Conserved Protein Domain Family
PEN-2

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pfam10251: PEN-2 (this model, PSSM-Id:192496 is obsolete and has been replaced by 402042)
Presenilin enhancer-2 subunit of gamma secretase
This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyses the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.
Statistics
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PSSM-Id: 192496
Aligned: 11 rows
Threshold Bit Score: -1
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5JN39        50 LPLEEAEGHARRFFLWGFACLPFLWAINCCYFwpvLRSPATFPSSAAFSRIRPYVVRSAIGFTIFSVVLLTWATTFIIgg 129 Oryza sativa Ja...
Q7Q3Y1         6 APNERKLYLCKWYFKAGFALLPFLWSINTVWF---FNEAFRKPAYEEQKEIKKYVIFSLVGTLVWVVAIISWVVTFQL-- 80  Anopheles gambi...
Q178A8         6 VPNERKLYLCKWYFKVGFALLPFVWAINTVWF---FSEAFRKPAYDEQKEIRKYVIFSAIGSLIWFTLILTWVMTFQL-- 80  yellow fever mo...
Q2F5X1         6 LPNDMKLQLCKSYFKVGCLFLPFVWAVNVCWF---FRDAFIKPAYDEQKLIKKFVIMSAIGAFVWAVILVTWITVYQT-- 80  domestic silkworm
Q28GF7         6 VPNEEKLQLCRKYYLGGFALLPFLWLVNVVWF---FKEAFFKPAYTEQPLIQSYVKRSALGLFVWVVILTTWISVYQT-- 80  western clawed ...
Q5G235         6 VSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWF---FREAFIVPAYTEQSQIKGYVWRSAVGFFLWVIVLSTWITIFQI-- 80  cattle
Q4RHS1         6 LPNEEKLSLCRKYYLGGFAFLPFLWLVNVVWF---FREAFIKPTYTEQLQIKTYVKRSAAGLLLWVAVLTTWITIFQH-- 80  spotted green p...
Q9U357         6 LTDVKKVDLCKKYFLIGACFLPLVWIVNTFWF---FSDAFCKPINAHRRQIRKYVIASIVGSIFWIIVLSAWEIFFQH-- 80  Caenorhabditis ...
Q9FY84        47 LTEEASVDYARRFYKFGFALLPWLWFVNCFYFwpvLRHSRAFP------QIRNYVVRSAIGFSVFTALLSAWALTFSIgg 120 thale cress
NP_788401      6 APNPRKLELCRKYFFAGFAFLPFVWAINVCWF---FTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQT-- 80  fruit fly
XP_001638160   6 VSDEEKVKLCRKYTLVGLAFLPFLWLVNAIWF---FREAFCRESFPGQKSMRSNVIKSFIGFSIWAAGLSTWIVMYQT-- 80  starlet sea ane...
Q7Q3Y1         6 APNERKLYLCKWYFKAGFALLPFLWSINTVWF---FNEAFRKPAYEEQKEIKKYVIFSLVGTLVWVVAIISWVVTFQL-- 80  Anopheles gambi...
Q178A8         6 VPNERKLYLCKWYFKVGFALLPFVWAINTVWF---FSEAFRKPAYDEQKEIRKYVIFSAIGSLIWFTLILTWVMTFQL-- 80  yellow fever mo...
Q2F5X1         6 LPNDMKLQLCKSYFKVGCLFLPFVWAVNVCWF---FRDAFIKPAYDEQKLIKKFVIMSAIGAFVWAVILVTWITVYQT-- 80  domestic silkworm
Q28GF7         6 VPNEEKLQLCRKYYLGGFALLPFLWLVNVVWF---FKEAFFKPAYTEQPLIQSYVKRSALGLFVWVVILTTWISVYQT-- 80  western clawed ...
Q5G235         6 VSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWF---FREAFIVPAYTEQSQIKGYVWRSAVGFFLWVIVLSTWITIFQI-- 80  cattle
Q4RHS1         6 LPNEEKLSLCRKYYLGGFAFLPFLWLVNVVWF---FREAFIKPTYTEQLQIKTYVKRSAAGLLLWVAVLTTWITIFQH-- 80  spotted green p...
Q9U357         6 LTDVKKVDLCKKYFLIGACFLPLVWIVNTFWF---FSDAFCKPINAHRRQIRKYVIASIVGSIFWIIVLSAWEIFFQH-- 80  Caenorhabditis ...
Q9FY84        47 LTEEASVDYARRFYKFGFALLPWLWFVNCFYFwpvLRHSRAFP------QIRNYVVRSAIGFSVFTALLSAWALTFSIgg 120 thale cress
NP_788401      6 APNPRKLELCRKYFFAGFAFLPFVWAINVCWF---FTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQT-- 80  fruit fly
XP_001638160   6 VSDEEKVKLCRKYTLVGLAFLPFLWLVNAIWF---FREAFCRESFPGQKSMRSNVIKSFIGFSIWAAGLSTWIVMYQT-- 80  starlet sea ane...
Q5JN39       130 ERLFGPGWNDLVMYNVAdkLG 150 Oryza sativa Japonica Group
Q7Q3Y1        81 KRTDWGEFADNISFIIP--LG 99  Anopheles gambiae str. PEST
Q178A8        81 KRTEWGDFADSISFIIP--LG 99  yellow fever mosquito
Q2F5X1        81 NRVSWGATGDALSFIVP--LG 99  domestic silkworm
Q28GF7        81 HRAGWGATGDYLSFTIP--LG 99  western clawed frog
Q5G235        81 YRPRWGALGDYLSFTIP--LG 99  cattle
Q4RHS1        81 YRSEWGEVGDSISFTIP--LG 99  spotted green pufferfish
Q9U357        81 YRAQGLVWTDFLTFVFP--TG 99  Caenorhabditis elegans
Q9FY84       121 EQLFGPLYDKLVMYNVAdrLG 141 thale cress
NP_788401     81 NRTAWGATADYMSFIIP--LG 99  fruit fly
XP_001638160  81 NRASWGELGDTLSFLIP--LG 99  starlet sea anemone
Q7Q3Y1        81 KRTDWGEFADNISFIIP--LG 99  Anopheles gambiae str. PEST
Q178A8        81 KRTEWGDFADSISFIIP--LG 99  yellow fever mosquito
Q2F5X1        81 NRVSWGATGDALSFIVP--LG 99  domestic silkworm
Q28GF7        81 HRAGWGATGDYLSFTIP--LG 99  western clawed frog
Q5G235        81 YRPRWGALGDYLSFTIP--LG 99  cattle
Q4RHS1        81 YRSEWGEVGDSISFTIP--LG 99  spotted green pufferfish
Q9U357        81 YRAQGLVWTDFLTFVFP--TG 99  Caenorhabditis elegans
Q9FY84       121 EQLFGPLYDKLVMYNVAdrLG 141 thale cress
NP_788401     81 NRTAWGATADYMSFIIP--LG 99  fruit fly
XP_001638160  81 NRASWGELGDTLSFLIP--LG 99  starlet sea anemone
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