Conserved Protein Domain Family
PTPLA

?
pfam04387: PTPLA (this model, PSSM-Id:202993 is obsolete and has been replaced by 427914)
Protein tyrosine phosphatase-like protein, PTPLA
This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types.
Statistics
?
PSSM-Id: 202993
Aligned: 72 rows
Threshold Bit Score: -1
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q00WS0        504 QTAAVLEIVHAAIGLARSP-VVVTAM-----------------------------QVSSRLMVVWGVLILAPESRTakmg 553  Ostreococcus ...
Q5NVQ2        197 QMLAVVETINAAIGVTTSP-VLPSLI-----------------------------QLLGRNFILFIIFGTMEEMQN---- 242  Sumatran oran...
Q4SLY6        189 QILASVEVLNAAFGLVRTS-VVPTLI-----------------------------QVIGRNFILFIIFGSLEEMHN---- 234  spotted green...
Q7SY06        192 QMLAIMEVINPAVGLVKTG-VMPAFI-----------------------------QVMGRNFILFVIFGSLEDMQN---- 237  zebrafish
Q4RGI0        226 QMMAVLEVVNPLLGLVKTG-FFPAMIqvnrrlllprppvggssprfsdpaallppQVAGRNVILFVIFGSLEEMQN---- 300  spotted green...
Q5C3R0         74 QILAILEPFHALLGWIRSGnVLASFF-----------------------------QVFGRSLVLFFIVLPHPQFHS---- 120  Schistosoma j...
Q29PA2        197 QLLQYLEVMHPLFGYTKGS-PLVPFF-----------------------------QVSGRNFILFLMIELEPRMHA---- 242  Drosophila ps...
Q018N9         50 QIASFAEVLHALIGLTRTP-AAAALM-----------------------------QWAGRTHCLLCALDGVRSNHS---- 95   Ostreococcus ...
Q0DHK0         52 QTWAILETIHAAIGLVHTS-PLLAFL-----------------------------QWGGRTHFVLAVVRQIPEVQS---- 97   Oryza sativa ...
XP_001418068   50 QLASFAEIAHAVAGLTPTP-AAAALA-----------------------------QWSGRTHCLKCALDAVKTSHA---- 95   Ostreococcus ...
Q5NVQ2        197 QMLAVVETINAAIGVTTSP-VLPSLI-----------------------------QLLGRNFILFIIFGTMEEMQN---- 242  Sumatran oran...
Q4SLY6        189 QILASVEVLNAAFGLVRTS-VVPTLI-----------------------------QVIGRNFILFIIFGSLEEMHN---- 234  spotted green...
Q7SY06        192 QMLAIMEVINPAVGLVKTG-VMPAFI-----------------------------QVMGRNFILFVIFGSLEDMQN---- 237  zebrafish
Q4RGI0        226 QMMAVLEVVNPLLGLVKTG-FFPAMIqvnrrlllprppvggssprfsdpaallppQVAGRNVILFVIFGSLEEMQN---- 300  spotted green...
Q5C3R0         74 QILAILEPFHALLGWIRSGnVLASFF-----------------------------QVFGRSLVLFFIVLPHPQFHS---- 120  Schistosoma j...
Q29PA2        197 QLLQYLEVMHPLFGYTKGS-PLVPFF-----------------------------QVSGRNFILFLMIELEPRMHA---- 242  Drosophila ps...
Q018N9         50 QIASFAEVLHALIGLTRTP-AAAALM-----------------------------QWAGRTHCLLCALDGVRSNHS---- 95   Ostreococcus ...
Q0DHK0         52 QTWAILETIHAAIGLVHTS-PLLAFL-----------------------------QWGGRTHFVLAVVRQIPEVQS---- 97   Oryza sativa ...
XP_001418068   50 QLASFAEIAHAVAGLTPTP-AAAALA-----------------------------QWSGRTHCLKCALDAVKTSHA---- 95   Ostreococcus ...
Q00WS0        554 vvgplELGVPSLILAWGVTEVIRYSFYFFKVatkDGEVPRAIVWCRYTLFIVLYPLGVS-SELFLAKSGFAQlvkTNPLA 632  Ostreococcus ...
Q5NVQ2        243 -----KAVVFFVFYLWSAIEIFRYSFYMLTC---IDMDWEVLTWLRYTLWIPLYPLGCL-AEAVSVVQSIPIfneTGRFS 313  Sumatran oran...
Q4SLY6        235 -----KAVVFFVFYLWSAIEVVRYPFYMINC---VGADWKVLTWLRYTVWIPLYPLGVL-AEAVAVVQSIPIfdeTNLFS 305  spotted green...
Q7SY06        238 -----KPVVFFVFYLWSTIEIFRYPFYMLAC---IDTEWKLLTWLRYTIWMPLYPLGVL-AEAVAVIQSIPIfdeTKLLS 308  zebrafish
Q4RGI0        301 -----RPVVFFVFYLWSTIEVFRYPFYMLAC---IGTEWRPLTWVRYSIWVPLYPLGVL-AEAVAVIQSLPVfdeTRRFS 371  spotted green...
Q5C3R0        121 -----ESTTYWLFFAWSLIEIVRYPYYILSL---LSFQNALITYLRHTLWIVLYPIGFI-CEGKLIIRSLPLlieSRKFC 191  Schistosoma j...
Q29PA2        243 -----KPVVFYVFIIWSLVELIRYPFYLSQL---LGREVGLLTWLRYTIWIPLYPMGIV-CEGIIVLRNIPYieeTKRFT 313  Drosophila ps...
Q018N9         96 -----SDAATVLVFAWAITEVIRYPAYVCGL---LGIESKALTWARYTVFVPLYPLGAG-AEMKLMYDARAHarrTKMYA 166  Ostreococcus ...
Q0DHK0         98 -----SPSVFITFMAWSISEVIRYSHYALTT---LKVCPPWLTYLRYTAFIPLYPIGVGpGEMWTMYQALPF---VKERK 166  Oryza sativa ...
XP_001418068   96 -----SVAATALVFAWALTEVVRYPSYVGGL---IGRSPKWLTWSRYTVFVPLYPLGAA-AEMKLMYDARAHarkTKMYA 166  Ostreococcus ...
Q5NVQ2        243 -----KAVVFFVFYLWSAIEIFRYSFYMLTC---IDMDWEVLTWLRYTLWIPLYPLGCL-AEAVSVVQSIPIfneTGRFS 313  Sumatran oran...
Q4SLY6        235 -----KAVVFFVFYLWSAIEVVRYPFYMINC---VGADWKVLTWLRYTVWIPLYPLGVL-AEAVAVVQSIPIfdeTNLFS 305  spotted green...
Q7SY06        238 -----KPVVFFVFYLWSTIEIFRYPFYMLAC---IDTEWKLLTWLRYTIWMPLYPLGVL-AEAVAVIQSIPIfdeTKLLS 308  zebrafish
Q4RGI0        301 -----RPVVFFVFYLWSTIEVFRYPFYMLAC---IGTEWRPLTWVRYSIWVPLYPLGVL-AEAVAVIQSLPVfdeTRRFS 371  spotted green...
Q5C3R0        121 -----ESTTYWLFFAWSLIEIVRYPYYILSL---LSFQNALITYLRHTLWIVLYPIGFI-CEGKLIIRSLPLlieSRKFC 191  Schistosoma j...
Q29PA2        243 -----KPVVFYVFIIWSLVELIRYPFYLSQL---LGREVGLLTWLRYTIWIPLYPMGIV-CEGIIVLRNIPYieeTKRFT 313  Drosophila ps...
Q018N9         96 -----SDAATVLVFAWAITEVIRYPAYVCGL---LGIESKALTWARYTVFVPLYPLGAG-AEMKLMYDARAHarrTKMYA 166  Ostreococcus ...
Q0DHK0         98 -----SPSVFITFMAWSISEVIRYSHYALTT---LKVCPPWLTYLRYTAFIPLYPIGVGpGEMWTMYQALPF---VKERK 166  Oryza sativa ...
XP_001418068   96 -----SVAATALVFAWALTEVVRYPSYVGGL---IGRSPKWLTWSRYTVFVPLYPLGAA-AEMKLMYDARAHarkTKMYA 166  Ostreococcus ...
Q00WS0        633 LEMPNKLNIAFHFPTFMVLFFLG-YVPG--FPMLYGYMLDARKKVLGTKS 679  Ostreococcus tauri
Q5NVQ2        314 FTLPYPVKIKVRFSFFLQIYLIM-IFLG--LYINFRHLYKQRRRRYGQKK 360  Sumatran orangutan
Q4SLY6        306 IPLPKAAGSSVSFSYFLYFYLVL-MFMG-----------KHSKEHSKMKK 343  spotted green pufferfish
Q7SY06        309 IPLPKATGLSLSFSYILQLYLVV-MFLG--LFINFRHLFKQRTRRFRTKK 355  zebrafish
Q4RGI0        372 LPLPALLGGSLSFSYPLQLYLVL-MFLGvlLCVVYALTLKERLPLLRVST 420  spotted green pufferfish
Q5C3R0        192 LELPNPTNFSFDFPIFLQIYLLV-MLFG--LYYLMRHLYVKRRKIIGPRP 238  Schistosoma japonicum
Q29PA2        314 VEMPNKLNFTFDMVLFLKLYLLLlILPG--TYLVMSHMSKLRAKKLGRGR 361  Drosophila pseudoobscura
Q018N9        167 IEMPNAYNFAFDYPTFLNALLVL-YPFL--FHGLYSYMFAQRRKKLGGKE 213  Ostreococcus tauri
Q0DHK0        167 LYSGFFGKFSMSYHSFLVAVLAV-YPFL--WMKLYLHVFKQRRSKLGKSG 213  Oryza sativa Japonica Group
XP_001418068  167 VTMPNAYNFAFDYVTFLNALLVA-YPFL--FYTLYRYMFAQRRKKLGKAK 213  Ostreococcus lucimarinus CCE9901
Q5NVQ2        314 FTLPYPVKIKVRFSFFLQIYLIM-IFLG--LYINFRHLYKQRRRRYGQKK 360  Sumatran orangutan
Q4SLY6        306 IPLPKAAGSSVSFSYFLYFYLVL-MFMG-----------KHSKEHSKMKK 343  spotted green pufferfish
Q7SY06        309 IPLPKATGLSLSFSYILQLYLVV-MFLG--LFINFRHLFKQRTRRFRTKK 355  zebrafish
Q4RGI0        372 LPLPALLGGSLSFSYPLQLYLVL-MFLGvlLCVVYALTLKERLPLLRVST 420  spotted green pufferfish
Q5C3R0        192 LELPNPTNFSFDFPIFLQIYLLV-MLFG--LYYLMRHLYVKRRKIIGPRP 238  Schistosoma japonicum
Q29PA2        314 VEMPNKLNFTFDMVLFLKLYLLLlILPG--TYLVMSHMSKLRAKKLGRGR 361  Drosophila pseudoobscura
Q018N9        167 IEMPNAYNFAFDYPTFLNALLVL-YPFL--FHGLYSYMFAQRRKKLGGKE 213  Ostreococcus tauri
Q0DHK0        167 LYSGFFGKFSMSYHSFLVAVLAV-YPFL--WMKLYLHVFKQRRSKLGKSG 213  Oryza sativa Japonica Group
XP_001418068  167 VTMPNAYNFAFDYVTFLNALLVA-YPFL--FYTLYRYMFAQRRKKLGKAK 213  Ostreococcus lucimarinus CCE9901
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap