17536815 3 LRKVRS--------NIDRIFDKSLTDLIRGIRNNKDNESR---YITQCMEEIKQELRQDSIYVKANAIEKLAYLQML-GY 70 Caenorhabditis el... 15221961 1 MSSSSTs-------IMDNLFQRSLEDLIKGFRLQLLGESN---FISRAVEEIRREIKATDLSTKSTALHKLSYLAALhGV 70 thale cress 25395482 6 vrsnidrifdksltdlirgirnnkdnesryitqcmeeikqelrqdsiyvkanaieklaylqmlgydiswasfnvievmas 85 Caenorhabditis el... 20137255 3 LKMVKG--------SIDRMFDKNLQDLVRGIRNHKEDEAK---YISQCIDEIKQELKQDNIAVKANAVCKLTYLQML-GY 70 human 19115579 1 -----------------MVFERTLIDLIKGIRSHANDEEA---FIATCLLECRKEATSQDADLKSEAILKLAYLEML-GV 59 fission yeast 6325061 4 LYAPGAedirqrlrPFGFFFEKSLKDLIKGIRSHNETPEKldqFFKQVLSECREEVNSPDLNSKTNAVLKLTYLEMY-GF 82 baker's yeast 22832217 1 ------------malkkvkgnffermfdknltdlvrgirnnkdneakyistcieeikqelrqdnisvkcnavakltyiqm 68 fruit fly
17536815 71 DISWASFNVIEVMASTKYTEKRIGYLAAAQSFHDETDVLMLTTNLIRKDVN---SSNMYESGIALGGLSCFVTPDLARDL 147 Caenorhabditis el... 15221961 71 DMSWAAFHAVEVVSSSRFQHKRIGYQAITQSFNDQTSVMLLITNQVRKDLN---SANEYEVSLALECLSRIGTHDLARDL 147 thale cress 25395482 86 tkytekriglvfirfllnfdlktpvktylaaaqsfhdetdvlmlttnlirkdvnssnmyesgialgglscfvtpdlardl 165 Caenorhabditis el... 20137255 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLS---SPSQYDTGVALTGLSCFVTPDLARDL 147 human 19115579 60 DISWASFQIVEVMSSSKILQKQKGYLAAVQSFKPDTDVLMLTTNLLKKDLM---SSKVPEITLAIDGLSHFSTLGLARDL 136 fission yeast 6325061 83 DMAWCNFHILEVMSSNKLQQKRVGYLAASQSFYKDSDILMLATNLLKKDLKydgNNDVVKVGIALSGLSTIITPSLARDI 162 baker's yeast 22832217 69 lgydiswagfniievmsssrftckrigylaasqcfhpdsellmlttnmirkdlnsqnqydagvalsglscfispdlsrdl 148 fruit fly
17536815 148 AADVVNLLSCSRNYTRKRAVLLLYKIFLKYPDALRPTFPRLKEKLEDPDPGVQSSAVNVICELARKNPKNYLTLAPVFFK 227 Caenorhabditis el... 15221961 148 TPEVFTLLGSSKSFVKKKAIGVVLRVFEKYHDAVKVCFKRLVENLETSDPQILSAVVGVFCELATKDPQSCLPLAPEFYK 227 thale cress 25395482 166 aadvvnllscsrnytrkravlllykiflkypdalrptfprlkekledpdpgvqssavnvicelarknpknyltlapvffk 245 Caenorhabditis el... 20137255 148 ANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFK 227 human 19115579 137 YRDVLILLNHSVPYVRKRTILLLYRLCLQYPEAISACIPKLRERLDDPDTSVVNAAVSVICELARRAPKNYLEFAPDLFH 216 fission yeast 6325061 163 ADDLFTMLNSTRPYIRKKAITALFKVFLQYPEALRDNFDKFVSKLDDDDISVVSAAVSVICELSKKNPQPFIQLSPLLYE 242 baker's yeast 22832217 149 andimtlmsstkpylrmkavlmmykvflrypealrpafpklkekledpdpgvqsaavnvicelarknpknylplapiffk 228 fruit fly
17536815 228 LMTTSSNNWMLIKIIKLFGALVPLEPRLGKKLLEPLTNLINSTSAMSLLYECINTVIAVliSISAGG-DHTASIQLCVQK 306 Caenorhabditis el... 15221961 228 VLVDSRNNWVLIKVLKIFAKLALIEPRLGKKVAEPICEHMRRTVAKSLVFECVRTVVSS-------LsDNEAAVKLAVAK 300 thale cress 25395482 246 lmttssnnwmlikiiklfgalvpleprlgkkllepltnlinstsaMSLLYECINTVIAVliSISAGG-DHTASIQLCVQK 324 Caenorhabditis el... 20137255 228 LMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVliSLSSGMpNHSASIQLCVQK 307 human 19115579 217 LLTTSSNNWMLIKLIKLFASLTPYEPRLVKKLIPSLTDIIENTHAMSLLYECINTIVSG--NMLVGHsQCDKLASLCASK 294 fission yeast 6325061 243 ILVTIDNNWIIIRLLKLFTNLSQVEPKLRAKLLPKILELMESTVATSVIYESVNCIVKG--NMLEe--DDFETAMACLER 318 baker's yeast 22832217 229 lmttstnnwmlikiiklfgaltpleprlgkkliepltnlihstsaMSLLYECINTVIAVliSISSGMpNHSASIQLCVQK 308 fruit fly
17536815 307 LGVLIEDSDQNLKYLGLLAMGKILKTHPKAVQAHKDIVLRCLDDKDESIRIRSLDLLYGMVSKKNIVEIVKKLMEHVEAA 386 Caenorhabditis el... 15221961 301 IREFLVEDDPNLKYLGLNALSIVAPKHLWAVLENKEVVVKAMSDEDPNVKLEALHLLMAMVNEDNVSEISRILMNYALKS 380 thale cress 25395482 325 LGVLIEDSDQNLKYLGLLAMGKILKTHPKAVQAHKDIVLRCLDDKDESIRIRSLDLLYGMVSKKNIVEIVKKLMEHVEAA 404 Caenorhabditis el... 20137255 308 LRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKA 387 human 19115579 295 LRGFFEDTDQNLKYIALLCLRKLANTHPSLVSAQLDIILKCLVDTDTSIRLRALDLVNEIVNKENIRTIVKTLMLQLIVS 374 fission yeast 6325061 319 LHTFCDSQDPNLRYISCILFYKIGKINTDFISRFDQLIIRLLSDVDVSIRSKAIELVEGIVDEDNLKAIVQTLMKQFVDE 398 baker's yeast 22832217 309 LRILIEDSDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERA 388 fruit fly
17536815 387 EG----S-----------------HYRDELLSRIIGICSWSNYQYITNFEWYISVLVELTKVEG----TEHGAKIAEQIQ 441 Caenorhabditis el... 15221961 381 DP----------------------LFCNEIIFSVLSACSRNAYEIIVDFDWYLSLLGEMARIPH----CQRGEDIEHQLI 434 thale cress 25395482 405 EG----S-----------------HYRDELLSRIIGICSWSNYQYITNFEWYISVLVELTKVEG----TEHGAKIAEQIQ 459 Caenorhabditis el... 20137255 388 EG----T-----------------TYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEG----TRHGHLIAAQML 442 human 19115579 375 SDesavE-----------------DIRNSTATRIIEMTSKSTYMNIADFEWLLTVYVDLANIPG----IDTGTLLNNQII 433 fission yeast 6325061 399 DVvilqTgsivyekskripiiipeNYKIKMVNVIISICSADNYSSVNDFEWYNAVIMDLAMLCQdisdKSLGSKIGEQFR 478 baker's yeast 22832217 389 EG----S-----------------AYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAg---SRHGRLIAEQLL 444 fruit fly
17536815 442 DVTVRVESIRHFSVSQMALLVENAhvLLAGSAQQRSNMCEVLLAAAWICGEYSQHVRNQQGVLESMLKAKPSVMPGHILS 521 Caenorhabditis el... 15221961 435 DIGMRVRDARPQLVRVSWALLIDP------ALLGNLFLHPILSAAAWVSGEYVEFSKNPYETVEALLQPRTDLLPPSIKA 508 thale cress 25395482 460 DVTVRVESIRHFSVSQMALLVENAhvLLAGSAQQRSNMCEVLLAAAWICGEYSQHVRNQQGVLESMLKAKPSVMPGHILS 539 Caenorhabditis el... 20137255 443 DVAIRVKAIRKFAVSQMSALLDSAh-LLASSTQRNG-ICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQA 520 human 19115579 434 DLCVRVKALRPFSVDIFSQAILDPsyVSTTDCSVSEKRTDILPAIIWCLGEYAEFIEEYLDILDALTRPSFKKCSNLAHR 513 fission yeast 6325061 479 NLMIKVPSMREVTIANIIKLIS--------NDNINKQLPTVLRECIWCLGEFSTLVENGNDLIKIMTENIS-YYSHSVQE 549 baker's yeast 22832217 445 DVAIRVPVVRQFAVNEMTNLLD----TFTVSAQSNS-MYEVLYAAAWIVGEFAGELEDAEKTLNILLRPR--LLPGHIQG 517 fruit fly
17536815 522 VYVQNIGK--LYCS--LMSQAEEED-----------------DWDAIDSL-DNLMLSKLPQFELSEHLEAQER---ACNL 576 Caenorhabditis el... 15221961 509 IYIHSAFKvlVFCLgsYFSSQEPTSsslaqesssgsllvnvfTHESILSL-VNVIELGLGPLSGYHDVEVQERaknVLGY 587 thale cress 25395482 540 VYVQNIGK--LYCS--LMSQAEEED-----------------DWDAIDSL-DNLMLSKLPQFELSEHLEAQER---ACNL 594 Caenorhabditis el... 20137255 521 VYVQNVVK--LYAS--ILQQKEQAG-----------------EAEGAQAV-TQLMVDRLPQFVQSADLEVQERascILQL 578 human 19115579 514 LLLQAITK--IFCQ--WCLEEEPTWg---------------vEKFGLVKLwVEKIVSFIEQFLNFQDMEIQRRaseFYIL 574 fission yeast 6325061 550 VLILALVK--VFSN--WCNNFQEDK-----------------RFEIKMVL--KELIEFFENLSYSSTFEVQERsveVLEF 606 baker's yeast 22832217 518 VYVQNVIK--LFAR--LATTCLELQ-----------------DLPGLVTL-CDHVLDKLQHFNGSSDIEVQERansACML 575 fruit fly
17536815 577 MAIIRIVEKLHQDRQKMG---------------SEVQKLYDGELNPVATKAQRKVPVPDGLDLDAWIGEEWAAA----SE 637 Caenorhabditis el... 15221961 588 ISVIKQEIAEQLNLQDNEteas--------rvtAFMEDVFSEEFGPISATAQEKVCVPDGLELKENLGDLEEICgehlKP 659 thale cress 25395482 595 MAIIRIVEKLHQDRQKMG---------------SEVQKLYDGELNPVATKAQRKVPVPDGLDLDAWIGEEWAAA----SE 655 Caenorhabditis el... 20137255 579 VKHIQKLQAKDVPVAEEV------------------SALFAGELNPVAPKAQKKVPVPEGLDLDAWINEP---------- 630 human 19115579 575 FNQVSDIVNTSDTMEVLElqkkpp----yivqnTMYKLFFGEPLNPVAVKAQRKVMPDENLDLNCPINGVIEVP-----K 645 fission yeast 6325061 607 LRLSLEALEEDTEGLPMLls------------eVLPSFFNAYELAPIARGTQLKLAVDENLDLETPFLTKEAAD-----E 669 baker's yeast 22832217 576 IEMLRNQLSTSTDAMAMDttteggipplaieivQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAPPPED----AA 651 fruit fly
17536815 638 DESDDESDIEEMFGAPAtrpkmleneeqepvvqDLEELGGGKKKKgkngAEIAMSKEEIEKRR----KLREQEIENNPYY 713 Caenorhabditis el... 15221961 660 VESDSVSYTDKISFS-------------------VSKLRIRDQQE-----ATSSSSPPHEASS----LLAEHRKRHGMYY 711 thale cress 25395482 656 DESDDESDIEEMFGAPAtrpkmleneeqepvvqDLEELGGGKKKKgkngAEIAMSKEEIEKRR----KLREQEIENNPYY 731 Caenorhabditis el... 20137255 631 -LSDSESEDERPRAVFH------------------EEEQRRPKHR----PSE-ADEEELARRR----EARKQEQANNPFY 682 human 19115579 646 ELLENIIQSDDSLINFD------------------TEVPSSGIDT--------FSKKQFNSLE----SVPVQRDLSSPFY 695 fission yeast 6325061 670 LLDEQKSDAISDLMSDIs---------------MDEQVELKFVDDs---DTSYEEKEKLDDFEnpfeIEREKERMSNPYY 731 baker's yeast 22832217 652 SSSSSEHDKDELFVSat---------------qAGTGADGGEKRR----QSLELTPEQLERQR----MARLIEQSNNPHY 708 fruit fly
17536815 714 VKGSATAPKRptrfGNPLERVEIVEKEKE-IQSPLEIPGVVGLHryMEQQdstlswkkAKEDDIIGGGKKKKSTKKDGKK 792 Caenorhabditis el... 15221961 712 LTSQKEDQDS----NGTSSDYPLAN---E-LANEISQDSFNP------------------KRKPNQSKPRPVVVKLDDGD 765 thale cress 25395482 732 VKGSATAPKRptrfGNPLERVEIVEKEKE-IQSPLEIPGVVGLHryMEQQdstlswkkAKEDDIIGGGKKKKSTKKDGKK 810 Caenorhabditis el... 20137255 683 IKSSPSPQK-------RYQDTPGVEHIPV-VQIDLSVPLKVPGLpmSDQYv------kLEEERRHRQKLEKDKRRKKRKE 748 human 19115579 696 LSSNQHTTT-------TNSEPENLN-----VETSMSDEAFN-------------------ADKVTKGLLMLLIILFLLII 744 fission yeast 6325061 732 LGEEDEERTKnskdLLDLNEEESSDKKPEtIRLNRTDNSLNSLS--LSTT--------EISRKKKKGKKKNRVQVLSDEP 801 baker's yeast 22832217 709 LKSTPTASG-----ASNADQYDNIDDIPI-TELPLDMEGVAALRvgITKRsd----kyLQEQQAAQGSKDGKKKHKKGKK 778 fruit fly
17536815 793 NGKKSGKKRRTTSTSSEEEDRI----VHKVNRNDGEMPEGAKSTDDEDE--KITSIDEFRALDMDLDAPLRPDEIVKAPQ 866 Caenorhabditis el... 15221961 766 ESRITPQAKTNIQTANDDE-SL----SRAIQSALLVKNKGKEKDRYEGN---PNSGQQEKEESSRIENHQNSEKK----- 832 thale cress 25395482 811 NGKKSGKKRRTTSTSSEEEDRI----VHKVNRNDGEMPEGAKSTDDEDE--KITSIDEFRALDMDLDAPLRPDEIVKAPQ 884 Caenorhabditis el... 20137255 749 KEKKGKRRHSSLPTESDEDIAP----AQQVDIVTEEMPENALPSDEDDK---D-PNDPYRALDIDLDKPLADSEKLPIQK 820 human 19115579 745 LVTKNKRRRKIFTSPS----------LQAMVVAQDEVPEGISLADIENK---ENPSNSNVYSLISLDPPLSTNQG----- 806 fission yeast 6325061 802 VIEAAPKRKDAFQKPHDNHSTQnplkKDKINLRMHSQLENFDFSNFGQSsnAGRGSQEEGNLRKEDELELSRLEANLIVK 881 baker's yeast 22832217 779 SKKAKNKVAYNSSSESEGEPKP----LHIVN-TTLDMPEGVSMSDSEDKdgKYDPNDPHRALDIELDItefeapavrsas 853 fruit fly
17536815 867 ayTRVypsqqkqgplvprppttfeprLVAQQQEPAVKLVKEK----KKKTGKKTTTATAVAKLKKKKSLPE 933 Caenorhabditis elegans 15221961 833 --------------------------KKKKKKKKGEGSSKHK----SRRQNEVASASEQVIIPDFLL---- 869 thale cress 25395482 885 ayTRVypsqqkqgplvprppttfeprLVAQQQEPAVKLVKEK----KKKTGKKTTTATAVAKLKKKKSLPE 951 Caenorhabditis elegans 20137255 821 hrNt----------------------ETSKSPEKDVPMVEKK----SKKPKKKEKKHKEKERDKEKKKEKE 865 human 19115579 807 --SMG---------------------DIVLETKSPIRVEKKK----SKKKKKKKV---------------- 834 fission yeast 6325061 882 --DEK---------------------DNLSDTEEVIVIKKKKkgkkSKSKNKLKTKAKNSPEPNEFLRDQS 929 baker's yeast 22832217 854 kksaadkenlktpadsagggnaakkdrkkdkdkdkerkvkrehreskrerkeaavqsvidlidadtptpsp 924 fruit fly
Jiyao W et al.(2023). "The conserved domain database in 2023.",