Conserved Protein Domain Family
PI3Kc

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smart00146: PI3Kc (this model, PSSM-Id:197542 is obsolete and has been replaced by 214538)
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Phosphoinositide 3-kinase, catalytic domain
Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Statistics
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PSSM-Id: 197542
View PSSM: smart00146
Aligned: 41 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 12-Jul-2011
Updated: 18-Jul-2011
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00146 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HHM_A        822 IIFKNGDDLRQDMLTLQIIRIMENIWQN----QGLDLRMLPYGCLSIGDCVGLIEVV--------RNSH----------- 878
gi 148682872 2215 FLLKGHEDLRQDERVMQLFGLVNTLLANdptsLRKNLSIQRYAVIPLSTNSGLIGWV--------PHCD----------- 2275
gi 32563909  2355 FLLKGHEDPRQDERVMQLFGLVNTLLANnsetCRRNLTIQRYSIVALSKDSGLIGWV--------PNCD----------- 2415
gi 151945134 2122 yvLKGHEDIRQDSLVMQLFGLVNTLLKNdsecFKRHLDIQQYPAIPLSPKSGLLGWV--------PNSD----------- 2182
gi 148693849 2721 QLVKGRDDLRQDAVMQQVFQMCNTLLQRntetRKRKLTICTYKVVPLSQRSGVLEWC--------TGTV----------- 2781
gi 313004681  746 LICKKDDDLSKDYHFTKMVEMCNDLLMKdeqtRIQKMTATTYSVIPLGKQGGIIEFM--------EGVT----------- 806
gi 13936336   501 FLVKGGEDLRQDQRVEQLFQVMNGILAQdsacSQRALQLRTYSVVPMTSRLGLIEWL--------ENTV----------- 561
gi 19113774  3315 LQYPATRHSRREERMLQLLGTFNTVLRSkieiQNRNFSFQIPSSIPLSSHMRIIADK--------PSYV----------- 3375
gi 256273228 3405 VQYPAVRHSRREERMFQLYRLFNKSLSKnvetRRRSIQFNLPIAIPLSPQVRIMNDS--------VSFT----------- 3465
gi 71984157  3712 FYLKKSVQDEPTNRVPQMFKHLDHVLQTdresARRHLHAPTVLQMRVGQKTTLYEVAsvqpyampPDCTrnypasqidiv 3791
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HHM_A        879 --------------------------------TIMQIQ--------------------C--------------------- 885
gi 148682872 2276 --------------------------------TLHALI--------------------Rdyrekkkillniehrim---- 2299
gi 32563909  2416 --------------------------------TLHTLV--------------------Keyrekkakiplsiehkt---- 2439
gi 151945134 2183 --------------------------------TFHVLI--------------------Rehrdakkiplniehwvm---- 2206
gi 148693849 2782 --------------------------------PIGEYL--------------------Vnsedgahrryrpndfsan--- 2806
gi 313004681  807 --------------------------------SFYETL--------------------Dklmgmtsgewleklk------ 828
gi 13936336   562 --------------------------------TLKDLLlntmsqeekaaylsdprappCeykdwltkmsgkhdvg----- 604
gi 19113774  3376 --------------------------------TMQTIS--------------------Deycknrgmpldygirfyfdrl 3403
gi 256273228 3466 --------------------------------TLHEIH--------------------Nefckkkgfdpddiqdfmadk- 3492
gi 71984157  3792 hpydvltatfngsyypddmvlhfferfaqsssSIGQPL--------------------Ptptnqdgtvapp--------- 3842
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HHM_A        886 -------------------------------------KGGLKGALQFNSHTLHQWLKDKNK--GeIYDAAIDLFTRSCAG 926
gi 148682872 2300 ---------------------lrmapdydhltlmqkvEVFEHAVNNTAGDDLAKLLWLKSPs-SeVWFDRRTNYTRSLAV 2357
gi 32563909  2440 --------------------lqklsletehltlmqklQLFESALSVTQGEDLRHVLWLKSPs-SeVWFDRRTNYTRSVAC 2498
gi 151945134 2207 ---------------------lqmapdyenltllqkiEVFTYALDNTKGQDLYKILWLKSRs-SeTWLERRTTYTRSLAV 2264
gi 148693849 2807 --------------------qcqkkmmevqkksfeekYDTFMTICQNFEPVFRYFCMEKFLdpA-VWFEKRLAYTRSVAT 2865
gi 313004681  829 ----------------------fwnthmkpmgkeertKYFREVACKNTPVVMGKWFRIQYPe-AgQWFASRKLFAKSTAV 885
gi 13936336   605 ----------------------aymlmykganrtetvTSFRKRESKVPADLLKRAFVRMSTsp-eAFLALRSHFASSHAL 661
gi 19113774  3404 qtgliqlkrasasmlsnstveekkqifrqralqlrmqLLETLNSSVFPESIYYDYFYKTFEry-cDFWFFRRTFTTQYAY 3482
gi 256273228 3493 -----------------lnaahddalpapdmtilkveIFNSIQTMFVPSNVLKDHFTSLFTqf-eDFWLFRKQFASQYSS 3554
gi 71984157  3843 --------------------------rlteahhikniIYEDFARDMIPFRLLYDYLTARYPdp-vMYYAMKKQLLHSLAV 3895
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HHM_A        927 YCVATFILGIGDRHNSNIMV-K-D-D-GQLFHIDFGHFLDHKKKK-----------------F---GYkrERVPFVLTQD 982
gi 148682872 2358 MSMVGYILGLGDRHPSNLML-DrL-S-GKILHIDFGDCFEVAMTR-----------------E---KFp-EKIPFRLTRM 2413
gi 32563909  2499 MSMVGYILGLGDRHPSNLML-DrL-T-GKVVHIDFGDCFEVAMLR-----------------E---KFp-ERVPFRLTRM 2554
gi 151945134 2265 MSMTGYILGLGDRHPSNLML-DrI-T-GKVIHIDFGDCFEAAILR-----------------E---KYp-EKVPFRLTRM 2320
gi 148693849 2866 SSIVGYILGLGDRHVQNILI-N-EqS-AELVHIDLGVAFEQGKIL-----------------P---TP--ETVPFRLSRD 2920
gi 313004681  886 MSVIGYIFGLGDRHTKNLMV-H-T-T-GKCIHVDFDMIFNKGETL-----------------G---TP--ELVPFRLTQN 939
gi 13936336   662 ICISHWILGIGDRHLNNFMV-AmE-T-GGVIGIDFGHAFGSATQF-----------------L---PVp-ELMPFRLTRQ 717
gi 19113774  3483 MIIMTYVFNIGGRSPQKLFIvK-D-S-GQVMSQDLLPSMTSNQPV-----------------F---HNt-EAVPFRLTPP 3538
gi 256273228 3555 FVFMSYMMMINNRTPHKIHV-D-K-TsGNVFTLEMLPSRFPYERVkpllknhdlslppdspiF---HNn-EPVPFRLTPN 3627
gi 71984157  3896 LSTIEYHCNLTPMGPDQMMM-TmN-T-GVLSNPSYRFEIRGGRSL-----------------HdiqHFg-HEVPFRLTPN 3954
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
3HHM_A        983 FLIVISkgaqectKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFD 1040
gi 148682872 2414 LTNAME-------VTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMD 2464
gi 32563909  2555 LINAME-------VTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVE 2605
gi 151945134 2321 LTYAME-------VSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWgfdl 2371
gi 148693849 2921 IVDGMG-------ITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNP 2971
gi 313004681  940 MINGMG-------EVALDGEFRTVCEQALRVFRENSYEIEKYIADLpnlvadfpsnkr 990
gi 13936336   718 FINLML-------PMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFE 768
gi 19113774  3539 IQYLIS-------DLGVEGLLSGLVMSIAQSLSSPTTDIKQYLSLYVRDEVFWWSKQQ 3589
gi 256273228 3628 IQSLIG-------DSALEGIFAVNLFTISRALIEPDNELNTYLALFIRDEIISWFSNL 3678
gi 71984157  3955 LSILVG-------VAQDGDLLWSMAAASKCLMKKEPEVIMRPLVWDEFANNTDCDKSV 4005
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