2DKX


Conserved Protein Domain Family
SAM_PNT-PDEF-like

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cd08532: SAM_PNT-PDEF-like 
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Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor
SAM Pointed domain of PDEF-like (Prostate-Derived ETS Factor) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. In human males this activator is highly expressed in the prostate gland and enhances androgen-mediated activation of the PSA promoter though interaction with the DNA binding domain of androgen receptor. PDEF may play a role in prostate cancer development as well as in goblet cell formation and mucus production in the epithelial lining of respiratory and intestinal tracts.
Statistics
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PSSM-Id: 188878
Aligned: 13 rows
Threshold Bit Score: 136.338
Threshold Setting Gi: 74964009
Created: 28-Jan-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DKX_A        11 IETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPp---MGKAFQeLAGKELCAMSEEQFRQRSPL-GGDVLHAHLDIW 86  human
P29775       263 ADAICAELQISQDPNGWSPAQVHAWLRSTLAQFRLPpvadLELHFC-ENGAALALLSEEEFVRRLPE-SGSTLHAQLEIW 340 fruit fly
Q19695        71 ISTTCAKLGLPNDFYLWSSEHGARWINEMCMQFNLQ----PPRNCS-ITGIDLLGMSQKDFEMILPA-GGDTLHAQLQVW 144 Caenorhabditis ...
XP_968441    308 VDTTCAALGISPDPTQWSAADVLSWLQWTSRQFGLTe--pVPDHWD-MNGPSLAALSEEDFTRRAPQ-GGMILHAQLEIW 383 red flour beetle
XP_425831     95 IETACKLLNIAADPADWSPGNVQKWILWTEHQYRLPq---LGKSFQeLSGKELCAMSEEQFCQRSPL-CGDVLHAHLDIW 170 chicken
NP_001072412 114 IETACKLLNISADPMEWSAGNVQKWILWTEHQYRLPq---VGRSFQeLTGKDLCALSEDNFRERSPL-CGDVLYAHLDIW 189 western clawed ...
XP_001607130 310 FDNTCVALGIHPEPRRWSTADVAAWVQWAKKQLQLPt--vPLECFN-IDGVTLVSLSEEEFCRRAPQ-CGSMLHAQLEIW 385 jewel wasp
XP_001650415 307 IHSTCTLLGISPDPHQWSQDQVQQWLQLMMSKYNLPplinTATLFP-ESGNQLALLSMDEFVRRIPQ-GGDKLHGQLDLW 384 yellow fever mo...
XP_564145      1 MQATCTELGISSDPKQWTTAKVHQWLELAMGKYFLPrldnLAALFP-ENGAQLAALPLEEFVRRIPQ-GGDKLHGYLDLW 78  Anopheles gambi...
XP_001899554 101 INTTCTKLGLPTDPQAWSAEHSARWMSEMCVQFQLP----PPRQLY-MNGRTLLSMTQDDFMVRAPEgGGDTLHAQLQLW 175 agent of lympha...
XP_002434893 148 IDVACQILNISPDPYHWSVNNVHSWLVWTQQQYGCPa--iKPEYFN-MDGSALCTLSEDDFRMRAPG-SGDILSAQLEIW 223 black-legged tick
XP_002430905 353 VDNTCNLLGISSDPTQWTEDDVKAWLIWTIRQYSLPm--iDTNCFK-MDGVTFCQLTENDFQQRAPQ-SSSTLHAHLEIW 428 human body louse
CAG11835      86 IETACKLLNITPDPIEWNTGNVQKWLLWTEHLYRLPh---AGKAFQdLTGKDLCAMSEEEFHQRSPQ-CGDTLHAHLDIW 161 spotted green p...
P29775       263 ADAICAELQISQDPNGWSPAQVHAWLRSTLAQFRLPpvadLELHFC-ENGAALALLSEEEFVRRLPE-SGSTLHAQLEIW 340 fruit fly
Q19695        71 ISTTCAKLGLPNDFYLWSSEHGARWINEMCMQFNLQ----PPRNCS-ITGIDLLGMSQKDFEMILPA-GGDTLHAQLQVW 144 Caenorhabditis ...
XP_968441    308 VDTTCAALGISPDPTQWSAADVLSWLQWTSRQFGLTe--pVPDHWD-MNGPSLAALSEEDFTRRAPQ-GGMILHAQLEIW 383 red flour beetle
XP_425831     95 IETACKLLNIAADPADWSPGNVQKWILWTEHQYRLPq---LGKSFQeLSGKELCAMSEEQFCQRSPL-CGDVLHAHLDIW 170 chicken
NP_001072412 114 IETACKLLNISADPMEWSAGNVQKWILWTEHQYRLPq---VGRSFQeLTGKDLCALSEDNFRERSPL-CGDVLYAHLDIW 189 western clawed ...
XP_001607130 310 FDNTCVALGIHPEPRRWSTADVAAWVQWAKKQLQLPt--vPLECFN-IDGVTLVSLSEEEFCRRAPQ-CGSMLHAQLEIW 385 jewel wasp
XP_001650415 307 IHSTCTLLGISPDPHQWSQDQVQQWLQLMMSKYNLPplinTATLFP-ESGNQLALLSMDEFVRRIPQ-GGDKLHGQLDLW 384 yellow fever mo...
XP_564145      1 MQATCTELGISSDPKQWTTAKVHQWLELAMGKYFLPrldnLAALFP-ENGAQLAALPLEEFVRRIPQ-GGDKLHGYLDLW 78  Anopheles gambi...
XP_001899554 101 INTTCTKLGLPTDPQAWSAEHSARWMSEMCVQFQLP----PPRQLY-MNGRTLLSMTQDDFMVRAPEgGGDTLHAQLQLW 175 agent of lympha...
XP_002434893 148 IDVACQILNISPDPYHWSVNNVHSWLVWTQQQYGCPa--iKPEYFN-MDGSALCTLSEDDFRMRAPG-SGDILSAQLEIW 223 black-legged tick
XP_002430905 353 VDNTCNLLGISSDPTQWTEDDVKAWLIWTIRQYSLPm--iDTNCFK-MDGVTFCQLTENDFQQRAPQ-SSSTLHAHLEIW 428 human body louse
CAG11835      86 IETACKLLNITPDPIEWNTGNVQKWLLWTEHLYRLPh---AGKAFQdLTGKDLCAMSEEEFHQRSPQ-CGDTLHAHLDIW 161 spotted green p...
2DKX_A        87 KSAAS 91  human
P29775       341 KMAYA 345 fruit fly
Q19695       145 KTAFE 149 Caenorhabditis elegans
XP_968441    384 KAAYS 388 red flour beetle
XP_425831    171 KSAAW 175 chicken
NP_001072412 190 KSAAW 194 western clawed frog
XP_001607130 386 KAAVE 390 jewel wasp
XP_001650415 385 KIAVG 389 yellow fever mosquito
XP_564145     79 KQINR 83  Anopheles gambiae str. PEST
XP_001899554 176 KTAYD 180 agent of lymphatic filariasis
XP_002434893 224 KSAAH 228 black-legged tick
XP_002430905 429 KAAGN 433 human body louse
CAG11835     162 KSAAW 166 spotted green pufferfish
P29775       341 KMAYA 345 fruit fly
Q19695       145 KTAFE 149 Caenorhabditis elegans
XP_968441    384 KAAYS 388 red flour beetle
XP_425831    171 KSAAW 175 chicken
NP_001072412 190 KSAAW 194 western clawed frog
XP_001607130 386 KAAVE 390 jewel wasp
XP_001650415 385 KIAVG 389 yellow fever mosquito
XP_564145     79 KQINR 83  Anopheles gambiae str. PEST
XP_001899554 176 KTAYD 180 agent of lymphatic filariasis
XP_002434893 224 KSAAH 228 black-legged tick
XP_002430905 429 KAAGN 433 human body louse
CAG11835     162 KSAAW 166 spotted green pufferfish
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