1FZQ


Conserved Protein Domain Family
Arl3

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cd04155: Arl3 
Click on image for an interactive view with Cn3D
Arf-like 3 (Arl3) GTPase
Arl3 (Arf-like 3) is an Arf family protein that differs from most Arf family members in the N-terminal extension. In is inactive, GDP-bound form, the N-terminal extension forms an elongated loop that is hydrophobically anchored into the membrane surface; however, it has been proposed that this region might form a helix in the GTP-bound form. The delta subunit of the rod-specific cyclic GMP phosphodiesterase type 6 (PDEdelta) is an Arl3 effector. Arl3 binds microtubules in a regulated manner to alter specific aspects of cytokinesis via interactions with retinitis pigmentosa 2 (RP2). It has been proposed that RP2 functions in concert with Arl3 to link the cell membrane and the cytoskeleton in photoreceptors as part of the cell signaling or vesicular transport machinery. In mice, the absence of Arl3 is associated with abnormal epithelial cell proliferation and cyst formation.
Statistics
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PSSM-Id: 206721
Aligned: 10 rows
Threshold Bit Score: 270.037
Threshold Setting Gi: 68127912
Created: 1-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             ######                                                  
1FZQ_A      2 LLSILRKLKSapdqevRILLLGLDNAGKTTLLKQLASE----DISHITPTQGFNIKSVQSq-gFKLNVWDIGGQRKIRPY 76  house mouse
CAI40862    3 LLSILRKLKSapdqevRILLLGLDNAGKTTLLKQLASE----DISHITPTQGFNIKSVQSq-gFKLNVWDIGGQRKIRPY 77  human
AAF55936    3 LLSLLRKLRPnpekeaRILLLGLDNAGKTTILKQLASE----DITTVTPTAGFNIKSVAAd-gFKLNVWDIGGQWKIRPY 77  fruit fly
NP_497037   3 LIDVLKSFKSpsgreiRILLLGLDNAGKTTILKQLSSE----DVQHVTPTKGFNVKTVAAmgdIRLNVWDIGGQRSIRPY 78  nematode
CAJ09598    3 ILDFLMRIRPtsr-paGILILGLDNAGKTSILRQLSDE----DISHVASTQGFQIKKLVTg-gIKINVWDMGGQRAARYY 76  Leishmania major
CAJ06507    1 MLRGLRNRMKren-epRVLILGLDNAGKTTILNKLGVAeersVEAPEGPTQGFNVMNVNRd-gKRAKLCDLGGQRALREF 78  Leishmania major
AAC32774    3 LLEFLLKIRPfsrrtrRILMLGLDNAGKTRLLRRICEE----EVSDTFPTQGFNIQNITAd-eLKFVVWDVGGQKSLRSY 77  Trypanosoma brucei
CAI44572    6 LLNIIRKIKKsek-elRILVLGLDNAGKTTILKALSNE----DINQIAPTHGFNIKNLQHe-gFKLNVWDVGGQEKLREY 79  Paramecium tetraur...
CAF99187    4 LLSAFRRLKQsqeqevHLLLLGLDNAGKTTVLKQLAAE----NISHITPTQGFNLKSVESd-gFKLNVWDIGGQRKIRPY 78  Tetraodon nigrovir...
AAH87495    3 LLSILRKLKSapdqevRILLLGLDNAGKTTLLKQLASE----DISHITPTQGFNIKSVQSq-gFKLNVWDIGGQRKIRPY 77  African clawed frog
CAI40862    3 LLSILRKLKSapdqevRILLLGLDNAGKTTLLKQLASE----DISHITPTQGFNIKSVQSq-gFKLNVWDIGGQRKIRPY 77  human
AAF55936    3 LLSLLRKLRPnpekeaRILLLGLDNAGKTTILKQLASE----DITTVTPTAGFNIKSVAAd-gFKLNVWDIGGQWKIRPY 77  fruit fly
NP_497037   3 LIDVLKSFKSpsgreiRILLLGLDNAGKTTILKQLSSE----DVQHVTPTKGFNVKTVAAmgdIRLNVWDIGGQRSIRPY 78  nematode
CAJ09598    3 ILDFLMRIRPtsr-paGILILGLDNAGKTSILRQLSDE----DISHVASTQGFQIKKLVTg-gIKINVWDMGGQRAARYY 76  Leishmania major
CAJ06507    1 MLRGLRNRMKren-epRVLILGLDNAGKTTILNKLGVAeersVEAPEGPTQGFNVMNVNRd-gKRAKLCDLGGQRALREF 78  Leishmania major
AAC32774    3 LLEFLLKIRPfsrrtrRILMLGLDNAGKTRLLRRICEE----EVSDTFPTQGFNIQNITAd-eLKFVVWDVGGQKSLRSY 77  Trypanosoma brucei
CAI44572    6 LLNIIRKIKKsek-elRILVLGLDNAGKTTILKALSNE----DINQIAPTHGFNIKNLQHe-gFKLNVWDVGGQEKLREY 79  Paramecium tetraur...
CAF99187    4 LLSAFRRLKQsqeqevHLLLLGLDNAGKTTVLKQLAAE----NISHITPTQGFNLKSVESd-gFKLNVWDIGGQRKIRPY 78  Tetraodon nigrovir...
AAH87495    3 LLSILRKLKSapdqevRILLLGLDNAGKTTLLKQLASE----DISHITPTQGFNIKSVQSq-gFKLNVWDIGGQRKIRPY 77  African clawed frog
Feature 1                                                     ## ##                           
1FZQ_A     77 WRSYFENTDILIYVIDSADRKRFEETGQELTELLEEEKlscVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQS 156 house mouse
CAI40862   78 WKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKlscVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQS 157 human
AAF55936   78 WKNYFANTDVLIYVIDCTDRTRLPEAGSELFEMLMDNRlkqVPVLIFANKQDMPDAMSAAEVAEKMSLVQLQGRTWEIKA 157 fruit fly
NP_497037  79 WSNYYENIDTLIFVIDSNDKKRFDEMNIELGELLDEEKlrkVPVLIFANKQDLVTAASSEEITRKLNLDLLRDRTWHIQA 158 nematode
CAJ09598   77 WRQYFKEADVVIYVIDAADPRRIREARRELEHLLEEEKvagVPMLVFANKQDLLGAMPVEEVSVALNLTDLRDRSWHIQA 156 Leishmania major
CAJ06507   79 WEDYYANTDCIMYVVDSSDQRRLHEAHEAFVDVVKGVPk--VPVLVLANKQDLATAKDPQKVAEALELSDYRDRSWHIQG 156 Leishmania major
AAC32774   78 WRHYFDHTDALVFVIDSADMERIEEARTELHYILEEEKlvgVPLLLFANKQDIPEAASQEEVMSSLNLADTINRPWHIEL 157 Trypanosoma brucei
CAI44572   80 WSNFYENTDALVFVIDSSDQMRLEEGGKELDKLLGEAElkkVPLLVFANKQDLVQALPADEISDSLKLNKITDRQWSIVA 159 Paramecium tetraur...
CAF99187   79 WRNYFENTDVLIYVIDSSDTKRFEEASLNLTELLEERMlanVPLLVFANKQDLATAVPVAELAEVLSLHTIQDRMWQVQA 158 Tetraodon nigrovir...
AAH87495   78 WRNYFENTDVLIYVIDSADRKRFEETGQELAELLDEEKlsgVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQS 157 African clawed frog
CAI40862   78 WKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKlscVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQS 157 human
AAF55936   78 WKNYFANTDVLIYVIDCTDRTRLPEAGSELFEMLMDNRlkqVPVLIFANKQDMPDAMSAAEVAEKMSLVQLQGRTWEIKA 157 fruit fly
NP_497037  79 WSNYYENIDTLIFVIDSNDKKRFDEMNIELGELLDEEKlrkVPVLIFANKQDLVTAASSEEITRKLNLDLLRDRTWHIQA 158 nematode
CAJ09598   77 WRQYFKEADVVIYVIDAADPRRIREARRELEHLLEEEKvagVPMLVFANKQDLLGAMPVEEVSVALNLTDLRDRSWHIQA 156 Leishmania major
CAJ06507   79 WEDYYANTDCIMYVVDSSDQRRLHEAHEAFVDVVKGVPk--VPVLVLANKQDLATAKDPQKVAEALELSDYRDRSWHIQG 156 Leishmania major
AAC32774   78 WRHYFDHTDALVFVIDSADMERIEEARTELHYILEEEKlvgVPLLLFANKQDIPEAASQEEVMSSLNLADTINRPWHIEL 157 Trypanosoma brucei
CAI44572   80 WSNFYENTDALVFVIDSSDQMRLEEGGKELDKLLGEAElkkVPLLVFANKQDLVQALPADEISDSLKLNKITDRQWSIVA 159 Paramecium tetraur...
CAF99187   79 WRNYFENTDVLIYVIDSSDTKRFEEASLNLTELLEERMlanVPLLVFANKQDLATAVPVAELAEVLSLHTIQDRMWQVQA 158 Tetraodon nigrovir...
AAH87495   78 WRNYFENTDVLIYVIDSADRKRFEETGQELAELLDEEKlsgVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQS 157 African clawed frog
Feature 1      ###               
1FZQ_A    157 CSALTGEGVQDGMNWVCKN 175 house mouse
CAI40862  158 CSALTGEGVQDGMNWVCKN 176 human
AAF55936  158 CTAVDGTGLKEGMDWVCKN 176 fruit fly
NP_497037 159 CSALKNEGINDGITWVASN 177 nematode
CAJ09598  157 CSAKTGEGLDEGISWAVKQ 175 Leishmania major
CAJ06507  157 CSAKSGDGLEEGVAWIFEA 175 Leishmania major
AAC32774  158 CSAETGEGLSSGLSWVVDT 176 Trypanosoma brucei
CAI44572  160 CSAKTQEGLQEGMEWLIKT 178 Paramecium tetraurelia
CAF99187  159 CSAVTAEGLQEGMNWVCRN 177 Tetraodon nigroviridis
AAH87495  158 CSALTGEGVQDGMNWVCKN 176 African clawed frog
CAI40862  158 CSALTGEGVQDGMNWVCKN 176 human
AAF55936  158 CTAVDGTGLKEGMDWVCKN 176 fruit fly
NP_497037 159 CSALKNEGINDGITWVASN 177 nematode
CAJ09598  157 CSAKTGEGLDEGISWAVKQ 175 Leishmania major
CAJ06507  157 CSAKSGDGLEEGVAWIFEA 175 Leishmania major
AAC32774  158 CSAETGEGLSSGLSWVVDT 176 Trypanosoma brucei
CAI44572  160 CSAKTQEGLQEGMEWLIKT 178 Paramecium tetraurelia
CAF99187  159 CSAVTAEGLQEGMNWVCRN 177 Tetraodon nigroviridis
AAH87495  158 CSALTGEGVQDGMNWVCKN 176 African clawed frog

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