Conserved Protein Domain Family
CDC37_N

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smart01071: CDC37_N 
Cdc37 N terminal kinase binding
Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.
Statistics
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PSSM-Id: 198139
Aligned: 22 rows
Threshold Bit Score: 82.0801
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_456605      2 PIDYSKWDKIELSDDSDIEVHPNVDKNSFIKWKQRDIHEKRQQRNIEIKSILVQLTMYAKLNERVDFLLSDVDEEQLldd 81  Debaryomyces ha...
NP_595752      2 AIDYSKWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAVRKQKMEDIKGAMAMNRRLLSRISEMETVLEKESP--- 78  Schizosaccharom...
XP_504105      2 VLDYSKWDKIELSDDSDVEVHPNVDKKSFIRWKQRDIHEKRDRNKMEIASLELTMKIDVELVERLDKLLSLPQAQLA--- 78  Yarrowia lipoly...
XP_001512153  36 MVDYSVWDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQ-------------KEKEELDRGCRDC----- 92  platypus
NP_058022      1 MVDYSVWDHIEVSDDED-ETHPNIDTASLFRWR----HQARVERMEQFQ-------------KEKEELDRGCREC----- 57  house mouse
NP_001015912   1 MVDYSVWDHIEVSDDED-DTHPNIDTASLFRWR----HQARVERMEQFD-------------KEKEELSKGTSDC----- 57  western clawed ...
NP_957332      3 tIDYSVWDHIEVSDDED-DTHPNIDTPSLFRWR----HQARVERMEAF-------------TQKGVELEKSLMESR---- 60  zebrafish
Q9DGQ7         3 RIDYSVWDHIEVSDDEDV-SHPNIDTPSLFRWR----HQARVERMEDFK-------------KKGDDLNKGLQECR---- 60  green pufferfish
AAO45184       1 MVDYSKWKNIEISDDED-DTHPNIDTPSLFRWR----HQARVERMAEMD-------------HEKDELKKKRQ------- 55  fruit fly
XP_001660603   1 MVDYSKWKD-IEISDDEDDTHPNIDTPSLFRWR----HQARIERMEEHK-------------REKEKLDEKKRITE---- 58  yellow fever mo...
XP_456605     82 slimkklndkfdktekfdydllkkekgdtlrkglkdlsfS----------------------------AEeidnTPPYNE 133 Debaryomyces ha...
NP_595752     79 ---------------------------------------Sdpyvllgsfle------akksedmdsaiPG----GMSYHH 109 Schizosaccharom...
XP_504105     79 ---------------------------------------KdsieellvkskeglkakdtptapnpqkeGE----QMNCDD 115 Yarrowia lipoly...
XP_001512153  93 ------------------------------------------------------------------------------QR 94  platypus
NP_058022     58 ------------------------------------------------------------------------------KR 59  house mouse
NP_001015912  58 ------------------------------------------------------------------------------KK 59  western clawed ...
NP_957332     61 -------------------------------------------------------------------------------R 61  zebrafish
Q9DGQ7        61 -------------------------------------------------------------------------------R 61  green pufferfish
AAO45184      56 ----------------------------------------------------------------------------SYQA 59  fruit fly
XP_001660603  59 -------------------------------------------------------------------------------R 59  yellow fever mo...
XP_456605    134 MIEDLFIQVKEDHP----DAAKDAAKLTQYLKE---HRAKIDDVLSRQAIKLDDLLYQKSMLISSDDI--HTGFDKS 201 Debaryomyces hanse...
NP_595752    110 MLMSLLKVIKDAEDtteeKSMDDSDKCLRRLKS---HKERLLKLLEDAQKEYDTLEAESKNYITSEDL--HLGFDST 181 Schizosaccharomyce...
XP_504105    116 MLESLLDMIKPDVD----TDNG--ATFYDKLKE---HRDKLVDHDKSHRERLAELYDEKAKYITSEDV--HDVYNST 181 Yarrowia lipolytic...
XP_001512153  95 KVAECQQKL-KALE----VADREGEGAQGEWQRlqaEAQELRKEEKTWERKLDELHRKEKSMPWNVDTlsrdglqqg 166 platypus
NP_058022     60 KVAECQRKL-KELE----VAESDGQVELERLRA---EAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTlsKDGFSKS 128 house mouse
NP_001015912  60 KLAECQKKLN-DLG----LKDGGQSDVQ-KLQS---DLCQLKKEQKDWEKKENELRKKEKNMPWNVDTlsKEGFSKS 127 western clawed frog
NP_957332     62 RLAEAQRRVQ---E----LSSSSSSTELSRAQA---EEKQLKKEERSLQRKMEEHRAEEKKMPWNVDTlsREGFSKS 128 zebrafish
Q9DGQ7        62 KLAEAQKKVRELSI----SAAGDAKAELTKTQT---EEKKLKKEERDWARKLEEHNHEEKKMPWNVDTlsKDGFSKS 131 green pufferfish
AAO45184      60 RLMDVKERISK------------KDGDEEALKK---ELEKIEAEGKELDRIESEMIKKEKKTPWNVDTisKPGFEKT 121 fruit fly
XP_001660603  60 KLKEVQEKLKK------------SDGNLDELKK---SMDELEKEQARMRLEEDEWKKKDKLQPWNVDTisKEGFQKT 121 yellow fever mosquito
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