1LNZ,1JAL,1WXQ,2E87,2QU8


Conserved Protein Domain Family
Obg_like

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cd01881: Obg_like 
Click on image for an interactive view with Cn3D
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1
The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.
Statistics
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PSSM-Id: 206668
Aligned: 7 rows
Threshold Bit Score: 169.497
Threshold Setting Gi: 99031619
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1LNZ: Bacillus subtilis Obg binds guanosine-5',3'-tetraphosphate, a GTP analog and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ######                                                                    
1LNZ_B    162 GLVGFPSVGKSTLLSVVSSakpkiADYHFTTLVPNLGXVEtdd-----------------------grSFVXADLPGLIE 218 Bacillus subtilis
1JAL_A      6 GIVGLPNVGKSTLFNALTKagieaANYPFCTIEPNTGVVPmpdprldalae-------ivkperilptTMEFVDIAGLVA 78  Haemophilus influe...
1WXQ_A      4 GVVGKPNVGKSTFFSAATLvdveiANYPFTTIEANVGVTYaitdhpckelgcspnpqnyeyrnglaliPVKXVDVAGLVP 83  Pyrococcus horikos...
2E87_A    171 VIAGHPNVGKSTLLKALTTakpeiASYPFTTRGINVGQFEdg------------------------yfRYQIIDTPGLLD 226 Pyrococcus horikoshii
2QU8_A     33 ILSGAPNVGKSSFMNIVSRanvdvQSYSFTTKNLYVGHFDhk------------------------lnKYQIIDTPGLLD 88  Plasmodium falcipa...
CAD21398   68 ALVGFPSVGKSTFLSKVTKtksevASYAFTTLTAIPGVLEyg------------------------gaEIQLLDLPGIIE 123 Neurospora crassa
CAI74532  185 AFIGLPNSGKTSLISSLTSymtriGPEEGSTTRPHIALIKfld-----------------------gvDIRVMDLPPLSQ 241 Theileria annulata
1JAL_A      6 GIVGLPNVGKSTLFNALTKagieaANYPFCTIEPNTGVVPmpdprldalae-------ivkperilptTMEFVDIAGLVA 78  Haemophilus influe...
1WXQ_A      4 GVVGKPNVGKSTFFSAATLvdveiANYPFTTIEANVGVTYaitdhpckelgcspnpqnyeyrnglaliPVKXVDVAGLVP 83  Pyrococcus horikos...
2E87_A    171 VIAGHPNVGKSTLLKALTTakpeiASYPFTTRGINVGQFEdg------------------------yfRYQIIDTPGLLD 226 Pyrococcus horikoshii
2QU8_A     33 ILSGAPNVGKSSFMNIVSRanvdvQSYSFTTKNLYVGHFDhk------------------------lnKYQIIDTPGLLD 88  Plasmodium falcipa...
CAD21398   68 ALVGFPSVGKSTFLSKVTKtksevASYAFTTLTAIPGVLEyg------------------------gaEIQLLDLPGIIE 123 Neurospora crassa
CAI74532  185 AFIGLPNSGKTSLISSLTSymtriGPEEGSTTRPHIALIKfld-----------------------gvDIRVMDLPPLSQ 241 Theileria annulata
Feature 1                                                                                     
1LNZ_B    219 GAhqgvglgh--qflrhieRTRVIVHVIDXsgle---------------------------------------------- 250 Bacillus subtilis
1JAL_A     79 GAskgeglgn--kflanirETDAIGHVVRCfenddivh------------------------------------------ 114 Haemophilus influe...
1WXQ_A     84 GAhegrglgn--kflddlrXASALIHVVDAtgktdpeg------------------------------------------ 119 Pyrococcus horikos...
2E87_A    227 RPiserneiekqailalryLGNLIIYIFDPsehc---------------------------------------------- 260 Pyrococcus horikoshii
2QU8_A     89 RAfenrntiemttitalahINGVILFIIDIseqc---------------------------------------------- 122 Plasmodium falcipa...
CAD21398  124 GAsegkgrgr--qvisaakTSDLILMVLDAtkraeqralleaeleavgirlnreppniylkpkkaggmkitfqtppkngl 201 Neurospora crassa
CAI74532  242 NTdkdmvkk----itrhlyRSKLIAYVISAaed----------------------------------------------- 270 Theileria annulata
1JAL_A     79 GAskgeglgn--kflanirETDAIGHVVRCfenddivh------------------------------------------ 114 Haemophilus influe...
1WXQ_A     84 GAhegrglgn--kflddlrXASALIHVVDAtgktdpeg------------------------------------------ 119 Pyrococcus horikos...
2E87_A    227 RPiserneiekqailalryLGNLIIYIFDPsehc---------------------------------------------- 260 Pyrococcus horikoshii
2QU8_A     89 RAfenrntiemttitalahINGVILFIIDIseqc---------------------------------------------- 122 Plasmodium falcipa...
CAD21398  124 GAsegkgrgr--qvisaakTSDLILMVLDAtkraeqralleaeleavgirlnreppniylkpkkaggmkitfqtppkngl 201 Neurospora crassa
CAI74532  242 NTdkdmvkk----itrhlyRSKLIAYVISAaed----------------------------------------------- 270 Theileria annulata
Feature 1                                                                                     
1LNZ_B    251 ----grdpYDDYLTINQELSEYnlr------------------------------------------------------- 271 Bacillus subtilis
1JAL_A    115 -vagkidpLDDIDTINTELALAdldsceraiqrlqkrakggdkeakfelsvmek---------ilpvlenagmirsvgld 184 Haemophilus influe...
1WXQ_A    120 qptdyhdpVEDIEFLEREIDYWiygilskgwdkfakriklqkiklesaiaehlsgigvnendvweaxhklnlpedptkws 199 Pyrococcus horikos...
2E87_A    261 -----gfpLEEQIHLFEEVHGEf--------------------------------------------------------- 278 Pyrococcus horikoshii
2QU8_A    123 -----gltIKEQINLFYSIKSVf--------------------------------------------------------- 140 Plasmodium falcipa...
CAD21398  202 dekmvmniLRDYKILNCEVLVRdenvtvddfi------------------------------------------------ 233 Neurospora crassa
CAI74532  271 -----gdhMETLKSLREIVSGSktf------------------------------------------------------- 290 Theileria annulata
1JAL_A    115 -vagkidpLDDIDTINTELALAdldsceraiqrlqkrakggdkeakfelsvmek---------ilpvlenagmirsvgld 184 Haemophilus influe...
1WXQ_A    120 qptdyhdpVEDIEFLEREIDYWiygilskgwdkfakriklqkiklesaiaehlsgigvnendvweaxhklnlpedptkws 199 Pyrococcus horikos...
2E87_A    261 -----gfpLEEQIHLFEEVHGEf--------------------------------------------------------- 278 Pyrococcus horikoshii
2QU8_A    123 -----gltIKEQINLFYSIKSVf--------------------------------------------------------- 140 Plasmodium falcipa...
CAD21398  202 dekmvmniLRDYKILNCEVLVRdenvtvddfi------------------------------------------------ 233 Neurospora crassa
CAI74532  271 -----gdhMETLKSLREIVSGSktf------------------------------------------------------- 290 Theileria annulata
Feature 1                           ## #                               ##                     
1LNZ_B    272 ------------ltERPQIIVANKXDxpeaaenlea-------fkekltddyPVFPISAVtre----------------- 315 Bacillus subtilis
1JAL_A    185 keelqaiksynfltLKPTMYIANVNEdgfennpyldr-----vreiaakegaVVVPVCAAieseiaelddeekv------ 253 Haemophilus influe...
1WXQ_A    200 qddllafaseirrvNKPXVIAANKADaasdeqikrl-------vreeekrgyIVIPTSAAaeltlrkaakagfieyipga 272 Pyrococcus horikos...
2E87_A    279 -------------kDLPFLVVINKIDvadeenikrl-------ekfvkekglNPIKISALkgt----------------- 321 Pyrococcus horikoshii
2QU8_A    141 -------------sNKSIVIGFNKIDkcnmdslsidnkllikqildnvknpiKFSSFSTLtgv----------------- 190 Plasmodium falcipa...
CAD21398  234 -----dvimkdhrkYIKCLYVYNKIDsvsldfl------------dklarepYTCVMSCEldl----------------- 279 Neurospora crassa
CAI74532  291 ------------vdSKLEMIIMTKCDmihrntlfnlds--lyyklldsqpeiPVVATSAThrl----------------- 339 Theileria annulata
1JAL_A    185 keelqaiksynfltLKPTMYIANVNEdgfennpyldr-----vreiaakegaVVVPVCAAieseiaelddeekv------ 253 Haemophilus influe...
1WXQ_A    200 qddllafaseirrvNKPXVIAANKADaasdeqikrl-------vreeekrgyIVIPTSAAaeltlrkaakagfieyipga 272 Pyrococcus horikos...
2E87_A    279 -------------kDLPFLVVINKIDvadeenikrl-------ekfvkekglNPIKISALkgt----------------- 321 Pyrococcus horikoshii
2QU8_A    141 -------------sNKSIVIGFNKIDkcnmdslsidnkllikqildnvknpiKFSSFSTLtgv----------------- 190 Plasmodium falcipa...
CAD21398  234 -----dvimkdhrkYIKCLYVYNKIDsvsldfl------------dklarepYTCVMSCEldl----------------- 279 Neurospora crassa
CAI74532  291 ------------vdSKLEMIIMTKCDmihrntlfnlds--lyyklldsqpeiPVVATSAThrl----------------- 339 Theileria annulata
Feature 1                                                 
1LNZ_B    316 -------------------------------glRELLFEVANQL 328 Bacillus subtilis
1JAL_A    254 --------------------eflqdlgieepglNRVIRAGYALL 277 Haemophilus influenzae
1WXQ_A    273 sefkvlrdxsekqkralxvikekvldrfgstgvQEVINRVVFDL 316 Pyrococcus horikoshii OT3
2E87_A    322 -------------------------------giDLVKEEIIKTL 334 Pyrococcus horikoshii
2QU8_A    191 -------------------------------gvEQAKITACELL 203 Plasmodium falciparum 3D7
CAD21398  280 -------------------------------giQDVIDRCWKEL 292 Neurospora crassa
CAI74532  340 -------------------------------glDRCVRTIRDLL 352 Theileria annulata
1JAL_A    254 --------------------eflqdlgieepglNRVIRAGYALL 277 Haemophilus influenzae
1WXQ_A    273 sefkvlrdxsekqkralxvikekvldrfgstgvQEVINRVVFDL 316 Pyrococcus horikoshii OT3
2E87_A    322 -------------------------------giDLVKEEIIKTL 334 Pyrococcus horikoshii
2QU8_A    191 -------------------------------gvEQAKITACELL 203 Plasmodium falciparum 3D7
CAD21398  280 -------------------------------giQDVIDRCWKEL 292 Neurospora crassa
CAI74532  340 -------------------------------glDRCVRTIRDLL 352 Theileria annulata

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