2DBF


Conserved Protein Domain Family
Death_NFkB1_p105

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cd08797: Death_NFkB1_p105 (this model, PSSM-Id:176775 is obsolete and has been replaced by 260063)
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Death domain of the Nuclear Factor-KappaB1 precursor protein p105
Death Domain (DD) of the Nuclear Factor-KappaB1 (NF-kB1) precursor protein p105. The NF-kB family of transcription factors play a central role in cardiovascular growth, stress response, and inflammation by controlling the expression of a network of different genes. There are five NF-kB proteins, all containing an N-terminal REL Homology Domain (RHD). NF-kB1 (or p50) is produced from the processing of the precursor protein p105, which contains ANK repeats and a C-terminal DD in addition to the RHD. It is regulated by the classical (or canonical) NF-kB pathway. In the cytosol, p50 forms an inactive complex with RelA (or p65) and the Inhibitor of NF-kB (IkB). Activation is triggered by the phosphorylation and degradation of IkB, resulting in the active DNA-binding p50-RelA dimer to migrate to the nucleus. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 176775
View PSSM: cd08797
Aligned: 5 rows
Threshold Bit Score: 124.957
Threshold Setting Gi: 189544922
Created: 18-Feb-2010
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DBF_A        16 VKLQLYKLLEipdpdKNWATLAQKLgLGILNNAFRLSpAPSKTLMDNYEVSggTVRELVEALRQMGyTEAIEVIQA 91   human
547761       814 SKQQLYKLLEtpdpsKNWSTLAEKLgLGILNNAFQLSpSPSKTLLDNYKISggTGQELIAAFTQMDhTEAIEVIQK 889  chicken
AAH81252     801 VNQKLYNLLEsqdldKNWATLAQKLgLGMLNNAFRLSpLPSKTLLDNFEVSggTIRELLDALKRMHyTEAIEAIEQ 876  African clawed frog
ABN58794     806 VKQEVCRALEs---eGCWENLAHSLgLGILKVAFRLSpSPAKTLLDSYEVSggTVRDLLAGLRSVGeCRALSVLEE 878  Chinese perch
XP_001922860 161 VKQDLCSALDgp--aGGWETLADVLgLGILNSAFRLSsCPAGKLLDSYEVSggTVLELLEGLKRVGnCSAVTLLQN 234  zebrafish
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