Conserved Protein Domain Family
STKc_Nek6

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cd08228: STKc_Nek6 (this model, PSSM-Id:173768 is obsolete and has been replaced by 270865)
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 6
Serine/Threonine Kinases (STKs), Never In Mitosis gene A (NIMA)-related kinase 6 (Nek6) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek6 subfamily is one of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis.
Statistics
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PSSM-Id: 173768
View PSSM: cd08228
Aligned: 4 rows
Threshold Bit Score: 575.821
Threshold Setting Gi: 33468587
Created: 15-Dec-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #####   #            # #                               #               
AAG13417      67 LADFQIEKKIGRGQFSEVYKATCllDRKTVALKKVQIFEMMDAKaRQDCVKEIGLLKQLNHPNIIKYLDSFIEDneLNIV 146 human
NP_001012549  43 LADFQIEKKIGRGQFSEVYKATCllDRKPVALKKVQIFEMMDAKaRQDCIKEIDLLKQLNHPNIIKYLDSFIEDneLNIV 122 chicken
AAI29548      39 LANFKIEKKIGRGQFSEVYRAMChlDRKPVALKKVQIFEMMDAKaRQDCIKEIDLLKQLNHPNVIKYLDSFIEDneLNIV 118 African clawed ...
CAE30393      13 LSNFLIEKKIGRGQFSEVYRATCllNNQKVALKKVQIFEMMDAKaRQDCVKEIDLLKQLNHPNVIKYLDSFIANneLNIV 92  zebrafish
Feature 1        ####   # #                                        # # ## #          #  # #      
AAG13417     147 LELADAGDLSQMIKYFKKqkRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITatGVVKLGDLGLGRFFSSET 226 human
NP_001012549 123 LELADAGDLSQMIKYFKKqkRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITatGVVKLGDLGLGRFFSSKT 202 chicken
AAI29548     119 LELADAGDLSQMIKYFKKqkRLIPERTVWKYFVQLCSAVEHMHSRRIMHRDIKPANVFITatGVVKLGDLGLGRFFSSKT 198 African clawed ...
CAE30393      93 LELASAGDLSQMIMHFKKkrRLIPERTIWKYFVQLCSALEHMHSRRVMHRDIKPANVFITasGEVKLGDLGLGRFFSSKT 172 zebrafish
Feature 1               ####                                                                     
AAG13417     227 TAAHSLVGTPYYMSPERIHENgYNFKSDIWSLGCLLYEMAALQSPFYGDkmNLFSLCQKIEQCDYPPLPgeHYSEKLREL 306 human
NP_001012549 203 TAAHSLVGTPYYMSPERIHENgYNFKSDIWSLGCLLYEMAALQSPFYGDkmNLFSLCQKIEQCDYPPLPaeHYSEKLREL 282 chicken
AAI29548     199 TAAHSLVGTPYYMSPERIHENgYNFKSDIWSLGCLLYEMAVLQSPFYGDkmNLFSLCQKIEQCDYPPLPkeHYSEKLREL 278 African clawed ...
CAE30393     173 TAAHSLVGTPYYMSPERIHENgYNFKSDIWSLGCLLYEMAALHSPFYSDkmNLLSLCHKIEQCEYPPLPteHYSQKFRDL 252 zebrafish
Feature 1                                   
AAG13417     307 VSMCICPdPHQRPDiGYVHQVAKQMHI 333 human
NP_001012549 283 VSMCIYPdPDQRPDiGYVHQIAKQMHV 309 chicken
AAI29548     279 VSMCIYPdPDQRPDiGYVHQIAKQMQV 305 African clawed frog
CAE30393     253 VSMCINPePDQRPDiSFVLQFSTQMKL 279 zebrafish

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