1LKY,2JV3,2E8P,1SXD,2YTU,2DKX,1SV0


Conserved Protein Domain Family
SAM_PNT

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cd08203: SAM_PNT 
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Sterile alpha motif (SAM)/Pointed domain
Sterile alpha motif (SAM)/Pointed domain is found in about 40% of transcriptional regulators of ETS family (initially named for Erythroblastosis virus, E26-E Twenty Six). SAM Pointed domain containing proteins of this family additionally have a C-terminal ETS DNA-binding domain. In a few cases, SAM Pointed domain appears as a single domain protein. Members of this group are mostly involved in regulation of embryonic development and growth control in eukaryotes. SAM Pointed domains mediate protein-protein interactions. Depending on the subgroup, they can interact with other SAM Pointed domains forming homo or hetero dimers/oligomers and/or they can recruit a protein kinase to its target which can be a SAM Pointed domain containing protein itself or another protein that has no kinase docking site. Thus, SAM Pointed domains participate in transcriptional regulation and signal transduction. Some genes coding ETS family transcriptional regulators are proto-oncogenes. They are prone to chromosomal translocations resulting in gene fusions. Chimeric proteins with SAM Pointed domains were found in a number of different human tumors including myeloid leukemia, lymphoblastic leukemia, Ewing's sarcoma and primitive neuroectodermal tumor. Members of this family are potential targets for cancer therapy.
Statistics
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PSSM-Id: 188876
Aligned: 18 rows
Threshold Bit Score: 71.5866
Threshold Setting Gi: 193636572
Created: 1-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1LKY_A        11 QPIYWSRDDVAQWLKWAEneFSLRp--iDSNTFE-MNGKALLLLTKEDFRYRSPh--SGDRLYELLQHILK 76  human
2JV3_A        40 DPRQWTETHVRDWVMWAVneFSLKg--vDFQKFC-MSGAALCALGKECFLELAPd-fVGDILWEHLEILQK 106 house mouse
2E8P_A        23 QPQFWSKTQVLDWISYQVekNKYDasaiDFSRCD-MDGATLCNCALEELRLVFGp--LGDQLHAQLRDLTS 90  human
1SXD_A        22 DPIHWSTDQVLHWVVWVMkeFSMTd--iDLTTLN-ISGRELCSLNQEDFFQRVP---RGEILWSHLELLRK 86  house mouse
2YTU_A        37 DPTLWTQEHVRQWLEWAIkeYSLMe--iDTSFFQnMDGKELCKMNKEDFLRATTl-yNTEVLLSHLSYLRE 104 human
2DKX_A        23 DPMDWSPSNVQKWLLWTEhqYRLPp---MGKAFQeLAGKELCAMSEEQFRQRSPl--GGDVLHAHLDIWKS 88  human
1SV0_C        10 DPRDWTRADVWKWLINMAvsEGLEvtaeLPQKFP-MNGKALCLMSLDMYLCRVPv--GGKMLYRDFRVRLA 77  fruit fly
XP_002399482 251 DPRQWDSSDIRAWLSWVSakFGLSr--lDDTRFP-DNGPALCALTLSDFRERTDv-rSADILNTFLASRKL 317 black-legged tick
NP_999699    123 NVYCWTPEDVQKWLLCVAnrFELGe--lEMGHFY-INGPTLATLQDVDFRHRAPk--CGDILYSVVCLLKS 188 purple urchin
XP_001943031  25 DPLDWTNDHIAAWLKWCGkhLELWpi-pKSDDFP-DTGYNLCSLDRAEFDRRSRnrrSGRLLLLHLSLLRQ 93  pea aphid
2JV3_A        40 DPRQWTETHVRDWVMWAVneFSLKg--vDFQKFC-MSGAALCALGKECFLELAPd-fVGDILWEHLEILQK 106 house mouse
2E8P_A        23 QPQFWSKTQVLDWISYQVekNKYDasaiDFSRCD-MDGATLCNCALEELRLVFGp--LGDQLHAQLRDLTS 90  human
1SXD_A        22 DPIHWSTDQVLHWVVWVMkeFSMTd--iDLTTLN-ISGRELCSLNQEDFFQRVP---RGEILWSHLELLRK 86  house mouse
2YTU_A        37 DPTLWTQEHVRQWLEWAIkeYSLMe--iDTSFFQnMDGKELCKMNKEDFLRATTl-yNTEVLLSHLSYLRE 104 human
2DKX_A        23 DPMDWSPSNVQKWLLWTEhqYRLPp---MGKAFQeLAGKELCAMSEEQFRQRSPl--GGDVLHAHLDIWKS 88  human
1SV0_C        10 DPRDWTRADVWKWLINMAvsEGLEvtaeLPQKFP-MNGKALCLMSLDMYLCRVPv--GGKMLYRDFRVRLA 77  fruit fly
XP_002399482 251 DPRQWDSSDIRAWLSWVSakFGLSr--lDDTRFP-DNGPALCALTLSDFRERTDv-rSADILNTFLASRKL 317 black-legged tick
NP_999699    123 NVYCWTPEDVQKWLLCVAnrFELGe--lEMGHFY-INGPTLATLQDVDFRHRAPk--CGDILYSVVCLLKS 188 purple urchin
XP_001943031  25 DPLDWTNDHIAAWLKWCGkhLELWpi-pKSDDFP-DTGYNLCSLDRAEFDRRSRnrrSGRLLLLHLSLLRQ 93  pea aphid
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