3YGS,2VGQ,2NZ7,1DGN,3KAT,3CRD,3YGS


Conserved Protein Domain Family
CARD

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cd01671: CARD (this model, PSSM-Id:176719 is obsolete and has been replaced by 260018)
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Caspase activation and recruitment domain: a protein-protein interaction domain
Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form mutliprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 176719
View PSSM: cd01671
Aligned: 62 rows
Threshold Bit Score: 37.5664
Threshold Setting Gi: 10720034
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3YGS_P         10 LRRCRLRLVeel------qvDQLWDVLLsreLFRPHMIEDIQRAgsgsrrDQARQLIIDLEtRGSQALPLFISCLEDtg- 82
gi 125826514    4 IVTNKPNLIkwls----ldaTHLLQHVQskgIIKTEEYNDLMSLss--srIIVIHLLDLLIgKGESTCRSFLELLKEdd- 76
gi 13605449    13 RERKKLLEIlqh------dpDSILDTLTsrrLISEEEYETLENVtd--llKKSRKLLILVQkKGEATCQHFLKCLFStf- 83
1DGN_A          5 LRKKRRIFIhsvg---agtiNALLDCLLedeVISQEDMNKVRDEndt-vmDKARVLIDLVTgKGPKSCCKFIKHLCEed- 79
gi 11545912    34 FQAQRSQLVellvsgslegfESVLDWLLsweVLSWEDYEGFHLLgqp-lsHLARRLLDTVWnKGTWACQKLIAAAQEaq- 111
gi 10720034     6 HNKNPLKMLeslg---keliSGLLDDFVeknVLKLEEEEKKKIYdak-lqDKARVLVDSIRqKNQEAGQVFVQTFLNid- 80
3KAT_A         22 VDQYREQLIarv-----tsvEVVLDKLHg-qVLSQEQYERVLAEnt--rpSQXRKLFSLSQsWDRKCKDGLYQALKEth- 92
gi 47681493     4 VLENKVFLIgtls----adpDFILQHVQqdkIITKRDYDKLNHSyhp-raKIVTDLLDTVMnKGDATCCKFVDLLQReev 78
gi 169234902   11 IQRHKLELLealn----edpDFLLQHCHargILSNNEYNNIKDInt--rsKQARDILDYVIlKDNKHALTFLKLLKTpe- 83
gi 54111544     6 LKEKRKQFIrsvg---egtiNGLLGELLetrVLSQEEIEIVKCEnat-vmDKARALLDSVIrKGAPACQICITYICEed- 80
                          90
                  ....*....|.
3YGS_P         83 ---qdMLASFL 90
gi 125826514   77 ---vnESFPKL 84
gi 13605449    84 ----pQLAAIC 90
1DGN_A         80 ----pQLASKM 86
gi 11545912   112 ---adSQSPKL 119
gi 10720034    81 ---knSTSIKA 88
3KAT_A         93 ----pHLIXEL 99
gi 47681493    79 qdnfpDLKQLF 89
gi 169234902   84 ---iqETFPKL 91
gi 54111544    81 ----sHLAGTL 87
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