2GMX,1UKI,1JNK,3E7O


Conserved Protein Domain Family
STKc_JNK

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cd07850: STKc_JNK (this model, PSSM-Id:173746 is obsolete and has been replaced by 270840)
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Serine/Threonine Kinases (STKs), c-Jun N-terminal kinase (JNK) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions.
Statistics
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PSSM-Id: 173746
View PSSM: cd07850
Aligned: 15 rows
Threshold Bit Score: 635.217
Threshold Setting Gi: 7507342
Created: 18-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, on the structures of human JNK-1 and -2 bound with inhibitor, and on the structure of human JNK3 bound with Mg2AMP-PNP
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               ####### #             # #                #             # 
2GMX_B         9 NFYSVEIGDSTFTVLkRYQNLKpIGSGAQGIVCAAYDAi-lERNVAIKKLSRPFQnqTHAKRAYRELVLMKCVnHKNIIG 87  human
XP_002115959   1 MFRTEIVSDTTFTVLkRYEDLKvIGAGSQGIVCAADDTk-tGNRVAIKKLSRPFQnvTHAKRTFRELVLMLIMkHKNTIR 79  Trichoplax adha...
AAU93351       1 MFYSVQIGDTIFTILnRYQNLHpIGSGAQGMVCCAAYDtviKQKVAIKKLSRPFQnvTHAKRAFRELKLMKITnHKNIIG 80  Hydra vulgaris
XP_786040     24 QFYHVTVGDTHFQILkRYKNLKsVGSGAQGLVVAAYDVl-tNQSVAIKKLSRPFQnvTHAKRAYREYILMKLCnHKNIIG 102 purple urchin
BAE06525      33 EFYTVQVSDSVFTVLkRYQSLKpIGSGAQGMVCAAHDTv-lGQHVAIKKLSRPFQnpTHAKRAYRELVLMRAVnHKNIIG 111 Ciona intestinalis
1JNK_A        47 QFYSVEVGDSTFTVLkRYQNLKpIGSGAQGIVCAAYDAv-lDRNVAIKKLSRPFQnqTHAKRAYRELVLMKCVnHKNIIS 125 human
3E7O_A         7 QFYSVQVADSTFTVLkRYQQLKpIGSGAQGIVCAAFDTv-lGINVAVKKLSRPFQnqTHAKRAYRELVLLKCVnHKNIIS 85  human
XP_002408829   7 LFYTFEVNDTKFTILrRYQNLKsIGSGAQGIVCAAYDSv-tGHNVAIKKLSRPFQnvTHAKRAYREFKLMKLVnHKNIIG 85  black-legged tick
AAP42290       7 QFYTVEVGDSTFTILkRYQHLRpIGSGAQGIVCAACDMl-tDTNVAIKKLSRPFQnvTHAKRAYREFVLMKLVnHKNIIG 85  California sea ...
P92208         7 QHYTVEVGDTNFTIHsRYINLRpIGSGAQGIVCAAYDTi-tQQNVAIKKLSRPFQnvTHAKRAYREFKLMKLVnHKNIIG 85  fruit fly
Feature 1                            ####### ##                                 # # ## #         
2GMX_B        88 LLNVFTPQKSLeeFQDVYIVMELMDANLCQVIQMeLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167 human
XP_002115959  80 LLNLFTPNRSLeeFSELYLVMELMDANLCQVINLeLDHDRMSYLIYQLLCGLKYLHSAGILHRDLKPSNIVVKSDCTLKI 159 Trichoplax adha...
AAU93351      81 LLNVFTPDKSLedFMDLYLVMELMDASLCQVVQMdLDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCSLKI 160 Hydra vulgaris
XP_786040    103 LLNVFTPQRTFddFADIYLVMELMDASLVQVVQMdLDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKI 182 purple urchin
BAE06525     112 LLNVFSPQSSYedFSHVYLVMELMDASLCQVIQMdLDHERLSYLLYQLLCGIKHLHSAGIIHRDLKPSNIVVRSDCTLKI 191 Ciona intestinalis
1JNK_A       126 LLNVFTPQKTLeeFQDVYLVMELMDANLCQVIQMeLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205 human
3E7O_A        86 LLNVFTPQKTLeeFQDVYLVMELMDANLCQVIHMeLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 165 human
XP_002408829  86 LLNAFTPQKTLeeFQDVYLVMELMDANLCQVIQMdLDHERMSYLLYQMLCGIKHLHLAGIIHRDLKPSNIVVKSDCTLKI 165 black-legged tick
AAP42290      86 LLNAFTPQKSLdtFQDVYLVMELMDANLCQVIQMdLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 165 California sea ...
P92208        86 LLNAFTPQRNLeeFQDVYLVMELMDANLCQVIQMdLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKI 165 fruit fly
Feature 1        ##  #          # #### #                                    #                    
2GMX_B       168 LDFGLARTAGTSFmMEPEVVTRYYRAPEVILGmGYKENVDLWSVGCIMGEMVChKILFPGRDYIDQWNKVIEQLGTPCPE 247 human
XP_002115959 160 LDFGLARITGNEFmMTPYVVTRYYRAPEVVLGlGYQENVDVWSVGCIMGEMIRgTVLFPGDDHLDQWNKIIQQLGTPPDD 239 Trichoplax adha...
AAU93351     161 LDFGLARTAGSAFtMTPYVVTRYYRAPEIILGmGYSENVDVWSIGCIFGEMIRgSVMFPGTDHIDQWNKVTELLSTPPQS 240 Hydra vulgaris
XP_786040    183 LDFGLARTASTSFmMTPYVVTRYYRAPEVILGmGYKENVDIWSIGCIFGEMIRgQVMFPGSDHIDQWNKIADLLGTPTDI 262 purple urchin
BAE06525     192 LDFGLARTAGGSFmMTPYVVTRYYRAPEVILGmGYQEVVDIWSVGCIFGEMIRgQVLFPGNDHIDQWNKITEQLGTPSED 271 Ciona intestinalis
1JNK_A       206 LDFGLARTAGTSFmMTPYVVTRYYRAPEVILGmGYKENVDIWSVGCIMGEMVRhKILFPGRDYIDQWNKVIEQLGTPCPE 285 human
3E7O_A       166 LDFGLARTASTNFmMTPYVVTRYYRAPEVILGmGYKENVDIWSVGCIMGELVKgSVIFQGTDHIDQWNKVIEQLGTPSAE 245 human
XP_002408829 166 LDFGLARTAGTSFmMTPYVVTRYYRAPEVILGmGYKENVDIWSVGCIMGEMIRgAVLFPGTDHIDQWNKIIEQLGTPSQE 245 black-legged tick
AAP42290     166 LDFGLARTAGTGFmMTPYVVTRYYRAPEVILGmGYKANVDIWSVGCIMAELIRaTVMFPGTDHIDQWNKITEQLGTPSQD 245 California sea ...
P92208       166 LDFGLARTAGTTFmMTPYVVTRYYRAPEVILGmGYTENVDIWSVGCIMGEMIRgGVLFPGTDHIDQWNKIIEQLGTPSPS 245 fruit fly
Feature 1                                                                                        
2GMX_B       248 FMKKLq-pTVRTYVENRPKYAGYSFEKLFPDVLFPADseh---nklKASQARDLLSKMLVIDASKRISVDEALQHPYInV 323 human
XP_002115959 240 FLDKLghsTRNYILSQHGNRAGLPFKVLFPDSLFPNGsedd-dddnYTNQARDLLSKMLIMDASKRTSVVDALQHPYVrQ 318 Trichoplax adha...
AAU93351     241 FFDRLq-pSVRMYCANRPKQKGYTIDELFPEDLFPVGnk------qKVNQARDLLLKMLVVDPMRRITITQALNHPYVhV 313 Hydra vulgaris
XP_786040    263 FLSRLq-pMVKQYVENRTKCPGYSFEMLFPDELFYQAesstektklCVAQARNLLSKMLIVDPEQRISVDEALQHPYInV 341 purple urchin
BAE06525     272 FINKLq-pTVRNYVLNRPFQRGHPIHRLFPDSLFPADsesn--grlRSSQARDLLAKMLVVDPIGRITVDDALQHPYIkI 348 Ciona intestinalis
1JNK_A       286 FMKKLq-pTVRNYVENRPKYAGLTFPKLFPDSLFPADseh---nklKASQARDLLSKMLVIDPAKRISVDDALQHPYInV 361 human
3E7O_A       246 FMAALq-pTVRNYVENRPAYPGIAFEELFPDWIFPSEser---dkiKTSQARDLLSKMLVIDPDKRISVDEALRHPYItV 321 human
XP_002408829 246 FMRRLq-pTVRNYVENRPRYAGYPFDKLFPDVLFPSDspeh--sklKASQARDLLSKMLVIDPERRISVDDALAHPYInV 322 black-legged tick
AAP42290     246 FMSRLq-tTVRNYVENRPKHTGHSFEKLFPDVLFPPDsteh--qglRAMVARDLLSKMLVIDPEKRISVDEALMHPYInV 322 California sea ...
P92208       246 FMQRLq-pTVRNYVENRPRYTGYSFDRLFPDGLFPNDnnqn--srrKASDARNLLSKMLVIDPEQRISVDEALKHEYInV 322 fruit fly
Feature 1                                              
2GMX_B       324 WYDPSEAEApPPKIPDKQLDer-eHTIEEWKELIYKEV 360 human
XP_002115959 319 WYDASECEVpPPTRYDHTIDda-kYPVEKWKGKDLHQE 355 Trichoplax adhaerens
AAU93351     314 WYDAEEVEApAPMQYDHKIDei-dHTVEEWKAEPREII 350 Hydra vulgaris
XP_786040    342 WFDPGEVYGpPPIPYDHSIDdggdHILEEWKDEREHTL 379 purple urchin
BAE06525     349 WYDPSEVEGpGPKVDGGSIDev-dYSVEKWKEVIWTEV 385 Ciona intestinalis
1JNK_A       362 WYDPAEVEApPPQIYDKQLDer-eHTIEEWKELIYKEV 398 human
3E7O_A       322 WYDPAEAEApPPQIYDAQLEer-eHAIEEWKELIYKEV 358 human
XP_002408829 323 WFDETEVNApAPAAYDHSVDer-eHTVEQWKELIYKEV 359 black-legged tick
AAP42290     323 WYDEREVNGpAPGPYDHAVDer-eHSVLEWKMFIYNEV 359 California sea hare
P92208       323 WYDAEEVDApAPEPYDHSVDer-eHTVEQWKELIYEEV 359 fruit fly

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