3LS8_B 365 KYpvi-fkHGDDLR--QDQLIlQII---------------------------SLMDKLLRKENLDLKLTPYKVLATSTkh 414 human P42951 170 GS------SGSYFVygTRADEsVPVgvfkpkdeepyg----pfspkwtkwahRTFFPCLFGRSCLIPNLGYICESAAS-- 237 Saccharomyces cerevi... Q99M64 132 GS------SGSYFV--KDSQG-RIIavfkpkneepyg----nlnpkwtkwlqKLCCPCCFGRDCLVLNQGYLSEAGAS-- 196 Norway rat O06242 16 AS-------NATFLceSTLGLrSLHcvykp------------------vsgeRPLWDFPDGTLAGRELSAYLVSTQLGwn 70 Mycobacterium tuberc... Q9SXC6 378 NDmrqvldRDRRQR--------------------------------------CLFKRFSDEDRARNEAIAYLLDHPEDgh 419 thale cress O77353 161 GT------GGTYLL---YNAKkKICsvfkpldeeafap-fnprgyegkmyqeGFRAGVLSGEGASREIAAYLLDNCYN-- 228 Plasmodium falciparu... Q9SGW8 198 AT------GGTYLM--QDSSGlNYVsvfkpmdeepmav-nnpqqlpvssdgqGLKRGTRVGEGATREVAAYLLDHPKSgl 268 thale cress Q9FNF8 266 GS------GGAYFM--QDPSGhKYVsvfkpideepmav-nnphgqpvsvdgeGLKKGTQVGEGAIREVAAYILDYPMTgp 336 thale cress Q9ZPY9 264 GT------GGAYFM--QGPSGnKFVgvfkpideepmae-nnpqglplspngeGLKKGTKVGEGALREVAAYILDHPKSgn 334 thale cress Q9C671 171 GL------GGAYYF--KNSRG-ESVaivkptdeepyapnnpkgfvgkalgqpGLKRSVRVGETGYREVAAYLLDKE---- 237 thale cress P42951 170 GS------SGSYFVygTRADEsVPVgvfkpkdeepyg----pfspkwtkwahRTFFPCLFGRSCLIPNLGYICESAAS-- 237 Saccharomyces cerevi... Q99M64 132 GS------SGSYFV--KDSQG-RIIavfkpkneepyg----nlnpkwtkwlqKLCCPCCFGRDCLVLNQGYLSEAGAS-- 196 Norway rat O06242 16 AS-------NATFLceSTLGLrSLHcvykp------------------vsgeRPLWDFPDGTLAGRELSAYLVSTQLGwn 70 Mycobacterium tuberc... Q9SXC6 378 NDmrqvldRDRRQR--------------------------------------CLFKRFSDEDRARNEAIAYLLDHPEDgh 419 thale cress O77353 161 GT------GGTYLL---YNAKkKICsvfkpldeeafap-fnprgyegkmyqeGFRAGVLSGEGASREIAAYLLDNCYN-- 228 Plasmodium falciparu... Q9SGW8 198 AT------GGTYLM--QDSSGlNYVsvfkpmdeepmav-nnpqqlpvssdgqGLKRGTRVGEGATREVAAYLLDHPKSgl 268 thale cress Q9FNF8 266 GS------GGAYFM--QDPSGhKYVsvfkpideepmav-nnphgqpvsvdgeGLKKGTQVGEGAIREVAAYILDYPMTgp 336 thale cress Q9ZPY9 264 GT------GGAYFM--QGPSGnKFVgvfkpideepmae-nnpqglplspngeGLKKGTKVGEGALREVAAYILDHPKSgn 334 thale cress Q9C671 171 GL------GGAYYF--KNSRG-ESVaivkptdeepyapnnpkgfvgkalgqpGLKRSVRVGETGYREVAAYLLDKE---- 237 thale cress
3LS8_B 415 g------------------fmqFIQSV-PVAEVLDTE------------------------------------------- 432 human P42951 238 ----------------------LLDRRlETHLVPYTDtasiesfnfydnrkk---------------wvlgynlqkkkqk 280 Saccharomyces cerevi... Q99M64 197 ----------------------LVDQKlELNIVPRTKvvylasetfnysaidrvksrgkrlalekvpkvgqrfnriglpp 254 Norway rat O06242 71 lvphtiirdgpagigmlqlwvqQPGDAvDSDPLPGPDlvdlfp---------------------------------ahrp 117 Mycobacterium tuberc... Q9SXC6 420 --------------------rsQSEQIyGFSRVRRAVwvrcri---------------------------------knqm 446 thale cress O77353 229 ----------------------------NFSNVPCTImveacnphfnnksk-----------------lkyvdketnlkw 263 Plasmodium falciparu... Q9SGW8 269 --------------------rsVSKEVmGFAGVPPTAmvrsshkvynyp--------------------ngfsscatkda 308 thale cress Q9FNF8 337 --------------------rtFPHDQtGFAGVPPTTmvkclhkdfnhp---------------------ngysfspent 375 thale cress Q9ZPY9 335 --------------------ksMFGEEiGFAGVPPTAmieclhpgf--------------------------nhpkgikt 368 thale cress Q9C671 238 ----------------------------HFANVPPTAlvkithsifnvndg----------------vkaskpmekmlvs 273 thale cress P42951 238 ----------------------LLDRRlETHLVPYTDtasiesfnfydnrkk---------------wvlgynlqkkkqk 280 Saccharomyces cerevi... Q99M64 197 ----------------------LVDQKlELNIVPRTKvvylasetfnysaidrvksrgkrlalekvpkvgqrfnriglpp 254 Norway rat O06242 71 lvphtiirdgpagigmlqlwvqQPGDAvDSDPLPGPDlvdlfp---------------------------------ahrp 117 Mycobacterium tuberc... Q9SXC6 420 --------------------rsQSEQIyGFSRVRRAVwvrcri---------------------------------knqm 446 thale cress O77353 229 ----------------------------NFSNVPCTImveacnphfnnksk-----------------lkyvdketnlkw 263 Plasmodium falciparu... Q9SGW8 269 --------------------rsVSKEVmGFAGVPPTAmvrsshkvynyp--------------------ngfsscatkda 308 thale cress Q9FNF8 337 --------------------rtFPHDQtGFAGVPPTTmvkclhkdfnhp---------------------ngysfspent 375 thale cress Q9ZPY9 335 --------------------ksMFGEEiGFAGVPPTAmieclhpgf--------------------------nhpkgikt 368 thale cress Q9C671 238 ----------------------------HFANVPPTAlvkithsifnvndg----------------vkaskpmekmlvs 273 thale cress
3LS8_B 433 -GSIQNFFRKYAPSEng---pnGISAE----------------------------------------------------- 455 human P42951 281 kLGSFQLFLKEYINA-------DEFFHkyplpgmysdvkhsfhrkssgedinhkpettrnltdetepskqinsspistes 353 Saccharomyces cerevi... Q99M64 255 kVGSFQLFVEGYKDA-------DYWLRrfeae------------------------------------------------ 279 Norway rat O06242 118 rPGYLPVLRAYDYAG-------DEVV------------------------------------------------------ 136 Mycobacterium tuberc... Q9SXC6 447 kMGVLIEFLESSVTVqslgtvySEL------------------------------------------------------- 471 thale cress O77353 264 kCGSLQEFIDSRESV-------GNYD------------------------------------------------------ 282 Plasmodium falciparu... Q9SGW8 309 kVGSLQMFMKNNGSC-------EDIG------------------------------------------------------ 327 thale cress Q9FNF8 376 kIGSLQMFVSNVGSC-------EDMG------------------------------------------------------ 394 thale cress Q9ZPY9 369 kIGSLQMFTENDGSC-------EDMG------------------------------------------------------ 387 thale cress Q9C671 274 kIASLQQFIPHDYDA-------SEHG------------------------------------------------------ 292 thale cress P42951 281 kLGSFQLFLKEYINA-------DEFFHkyplpgmysdvkhsfhrkssgedinhkpettrnltdetepskqinsspistes 353 Saccharomyces cerevi... Q99M64 255 kVGSFQLFVEGYKDA-------DYWLRrfeae------------------------------------------------ 279 Norway rat O06242 118 rPGYLPVLRAYDYAG-------DEVV------------------------------------------------------ 136 Mycobacterium tuberc... Q9SXC6 447 kMGVLIEFLESSVTVqslgtvySEL------------------------------------------------------- 471 thale cress O77353 264 kCGSLQEFIDSRESV-------GNYD------------------------------------------------------ 282 Plasmodium falciparu... Q9SGW8 309 kVGSLQMFMKNNGSC-------EDIG------------------------------------------------------ 327 thale cress Q9FNF8 376 kIGSLQMFVSNVGSC-------EDMG------------------------------------------------------ 394 thale cress Q9ZPY9 369 kIGSLQMFTENDGSC-------EDMG------------------------------------------------------ 387 thale cress Q9C671 274 kIASLQQFIPHDYDA-------SEHG------------------------------------------------------ 292 thale cress
3LS8_B 456 -----------VMDTYVKSCAGYCVITYILGVGDRHLDNLLL-------------------------------------- 486 human P42951 354 eenskfewtesSLSQFRLELEKLIILDYIMRNTDRGLDNWMVklik------------------------------lsnn 403 Saccharomyces cerevi... Q99M64 280 ------plpenTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIkydypmdnpn------------------crdtdwvmvr 335 Norway rat O06242 137 -----------LMHADDIRLRRMAVFDVLINNADRKGGHILc-------------------------------------- 167 Mycobacterium tuberc... Q9SXC6 472 -----------PDDVGAEEIHKIVVLDIRFGNIDRNLGNLLVqae--------------------------------prn 508 thale cress O77353 283 -----------YKQFSIRDIHKIAILDIRVMNLDRNDGNILVsplktlkdscnqfvyrnnkftssnnedmlkriitidkk 351 Plasmodium falciparu... Q9SGW8 328 -----------PGAFPVEEVHKICVFDIRMANADRHAGNILTgk----------------------------------se 362 thale cress Q9FNF8 395 -----------YRVFPVDQVHKISVLDIRLANADRHAGNILVsrd---------------------------------gk 430 thale cress Q9ZPY9 388 -----------PLSFPVEEVHKISVLDIRLANADRHGGNILMtk----------------------------------de 422 thale cress Q9C671 293 -----------TSNFPVSAVHRIGILDIRILNTDRHSGNLLVkkld------------------------------gdgm 331 thale cress P42951 354 eenskfewtesSLSQFRLELEKLIILDYIMRNTDRGLDNWMVklik------------------------------lsnn 403 Saccharomyces cerevi... Q99M64 280 ------plpenTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIkydypmdnpn------------------crdtdwvmvr 335 Norway rat O06242 137 -----------LMHADDIRLRRMAVFDVLINNADRKGGHILc-------------------------------------- 167 Mycobacterium tuberc... Q9SXC6 472 -----------PDDVGAEEIHKIVVLDIRFGNIDRNLGNLLVqae--------------------------------prn 508 thale cress O77353 283 -----------YKQFSIRDIHKIAILDIRVMNLDRNDGNILVsplktlkdscnqfvyrnnkftssnnedmlkriitidkk 351 Plasmodium falciparu... Q9SGW8 328 -----------PGAFPVEEVHKICVFDIRMANADRHAGNILTgk----------------------------------se 362 thale cress Q9FNF8 395 -----------YRVFPVDQVHKISVLDIRLANADRHAGNILVsrd---------------------------------gk 430 thale cress Q9ZPY9 388 -----------PLSFPVEEVHKISVLDIRLANADRHGGNILMtk----------------------------------de 422 thale cress Q9C671 293 -----------TSNFPVSAVHRIGILDIRILNTDRHSGNLLVkkld------------------------------gdgm 331 thale cress
3LS8_B 487 TKTGKLFHIDFGYILG--RDPKPLPPPMKLNK--------EMVEGMGG-----TQSEQYQEFRKQCYTAFLHLRRYSNLI 551 human P42951 404 KWRLKLAAIDNGLSFPwkHPDEWRLYPYGWLYlplqllakPFSEQMRShf--lPILTSTNWWEESYQEFLALFSRDQDFN 481 Saccharomyces cerevi... Q99M64 336 EPVIKVAAIDNGLAFPlkHPDSWRAYPFYWAWlpq--akvPFSQEIKDli--lPKISDPNFVKDLEEDLYELFKKDPGFD 411 Norway rat O06242 168 GIDGQVYGVDHGLCLH--VENKLRTVLWGWAG------------------------------KPIDDQILQAVAGLADAL 215 Mycobacterium tuberc... Q9SXC6 509 GSAAHLVPIDHELSFFn-DAHPYITCGACWIKwleq-idkDFSSQLVNyvaalDPDRDLEFLRHCGWEPNQRYIENFTVF 586 thale cress O77353 352 PSRYTLIPIDHGLILP--HIMDVAEIDLVWFEwpq--ikiPLDDEELEvvfsfDPDKDAEKVRNKLL-IREDCIRTMRVC 426 Plasmodium falciparu... Q9SGW8 363 EGKTLLIPIDHGYCLP----ENFEDCTFEWLYwpq--aklPFSADTIDyinslDSEQDIALLQLHGWNVPEAVSRTLRIS 436 thale cress Q9FNF8 431 DGQMVLTPIDHGYCFP----NKFEDCTFEWLYwpq--akePYSSETLEyikslDPEKDIELLRFHGWEIPPSCTRVLRIS 504 thale cress Q9ZPY9 423 SGKLVLVPIDHGYCLP----ESFEDCTFEWLYwpq--arkPYSAETQEyirslDAEEDIDLLKFHGWKMPAETAQTLRIS 496 thale cress Q9C671 332 FGQVELVPIDHGLCLP----ETLEDPYFEWIHwpq--asiPFSEDELKyianlDPLGDCEMLRRELPMVREASLRVLVLC 405 thale cress P42951 404 KWRLKLAAIDNGLSFPwkHPDEWRLYPYGWLYlplqllakPFSEQMRShf--lPILTSTNWWEESYQEFLALFSRDQDFN 481 Saccharomyces cerevi... Q99M64 336 EPVIKVAAIDNGLAFPlkHPDSWRAYPFYWAWlpq--akvPFSQEIKDli--lPKISDPNFVKDLEEDLYELFKKDPGFD 411 Norway rat O06242 168 GIDGQVYGVDHGLCLH--VENKLRTVLWGWAG------------------------------KPIDDQILQAVAGLADAL 215 Mycobacterium tuberc... Q9SXC6 509 GSAAHLVPIDHELSFFn-DAHPYITCGACWIKwleq-idkDFSSQLVNyvaalDPDRDLEFLRHCGWEPNQRYIENFTVF 586 thale cress O77353 352 PSRYTLIPIDHGLILP--HIMDVAEIDLVWFEwpq--ikiPLDDEELEvvfsfDPDKDAEKVRNKLL-IREDCIRTMRVC 426 Plasmodium falciparu... Q9SGW8 363 EGKTLLIPIDHGYCLP----ENFEDCTFEWLYwpq--aklPFSADTIDyinslDSEQDIALLQLHGWNVPEAVSRTLRIS 436 thale cress Q9FNF8 431 DGQMVLTPIDHGYCFP----NKFEDCTFEWLYwpq--akePYSSETLEyikslDPEKDIELLRFHGWEIPPSCTRVLRIS 504 thale cress Q9ZPY9 423 SGKLVLVPIDHGYCLP----ESFEDCTFEWLYwpq--arkPYSAETQEyirslDAEEDIDLLKFHGWKMPAETAQTLRIS 496 thale cress Q9C671 332 FGQVELVPIDHGLCLP----ETLEDPYFEWIHwpq--asiPFSEDELKyianlDPLGDCEMLRRELPMVREASLRVLVLC 405 thale cress
3LS8_B 552 LNLF---------SLMVDANIPDIAL 568 human P42951 482 VRMWkkqwavlkgQAFNVVETLKDPR 507 Saccharomyces cerevisiae S288c Q99M64 412 RGQFhkqiavmrgQILNLTQALKDNK 437 Norway rat O06242 216 GGPLaeal--agrIAAAEIGALRRRA 239 Mycobacterium tuberculosis Q9SXC6 587 ATFLkkav--sqgLTALQIGLLASYK 610 thale cress O77353 427 TRLLqiga--kmhLTLYEIAKISTRK 450 Plasmodium falciparum 3D7 Q9SGW8 437 TMLLkkgv--ernLTPYQIGSVMCRE 460 thale cress Q9FNF8 505 TMLLkkgs--akgLTPFTIGSIMCRE 528 thale cress Q9ZPY9 497 TMLLkkgv--ergLTAFEIGTIMCRE 520 thale cress Q9C671 406 TIFLkeaa--angLCLAEIGEMMTRE 429 thale cress P42951 482 VRMWkkqwavlkgQAFNVVETLKDPR 507 Saccharomyces cerevisiae S288c Q99M64 412 RGQFhkqiavmrgQILNLTQALKDNK 437 Norway rat O06242 216 GGPLaeal--agrIAAAEIGALRRRA 239 Mycobacterium tuberculosis Q9SXC6 587 ATFLkkav--sqgLTALQIGLLASYK 610 thale cress O77353 427 TRLLqiga--kmhLTLYEIAKISTRK 450 Plasmodium falciparum 3D7 Q9SGW8 437 TMLLkkgv--ernLTPYQIGSVMCRE 460 thale cress Q9FNF8 505 TMLLkkgs--akgLTPFTIGSIMCRE 528 thale cress Q9ZPY9 497 TMLLkkgv--ergLTAFEIGTIMCRE 520 thale cress Q9C671 406 TIFLkeaa--angLCLAEIGEMMTRE 429 thale cress
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",