP_810889  21 EVTLVGLQGAGKTTFLAAITDgte---------svRLHDTIPTIGLNTRKVTRGn-VCIKVWDIGGQPRFRGMWERYCRG 90  Trypanosoma cruzi
Feature 1                                                                                     
2AL7_A     91 VNAIVYMIDAADRe------------------------------------------------------------KIEASR 110 human
AAM48037   88 VSAIVYVVDAADPd------------------------------------------------------------NLSVSK 107 thale cress
XP_455200  93 VDLLVFMIDLSDLt------------------------------------------------------------NWEQAK 112 Kluyveromyces lact...
XP_503834  88 VNAVVFILDSADPs------------------------------------------------------------TFDTAK 107 Yarrowia lipolytic...
AAW43884   89 ADAIIYVVDAADHh------------------------------------------------------------SIPTAT 108 Cryptococcus neofo...
XP_639087  88 VNAIVFVVDSADRe------------------------------------------------------------KFEQSK 107 Dictyostelium disc...
EAL88680   81 VNAIVYIVDAADRa------------------------------------------------------------ALPVAT 100 Aspergillus fumiga...
XP_661538  68 VNAIVYIVDAADRa------------------------------------------------------------ALPVAT 87  Aspergillus nidula...
XP_757689  95 VSAIVFVVDSSVPlpsaksesggtstssavapitcsaaaaasatsttiaskpeassasaspsalvagqstqnsaAWSVAS 174 Ustilago maydis 521
XP_810889  91 VQSIVFVVDASDIs------------------------------------------------------------SFEEAR 110 Trypanosoma cruzi
AAM48037   88 VSAIVYVVDAADPd------------------------------------------------------------NLSVSK 107 thale cress
XP_455200  93 VDLLVFMIDLSDLt------------------------------------------------------------NWEQAK 112 Kluyveromyces lact...
XP_503834  88 VNAVVFILDSADPs------------------------------------------------------------TFDTAK 107 Yarrowia lipolytic...
AAW43884   89 ADAIIYVVDAADHh------------------------------------------------------------SIPTAT 108 Cryptococcus neofo...
XP_639087  88 VNAIVFVVDSADRe------------------------------------------------------------KFEQSK 107 Dictyostelium disc...
EAL88680   81 VNAIVYIVDAADRa------------------------------------------------------------ALPVAT 100 Aspergillus fumiga...
XP_661538  68 VNAIVYIVDAADRa------------------------------------------------------------ALPVAT 87  Aspergillus nidula...
XP_757689  95 VSAIVFVVDSSVPlpsaksesggtstssavapitcsaaaaasatsttiaskpeassasaspsalvagqstqnsaAWSVAS 174 Ustilago maydis 521
XP_810889  91 VQSIVFVVDASDIs------------------------------------------------------------SFEEAR 110 Trypanosoma cruzi
Feature 1                          ## ##                                                      
2AL7_A    111 NELHNLLDKPQLQGIPVLVLGNKRDLPNALDe------------------------------------------------ 142 human
AAM48037  108 SELHDLLSKTSLNGIPLLVLGNKIDKPGALSk------------------------------------------------ 139 thale cress
XP_455200 113 NKLHDVIIATNLEHVPILILGNKVDLIPKFHrdlyvaksdvsdqrssvensarkqtwnyvspllhnyeyedipkydlnpe 192 Kluyveromyces lact...
XP_503834 108 TELHSLLEKESMEGIPLLVLGNKNDIADAIPv------------------------------------------------ 139 Yarrowia lipolytic...
AAW43884  109 SELHALLNIPALASVPLLVLANKNDLHGAMGv------------------------------------------------ 140 Cryptococcus neofo...
XP_639087 108 QALQDLINKPPLAKIPLLVVANKNDLPNSAGv------------------------------------------------ 139 Dictyostelium disc...
EAL88680  101 EELHELMEKPSLDGIPLLVLGNKSDLPDKLSv------------------------------------------------ 132 Aspergillus fumiga...
XP_661538  88 EELHELMNKPTLDGIPLLVLGNKSDLPNKLSv------------------------------------------------ 119 Aspergillus nidula...
XP_757689 175 EELHALIERPHLSGVPLLVLATKNDIKGAARv------------------------------------------------ 206 Ustilago maydis 521
XP_810889 111 RSLHDLLGRPSLYGIPLLVLANKNDLEGACSa------------------------------------------------ 142 Trypanosoma cruzi
AAM48037  108 SELHDLLSKTSLNGIPLLVLGNKIDKPGALSk------------------------------------------------ 139 thale cress
XP_455200 113 NKLHDVIIATNLEHVPILILGNKVDLIPKFHrdlyvaksdvsdqrssvensarkqtwnyvspllhnyeyedipkydlnpe 192 Kluyveromyces lact...
XP_503834 108 TELHSLLEKESMEGIPLLVLGNKNDIADAIPv------------------------------------------------ 139 Yarrowia lipolytic...
AAW43884  109 SELHALLNIPALASVPLLVLANKNDLHGAMGv------------------------------------------------ 140 Cryptococcus neofo...
XP_639087 108 QALQDLINKPPLAKIPLLVVANKNDLPNSAGv------------------------------------------------ 139 Dictyostelium disc...
EAL88680  101 EELHELMEKPSLDGIPLLVLGNKSDLPDKLSv------------------------------------------------ 132 Aspergillus fumiga...
XP_661538  88 EELHELMNKPTLDGIPLLVLGNKSDLPNKLSv------------------------------------------------ 119 Aspergillus nidula...
XP_757689 175 EELHALIERPHLSGVPLLVLATKNDIKGAARv------------------------------------------------ 206 Ustilago maydis 521
XP_810889 111 RSLHDLLGRPSLYGIPLLVLANKNDLEGACSa------------------------------------------------ 142 Trypanosoma cruzi
Feature 1                                                 ###               
2AL7_A    143 ---------------------kQLIEKMNLsai-qdREICCYSISCKEKDNIDITLQWLIQH 182 human
AAM48037  140 ---------------------eALTDEMGLtsl-tdREVCCFMISCKNSTNIDQVIDWLVKH 179 thale cress
XP_455200 193 nqhvlskvevlskelgidlkhgLLHLPHDSkvk-lnRDIALFSVSCKDGTLIDTVIDWILEL 253 Kluyveromyces lactis NRRL Y-1140
XP_503834 140 ---------------------dKVIQTLGLkei-tdREVSCYSISVKEANNLSAVLKWLIAN 179 Yarrowia lipolytica CLIB99
AAW43884  141 ---------------------dDLIKEMRLgei-ggRAVSCYSTSNKTKHNLDIVLAWLTQR 180 Cryptococcus neoformans var. neoform...
XP_639087 140 ---------------------dEMIQNLDLrgi-vgREVCCYSISAKNSVNIDITLDWLIKH 179 Dictyostelium discoideum
EAL88680  133 ---------------------dELIDAMDLksi-trREVSCYGISAKEETNLDAVLHWLIAR 172 Aspergillus fumigatus Af293
XP_661538 120 ---------------------dDLIEQMNLksi-trREVSCYGISAKEETNLDAVLHWLIAR 159 Aspergillus nidulans FGSC A4
XP_757689 207 ---------------------dDVIRVMKLdti-anREVSCYSISSKNQVNIDVTLKWLVAR 246 Ustilago maydis 521
XP_810889 143 ---------------------eTLISELYLlklaadRETACYSVSAKDYTNIDVTLKWLMRH 183 Trypanosoma cruzi
AAM48037  140 ---------------------eALTDEMGLtsl-tdREVCCFMISCKNSTNIDQVIDWLVKH 179 thale cress
XP_455200 193 nqhvlskvevlskelgidlkhgLLHLPHDSkvk-lnRDIALFSVSCKDGTLIDTVIDWILEL 253 Kluyveromyces lactis NRRL Y-1140
XP_503834 140 ---------------------dKVIQTLGLkei-tdREVSCYSISVKEANNLSAVLKWLIAN 179 Yarrowia lipolytica CLIB99
AAW43884  141 ---------------------dDLIKEMRLgei-ggRAVSCYSTSNKTKHNLDIVLAWLTQR 180 Cryptococcus neoformans var. neoform...
XP_639087 140 ---------------------dEMIQNLDLrgi-vgREVCCYSISAKNSVNIDITLDWLIKH 179 Dictyostelium discoideum
EAL88680  133 ---------------------dELIDAMDLksi-trREVSCYGISAKEETNLDAVLHWLIAR 172 Aspergillus fumigatus Af293
XP_661538 120 ---------------------dDLIEQMNLksi-trREVSCYGISAKEETNLDAVLHWLIAR 159 Aspergillus nidulans FGSC A4
XP_757689 207 ---------------------dDVIRVMKLdti-anREVSCYSISSKNQVNIDVTLKWLVAR 246 Ustilago maydis 521
XP_810889 143 ---------------------eTLISELYLlklaadRETACYSVSAKDYTNIDVTLKWLMRH 183 Trypanosoma cruzi

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