Conserved Protein Domain Family
PP2C

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pfam00481: PP2C (this model, PSSM-Id:201254 is obsolete and has been replaced by 306885)
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Protein phosphatase 2C
Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.
Statistics
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PSSM-Id: 201254
View PSSM: pfam00481
Aligned: 32 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 5-Jan-2012
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00481 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KDJ_B        23 MEDAVSTIPRFLQSSSGSMLDGR----F------DPQSAAHFFGVYDGHGGSQVANYCRERMHlalaeEIAKEKPMLSDG 92
gi 117794   1032 SDISAGKNNRVLKFVYDNLASCLaheiN------AADSSSEQICNALRRGFLRLNKKLGNVIH-------YDLRKSSEGD 1098
gi 1345878  1742 FGLFDGRGHGAHVGSRIAHHLAEw---------sGHRLSWEFQKHQNEMTAEPVSVPDALRRA------FLRLQKDYADA 1806
gi 1169151  1373 RDVTFERFRGNDDECLLCLHDSKnqnaDy-----GHNISRIVRDIYDKILIRQLERYGDETDDn----IKTALRFSFLQL 1443
gi 117793   1189 RDVTFERFRGREDECLICLYDGKnenaSs-----GHKISKIIRDIYDKILIRLLEKYGEESDG-----IKRALRYSFLQL 1258
gi 67476867 1568 FDLVVPRLGSVETDTLVALFDGKel-sTg-----GSKIAKFLYEEFSRLFILELEKVKGKPNEn----PADALRRTFLSV 1637
gi 2492894  1449 IDLVVPRFNSNDSETLLGLFDGQal-sSg-----GSKIAKYLQENFGHIFSQELRDLKN--TEn----PADALRRSFLSL 1516
gi 49066025  108 YARRFPEGNYWKHKLSTFEKFYNkfikNcnskqeLLLMKEGDSAILGQNGGRMIFDKMGNIIDkiallTELDRLRLFYGF 187
gi 55584078  181 EDGKSIEKDLYFFGIFDGHGGPFtsekLs-------KDLVRYVAYQLGQVYDQNKTVFHSDPN-----QLIDSAISKGFL 248
2POP_C        71 NGYDGNRVTNFVAQRLSAELLLGqlnaEh----aEADVRRVLLQAFDVVERSFLESIDDALAE------KASLQle---- 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KDJ_B        93 dtwlekwkkALFNSFLR------VDSeie-----svaPETVGSTSVVAVVFPSH---IFVANCGDSRAVLCRGKTAL--- 155
gi 117794   1099 v-------dSNYVTTMNis--ekGYSmd-------ssCLDIGVSIILVYVRDTR---AFVANVGTSMAIMSTRNDSEp-- 1157
gi 1345878  1807 lind--gsrKLSEAHAEaaadvtRSSapaiaaasnkhDWRAGASAILAYVVDHT---LYIANAGDALAVMSRNGGTAh-- 1879
gi 1169151  1444 nke----inGMLNSVDNga--dvANls--------yaDLLSGACSTVIYIRGKK---LFAANLGDCMAILSKNNGDYq-- 1504
gi 117793   1259 nke----inGMLVSVEDgn--tdSGlt--------saDLLSGSSATVVYLKGKK---IYTANIGDTMAVLSKNNGDFv-- 1319
gi 67476867 1638 nkl----lmSLSNSADErgl-dsHPSrnyahtvltkeDLNSGCVATVAYLSELK---LYVANVGDVQGMLIQANGSFk-- 1707
gi 2492894  1517 nkd----liAAGNTHTEdrslmvHRgstapl-vlsreDMNSGGVATIVYIQNQD---LYVANVGDVQAMIIKSDSTHv-- 1586
gi 49066025  188 arfd--ldqCCGLGTAAgstassIFLypyd---dpnaPIDEGKDDDSWIISHSGllkLIVTQVGDSKIILCDQDGIAh-- 260
gi 55584078  249 kld----ndLVIESFRKlfqdpnNTNian------tlPAISGSCALLSLYNSTNs-iLKVAVTGDSRALICGLDNEGnwt 317
2POP_C       137 ----------------------rLKTle--------rEISGGAMAVVAVLLNNK---LYVANVGTNRALLCKSTVDGlq- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KDJ_B       156 --PLSVDHKPDREDEAARIEAAGGKVIqw--nGARVFGVLAMSRSIGDRYLK---------------------------- 203
gi 117794   1158 -tTLSVMHDVYNRDEIRRIVDSCGFIS------GEIKST--TTRAIGRLSQFp--------------------------- 1201
gi 1345878  1880 --LISNKHEPFDRAEIERIRSAEGWVSl----RGYVNDMLDVSRSFGYFHLFp--------------------------- 1926
gi 1169151  1505 --TLTKQHLPTKREEYERIRISGGYVN-----NGKLDGVVDVSRAVGFFDLLp--------------------------- 1550
gi 117793   1320 --TLTKLHVPAEREEYERIRTSGGYVN-----NQKLDGVSEVSRAVGFFDLLp--------------------------- 1365
gi 67476867 1708 --MLTKKHDPADPVERSRIRNAGGWVSr----NGRLNDVLNVSRAFGYTELLp--------------------------- 1754
gi 2492894  1587 --MLTKKHDPADPNERTRIREAGGWVSr----NGRLNDLLEVSRAFGYLDLMp--------------------------- 1633
gi 49066025  261 --ALTTTHHINSSRERHRLSIDPSRLDpdafgETRFLNNFANTRSFGDVAGKpygisse---------------pdifsf 323
gi 55584078  318 vkSLSTDQTGDNLDEVRRIRKEHPGEPnv-irNGRILGSLQPSRAFGDYRYKikevdgkplsdlpevaklyfrreprdfk 396
2POP_C       183 vtQLNVDHTTENEDELFRLSQLGLDAGki-kqVGIICGQ-ESTRRIGDYKVKygytdid----------------llsaa 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KDJ_B       204 -P-SIIPDPEVT--AVKRVKE-DDCLILASDGVWDVMTDEEACEMARKRILLWhkknavagGASLLADERRKEGKDPAAM 278
gi 117794   1202 ---GVQAVPYVN--VQYLSEL-NEFIILANQEFWSVLSKRTVIDVVRANRHS----------PLLASTKLRDYAIAYGAE 1265
gi 1345878  1927 ---IVNAAPAVT--TVQLTDS-DEFVIIANRTLWQYVSYQTAVDIARTQRND----------PMIAAQKLRDFAISYGAE 1990
gi 1169151  1551 ---HIHASPDIS--VVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTD----------PLRAAAELKDHAMAYGCT 1614
gi 117793   1366 ---HIHASPDIS--ETVLSYS-DEMLIIATHKLWEYLDYETVCDISRENKSQ----------PMSAAEKMKDYAISYGCS 1429
gi 67476867 1755 ---AVQAAPDIT--EHTIDDK-DETVLIASKELWEHLRPELIVDVARECRSD----------LMKASQKLRDLAIAYGST 1818
gi 2492894  1634 ---AVQSAPNIE--KHTIGEH-DEMILIATREVWEYLPKDVLVDVTRSVRQDP--------DPMRAAQKVRDLAMAYGCS 1699
gi 49066025  324 lVgNTLHLPRSErsKLPFNGD-ECFLALVTDGITNKLADQEVVDLITSTVNSWglk---kaTPQFVAEETIKFIQAIATK 399
gi 55584078  397 tPpYVTAEPVIT--SAKIGEN-TKFMVMGSDGLFELLTNEEIASLVIRWMDKN----------MNLAPVKAEPGKLPKVI 463
2POP_C       245 kSkPIIAEPEIH--GAQPLDGvTGFLVLMSEGLYKALEAAHGPGQANQEIAAM--------IDTEFAKQTSLDAVAQAVV 314

                 ...
3KDJ_B       279 SAA 281
gi 117794   1266 KNV 1268
gi 1345878  1991 ESI 1993
gi 1169151  1615 ENI 1617
gi 117793   1430 DNI 1432
gi 67476867 1819 NKL 1821
gi 2492894  1700 NKM 1702
gi 49066025  400 HSD 402
gi 55584078  464 DVS 466
2POP_C       315 DRV 317
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