Conserved Protein Domain Family
Hydrolase_4

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pfam12146: Hydrolase_4 
Putative lysophospholipase
This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. Many members are annotated as being lysophospholipases, and others as alpha-beta hydrolase fold-containing proteins.
BioAssay Targets and Results
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CID: 44563663
AID: 409757
GI: 47117040
IC50: 0.00028µM
more
Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain
Target Name: Monoglyceride lipase
Chemical Name: CHEMBL512224
IC50: 0.00028µM
CID: 44563661
AID: 409757
GI: 47117040
IC50: 0.00014µM
more
Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain
Target Name: Monoglyceride lipase
Chemical Name: CHEMBL462610
IC50: 0.00014µM
CID: 44563662
AID: 409757
GI: 47117040
IC50: 7e-005µM
more
Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain
Target Name: Monoglyceride lipase
Chemical Name: CHEMBL462582
IC50: 7e-005µM
Statistics
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PSSM-Id: 204836
View PSSM: pfam12146
Aligned: 138 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 5-Jan-2012
Structure
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Aligned Rows:
pfam12146 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122415755  12 NTHYLHHTfFEPSHSdtviSATLLIVHGMAEHSGRYADVAQFLADHGIAVATYDQLGHGKT-----VksakdlG-----F 81
gi 122465427  42 NLNIGWVS-LTGYNh----DKAIIVVNGRIESYWKYQELFYDLVKKGYDVYAIDHRGQGIS-----Drla-qdN-----E 105
gi 122473092  22 GIPIRWI---SIRHPq--nERCVVIVNGRNESFWKYQELCYELSRKGYDVYAYDHRGQGAS-----Grlt-ndS-----E 85
gi 122468893  42 DKTISHVS-IATGn-----SRVIVISQGRSETTLKYKELAFELNKQGFDIYLIDHRGQGFS-----Erf---gGs---kS 104
gi 340049733  41 KTHIYWCS-LKHPEh----QKAVVIVNGRIESAWKYQELCYDLFRQGFDVYTYDHRGQGRSerlteD------R-----Q 104
gi 113972241  46 GLTLAYMM-VKHPKAh----ASIVISSGRVESYLKYQELVFDLYQQGYSVFAIDHRGQGLS-----Srmt-anP-----H 109
gi 149191490  42 GTKLFWCK-LTR--Pe--hQKALVVVNGRIESAWKYQELFYDFFQQGYDIYSFDHRGQGLS-----T------H------ 99
gi 84393549   42 KKKLYWCS-LT--SPt--hTKAIVISNGRIECCLKYQELFYDFYQQGYDVYSFDHQGQGQS------------------E 98
gi 160877597  36 GITLAYMM-VKHPQa----HTAIVLSSGRVESYLKYQELVFDLYQQGYSVYAIDHRGQGLS-----D------------R 93
gi 157959924  45 DISLAYAR-IT--HPn--sIGTIVISSGRVESYLKYKELMFDLYQQGYSLFAIDHRGQGLS-----A------RttanpH 108
                         90       100
                 ....*....|....*....|....*
gi 122415755  82 FGEEHPVQSLLK--D-VIVM---AD 100
gi 122465427 106 LGHVEEFDDYVT--D-LKTF---FD 124
gi 122473092  86 LGHVICFNDYVS--D-LHSF---IT 104
gi 122468893 105 RGHVRFFQDYIT--D-FNTY---IC 123
gi 340049733 105 IGHVHEFQDYVT--D-LKAL---VE 123
gi 113972241 110 QGHVRRFNDYID--D-FALF---MQ 128
gi 149191490 100 LAPNPEMG-HVH--E-FDDYlddMQ 120
gi 84393549   99 RMVTDSDIGHIH--E-FDDY---AS 117
gi 160877597  94 MTINPHMGHVRRfnDyIDDF---AL 115
gi 157959924 109 QGHIDKFQRYVD--D-FAEF---VT 127
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