1KK3,1S0U,2AHO


Conserved Protein Domain Family
eIF2_gamma

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cd01888: eIF2_gamma 
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Gamma subunit of initiation factor 2 (eIF2 gamma)
eIF2 is a heterotrimeric translation initiation factor that consists of alpha, beta, and gamma subunits. The GTP-bound gamma subunit also binds initiator methionyl-tRNA and delivers it to the 40S ribosomal subunit. Following hydrolysis of GTP to GDP, eIF2:GDP is released from the ribosome. The gamma subunit has no intrinsic GTPase activity, but is stimulated by the GTPase activating protein (GAP) eIF5, and GDP/GTP exchange is stimulated by the guanine nucleotide exchange factor (GEF) eIF2B. eIF2B is a heteropentamer, and the epsilon chain binds eIF2. Both eIF5 and eIF2B-epsilon are known to bind strongly to eIF2-beta, but have also been shown to bind directly to eIF2-gamma. It is possible that eIF2-beta serves simply as a high-affinity docking site for eIF5 and eIF2B-epsilon, or that eIF2-beta serves a regulatory role. eIF2-gamma is found only in eukaryotes and archaea. It is closely related to SelB, the selenocysteine-specific elongation factor from eubacteria. The translational factor components of the ternary complex, IF2 in eubacteria and eIF2 in eukaryotes are not the same protein (despite their unfortunately similar names). Both factors are GTPases; however, eubacterial IF-2 is a single polypeptide, while eIF2 is heterotrimeric. eIF2-gamma is a member of the same family as eubacterial IF2, but the two proteins are only distantly related. This family includes translation initiation, elongation, and release factors.
Statistics
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PSSM-Id: 206675
Aligned: 28 rows
Threshold Bit Score: 288.397
Threshold Setting Gi: 75756517
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # ####                                                                 
1KK3_A     11 VNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFADAEIRRCPNCGRys----tsPVCPYCGh--ETEFVRR 84  Pyrococcus abyssi
1S0U_A      9 VNIGMVGHVDHGKTSLTKALTGVWTDRHSEELRRGISIRLGYADCEIRKCPQCGTyt----tkPRCPNCLa--ETEFLRR 82  Methanocaldococcus...
2AHO_A      9 VNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKpeay-vtePSCKSCGsddEPKFLRR 87  Sulfolobus solfata...
O26361      7 INIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEApmcy-ttaEICERCGt--ETELLRK 83  Methanothermobacte...
NP_069426  26 VNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRGISIKLGYADATFRKCPECEPpeay-tveEICPIHGv--ETEILRT 102 Archaeoglobus fulg...
Q9HLA7     12 VNIGMVGHVDHGKSTLTLALTGTKTDTHSEEIKRGISIKLGYADTPIYRCYDSSGnv-----hYTREKGE---NCDLERV 83  Thermoplasma acido...
NP_280731  10 VNIGLVGHVDHGKTTLVRALSGEWTDQHSEEMKRGISIRLGYADATLRRCPDCDEpecy-tvaETCPEHDt--ATEIERT 86  Halobacterium sp. ...
NP_558353   8 AIVSTAGHVDHGKTQTTYALSGVWVMRHSEEIKKAMTIKLGYTQIGIYDCGEEYYysdgilqnGKCPNGA---EPKLIRR 84  Pyrobaculum aeroph...
NP_614730  11 MNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRCPECDTys----veEKCPECGa--ETEWLRR 84  Methanopyrus kandl...
Q8TJT7     41 VNIGMVGHVDHGKTTLVKALSGVWTDTHSEEVKRGISIRLGYADSPFMKCPKCPApqcy-tveKTCPNCGe--KTEEHRI 117 Methanosarcina ace...
1S0U_A      9 VNIGMVGHVDHGKTSLTKALTGVWTDRHSEELRRGISIRLGYADCEIRKCPQCGTyt----tkPRCPNCLa--ETEFLRR 82  Methanocaldococcus...
2AHO_A      9 VNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKpeay-vtePSCKSCGsddEPKFLRR 87  Sulfolobus solfata...
O26361      7 INIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEApmcy-ttaEICERCGt--ETELLRK 83  Methanothermobacte...
NP_069426  26 VNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRGISIKLGYADATFRKCPECEPpeay-tveEICPIHGv--ETEILRT 102 Archaeoglobus fulg...
Q9HLA7     12 VNIGMVGHVDHGKSTLTLALTGTKTDTHSEEIKRGISIKLGYADTPIYRCYDSSGnv-----hYTREKGE---NCDLERV 83  Thermoplasma acido...
NP_280731  10 VNIGLVGHVDHGKTTLVRALSGEWTDQHSEEMKRGISIRLGYADATLRRCPDCDEpecy-tvaETCPEHDt--ATEIERT 86  Halobacterium sp. ...
NP_558353   8 AIVSTAGHVDHGKTQTTYALSGVWVMRHSEEIKKAMTIKLGYTQIGIYDCGEEYYysdgilqnGKCPNGA---EPKLIRR 84  Pyrobaculum aeroph...
NP_614730  11 MNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRCPECDTys----veEKCPECGa--ETEWLRR 84  Methanopyrus kandl...
Q8TJT7     41 VNIGMVGHVDHGKTTLVKALSGVWTDTHSEEVKRGISIRLGYADSPFMKCPKCPApqcy-tveKTCPNCGe--KTEEHRI 117 Methanosarcina ace...
Feature 1                                                                 ## #                
1KK3_A     85 VSFIDAPGHEALMTTMLAGASLMDGAILVIAANEPCPRPQTREHLMALQIigqKNIIIAQNKIELVdkekALENYRQIKE 164 Pyrococcus abyssi
1S0U_A     83 VSFVDSPGHETLMATMLSGASLMDGAILVIAANEPCPQPQTKEHLMALEIlgiDKIIIVQNKIDLVdekqAEENYEQIKE 162 Methanocaldococcus...
2AHO_A     88 ISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIigvKNLIIVQNKVDVVskeeALSQYRQIKQ 167 Sulfolobus solfata...
O26361     84 VSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVigvKDVIVVQNKIDIVskerALESYREIKE 163 Methanothermobacte...
NP_069426 103 VSFVDSPGHEMLMATMLSGAAIMDGAVLVIAANEKCPRPQTKEHLMALQIigiDKIVIAQNKIDIVsrerVLENYQEIKE 182 Archaeoglobus fulg...
Q9HLA7     84 ISIVDAPGHETLMATMLSGSALMNGALLVIAANEHCPQPQTREHLTALEImgiKNIIIVQNKIDLVtrerAIESYREIKN 163 Thermoplasma acido...
NP_280731  87 VSFVDAPGHETLMATMLSGAALMDGAVLVVGANEPVPQPQTEEHLMALDIigiENIVIAQNKVDLVdaeeARQNYEEIQA 166 Halobacterium sp. ...
NP_558353  85 ISLLDVPGHEVLVATMVSGAAVVDGALLVVDASQPAPQPQTVEHFAVLDIigvRHMVVAQNKIDLVtkekALENYEQIKN 164 Pyrobaculum aeroph...
NP_614730  85 VSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPCPQPQTREHLMALEIigtEDVIVVQNKIDLVtpeeAREHYEQIVQ 164 Methanopyrus kandl...
Q8TJT7    118 VSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEECPQPQTKEHLMALDIigiKNIVIVQNKIDLVsrekLVENYHQIKE 197 Methanosarcina ace...
1S0U_A     83 VSFVDSPGHETLMATMLSGASLMDGAILVIAANEPCPQPQTKEHLMALEIlgiDKIIIVQNKIDLVdekqAEENYEQIKE 162 Methanocaldococcus...
2AHO_A     88 ISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIigvKNLIIVQNKVDVVskeeALSQYRQIKQ 167 Sulfolobus solfata...
O26361     84 VSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVigvKDVIVVQNKIDIVskerALESYREIKE 163 Methanothermobacte...
NP_069426 103 VSFVDSPGHEMLMATMLSGAAIMDGAVLVIAANEKCPRPQTKEHLMALQIigiDKIVIAQNKIDIVsrerVLENYQEIKE 182 Archaeoglobus fulg...
Q9HLA7     84 ISIVDAPGHETLMATMLSGSALMNGALLVIAANEHCPQPQTREHLTALEImgiKNIIIVQNKIDLVtrerAIESYREIKN 163 Thermoplasma acido...
NP_280731  87 VSFVDAPGHETLMATMLSGAALMDGAVLVVGANEPVPQPQTEEHLMALDIigiENIVIAQNKVDLVdaeeARQNYEEIQA 166 Halobacterium sp. ...
NP_558353  85 ISLLDVPGHEVLVATMVSGAAVVDGALLVVDASQPAPQPQTVEHFAVLDIigvRHMVVAQNKIDLVtkekALENYEQIKN 164 Pyrobaculum aeroph...
NP_614730  85 VSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPCPQPQTREHLMALEIigtEDVIVVQNKIDLVtpeeAREHYEQIVQ 164 Methanopyrus kandl...
Q8TJT7    118 VSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEECPQPQTKEHLMALDIigiKNIVIVQNKIDLVsrekLVENYHQIKE 197 Methanosarcina ace...
Feature 1                       ###                     
1KK3_A    165 FIEGTv---AENAPIIPISALhgaNIDVLVKAIEDFIPTPKR 203 Pyrococcus abyssi
1S0U_A    163 FVKGTi---AENAPIIPISAHheaNIDVLLKAIQDFIPTPKR 201 Methanocaldococcus jannaschii
2AHO_A    168 FTKGTw---AENVPIIPVSALhkiNIDSLIEGIEEYIKTPYR 206 Sulfolobus solfataricus
O26361    164 FVKGTc---AEDAPIIPVSAQqgaNIDILIETIEERIKTPKR 202 Methanothermobacter thermautotrophicus str. Delta H
NP_069426 183 FVKGTv---AENAPIIPISAQqkvNMDALIEAIEETIPTPER 221 Archaeoglobus fulgidus DSM 4304
Q9HLA7    164 FVKGSi---AENAPIIPVSAYhstNIDALFEAIEKYIPSPKF 202 Thermoplasma acidophilum
NP_280731 167 FVEGTv---AEDAPVVPVSAEqeiNVDLVIDALQTEIATPDR 205 Halobacterium sp. NRC-1
NP_558353 165 FLKGTw---AEKAKVVPISALhrvNIDALVTYLAKEIPKREA 203 Pyrobaculum aerophilum str. IM2
NP_614730 165 FLEEEthldPDKTPIIPVSAQhkaNLDVLVEAMYEHFEPPEY 206 Methanopyrus kandleri AV19
Q8TJT7    198 FVKGTv---AENAPIIPISAQqniNIDVLIDALETQIPTPVH 236 Methanosarcina acetivorans
1S0U_A    163 FVKGTi---AENAPIIPISAHheaNIDVLLKAIQDFIPTPKR 201 Methanocaldococcus jannaschii
2AHO_A    168 FTKGTw---AENVPIIPVSALhkiNIDSLIEGIEEYIKTPYR 206 Sulfolobus solfataricus
O26361    164 FVKGTc---AEDAPIIPVSAQqgaNIDILIETIEERIKTPKR 202 Methanothermobacter thermautotrophicus str. Delta H
NP_069426 183 FVKGTv---AENAPIIPISAQqkvNMDALIEAIEETIPTPER 221 Archaeoglobus fulgidus DSM 4304
Q9HLA7    164 FVKGSi---AENAPIIPVSAYhstNIDALFEAIEKYIPSPKF 202 Thermoplasma acidophilum
NP_280731 167 FVEGTv---AEDAPVVPVSAEqeiNVDLVIDALQTEIATPDR 205 Halobacterium sp. NRC-1
NP_558353 165 FLKGTw---AEKAKVVPISALhrvNIDALVTYLAKEIPKREA 203 Pyrobaculum aerophilum str. IM2
NP_614730 165 FLEEEthldPDKTPIIPVSAQhkaNLDVLVEAMYEHFEPPEY 206 Methanopyrus kandleri AV19
Q8TJT7    198 FVKGTv---AENAPIIPISAQqniNIDVLIDALETQIPTPVH 236 Methanosarcina acetivorans

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