15238188 1 MHGRKREEDPNPEE------TAAKALELRSLQSQFMSNHHQKIYTKEAIQLSAKLLITNPEFYTAWNYPKLAFESRLD-E 73 thale cress 7290303 1 MEEERNEKKVLCEKiirdinAVFLKDQDLASFEIIPKEANCNKSPVVHVEHNLGLESWCAQHVYDHAHRTLISHRRQTtA 80 fruit fly 7296795 1 MHGRVKVRTTEEERerkkkeQALKVRAYRAAMGRIQKKREAGELDNEMLSLTVQILLRNPDVSMLWNIRRECVLEKLFrL 80 fruit fly 15236132 1 MHGRPRNAS-KPEEea---aSAAKAVQLRSLQSQFMTNHHDKIYTNEAIELSTKLLEINPEAYTAWNYRKLAVEDRLArI 76 thale cress 17541576 1 MHFVKKVPTTEEEKaakqkeHTKRSQQFLHVRDKIVAKREKGEYDDEILSLTQAILEKNADIYTFWNIRRTTIELRMEaN 80 Caenorhabditis elegans 19074025 1 -MSFTSSFVITNSFpwdltlRRFFTGLLSRNFSILSILQRVLSRDSHHPMTGRSHSKKRKPQMIVHNVEEGQYTEDKA-- 77 Encephalitozoon cun... 6093707 1 MHGRLKVKTSEEQAeakrleREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLET-- 78 human 19075963 1 MHGILRVKLSEEQRklkaekERAKIEEYRGLVSRFQEARKRKDYSEGNLKLTTELLDWNPETYSVWNYRREILLNDVFp- 79 fission yeast 728961 1 -------------------------------------MRDEKIYSIEALKKTSELLEKNPEFNAIWNYRRDIIASLAS-- 41 baker's yeast
15238188 74 ----------------------DSDPSLVNS--------IIDEELGVVQNALERNVKSYGAWYHRKWVLSKKGHYy-pSL 122 thale cress 7290303 81 q---------------------QLRTLQQQQ--------QSDSLAKYLNVALLINPDVTTFWHIRRQLVQKNRLS----I 127 fruit fly 7296795 81 keeeatcetpseekpekenqtgENKPSEKKAagedkahsIFTCELDLTEQCLMVNPKSYNAWHHRCWTLEQNPRA---DW 157 fruit fly 15236132 77 ----------------------EPDPNLVSA--------ILDEELRVVESALRQNFKSYGAWHHRKWVLS-KGHS---SV 122 thale cress 17541576 81 ekvq---------------qsaDAEEEEKTKssqk-ienLLAGELFLSYECIKSNPKSYSAWYQRAWALQRQSAP---DF 141 Caenorhabditis elegans 19074025 78 ----------------------ALEELLKLR--------SLPESIEKHMAIVQMVADDYFSWNKLKEHLLSNPSD----F 123 Encephalitozoon cun... 6093707 79 ----------------------QKSPEELAA--------LVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEP---NW 125 human 19075963 80 ----------------------KISLNEKQD--------LLDNELKYVLSKMKVFPKVYWIFNHRRWCLENAPYP---NW 126 fission yeast 728961 42 -------------------------ELEIP---------FWDKELVFVMMLLKDYPKVYWIWNHRLWVLKHYPTSspkVW 87 baker's yeast
15238188 123 ENELQLLNDYQKqahqkQDdekqddpSRNFHAWNYRRFVVELTKTS-----EEDELQYTTDMISDiSFTIYSAWHYRSVL 197 thale cress 7290303 128 NKELQFSALVLS-----IK-------PKSNEAFAYRRWLYSFQSADai--dWPNEIGICERAADR-CASNYHAWSHRQWI 192 fruit fly 7296795 158 QQEVKLCNKYLK-----FD-------ERNFHTWDYRRYVTGKAMVP-----ATQELDFCTEKIRA-NFSNYSSWHHRSLL 219 fruit fly 15236132 123 GNELRLLEKFQK-----LD-------SRNFHAWNYRRFVVELTNRS-----EQDELQYTDDMINN-NFSNYSAWHNRSVL 184 thale cress 17541576 142 KKELALCEKALQ-----LD-------CRNFHCWDHRRIVARMAKRS-----EAEELEFSNKLIND-NFSNYSAWHYRSIA 203 Caenorhabditis elegans 19074025 124 GTQLRICENALR-----GN-------PKSYQPWHHRKFMMERFQKQre--kHLGREDFLTKLLLDsDPRNFHCWNYRMLF 189 Encephalitozoon cun... 6093707 126 TRELELCARFLE-----VD-------ERNFHCWDYRRFVATQAAVP-----PAEELAFTDSLITR-NFSNYSSWHYRSCL 187 human 19075963 127 NYEMMITEKLLS-----AD-------ARNFHGWHYRRYVVSQIERAgncslAKKEMEYTTSAIAT-NFSNFSALHNRTKL 193 fission yeast 728961 88 QTELAVVNKLLE-----QD-------ARNYHGWHYRRIVVGNIESItnkslDKEEFEYTTIKINN-NISNYSAWHQRVQI 154 baker's yeast
15238188 198 VSSLVAKKADG----FMPKETIRRELDYVHSAIFTLEEKQSGWFY-YLWLLDQTVKMEiplrfsswpsdgsiiilsgpdC 272 thale cress 7290303 193 LQ-------NG-------PCLLQSELLRTEKFMRKHISDYSCYHY-RQVLLSR--------------------------A 231 fruit fly 7296795 220 LPELYPNQQRDr---PMSEEKLQKELEMVLTAAFTDPNDSSAWFY-QRWLLGSGAQLDrapri------------aafrL 283 fruit fly 15236132 185 LSSLLAQNADG----FMPNIKIPEEYDFVHSAIFTEPDDQSGWFY-HLWLLDQTLNVEtplltsswpshgssiilsgagC 259 thale cress 17541576 204 LKNIHRDEKTGa--pKIDDELIASELQKVKNAFFMDAEDQSAWTY-TRWLLEVGSGKEf--------------------L 260 Caenorhabditis elegans 19074025 190 LRTRTGRDLFN-----YSYLHHCSGSEDPLSIIYTDPLDPTCWEYfYIWRERRRMRRG---------------------M 243 Encephalitozoon cun... 6093707 188 LPQLHPQPDSGpq-gRLPEDVLLKELELVQNAFFTDPNDQSAWFY-HRWLLGR---ADpqd---------------alrC 247 human 19075963 194 IETILNLEADPnsqkALAKQILEQELDMIHQAVFTDPDDSSVWIY-HRWLMGHc-------------------------n 247 fission yeast 728961 155 ISRMFQKGEVGn-----QKEYIRTEISYIINAMFTDAEDQSVWFY-IKWFIKN--------------------------- 201 baker's yeast
15238188 273 FNASSSttkltTFCSESGSFPLILYFDQAVSGVSSstvTIGSELKDlvw---epVSDKKNsqvdscvwvarlkFDCREPC 349 thale cress 7290303 232 YELSFA-------LPKDSGASGSSTLASLQHLMTS----YGLECEAn-------AEDLLG--------------LLLPHV 279 fruit fly 7296795 284 E--SHG-----AVLALDKPYPDIKQLKTELVGGGQ---TILLEFWL--------PVDKRGt-----------sWKCQQNF 334 fruit fly 15236132 260 LSGSSSmf--tTFCSESGSFPLILYFDQAVGGVSSstvTIDSELKGneglvwepIPNK-Nsqvscv-wvarlkYVSSDPC 335 thale cress 17541576 261 RPESHTp---iELISASFHGNNTTLVFSRAVTIQFlltFVDTENTT-------------G-------------WRAFSST 311 Caenorhabditis elegans 19074025 244 YIRRYS-----KHLEIRFEEPFWGKLVFEGGGVER---MVSSEFAT--------KIVMIG-------------ESVEALG 294 Encephalitozoon cun... 6093707 248 LHVSRDe----ACLTVSFSRPLLVGSRMEILLLMVddsPLIVEWRT--------P-DGRNrps--------hvWLCDLPA 306 human 19075963 248 PN-SMT-----PLISMITIEERIQYLQKEIELIQE-----LHEMEPe---------NR---------------WCCESLV 292 fission yeast 728961 202 DIVCKT-------LDEQEYLKMLKDLRENILLINNd----EIEFSG-----------KQNi------------WCLKILL 247 baker's yeast
15238188 350 fsrketkvkvslggivssmgcNLTAPYEfvfTLRIHDTVEvelSQQESIVSWTDGFDNWDDnALSNDLNSLTa---LNAD 426 thale cress 7290303 280 ---------------------DLSSVSK-------QRLIS------FLYCCNVAANDMRLCaEQRLMYGSRD----CFEL 321 fruit fly 7296795 335 d-------------------yQRNSAYS--------LRLS---DQKVDLSPLSGSENGAY--YIAPPHGTTS----C-SK 377 fruit fly 15236132 336 eykvkirvgn-spgivssrgyNFNAPYEfvfTAHVHDTVE---DSQEGIVSWTDGFDIWD--AKSKDLNSLVtldrLNAE 409 thale cress 17541576 312 s-------------------pNPTSSRVwqyLSDTPLRVVtsnPTDLENISWTELNEQPY--VNLDRLKTIYd---VVEV 367 Caenorhabditis elegans 19074025 295 ---------------------KYRVALN---GKEVDLGPE---KEDFGFLHEVLEAESRCHgALLALLDYVD------EE 341 Encephalitozoon cun... 6093707 307 as------------------lNDQLPQH---TFRVIWTAG---DVQKECVLLKGRQEGWCR-DSTTDEQLFRc---ELSV 358 human 19075963 293 ---------------------NYEALCK--------T-LE-------KQKPTEADIKRWT--LLVDKMIKVD----PQRR 329 fission yeast 728961 248 ---------------------VLEDILE-----------E-------KEALTERSSEQYL--VQLIDADPLR-------K 279 baker's yeast
15238188 427 TGFEWRKKAIKIEIELFRTLPDSKIGKLILARLLMAEETMISNgv----hyKEILQLYNDLMALDSWHNQYYKDEHSVAL 502 thale cress 7290303 322 HRRAALKFIVEQCVRLQMGLPNGQLLPVASGDLRSHLGNFDFEd-------NPFLSAVRREESTLGGKHRRWCNLHLSFG 394 fruit fly 7296795 378 DLLAELQTQLQSCLDLLEFEPDSKWTLLTSALLMRAIDFSANH--------ETSLAHLAKLEKVDFLREGYYKDLAARWT 449 fruit fly 15236132 410 MDFKWRQEAIDSEVECFGILPDSKIGKLTLARLLMAREAMVSDdavkgvhyEEILQLYNDLMALDSSHYQYYKDEHSKAF 489 thale cress 17541576 368 PQPAYIGELLEDCKQLIELEPKNKWPLYMRTLVLLEYQPIKSYe-------EIIKNLENLSENLDPKRSELYKSLISRQN 440 Caenorhabditis elegans 19074025 342 TERASIIERIATLDPARRSYYSTLHGRFYCVYIPGSGE------------------------------------------ 379 Encephalitozoon cun... 6093707 359 EKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYE--------KETLQYFQTLKAVDPMRATYLDDLRSKFL 430 human 19075963 330 GRYRTLQEKINNLNK----------------------------------------------------------------- 344 fission yeast 728961 280 NRYLHLLEQHK--------------------------------------------------------------------- 290 baker's yeast
15238188 503 IHK 505 thale cress 7290303 395 YPA 397 fruit fly 7296795 450 LEW 452 fruit fly 15236132 490 LHK 492 thale cress 17541576 441 LNF 443 Caenorhabditis elegans 19074025 --- Encephalitozoon cuniculi 6093707 431 LEN 433 human 19075963 --- fission yeast 728961 --- baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",