Conserved Protein Domain Family
C2B_Tricalbin-like

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cd04052: C2B_Tricalbin-like 
C2 domain second repeat present in Tricalbin-like proteins
5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-II topology.
Statistics
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PSSM-Id: 176017
View PSSM: cd04052
Aligned: 44 rows
Threshold Bit Score: 101.14
Threshold Setting Gi: 254571211
Created: 11-Jan-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075362   689 VGDVTAEEGselPSSYVCVDLDDtLVYKTRTKVFTSNPIYNAGSEKFVKDWRNAMLCFTVRDFKlrehDSILGVVNIPLA 768
gi 190348199  457 KDLDISRSVvglLNPYAEIYVNNeLTKSCRRLRQTNEPSWNQSFESLITQQSETQVQVLIKDSAd---DDIVAKLDASLQ 533
gi 50293707   639 KNLDLSSSIsgtLNPQAELLMDGqLIKTFRKVKRNNEPNWEESVEFLVPSQTDSKLTLKIWDDHks-hREFLCEYSGTAS 717
gi 156841154  646 RSLDLSYAVggvISPSAELRLNGrLVKRYRTLKKTNEPSWNETIELFVNSKSSSVLELTVFDERsk-rRAVLCSIKASLA 724
gi 45190753   618 KYLSTSTSItgsLSPSAELFVDSkKVKSYRTLRHMNEPSWEDPVEILIPSKRTTEFTLKIYDERfs-gKELICEFSAPFE 696
gi 50303603   634 KYLNKSAALtgfLSPCAELFIDGkKVKSYRTLRRINEPSWEETIEILIPSKSKSELSLKLYDDQmh-gKRQLAEYTASME 712
gi 2497080    673 KYLDTTSSMtgsLSPCAELFIDGqKVKSYRTLRRINEPSWNETIEVLVPSKSNSKFVLKIFDDRmn-gKALICEYSSSLD 751
gi 254579178  756 KYLNTAVALtgtLSPSATLFLNGnVVKEFRTLKRINEPSWGETIELFIPSREESELRLEVYDNGlr-eKKLICEYGSTLE 834
gi 255714300  662 TNLKHATAVqgaLSPSAELFVDGkSVMHFRTLRRINEPSWEQSIEVLVPSKKNSTLLLKVYDQGia-gREELCKYSTSME 740
gi 260950999  529 TNLDISHSVtgvLNPYAEIYINNkFVKRSRNLRETNEPDFGVSFESFITQQSETQIQVLVKDAAe---DLVVGKLDTNLQ 605
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19075362   769 TTLTTSSQLTKWYPIqg---giGFGSVRISILFRSM 801
gi 190348199  534 DLIFETSRGQQWITCqpireggPHSRIKISAGWKPL 569
gi 50293707   718 EIMDSLSMGASSLEAs------PQGYINVDLQWKSV 747
gi 156841154  725 TFFEVISIGQDYINAs------PKGQIYFFAQWKPV 754
gi 45190753   697 ELLNIASSDSEYLTGs------PQGEIYFTAVWKPV 726
gi 50303603   713 DVIELFEQGQTFVQAs------PQGEIYITSSWKPV 742
gi 2497080    752 DIMTTLDTAQEFVKGs------PQGDIYLDVSWKSI 781
gi 254579178  835 DIFENLQNGEPFVKGs------PQGEIYMNAEWKPV 864
gi 255714300  741 DVLSMADAGQSVLQAs------PQGRIYMSAAWKPV 770
gi 260950999  606 DLIFETSRGQQWLSApsvaeggEPAKFKIGAKWKAI 641
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