2GMX,1UKI,1JNK,3E7O


Conserved Protein Domain Family
STKc_JNK

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cd07850: STKc_JNK (this model, PSSM-Id:173746 is obsolete and has been replaced by 270840)
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Serine/Threonine Kinases (STKs), c-Jun N-terminal kinase (JNK) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions.
Statistics
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PSSM-Id: 173746
View PSSM: cd07850
Aligned: 15 rows
Threshold Bit Score: 635.217
Threshold Setting Gi: 7507342
Created: 18-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, on the structures of human JNK-1 and -2 bound with inhibitor, and on the structure of human JNK3 bound with Mg2AMP-PNP
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               ####### #             # #                #             # 
2GMX_B         9 NFYSVEIGDSTFTVLkRYQNLKpIGSGAQGIVCAAYDAi-lERNVAIKKLSRPFQnqTHAKRAYRELVLMKCVnHKNIIG 87
gi 196012192   1 MFRTEIVSDTTFTVLkRYEDLKvIGAGSQGIVCAADDTk-tGNRVAIKKLSRPFQnvTHAKRTFRELVLMLIMkHKNTIR 79
gi 53760457    1 MFYSVQIGDTIFTILnRYQNLHpIGSGAQGMVCCAAYDtviKQKVAIKKLSRPFQnvTHAKRAFRELKLMKITnHKNIIG 80
gi 115678918  24 QFYHVTVGDTHFQILkRYKNLKsVGSGAQGLVVAAYDVl-tNQSVAIKKLSRPFQnvTHAKRAYREYILMKLCnHKNIIG 102
gi 70570044   33 EFYTVQVSDSVFTVLkRYQSLKpIGSGAQGMVCAAHDTv-lGQHVAIKKLSRPFQnpTHAKRAYRELVLMRAVnHKNIIG 111
1JNK_A        47 QFYSVEVGDSTFTVLkRYQNLKpIGSGAQGIVCAAYDAv-lDRNVAIKKLSRPFQnqTHAKRAYRELVLMKCVnHKNIIS 125
3E7O_A         7 QFYSVQVADSTFTVLkRYQQLKpIGSGAQGIVCAAFDTv-lGINVAVKKLSRPFQnqTHAKRAYRELVLLKCVnHKNIIS 85
gi 241621633   7 LFYTFEVNDTKFTILrRYQNLKsIGSGAQGIVCAAYDSv-tGHNVAIKKLSRPFQnvTHAKRAYREFKLMKLVnHKNIIG 85
gi 32396106    7 QFYTVEVGDSTFTILkRYQHLRpIGSGAQGIVCAACDMl-tDTNVAIKKLSRPFQnvTHAKRAYREFVLMKLVnHKNIIG 85
gi 30315963    7 QHYTVEVGDTNFTIHsRYINLRpIGSGAQGIVCAAYDTi-tQQNVAIKKLSRPFQnvTHAKRAYREFKLMKLVnHKNIIG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ####### ##                                 # # ## #         
2GMX_B        88 LLNVFTPQKSLeeFQDVYIVMELMDANLCQVIQMeLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167
gi 196012192  80 LLNLFTPNRSLeeFSELYLVMELMDANLCQVINLeLDHDRMSYLIYQLLCGLKYLHSAGILHRDLKPSNIVVKSDCTLKI 159
gi 53760457   81 LLNVFTPDKSLedFMDLYLVMELMDASLCQVVQMdLDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCSLKI 160
gi 115678918 103 LLNVFTPQRTFddFADIYLVMELMDASLVQVVQMdLDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKI 182
gi 70570044  112 LLNVFSPQSSYedFSHVYLVMELMDASLCQVIQMdLDHERLSYLLYQLLCGIKHLHSAGIIHRDLKPSNIVVRSDCTLKI 191
1JNK_A       126 LLNVFTPQKTLeeFQDVYLVMELMDANLCQVIQMeLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205
3E7O_A        86 LLNVFTPQKTLeeFQDVYLVMELMDANLCQVIHMeLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 165
gi 241621633  86 LLNAFTPQKTLeeFQDVYLVMELMDANLCQVIQMdLDHERMSYLLYQMLCGIKHLHLAGIIHRDLKPSNIVVKSDCTLKI 165
gi 32396106   86 LLNAFTPQKSLdtFQDVYLVMELMDANLCQVIQMdLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 165
gi 30315963   86 LLNAFTPQRNLeeFQDVYLVMELMDANLCQVIQMdLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #          # #### #                                    #                    
2GMX_B       168 LDFGLARTAGTSFmMEPEVVTRYYRAPEVILGmGYKENVDLWSVGCIMGEMVChKILFPGRDYIDQWNKVIEQLGTPCPE 247
gi 196012192 160 LDFGLARITGNEFmMTPYVVTRYYRAPEVVLGlGYQENVDVWSVGCIMGEMIRgTVLFPGDDHLDQWNKIIQQLGTPPDD 239
gi 53760457  161 LDFGLARTAGSAFtMTPYVVTRYYRAPEIILGmGYSENVDVWSIGCIFGEMIRgSVMFPGTDHIDQWNKVTELLSTPPQS 240
gi 115678918 183 LDFGLARTASTSFmMTPYVVTRYYRAPEVILGmGYKENVDIWSIGCIFGEMIRgQVMFPGSDHIDQWNKIADLLGTPTDI 262
gi 70570044  192 LDFGLARTAGGSFmMTPYVVTRYYRAPEVILGmGYQEVVDIWSVGCIFGEMIRgQVLFPGNDHIDQWNKITEQLGTPSED 271
1JNK_A       206 LDFGLARTAGTSFmMTPYVVTRYYRAPEVILGmGYKENVDIWSVGCIMGEMVRhKILFPGRDYIDQWNKVIEQLGTPCPE 285
3E7O_A       166 LDFGLARTASTNFmMTPYVVTRYYRAPEVILGmGYKENVDIWSVGCIMGELVKgSVIFQGTDHIDQWNKVIEQLGTPSAE 245
gi 241621633 166 LDFGLARTAGTSFmMTPYVVTRYYRAPEVILGmGYKENVDIWSVGCIMGEMIRgAVLFPGTDHIDQWNKIIEQLGTPSQE 245
gi 32396106  166 LDFGLARTAGTGFmMTPYVVTRYYRAPEVILGmGYKANVDIWSVGCIMAELIRaTVMFPGTDHIDQWNKITEQLGTPSQD 245
gi 30315963  166 LDFGLARTAGTTFmMTPYVVTRYYRAPEVILGmGYTENVDIWSVGCIMGEMIRgGVLFPGTDHIDQWNKIIEQLGTPSPS 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2GMX_B       248 FMKKLq-pTVRTYVENRPKYAGYSFEKLFPDVLFPADseh---nklKASQARDLLSKMLVIDASKRISVDEALQHPYInV 323
gi 196012192 240 FLDKLghsTRNYILSQHGNRAGLPFKVLFPDSLFPNGsedd-dddnYTNQARDLLSKMLIMDASKRTSVVDALQHPYVrQ 318
gi 53760457  241 FFDRLq-pSVRMYCANRPKQKGYTIDELFPEDLFPVGnk------qKVNQARDLLLKMLVVDPMRRITITQALNHPYVhV 313
gi 115678918 263 FLSRLq-pMVKQYVENRTKCPGYSFEMLFPDELFYQAesstektklCVAQARNLLSKMLIVDPEQRISVDEALQHPYInV 341
gi 70570044  272 FINKLq-pTVRNYVLNRPFQRGHPIHRLFPDSLFPADsesn--grlRSSQARDLLAKMLVVDPIGRITVDDALQHPYIkI 348
1JNK_A       286 FMKKLq-pTVRNYVENRPKYAGLTFPKLFPDSLFPADseh---nklKASQARDLLSKMLVIDPAKRISVDDALQHPYInV 361
3E7O_A       246 FMAALq-pTVRNYVENRPAYPGIAFEELFPDWIFPSEser---dkiKTSQARDLLSKMLVIDPDKRISVDEALRHPYItV 321
gi 241621633 246 FMRRLq-pTVRNYVENRPRYAGYPFDKLFPDVLFPSDspeh--sklKASQARDLLSKMLVIDPERRISVDDALAHPYInV 322
gi 32396106  246 FMSRLq-tTVRNYVENRPKHTGHSFEKLFPDVLFPPDsteh--qglRAMVARDLLSKMLVIDPEKRISVDEALMHPYInV 322
gi 30315963  246 FMQRLq-pTVRNYVENRPRYTGYSFDRLFPDGLFPNDnnqn--srrKASDARNLLSKMLVIDPEQRISVDEALKHEYInV 322
                        330       340       350
                 ....*....|....*....|....*....|....*...
Feature 1                                              
2GMX_B       324 WYDPSEAEApPPKIPDKQLDer-eHTIEEWKELIYKEV 360
gi 196012192 319 WYDASECEVpPPTRYDHTIDda-kYPVEKWKGKDLHQE 355
gi 53760457  314 WYDAEEVEApAPMQYDHKIDei-dHTVEEWKAEPREII 350
gi 115678918 342 WFDPGEVYGpPPIPYDHSIDdggdHILEEWKDEREHTL 379
gi 70570044  349 WYDPSEVEGpGPKVDGGSIDev-dYSVEKWKEVIWTEV 385
1JNK_A       362 WYDPAEVEApPPQIYDKQLDer-eHTIEEWKELIYKEV 398
3E7O_A       322 WYDPAEAEApPPQIYDAQLEer-eHAIEEWKELIYKEV 358
gi 241621633 323 WFDETEVNApAPAAYDHSVDer-eHTVEQWKELIYKEV 359
gi 32396106  323 WYDEREVNGpAPGPYDHAVDer-eHSVLEWKMFIYNEV 359
gi 30315963  323 WYDAEEVDApAPEPYDHSVDer-eHTVEQWKELIYEEV 359

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