1LB1,1AZT,1CEE,1F5N,1H65,1HE8,1JWY,1K5D,1LNZ,1MKY,1MKY,1MR3,1N0V,1NRJ,1PUI,1TPZ,1X18,1XZQ,2BMJ,2J68,2QAG,2QPT,2QTF,3DPU,3LLU,3LX5,3LXW,3RAB


Conserved Protein Domain Family
Ras_like_GTPase

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cd00882: Ras_like_GTPase 
Click on image for an interactive view with Cn3D
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.
Statistics
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PSSM-Id: 206648
View PSSM: cd00882
Aligned: 149 rows
Threshold Bit Score: 34.7396
Threshold Setting Gi: 16974840
Created: 10-Apr-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1CEE: Human cdc42 binds GTP and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D
  • Structure:3RAB: Rattus norvegicus Rab3a binds GppNHp, a GTP analog and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D
  • Structure:1MR3: Saccharomyces cerevisiae Arf2 binds GDP and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D
  • Structure:11HE8: Human Ras binds GppNHp, a GTP analog and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #######                                               #                    
1LB1_F       11 VIVGDGACGKTCLLIVFskdqfp--evyvpTv--fENYVAdievd--gkqvELALWDTAGqedydrlr-------plsyp 77
1CEE_A        7 VVVGDGAVGKTCLLISYttnkfp--seyvpTv--fDNYAVtvmig--gepyTLGLFDTAGqedydrlr-------plsyp 73
gi 25187967 420 KVVGACGVGKSAFLQAFlgrgl----ghqdTreqpPGYAIdtvqv--ngqeKYLILCEVGtdgllat---------slda 484
gi 56474179  41 LFIGDLIADKNELVNTYlngkyl--agksqKvd-nEVIVKrldd---egkcKVVIMTCEGeenypgnr-------krlye 107
gi 56790116  10 CVIGNEKIGKTSLVRRLledtfv--eestpFed-vSVNKKviy------dnKEVILNFMDplgtdist------tatfyn 74
gi 56790118  10 CIVGDEKCGKTSLTRRFigeef---keevePfp-eNLITKdity----egkKITLNLMDPlddgtgtt-------asfyn 74
gi 66811994  12 KILLSGDSGKSSFLNRAiddiyfennvyqcAps-lKFFNDpnssrenkyyyKNLIYKLCFiyryeyfqdrfrsignnpyr 90
gi 66811996  11 LVIGDCNVGKSSFVYQYcenfktkirsrerGdg-nTFIPKlirvd--dkncFLKFVKYYKrvnclpn--------yrfin 79
gi 67471079  16 SIIGDRGTGKTCLSERIvndqfm--stylpPtg-lDFKTKfysfe--tkkiRTCFWEICYsnrycpt--------gievk 82
gi 70832534  22 VVLGCERVGKSTFIDQVmkgtfr--sdyvpTtl-eTFIHRttvd---grnyVLHLCDSSGseafvrhr-------llyla 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                     ## #                              
1LB1_F       78 dtDVILMCFSIdspdslenipek-----wtpevkhfcpnvPIILVGNKKDlrndehtrrelakmkqe------------- 139
1CEE_A       74 qtDVFLVCFSVvspssfenvkek-----wvpeithhcpktPFLLVGTQIDlrddpstieklaknkqk------------- 135
gi 25187967 485 tcDVACLMFDGsdpksfahcas-------vykhhymdgqtPCLFVSSKADlpegvavsgps------------------- 538
gi 56474179 108 grDIVVLTYAVdnlesfknieel-----wlpevafydegaYLGLIGTHSEsdavvtqeev-------------------- 162
gi 56790116  75 daNLLIAMFDEtekdsiqncknw-----lsygdryigsqyLKLIVGNKIDsndkkiseee-------------------- 129
gi 56790118  75 haNCIIALFDLsnkdslqncknw-----lsygdryvdngyVKGVVGVKSDlerevtkeea-------------------- 129
gi 66811994  91 gaRFNFILFNVcdqesfdnvpky-----yfeaerygkediHIILIGVGIDdienriidyev------------------- 146
gi 66811996  80 iaDCIFILFDVcnresfdnvghy-----yneilkyssenlLITLIGCKADllnrevdqne-------------------- 134
gi 67471079  83 gsSIILFIFDLtnsesfeslkyy-----ynrfcqqfpllpPIFCVGTKSDlpptvserqi-------------------- 137
gi 70832534  89 raDGVLLFYSTtdkeslasvvgwvkelrearhnigvkaamPILLVGTKRDdrrsrvvtmpeaeavarsclsalslkmqhm 168
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
Feature 1                                   ###               
1LB1_F      140 ------pvkpeegrdmanrigafGYMECSAKtkd-gvrEVFEMATR 178
1CEE_A      136 ------pitpetaeklardlkavKYVECSALtqk-glkNVFDEAIL 174
gi 25187967 539 ------------paefcrkhrlpAPVPFSCAgpaepstTIFTQLAT 572
gi 56474179 163 -------------lqfaknnnipFVAEVSSKnys-nidETFFDLIL 194
gi 56790116 130 -------------ceevakslncEYFEVSAKtge-gikELYEQMMK 161
gi 56790118 130 --------------eevakglncEYFEVSNKtge-gctEVYDTLLK 160
gi 66811994 147 -------------aldlansnntPYFEVNNKspsplekEIYQRIIE 179
gi 66811996 135 -------------alefskkhniPYFEVNNFspseiekNVYQQISQ 167
gi 67471079 138 -------------lkqlkkmnypPLYYCSSQtgs-ackDIESDIIK 169
gi 70832534 169 nrkkvveaegfaklvrdaisstlPVVEVSALrtn-evlHALRIMIL 213

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