1OED,1OED,1OED


Conserved Protein Domain Family
Neur_chan_memb

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pfam02932: Neur_chan_memb (this model, PSSM-Id:202474 is obsolete and has been replaced by 308533)
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Neurotransmitter-gated ion-channel transmembrane region
This family includes the four transmembrane helices that form the ion channel.
Statistics
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PSSM-Id: 202474
View PSSM: pfam02932
Aligned: 50 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1OED_E         8 IIAPCVLISSLVVLVYFLPAQAGgQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMFVSMLIVMNCVIVL 87
gi 120759    282 TYLPCIMTVILSQVSFWLNRESVpARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALIEFATVNY 361
gi 399519    264 TYLPCIMTVILSQVSFWLNRESVpARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 343
gi 120752    257 TYLPCIMTVILSQVSFWLNRESVpARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 336
gi 143811394 263 TYIPCIMTVILSQVSFWINKESVpARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY 342
gi 341941084 247 IYTPCIMTVILSQVSFWINKESVpARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY 326
gi 120782    277 TYIPCILTVVLSWVSFWINKDAVpARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHY 356
gi 120784    279 TYIPCTLIVVLSWVSFWINKDAVpARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHY 358
gi 120789    260 TYIPCILTVVLSWVSFWIKKDATpARTTLGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNY 339
gi 462150    262 TYIPCILTVVLSWVSFWIKRDSTpARTSLGITTVLTMTTLSTISRKHLPRVSYITAMDLFVSVCFIFVFAALMEYATLNY 341
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1OED_E        88 NVSLRTP-NTHSLSEKIKHLFlgfLPKYLGMQLEPSEETPEKPQPRRRSSFGIMIKAEEYIlkkprselmfeeqkdrhgl 166
gi 120759    362 FTKRSWAwEGKKVPEALE---------MK-KKTPAVPTKKTSTTFNIVGTTYPIN------------------------- 406
gi 399519    344 FTKRGWAwDGKKALEAAK---------IK-KK-REVILNKSTNAFTTGKMSHPPN------------------------- 387
gi 120752    337 FTKRGYAwDGK---SVVP---------EK-PKKVKDPLIKKNNTYAPTATSYTPNL------------------------ 379
gi 143811394 343 FTNVQMEkAKRKTSKAPQEIS---AAPVLREKHPETPLQNTNANLSMRKRANALVHSESDV------------------- 400
gi 341941084 327 FTNLQSQkAERQAQTAAT------PPVAK-SKASESLQAEIVVHSDSKYHLKKRI------------------------- 374
gi 120782    357 FTSNNKGkTTRDRKLKS-------------KTSVSPGLHAGSTLIPMNNISMPQG------------------------- 398
gi 120784    359 FVSNRKPsKDKDKKKKNPLL-----RMFS-FKAPTIDIRPRSATIQMNNATHLQER------------------------ 408
gi 120789    340 YSSCRKPtIRKKKTSLLHPDS----TRWI-PDRISLQAPSNYSLLDMRPPPPVMITLNNSM------------------- 395
gi 462150    342 LVGNKKPlEHSSRKARLPPAG----AQVM-PSFTAINININNIMHWPPEIEEDED------------------------- 391
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1OED_E       167 KRVNKMTSDIDIGTTVDLYKDLANFAPEIKSCVEAC--------------NFIAKS------------------------ 208
gi 120759    407 -----LAKDTEFSAISKGAAPSTSSTPTIIASPkttcv------------------------------------------ 439
gi 399519    388 ------IPKEQTPAGTSNTTSVSVKPSEEKTS------------------------------------------------ 413
gi 120752    380 ----ARGDPGLATIAKSATIEPKEVKPETKPP------------------------------------------------ 407
gi 143811394 401 GSRTDVGNHSSKSSTVVQGSSEATPQSYLASSPNPFsranaaetisaaraIPSALPstpsrtgyvprqvpvgsastqhvf 480
gi 341941084 375 ------SSLTLPIVPSSEASKALSRTPILKSTPvsp-------------------------------------------- 404
gi 120782    399 -----EDDYGYQCLEGKDCATFFCCFEDCRTGSw---------------------------------------------- 427
gi 120784    409 -----DEEYGYECLDGKDCASFFCCFEDCRTGAw---------------------------------------------- 437
gi 120789    396 YWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSw---------------------------------------------- 429
gi 462150    392 ------DDPGSPCLEGKECERFFCCIEDCQTGMw---------------------------------------------- 419
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1OED_E       209 ---------------------------TKEQNDSgsenenwvlIGKVIDKACFWIALLLFSIGTLAIF 249
gi 120759    440 -----------------------qdipTETKTYN---------SVSKVDKISRIIFPVLFAIFNLVYW 475
gi 399519    414 ---------------------------ESKKTYN---------SISKIDKMSRIVFPVLFGTFNLVYW 445
gi 120752    408 ---------------------------EPKKTFN---------SVSKIDRLSRIAFPLLFGIFNLVYW 439
gi 143811394 481 gsrlqrikttvnsigtsgklsatttpsAPPPSGS---------GTSKIDKYARILFPVTFGAFNMVYW 539
gi 341941084 405 -------------------------plLLPATG----------GTSKIDQYSRILFPVAFAGFNLVYW 437
gi 120782    428 ---------------------------REGRIHI---------RIAKIDSYSRIFFPTAFALFNLVYW 459
gi 120784    438 ---------------------------RHGRIHI---------RIAKMDSYARIFFPTAFCLFNLVYW 469
gi 120789    430 ---------------------------RRGRIHI---------DVSELDSYSRVFFPTSFLLFNLVYW 461
gi 462150    420 ---------------------------REGRVRI---------HISRLDSYSRVFFPTAFLLFNIVYW 451
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