2NTY,3BWD,2WBL,2J0V


Conserved Protein Domain Family
Rop_like

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cd04133: Rop_like 
Click on image for an interactive view with Cn3D
Rho-related protein from plants (Rop)-like
The Rop (Rho-related protein from plants) subfamily plays a role in diverse cellular processes, including cytoskeletal organization, pollen and vegetative cell growth, hormone responses, stress responses, and pathogen resistance. Rops are able to regulate several downstream pathways to amplify a specific signal by acting as master switches early in the signaling cascade. They transmit a variety of extracellular and intracellular signals. Rops are involved in establishing cell polarity in root-hair development, root-hair elongation, pollen-tube growth, cell-shape formation, responses to hormones such as abscisic acid (ABA) and auxin, responses to abiotic stresses such as oxygen deprivation, and disease resistance and disease susceptibility. An individual Rop can have a unique function or an overlapping function shared with other Rop proteins; in addition, a given Rop-regulated function can be controlled by one or multiple Rop proteins. For example, Rop1, Rop3, and Rop5 are all involved in pollen-tube growth; Rop2 plays a role in response to low-oxygen environments, cell-morphology, and root-hair development; root-hair development is also regulated by Rop4 and Rop6; Rop6 is also responsible for ABA response, and ABA response is also regulated by Rop10. Plants retain some of the regulatory mechanisms that are shared by other members of the Rho family, but have also developed a number of unique modes for regulating Rops. Unique RhoGEFs have been identified that are exclusively active toward Rop proteins, such as those containing the domain PRONE (plant-specific Rop nucleotide exchanger). Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation.
Statistics
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PSSM-Id: 206705
View PSSM: cd04133
Aligned: 12 rows
Threshold Bit Score: 291.75
Threshold Setting Gi: 57899906
Created: 6-Dec-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Rho molecules assume an active conformation when bound to GTP and inactive when GTP is hydrolyzed to GDP
  • Comment:Mg2+ ion plays a key role in bringing together the functional regions of the phosphate-binding, switches I and II
  • Citation:PMID 9545299
  • Structure:2NTY: Arabidopsis thaliana Rop4 in complex with GDP; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  ######                                        ## #                    
2NTY_C         6 FIKCVTVGDGAVGKTCMLISYTSNt--FPTDYVPTVFDNFSANVVVDGNTVNLGLWDTAGQedynrLRPLSYRGADVFIL 83
gi 8979882     6 FIKCVTVGDGAVGKTCMLICYTSNk--FPTDYIPTVFDNFSANVSVDGSIVNLGLWDTAGQedysrLRPLSYRGADVFVL 83
gi 28393687    6 FIKCVTVGDGAVGKTCLLISYTSNt--FPTDYVPTVFDNFSANVIVDGNTINLGLWDTAGQedynrLRPLSYRGADVFLL 83
gi 7243743     6 FIKCVTVGDGAVGKTCMLISYTSNt--FPTDYVPTVFDNFSANVVVDGNTVNLGLWDTAGQedynrLRPLSYRGADVFLL 83
gi 57899906   23 AEVDEVVSRGDVQCPGAVVFNGDVhvdFRPDYIPTVFDNFSANVSVDGDIVNLGLWDTAGR-----LRLLSYRGADIFVL 97
gi 5902930     8 FIKCVTVGDGAVGKTCMLICYTSNk--FPTDYIPTVFDNFSANVVVDSTTVNLGLWDTAGQedynrLRPLSYRGADVFVL 85
3BWD_D         8 FIKCVTVGDGAVGKTCLLISYTSNt--FPTDYVPTVFDNFSANVVVNGATVNLGLWDTAGQedynrLRPLSYRGADVFIL 85
2WBL_C         6 FIKCVTVGDGAVGKTCMLISYTGNt--FPTDYVPTVFDNFSANVVVDGSTVNLGLWDTAGQedynrLRPLSYRGADVFLL 83
gi 294460272   6 FIKCVTVGDGAVGKTCMLISYTSNt--FPTDYVPTVFDNFSANVVVDGNTVNLGLWDTAGQedynrLRPLSYRGADVFLL 83
gi 302800670   6 FIKCVTVGDGAVGKTCMLISYTSNt--FPTDYVPTVFDNFSANVVVDGNTVNLGLWDTAGQedynrLRPLSYRGADVFLL 83
gi 346473343   6 FIKCVTVGDGAVGKTCMLISYTSNt--FPTDYVPTVFDNFSANVVVDGSTVNLGLWDTAGQedynrLRPLSYRGADVFLL 83
2J0V_A         9 FIKCVTVGDGAVGKTCMLICYTSNk--FPTDYIPTVFDNFSANVAVDGQIVNLGLWDTAGQedysrLRPLSYRGADIFVL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           # #                                         #
2NTY_C        84 AFSLISKASYENVAKKWIPELRHYAPGVPIILVGTKLDLRDDKQFFiDHPGAvpITTNQGEELKKLIGSP---IYIECSS 160
gi 8979882    84 AFSLISRASYENVLKKWVPELRRFAPNVPVVLVGTKLDLRDHRAYLaDHPGAsaVTTAQGEELRKQIGAA---AYIECSS 160
gi 28393687   84 AFSLVSKASYENVSKKWVPELRHYAPGVPIILVGTKLDLRDDKQFFaEHPGAvpISTAQGEELKKLIGAP---AYIECSA 160
gi 7243743    84 AFSLISKASYENISKKWIPELRHYAPSVPIILVGTKLDLRDDKQFFaDHPGAapITTSQGEELRKSIGAA---SYIECSS 160
gi 57899906   98 AFSLISRASYENALKKGMPELRRFAPNAPIVLVGTKLDLRDHKSYLaDHPAAssITTAQNIKALFDTAIK---VVLEPPR 174
gi 5902930    86 AFSLVSRASYENIMKKWIPELQHYAPGVPIVLVGTKLDLREDKHYLlDHPGMipVTTAQGEELRKQIGAA---YYIECSS 162
3BWD_D        86 AFSLISKASYENVSKKWIPELKHYAPGVPIVLVGTKLDLRDDKQFFiDHPGAvpITTVQGEELKKLIGAP---AYIECSS 162
2WBL_C        84 AFSLISKASYENIHKKWLPELKHYAPGIPIVLVGTKLDLRDDKQFLkDHPGAasITTAQGEELRKMIGAV---RYLECSS 160
gi 294460272  84 AFSLISKASYENISKKWIPELRHYAPNVPIILVGTKLDLRDDKQFFaDHPGAapITTPQGEELKKQIGAA---AYIECSS 160
gi 302800670  84 AFSLISRASYENISKKWIPELKHYAPTVPVILVGTKLDLRDDKQFFaDHPGAtpITTVQGEELRKQIGAA---AYIECSS 160
gi 346473343  84 AFSLISKASYENVAKKWIPELRHYAPGIPIVLVGTKLDLRDDDQFFvDHPGAvpISTAQGEEQEFVRVVCgehWFQWFES 163
2J0V_A        87 AFSLISKASYENVLKKWMPELRRFAPNVPIVLVGTKLDLRDDKGYLaDHTNV--ITSTQGEELRKQIGAA---AYIECSS 161
                        170
                 ....*....|....*....
Feature 1        #                  
2NTY_C       161 KTQQ-NVKAVFDAAIKVVL 178
gi 8979882   161 KTQQ-NVKSVFDTAIKVVL 178
gi 28393687  161 KTQQ-NVKAMFDAAIKVVL 178
gi 7243743   161 KTQQ-NVKAVFDAAIKVVL 178
gi 57899906  175 RRGE-TTMARKKTRRSTGC 192
gi 5902930   163 KTQQ-NVKGVFDAAIKVVI 180
3BWD_D       163 KSQE-NVKGVFDAAIRVVL 180
2WBL_C       161 KTQQ-NVKAVFDTAIRVAL 178
gi 294460272 161 KTQQ-NVKAVFDAAIKVVL 178
gi 302800670 161 KTQQ-NVKAVFDAAIKVVL 178
gi 346473343 164 LSTNyEVDSSTLHPSGKRR 182
2J0V_A       162 KTQQ-NVKAVFDTAIKVVL 179

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