Conserved Protein Domain Family
GST_C_eEF1b_like

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cd10308: GST_C_eEF1b_like 
Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
Glutathione S-transferase (GST) C-terminal domain family, eukaryotic translation Elongation Factor 1 beta (eEF1b) subfamily; eEF1b is a component of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of two functionally distinct units, EF1A and EF1B. EF1A catalyzes the GTP-dependent binding of aminoacyl-tRNA to the ribosomal A site concomitant with the hydrolysis of GTP. The resulting inactive EF1A:GDP complex is recycled to the active GTP form by the guanine-nucleotide exchange factor EF1B, a complex composed of at least two subunits, alpha and gamma. Metazoan EFB1 contain a third subunit, beta. eEF1b contains a GST_C-like alpha helical domain at the N-terminal region and a C-terminal guanine nucleotide exchange domain. The GST_C-like domain likely functions as a protein-protein interaction domain, similar to the function of the GST_C-like domains of EF1Bgamma and various aminoacyl-tRNA synthetases (aaRSs) from higher eukaryotes.
Links
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Statistics
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PSSM-Id: 198341
View PSSM: cd10308
Aligned: 14 rows
Threshold Bit Score: 91.3312
Threshold Setting Gi: 322783273
Created: 1-Apr-2011
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
putativeputative
Feature 1:putative protein interface 1 [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other family members
  • Comment:Protein interface 1 is a surface used by GST-fold domains to bind other GST-fold domains in this subfamily, to facilitate complex formation.
  • Comment:Protein interface 1 corresponds to the same interacting surface used in classical GST dimerization.
  • Comment:Saccharomyces cerevisiae Arc1p uses this interacting surface to bind methionyl-tRNA synthetase.

cd10308 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd10308 is a member of the superfamily cl02776.
cd00299:GST_C_familycd03177:GST_C_Delta_Epsiloncd03178:GST_C_Ure2p_likecd03180:GST_C_2cd03181:GST_C_EF1Bgamma_likecd03182:GST_C_GTT2_likecd03183:GST_C_Thetacd03184:GST_C_Omegacd03185:GST_C_Taucd03186:GST_C_SspAcd03187:GST_C_Phicd03188:GST_C_Betacd03189:GST_C_GTT1_likecd03190:GST_C_Omega_likecd03191:GST_C_Zetacd03192:GST_C_Sigma_likecd03193:GST_C_Metaxincd03194:GST_C_3cd03195:GST_C_4cd03196:GST_C_5cd03197:GST_C_mPGES2cd03198:GST_C_CLICcd03199:GST_C_GRX2cd03200:GST_C_AIMP2cd03201:GST_C_DHARcd03202:GST_C_etherase_LigEcd03203:GST_C_Lambdacd03204:GST_C_GDAP1_likecd03205:GST_C_6cd03206:GST_C_7cd03207:GST_C_8cd03208:GST_C_Alphacd03209:GST_C_Mucd03210:GST_C_Picd03211:GST_C_Metaxin2cd03212:GST_C_Metaxin1_3cd10289:GST_C_AaRS_likecd10290:GST_C_MetRS_N_fungicd10291:GST_C_YfcG_likecd10292:GST_C_YghU_likecd10293:GST_C_Ure2pcd10294:GST_C_ValRS_Ncd10295:GST_C_Sigmacd10296:GST_C_CLIC4cd10297:GST_C_CLIC5cd10298:GST_C_CLIC2cd10299:GST_C_CLIC3cd10300:GST_C_CLIC1cd10301:GST_C_CLIC6cd10302:GST_C_GDAP1L1cd10303:GST_C_GDAP1cd10304:GST_C_Arc1p_N_likecd10305:GST_C_AIMP3cd10306:GST_C_GluRS_Ncd10307:GST_C_MetRS_Ncd10308:GST_C_eEF1b_likecd10309:GST_C_GluProRS_Ncd10310:GST_C_CysRS_Ncd10424:GST_C_9322783273270006157332027446328787158242022374219126454328873426168024498455492592214865182458672132278698831696625530330498722405086816964683347213254322783273270006157332027446328787158242022374219126454328873426168024498455492592214865182458672132278698831696625530330498722405086816964683347213254
cd10308 Sequence Cluster
cd10308 Sequence Cluster
Sub-family Hierarchy
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 cd10308 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ### ###### ##                            #  #     ##                          
gi 24586721    20 SSAFAQLPVPAFAMGFgd--------------------lkTPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSGPPPA 79
gi 322786988   34 CGQLFTRSEHIFTMSIgd--------------------lkTDKGIENLNDYLANRSYIEGWQPTQADVAVFEALGKPPTQ 93
gi 322783273   25 KAAKADNTQEYREQSD------------------------INVELESLNDDLADVSYVCGWYPTSKDAELFDTLHVVLDD 80
gi 270006157   19 KYKAAKESKEKGQNGFspfg-----------------sklTEKHFEALNEYFSSRSYVSGYSPTTADEELYQIVSNNVKS 81
gi 242022374  818 MSQKITHPLHTLLHGIdasyfks-----------vnaasySKDIFAILNGFLSDKSYLQGHRPSLVDSQVLDALDGASLT 886
gi 221486518   67 TPSLRDKSKHSHLPFTlldkmvv----------pdfgnlkSDIGVGKLNEYLASRSFITGYSATQDDAIIFSKLLGAPNA 136
gi 219126454    4 SANGYTRNKHCLANRVtrcvseglfspqfplfcflqfdvsSDKGAAAFNGFMGSKSYIEGWSFSPADSEMFAKFESVPDA 83
gi 328873426   29 IWNERAEKKKRNILYVylmps--------------fadltTDAGVIDLNEYLKDKTYLVGFLPSNVDQEAVKKLGKAPCA 94
gi 332027446  751 FQFKYNANDRKLNNTCidvgngk----------wyqwtlnESCVQKALNNYLADYSYLDGYTPSQLDLSVYQSLKELNID 820
gi 328787158  751 DSNFDNENIQSANDIVvgdndw------------yqntlkEKCVQEALNNYLADYSYLDGYKPSQIDTKVYQAFIKLDND 818
                          90       100
                  ....*....|....*....|.
Feature 1                              
gi 24586721    80 d------LCHALRWYNHIKSY 94
gi 322786988   94 qs----vNYHVIRWYNHIKSY 110
gi 322783273   81 el---akWPHLSRWHVNMKSF 98
gi 270006157   82 -------CPHLNRWRTHIASF 95
gi 242022374  887 itdlnseFPHVTRWWRHIDSL 907
gi 221486518  137 t-----kFVDASRWYRHVSHF 152
gi 219126454   84 a-----kFPHSYRWYIHVAAL 99
gi 328873426   95 t-----kYPHANRWYNTIQAL 110
gi 332027446  821 fa----rHLHIKRWYNHIATF 837
gi 328787158  819 ft----nYPHLHRWYKHMTSY 835

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