Conserved Protein Domain Family
STKc_CDK12

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cd07864: STKc_CDK12 (this model, PSSM-Id:173753 is obsolete and has been replaced by 270847)
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 12 (CDK12) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing.
Statistics
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PSSM-Id: 173753
View PSSM: cd07864
Aligned: 9 rows
Threshold Bit Score: 575.572
Threshold Setting Gi: 26454617
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       ####    #            # #                #             #           
gi 12643825   719 WGKRCVdKFDIIGIIGEGTYGQVYKARDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLiHRSVVNMKEIVTDKqd 798
gi 72087356   490 WGERCVdVFEIINQIGEGTYGQVYKARDKdTGELVALKKVRTDNEKEGFPITAVREIKILRQLnHDSVIRLHEIVTDKqd 569
gi 24668141   796 WGERCVdVFEMIAQIGEGTYGQVYKARDHhTNDMVALKKVRLEHEKEGFPITAVREIKILRQLnHRNIVNLHEIVTDKqd 875
gi 120537647  272 WGKRCVdKFDIIGIIGEGTYGQVYKAKDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLnHRSVVNMKEIVTDKqd 351
gi 198282055  702 WGKRCVdKFDIIGIIGEGTYGQVYKAKDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLiHKSVVNMKEIVTDKqd 781
gi 118102964  719 WGKRCVdKFDIIGIIGEGTYGQVYKAKDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLiHRSVVNMKEIVTDKqd 798
gi 26454617   303 WYKTNLtHYTMLDQIGEGTYGQVYKAVNNlTGEQVALKRVRLENEKEGFPITAIREIKILRQLhHKNIVRLMDIVIDDi- 381
gi 198436214  664 WGSMCVdEYAFISITGEGTFGQVYKARDKhTDEICALKKVRLDNEREGFPITAVREIKILRQLqHRNIVCLKDVLTDKsd 743
gi 238657382  192 WGERSVtAFDTLIQVGEGTYGHVYKARDKiTGEYKALKKVRLENEREGFPITAVREIKILRQLrHPNIVNLCEIVTDKdd 271
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        ####  # ##                                     # # ## #          
gi 12643825   799 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNsGQIKLA 876
gi 72087356   570 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVNFSEEHVRSFMKQLLDGLNYCHKRNFLHRDIKCSNILLNNkGHIKLA 647
gi 24668141   876 aVEFRKDKG-SFYLVFEYMDHDLMGLLESG-MVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNrGKVKLA 953
gi 120537647  352 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVSFSHEHVQSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNsGQIKLA 429
gi 198282055  782 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNsGQIKLA 859
gi 118102964  799 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNsGQIKLA 876
gi 26454617   382 sMDELKRTRaNFYLVFEYVDHDLIGLLESKeLVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNkGELKIA 461
gi 198436214  744 aTDFRKEKEcAFYLVFEYMDHDLMGLLESG-MVHFNENHIKSFMKQLLDGLNHCHKKGFLHRDIKCSNILLNNkGEIKLA 822
gi 238657382  272 pTDFKKDKG-AFFLVFDYMDHDLYGILESG-LVTFSEQHIASLMKQLLDGLSFCHDRHFLHRDIKCSNILINNkGQLKLA 349
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #             # #### #                                     ##                
gi 12643825   877 DFGLARLYNSEEs-RPYTNKVITLWYRPPELLLGEErYTPAIDVWSCGCILGELFTkKPIFQANlELAQLELISRLCGSP 955
gi 72087356   648 DFGLARLYHADDktRPYTNKVITLWYRPPELLLGEErYGPAVDVWSCGCILGELFTqRPIFQANqELAQLELISRICGTP 727
gi 24668141   954 DFGLARLYNADDreRPYTNKVITLWYRPPELLLGEErYGPSIDVWSCGCILGELFVkRPLFQANaEMAQLETISKICGSP 1033
gi 120537647  430 DFGLARLYNSEEs-RPYTNKVITLWYRPPELLLGEErYSPAIDVWSCGCILGELFTkKPIFQANqELLQLELISRLCGSP 508
gi 198282055  860 DFGLARLYSSEEs-RPYTNKVITLWYRPPELLLGEErYTPAIDVWSCGCILGELFTkKPIFQANqELAQLELISRLCGSP 938
gi 118102964  877 DFGLARLYSSEEs-RPYTNKVITLWYRPPELLLGEErYTPAIDVWSCGCILGELFTkKPIFQANlELAQLELISRLCGSP 955
gi 26454617   462 DLGLARLWEKES--RLYTNRVITLWYRPPELLLGDErYGPAIDVWSTGCMLGELFTrKPLFNGNnEFGQLELISKVCGSP 539
gi 198436214  823 DFGLARFFNKDEq-RPYTNRVITLWYRPPELLLGEEmYTPSIDIWSCGCILAELFTkKPLFQADrELAQLECISRVCGSP 901
gi 238657382  350 DFGLARLYIAGDkeRPYTNKVITLWYRPPELLLGEErYGPAVDIWSCGCILGEMFTrRPMFQASeEVEQLEVISRICGYP 429
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                           
gi 12643825   956 CPAVWPdVIKLPYFNTMKPKKQYRRRLREEFSFI-PSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 1020
gi 72087356   728 TPAVWPdVIRLPLFNTMKPKKMYNRRLREEFSLL-PKDALDLLDGMLTLDPDKRTTAEDALNCGWL 792
gi 24668141  1034 VPAVWPnVIKLPLFHTLKQKKTHRRRLREDFEFM-PAPALDLLDKMLDLDPDKRITAEDALRSPWL 1098
gi 120537647  509 CPAAWPdVIRLPYFNTMRPKKQYRRRLREEFSFL-PTPALDLLDHMLTLDPSRRCTAEQALASQFL 573
gi 198282055  939 CPAVWPdVIKLPYFNTMKPKKQYRRRLREEFSFV-PTPALDLLDHMLTLDPSKRCTAEQTLQSDFL 1003
gi 118102964  956 CPAVWPdVIKLPYFNTMKPKKQYRRRLREEFSFI-PSSALDLLDHMLTLDPGKRCTAEQALQSDFL 1020
gi 26454617   540 NVDNWPeLTELVGWNTFRMKRTYQRRIREEFEHImPREAVDLLDKMLTLNPEKRISAKEALNHPWI 605
gi 198436214  902 CPAVWPdVIKLPHFHTMKPKRQHRRKLREDFSYL-PTLAIDLLDQMLTLDPSKRFTAEEALNCPWL 966
gi 238657382  430 DPAIWPnVEKLPFYSTIKPKKMYRRRLREEYHII-PPHAVDLLDHMLQLDPQKRCSAREALASPWL 494

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