Conserved Protein Domain Family
PI3Ka

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smart00145: PI3Ka (this model, PSSM-Id:197541 is obsolete and has been replaced by 214537)
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Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.
Statistics
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PSSM-Id: 197541
View PSSM: smart00145
Aligned: 26 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 12-Jul-2011
Updated: 18-Jul-2011
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00145 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HIZ_A        549 NElRENDKEQLKAISTRDPLSEITEQEKDFLWSHRhYCvT-IPEI----------LPKLL--LS-VKWNSRDEVAQMYCL 614
gi 24662891  1036 ASlDANLQEELLDTAEL--GYTGATERREVFWEKR-LYlQsYPNA----------LPKVL--HAaHSWDYAN-LIDLHAL 1099
gi 259016395  606 CIrDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRrYIqKqEPDL----------LI-VLseLA-FVWTDRENFSELYVM 673
gi 17567531   780 ATlDIETQEYLLELIENQDTSTLETDDQDLIWQKR-LHlTnQPEA----------LPLVL--SSlQDWSFGF-VMRVYQI 845
gi 929997     261 KPnSKIRKE-LESILSYPPSEELSLEEKDLIWKFR-FYlTrNKKA----------MTKFL--KS-VVWTDSSEVNQALSL 325
gi 6323269    298 KP-DIKKRDYLNKIINYPPGTKLTAHEKGSIWKYR-YYlMnNKKA----------LTKLL--QS-TNLREESERVEVLEL 362
gi 189054544  298 lawSISPYLAVQLPARFKNTEAIGNEVTRLV-RLDpGAvSdVPEA----------I-KFL-----VTWHTIDADAPELSH 360
gi 2499560    335 KPtPQLRDE-LLRIMIKPSNAESTDNEKNLIWKFRyYFsKnNSGNdpsnksvksfLPKFL--RS-INWENDYELDHTFKE 410
gi 987948     287 KP-YPSPRDQLKNIVSYPPSKPPTYEEQDLVWEFR-YYlTnQDKA----------LTKIL--TS-VIWDLPQGAKQALAL 351
gi 1854505    288 NPtASIRDQLHTIVYRYPPTYVLSSEEQDLLWKFRfYLs-sHKKA----------LTKFL--KC-INWKLEDEVTQALWM 353
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HIZ_A        615 VK--DW--PPIKPEQAMELLD----------CNYP-D------------------------PMVRGFAVRCL-EKyLTDD 654
gi 24662891  1100 LH--SW--APLSPLQSLELLL----------PRYP-D------------------------AKVREKAVEWI-SK-MPND 1138
gi 259016395  674 LE--KW--KPPSVAAALTLLG----------KRCT-D------------------------RVIRKFAVEKLnEQ-LSPV 713
gi 17567531   846 LE--EW--APLRPEIAMEFLL----------PKYP-D------------------------ERIRAHAVQSL-AR-GSTD 884
gi 929997     326 LD--SW--TEIDIDDALELLS----------PSFV-H------------------------PKVRAYAVSRL-ET-ASNE 364
gi 6323269    363 MD--SW--AEIDIDDALELLG----------STFK-N------------------------LSVRSYAVNRL-KK-ASDK 401
gi 189054544  361 VL--CW--APTDPPTGLSYFS----------SMYPpH------------------------PLTAQYGVKVL-RS-FPPD 400
gi 2499560    411 IIpfYWnvDKLQIGDALELLGdyfnpytlgkPTYQ-DdsmtsksskmksdekrfikiynnvCFLRKLAVERL-KL-ANSE 487
gi 987948     352 LG--KW--NPMDVEDSLELIS----------SHYT-N------------------------PTVRRYAVARL-RQ-ADDE 390
gi 1854505    354 LA--NW--APMDVEDALELLS----------PTFT-H------------------------PQVRKYAVSRL-AQ-APDE 392
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HIZ_A        655 KLSQ----------YLIQLVQVLKY-------E----------------------------------------------- 670
gi 24662891  1139 QLVD----------FLPQLVQSLKH-------D----------------------------------------------- 1154
gi 259016395  714 TFHL----------FILPLIQALKY-------E----------------------------------------------- 729
gi 17567531   885 FLYH----------TIPQFIEALRF-------E----------------------------------------------- 900
gi 929997     365 ELLL----------YLLQLVQALRYdnpissdE----------------------------------------------- 387
gi 6323269    402 ELEL----------YLLQLVEAVCF-------Enl--------------------------------------------- 419
gi 189054544  401 AILF----------YIPQIVQALRY-------D----------------------------------------------- 416
gi 2499560    488 ELLLyllqlvqalkY-----EALIY-------Eksppfcers-------------------------------------- 517
gi 987948     391 DLLM----------YLSQLVQALKY-------Enfddikngleptkkdsqssvsgnvsnsgins---------------- 437
gi 1854505    393 DLLL----------YLLQLVQALKY-------Edprhivhlhgcifperdvvrsilddngslldqsslsdlsatssglhg 455
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HIZ_A        671 -----------------------------------------------------------------------QYLDNLLVR 679
gi 24662891  1155 -----------------------------------------------------------------------TYEGSAMAR 1163
gi 259016395  730 -----------------------------------------------------------------------PRAQSEVGM 738
gi 17567531   901 -----------------------------------------------------------------------LYEKSALAD 909
gi 929997     388 -----------------------------------------------------------------------RFQPSPLAL 396
gi 6323269    420 ----------------------------------------------------------------------sTFSDKSNSE 429
gi 189054544  417 -------------------------------------------------------------------------KMGYVRE 423
gi 2499560    518 ---------------------------------------------------------------dqiednasSTLKSPLAD 534
gi 987948     438 ----------------------------------------aeidssqiitsplpsvsspppasktkevpdgENLEQDLCT 477
gi 1854505    456 svipanqraasvlaaiksdksvssgsaggsgsggqgsvalpnpsapatpgssslpcdsnsnalmlaegisfGSVPANLCT 535
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HIZ_A        680 F----------------LLKKALTNQ-------------------------------------RIGHFFFWHLKSE---- 702
gi 24662891  1164 F----------------LLSKCLESP-------------------------------------RFAHHMYWLLVHS---- 1186
gi 259016395  739 M----------------LLTRALCDY-------------------------------------RIGHRLFWLLRAE---- 761
gi 17567531   910 F----------------ILELSFVSL-------------------------------------DFTFEIYWQLQQRvdhc 936
gi 929997     397 F----------------LVNRAISSP-------------------------------------SIGNDLYWYLVVE---- 419
gi 6323269    430 FtivdavssqklsgdsmLLSTSHANQkllksissesetsgteslpivisplaeflirralvnpRLGSFFYWYLKSE---- 505
gi 189054544  424 Y----------------ILWAASKSQ-------------------------------------LLAHQFIWNMKTN---- 446
gi 2499560    535 F----------------LIERAVENE-------------------------------------KLGNFFYWYVKVE---- 557
gi 987948     478 F----------------LISRASKNS-------------------------------------TLANYLYWYVIVE---- 500
gi 1854505    536 F----------------LIQRACTNA-------------------------------------TLANYFYWYLSIE---- 558
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
3HIZ_A        703 -M------HN----KT----V--SQRFGLLLESYCRACGM-YLKHLNR 732
gi 24662891  1187 -Lp-----DD----PH----N--SIGAAMVDQEYDESQVT-QVRYYRR 1217
gi 259016395  762 -Iar---lRD----CDlkseE--YRRISLLMEAYLRGNEE-HIKIITR 798
gi 17567531   937 aV------DD----LP----Y--AIRCQNLQQKMIDEHENpNLKTDIK 968
gi 929997     420 -I------ED----EP----V--SKLFSSVMFLFQKELSK-SVEGRLi 449
gi 6323269    506 -S------ED----KP----Y--LDQILSSFWSRLDKKSR-NILNDqv 535
gi 189054544  447 -Iyl---dEE----GH----Qk-DPDIGDLLDQLVEEItgslsgpakd 481
gi 2499560    558 -N------EDqlnnPH----I--DGPIKIYMDILNRYIEL-LKAHCHE 591
gi 987948     501 -C------ED----QD----T--QQRDPKTHEMYLNVMRR-FSQALLK 530
gi 1854505    559 -VeevesvRK----QD----EraHDMYAMVLKMFLKVLEN-GNFNLRG 596
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