3EA3,1DJG,1AOD


Conserved Protein Domain Family
PLCXc

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smart00148: PLCXc 
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Phospholipase C, catalytic domain (part); domain X
Phosphoinositide-specific phospholipases C. These enzymes contain 2 regions (X and Y) which together form a TIM barrel-like structure containing the active site residues. Phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The bacterial enzyme appears to be a homologue of the mammalian PLCs.
Statistics
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PSSM-Id: 197543
View PSSM: smart00148
Aligned: 18 rows
Threshold Bit Score: 146.657
Threshold Setting Gi: 46251838
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EA3_A         19 DNIPLARISIPGTHDsgtfkL--------QNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIV-LHHGP-LYLY 88
gi 619519     443 MSRPLNEYLISSSHN-----T--------YLLGKQFGGESSIEGYIRSLQAGCKCIEIDCWDGPNG-PV-VCHGHtFTSM 507
gi 1762781    415 LDRPMHEYFISSSHN-----T--------YLMGRQVAGESSVEAYISALIKGCRCVEIDCWDGKDGRPI-VNHGHtMTRP 480
gi 114582415  400 MTQPLSHYYINASHN-----T--------YLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPI-LCNRNnMTTH 465
gi 945039     108 MTLPLSHYFIYTGHN-----S--------YLTGNQLSSDCSDVPIINALKRGVRVIELDIWPNASKDNIdVLHGRtLTTP 174
gi 6324987    382 YSKPLNHYFIASSHN-----T--------YLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENG-PV-VCHGF-LTSA 445
gi 15232770   107 MHAPLSHYFIHTSLN-----S--------YFTGNVFGKYS-ILPIIEALEQGVRVVELDLWPDGRGSIC-VRPSWnFEKP 171
gi 294850450   27 DGKHLTEINIPGSHDsgsftL--------KDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMIS-VHHGM-VYLH 96
gi 46251838    54 dttnLAALSIPGTHD-----TmsyngditWTLTKPLAQTQTMSLY-QQLEAGIRYIDIRAKDNLN-----IYHGPiF-LN 121
1DJG_A        166 MDQPLSHYLVSSSHN-----T--------YLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPI-IYHGYtFTSK 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EA3_A         89 VTLHEFINEAKQFLKDNPSETIIMSLKKE---YEDMKGAEGSFSSTFEKNYFVDPIFLKTEG-----NIKLGDARGKIVL 160
gi 619519     508 IKFNDVIDAIRKYAFVVSPYPLFISLEIHc-cPDQQRQMVSYMKQAFGDTLVMKPVTANESV-----LPSPEDLLNKILL 581
gi 1762781    481 IMFSDVMYTIAKYAFVKSHFPLWISLEVHc-nDAQQAAMAQIIKEACGDLLVTEPLDPSSQV-----LPSPSQLMDRILI 554
gi 114582415  466 VSFRSVIEVINKFAFVASEYPLILCLGNHc-sLPQQKVMAQQMKKVFGNKLYTEAPLPSESY-----LPSPEKLKRMIIV 539
gi 945039     175 VELIRCLRSIKDHAFVASEYPVVITLEDHl-tPDLQAKVAEMVTETFGDLLFTPNSESVKE------FPSPESLKKRIII 247
gi 6324987    446 IPLKTVIRVIKKYAFITSPYPLIISLEINc-nKDNQKLASLIMREVLAEQLYFVGTRTDK-------LPSPRELKHKILL 517
gi 15232770   172 LKLQECLDSIKEHAFTKCTYPLIITFKDGl-kPELQSKATQMIQQTFNHMVYHHDPH-SLEV-----FPSPQQLRNKILI 244
gi 294850450   97 HELGKFLDDAKYYLSAYPNETIVMSMKKd---YDSDSKVTKTFEEIFREYYYNNPQYQNLFYtgsnaNPTLKETKGKIVL 173
gi 46251838   122 ASLSGVLETITQFLKKNPKETIIMRLKDEqnsNDSFDYRIQPLINIYKDYFYTTPRTDTSNK-----IPTLKDVRGKILL 196
1DJG_A        232 ILFCDVLRAIRDYAFKASPYPVILSLENHc-sLEQQRVMARHLRAILGPILLDQPLDGVTTS-----LPSPEQlkgkill 305

                  ...
3EA3_A        161 LKR 163
gi 619519     582 KVK 584
gi 1762781    555 KVK 557
gi 114582415  540 KGK 542
gi 945039     248 STK 250
gi 6324987    518 KSK 520
gi 15232770   245 SRR 247
gi 294850450  174 FNR 176
gi 46251838   197 Lse 199
1DJG_A        306 kgk 308
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