Conserved Protein Domain Family
STKc_Nek8

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cd08220: STKc_Nek8 (this model, PSSM-Id:173760 is obsolete and has been replaced by 270859)
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 8
Serine/Threonine Kinases (STKs), Never In Mitosis gene A (NIMA)-related kinase 8 (Nek8) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek8 subfamily is one of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases.
Statistics
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PSSM-Id: 173760
Aligned: 6 rows
Threshold Bit Score: 451.234
Created: 11-Apr-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of MgADP to human Nek2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## ##   #              # #                              #                
Q86SG6         3 KYERIRVVGRGAFGIVHLCLRKa--DQKLVIIKQIPVEQMTkeERQAAQNECQVLKLLnHPNVIEYYENFLEDkaLMIAM 80  human
AAH75274       3 KYKKIRVVGRGAFGIVHLCLRKa--DQKLVIIKQIPVEQMTkdERLAAQNECQVLKLLsHPNIIEYYENFLEDkaLMIVM 80  western clawed ...
Q90XC2         3 KYEKTKVVGRGAFGIVHLCRRRt--DSALVILKEIPVEQMTrdERLAAQNECQVLKLLsHPNIIEYYENFLEDkaLMIAM 80  zebrafish
AAB54139       3 NYEKVRVVGRGAFGVCWLCRGKndaSHQKVIIKLINTHGMTekEENSIQSEVNLLKKVqHPLIIGYIDSFIMDnqLGIVM 82  nematode
XP_415822      3 KYERIRVVGRGAFGIVHLCLRKa--DQKLVILKQIPVEQMSkdERLAAQNECQVLKLLsHPNVIEYYENFLEDkaLMIAM 80  chicken
XP_002591460   3 KYERIRVVGRGAYGTVYLCKRLd--AQKEVIIKQIPIEQMTkdERQSALNEVRVLSMLhHPNIIEYYESFLEDkaLMIVM 80  Florida lancelet
Feature 1        ###   #                                                    # #                # 
Q86SG6        81 EYAPGGTLAEFIQkrc-------nsLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKhrMVVKIGDFGISKI 153 human
AAH75274      81 EYAPGGTLAEYIQkrc-------nsLLDEDTILHFFVQILLALHHVHTKLILHRDLKTQNILLDKhqMIVKIGDFGISKI 153 western clawed ...
Q90XC2        81 EYAPGGTLADYIQkrc-------nsLLDEDTILHSFVQILLALYHVHNKLILHRDLKTQNILLDKhqMIVKIGDFGISKI 153 zebrafish
AAB54139      83 QYAEGGTLERLINdqraikdsnmreYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRrkTVLKLSDFGISKE 162 nematode
XP_415822     81 EYAPGGTLAEFIHkrc-------nsLLDEDTILHFFVQILLALHHVHTKQILHRDLKTQNILLDKhrMIVKIGDFGISKI 153 chicken
XP_002591460  81 EYAPGGTIFEYLQqrg-------naLLDEEEILQFFVQMLLSLQHVHAKQILHRDLKTQNILLNRkkNVVKIGDFGISKI 153 Florida lancelet
Feature 1                                                                                        
Q86SG6       154 LSSKSKAYTVVGTPCYISPELCEGKpYNQKSDIWALGCVLYELasLKRAFEAANlPALVLKIMSGTFAPISDRYSPELRQ 233 human
AAH75274     154 LSSKSKAYTVVGTPCYISPELCEGKpYNQKSDIWALGCVLYELtsLKRAFEAANlPALVLKIMSGTFAPISDRYSPELRH 233 western clawed ...
Q90XC2       154 LVSKSKAYTVVGTPCYISPELCEGKpYNQKSDIWALGCVLYELasLKRAFEAANlPALVLKIMSGTFAPISDRYSPELRQ 233 zebrafish
AAB54139     163 LGTKSAASTVIGTPNYLSPEICESRpYNQKSDMWSLGCVLYELlqLERAFDGENlPAIVMKITRSKQNPLGDHVSNDVKM 242 nematode
XP_415822    154 LSSKSKAYTVVGTPCYISPELCEGKpYNQKSDIWALGCVLYELasLKRAFEAANlPALVLKIMSGTFAPISDRYSPDLRQ 233 chicken
XP_002591460 154 LSSKSKAYTVVGTPCYISPELCEGKpYNQKSDIWALGCVLYELasLKRAFEAANlPALVLKIMRGTFAPISDRYSEDLRR 233 Florida lancelet
Feature 1                                 
Q86SG6       234 LVLSLLSLePAQRPPlSHIMAQPLC 258 human
AAH75274     234 LILSMLNLdPSKRPQlNEIMAHPIC 258 western clawed frog
Q90XC2       234 LILNMLNLdPSKRPQlNEIMAHAIC 258 zebrafish
AAB54139     243 LVENLLKThTDKRPDvSQLLSDPLV 267 nematode
XP_415822    234 LILSMLNLdPSKRPQlNEIMAQSIC 258 chicken
XP_002591460 234 LILSMLHLdPSKRPTiTQIMAQPIV 258 Florida lancelet

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