Conserved Protein Domain Family
STKc_MPK1

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cd07857: STKc_MPK1 
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173750
View PSSM: cd07857
Aligned: 8 rows
Threshold Bit Score: 587.449
Threshold Setting Gi: 1173459
Created: 24-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #### ## #              # #                #              #               
Q92398     20 NFKVVKELGQGAYGIVCAARNVaskdqEAVAIKKITNVFSKSILTKRALREIKLLIHFRNHRNITCIYDLDIinp----y 95  Schizosaccharomyce...
Q00772     22 RFQLIKEIGHGAYGIVCSARFAeaaedTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIvfyp--dg 99  baker's yeast
AAD10000   20 GYEVIKGLGKGSYGVVCSAKNIevednNKVAIKKITNIFSKKMLAKRALREIMLLQHFRNHKNITTLYDMDIvdp----s 95  Pneumocystis carinii
P36005     22 HFHLTGKIGRGSHSLICSSTYTesneeTHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHPNIVWLFDTDIvfyp--ng 99  baker's yeast
XP_572911 201 RWKLLRPLGQGAYGLVIQVQDAet--eIPIAVKCVTRVFDKVILARRALREITLLRHFGEHDNLTGLVDMDNvw-----d 273 Cryptococcus neofo...
AAD24428   24 RYTVTKELGQGAYGIVCAATNVqt--gEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIprp----d 97  Emericella nidulans
AAO61669   21 PWQFVKELGQGAYGCVSSARNSst--gETCAVKKVTNVFQKKILTKRCLRELRLLHHFRGHKNITCLYDMDIvfdppgsg 98  Cryptococcus neofo...
1173459    37 YYEIIQFLGKGAYGTVCSVKFKgrspaARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIvts----s 112 baker's yeast
Feature 1             ####  # ##                                   # # ## #         ##  #     
Q92398     96 nFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLARGCS 175 Schizosaccharomyce...
Q00772    100 sINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYS 179 baker's yeast
AAD10000   96 kFNELYLYEELMQANLNSIIRSDQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPSNLLINADCKLKICDFGLSRGIS 175 Pneumocystis carinii
P36005    100 aLNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYS 179 baker's yeast
XP_572911 274 gYNEIYLYMEPMEADLHQIIRSGQPLGNAHIQFFIYQLLRGMKYIHSANVIHRDLKPGNLLVNSGCELKICDFGLARGFN 353 Cryptococcus neofo...
AAD24428   98 nFNETYLYEELMECDLAAIIRSGQPLTDAHYQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFS 177 Emericella nidulans
AAO61669   99 qFREVYLYEELMEADLHAIIRSGQPLSDAHFQSFLYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFQ 178 Cryptococcus neofo...
1173459   113 pYDGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIH 192 baker's yeast
Feature 1                   # #### #                                     #                    
Q92398    176 ENPEE----NPGFMTEYVATRWYRAPEIMLSfssYHKGIDVWSVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDEE 251 Schizosaccharomyce...
Q00772    180 ENPVE----NSQFLTEYVATRWYRAPEIMLSyqgYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDE 255 baker's yeast
AAD10000  176 VNQGQ----GTEYMTEYVTTRWYRAPEVMLSfqsYSKAIDLWSVGCILAELLGRKPFFKGSNYVDQLNQIFCILGTPNEN 251 Pneumocystis carinii
P36005    180 ENHKV----NDGFIKGYITSIWYKAPEILLNyqeCTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEE 255 baker's yeast
XP_572911 354 PVKGEepqgEEGKLTEYVATRWYRAPEIMLSnrrYTTAIDVWSIGCILAELLGLKPVFKGKDYIEQMTLILETLGTPDEE 433 Cryptococcus neofo...
AAD24428  178 IDPEE----NAGYMTEYVATRWYRAPEIMLSfqsYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPNEE 253 Emericella nidulans
AAO61669  179 PGAVQtdqgQAGFMTEYVATRWYRAPEIMLSfanYTSSIDMWSVGCILAELLGGKPIFKGEDYVDQLNKILNLLGTPTED 258 Cryptococcus neofo...
1173459   193 AGFFKchstVQPHITNYVATRWYRAPELLLSnqpYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKD 272 baker's yeast
Feature 1                                                                                     
Q92398    252 TLSHISSSRAQEYVRSLPKQRPIPFETNFPKA--NPLALDLLAKLLAFDPNRRISVDDALEHPYLAVWHDPSDEPv-cDS 328 Schizosaccharomyce...
Q00772    256 TLRRIGSKNVQDYIHQLGFIPKVPFVNLYPNA--NSQALDLLEQMLAFDPQKRITVDEALEHPYLSIWHDPADEPv-cSE 332 baker's yeast
AAD10000  252 IISKIKSASAQSYIRSLPTLPKMPYSKIFPYA--NPDALDLLNCLLTFDPYDRISCEEALEHPYLIIWHDPNKEPv-cSE 328 Pneumocystis carinii
P36005    256 TLQEIASQKVYNYIFQFGNIPGRSFESILPGA--NPEALELLKKMLEFDPKKRITVEDALEHPYLSMWHDIDEEFs-cQK 332 baker's yeast
XP_572911 434 TMARVASEKALTFLKTLPTYEKKDLGSIFPDA--DPLAVDLTDKLLEFDPTRRIDVPSALTHAYVERYHDPEDEPs-cDK 510 Cryptococcus neofo...
AAD24428  254 TLSRIGSPRAQEYVRNLPFMPKVPFQRLFPNA--NPDALDLLDRMLAFDPSSRISVEEALEHPYLAIWHDASDEPs-cPT 330 Emericella nidulans
AAO61669  259 TLRRVGSPRAQDYIRSLPIKPRVKFGTLYPNA--SPLALDLLSKLLTFDPAKRYGCEEALEHPYLAVWHDPADEPl-cEV 335 Cryptococcus neofo...
1173459   273 ILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPfaSHEAINLIESLLHWDSTHRLNVEQAISHPFLNEVRKPDDEPvclQG 352 baker's yeast
Feature 1                              
Q92398    329 VFDFSFEyi--eDANELRRVILDEV 351 Schizosaccharomyces pombe
Q00772    333 KFEFSFEsv--nDMEDLKQMVIQEV 355 baker's yeast
AAD10000  329 QFDFGFEai--dSIEEIRQMIINEV 351 Pneumocystis carinii
P36005    333 TFRFEFEhi--eSMAELGNEVIKEV 355 baker's yeast
XP_572911 511 IFDKWEEveslsTIEELKEAITREI 535 Cryptococcus neoformans var. neoformans JEC21
AAD24428  331 TFDFHFEvv--dDVQEMRRMIYEEV 353 Emericella nidulans
AAO61669  336 PFDFSFEee--dSVSGMRDLILEEV 358 Cryptococcus neoformans var. neoformans
1173459   353 PFDFTYEse-lnSMSKLRDYLVEEV 376 baker's yeast

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