Conserved Protein Domain Family
STKc_CDK12

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cd07864: STKc_CDK12 (this model, PSSM-Id:173753 is obsolete and has been replaced by 270847)
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 12 (CDK12) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing.
Statistics
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PSSM-Id: 173753
View PSSM: cd07864
Aligned: 9 rows
Threshold Bit Score: 575.572
Threshold Setting Gi: 26454617
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       ####    #            # #                #             #           
Q9NYV4        719 WGKRCVdKFDIIGIIGEGTYGQVYKARDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLiHRSVVNMKEIVTDKqd 798  human
XP_789337     490 WGERCVdVFEIINQIGEGTYGQVYKARDKdTGELVALKKVRTDNEKEGFPITAVREIKILRQLnHDSVIRLHEIVTDKqd 569  purple urchin
NP_730643     796 WGERCVdVFEMIAQIGEGTYGQVYKARDHhTNDMVALKKVRLEHEKEGFPITAVREIKILRQLnHRNIVNLHEIVTDKqd 875  fruit fly
AAI29249      272 WGKRCVdKFDIIGIIGEGTYGQVYKAKDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLnHRSVVNMKEIVTDKqd 351  zebrafish
NP_001128283  702 WGKRCVdKFDIIGIIGEGTYGQVYKAKDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLiHKSVVNMKEIVTDKqd 781  western clawe...
XP_425866     719 WGKRCVdKFDIIGIIGEGTYGQVYKAKDKdTGELVALKKVRLDNEKEGFPITAIREIKILRQLiHRSVVNMKEIVTDKqd 798  chicken
P46551        303 WYKTNLtHYTMLDQIGEGTYGQVYKAVNNlTGEQVALKRVRLENEKEGFPITAIREIKILRQLhHKNIVRLMDIVIDDi- 381  nematode
XP_002131391  664 WGSMCVdEYAFISITGEGTFGQVYKARDKhTDEICALKKVRLDNEREGFPITAVREIKILRQLqHRNIVCLKDVLTDKsd 743  Ciona intesti...
CAZ28459      192 WGERSVtAFDTLIQVGEGTYGHVYKARDKiTGEYKALKKVRLENEREGFPITAVREIKILRQLrHPNIVNLCEIVTDKdd 271  Schistosoma m...
Feature 1                        ####  # ##                                     # # ## #          
Q9NYV4        799 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNsGQIKLA 876  human
XP_789337     570 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVNFSEEHVRSFMKQLLDGLNYCHKRNFLHRDIKCSNILLNNkGHIKLA 647  purple urchin
NP_730643     876 aVEFRKDKG-SFYLVFEYMDHDLMGLLESG-MVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNrGKVKLA 953  fruit fly
AAI29249      352 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVSFSHEHVQSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNsGQIKLA 429  zebrafish
NP_001128283  782 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNsGQIKLA 859  western clawe...
XP_425866     799 aLDFKKDKG-AFYLVFEYMDHDLMGLLESG-LVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNsGQIKLA 876  chicken
P46551        382 sMDELKRTRaNFYLVFEYVDHDLIGLLESKeLVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNkGELKIA 461  nematode
XP_002131391  744 aTDFRKEKEcAFYLVFEYMDHDLMGLLESG-MVHFNENHIKSFMKQLLDGLNHCHKKGFLHRDIKCSNILLNNkGEIKLA 822  Ciona intesti...
CAZ28459      272 pTDFKKDKG-AFFLVFDYMDHDLYGILESG-LVTFSEQHIASLMKQLLDGLSFCHDRHFLHRDIKCSNILINNkGQLKLA 349  Schistosoma m...
Feature 1         #  #             # #### #                                     ##                
Q9NYV4        877 DFGLARLYNSEEs-RPYTNKVITLWYRPPELLLGEErYTPAIDVWSCGCILGELFTkKPIFQANlELAQLELISRLCGSP 955  human
XP_789337     648 DFGLARLYHADDktRPYTNKVITLWYRPPELLLGEErYGPAVDVWSCGCILGELFTqRPIFQANqELAQLELISRICGTP 727  purple urchin
NP_730643     954 DFGLARLYNADDreRPYTNKVITLWYRPPELLLGEErYGPSIDVWSCGCILGELFVkRPLFQANaEMAQLETISKICGSP 1033 fruit fly
AAI29249      430 DFGLARLYNSEEs-RPYTNKVITLWYRPPELLLGEErYSPAIDVWSCGCILGELFTkKPIFQANqELLQLELISRLCGSP 508  zebrafish
NP_001128283  860 DFGLARLYSSEEs-RPYTNKVITLWYRPPELLLGEErYTPAIDVWSCGCILGELFTkKPIFQANqELAQLELISRLCGSP 938  western clawe...
XP_425866     877 DFGLARLYSSEEs-RPYTNKVITLWYRPPELLLGEErYTPAIDVWSCGCILGELFTkKPIFQANlELAQLELISRLCGSP 955  chicken
P46551        462 DLGLARLWEKES--RLYTNRVITLWYRPPELLLGDErYGPAIDVWSTGCMLGELFTrKPLFNGNnEFGQLELISKVCGSP 539  nematode
XP_002131391  823 DFGLARFFNKDEq-RPYTNRVITLWYRPPELLLGEEmYTPSIDIWSCGCILAELFTkKPLFQADrELAQLECISRVCGSP 901  Ciona intesti...
CAZ28459      350 DFGLARLYIAGDkeRPYTNKVITLWYRPPELLLGEErYGPAVDIWSCGCILGEMFTrRPMFQASeEVEQLEVISRICGYP 429  Schistosoma m...
Feature 1                                                                           
Q9NYV4        956 CPAVWPdVIKLPYFNTMKPKKQYRRRLREEFSFI-PSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 1020 human
XP_789337     728 TPAVWPdVIRLPLFNTMKPKKMYNRRLREEFSLL-PKDALDLLDGMLTLDPDKRTTAEDALNCGWL 792  purple urchin
NP_730643    1034 VPAVWPnVIKLPLFHTLKQKKTHRRRLREDFEFM-PAPALDLLDKMLDLDPDKRITAEDALRSPWL 1098 fruit fly
AAI29249      509 CPAAWPdVIRLPYFNTMRPKKQYRRRLREEFSFL-PTPALDLLDHMLTLDPSRRCTAEQALASQFL 573  zebrafish
NP_001128283  939 CPAVWPdVIKLPYFNTMKPKKQYRRRLREEFSFV-PTPALDLLDHMLTLDPSKRCTAEQTLQSDFL 1003 western clawed frog
XP_425866     956 CPAVWPdVIKLPYFNTMKPKKQYRRRLREEFSFI-PSSALDLLDHMLTLDPGKRCTAEQALQSDFL 1020 chicken
P46551        540 NVDNWPeLTELVGWNTFRMKRTYQRRIREEFEHImPREAVDLLDKMLTLNPEKRISAKEALNHPWI 605  nematode
XP_002131391  902 CPAVWPdVIKLPHFHTMKPKRQHRRKLREDFSYL-PTLAIDLLDQMLTLDPSKRFTAEEALNCPWL 966  Ciona intestinalis
CAZ28459      430 DPAIWPnVEKLPFYSTIKPKKMYRRRLREEYHII-PPHAVDLLDHMLQLDPQKRCSAREALASPWL 494  Schistosoma mansoni

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