Conserved Protein Domain Family
STKc_CDK8_like

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cd07842: STKc_CDK8_like (this model, PSSM-Id:173740 is obsolete and has been replaced by 270834)
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 8 (CDK8)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions.
Statistics
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PSSM-Id: 173740
View PSSM: cd07842
Aligned: 19 rows
Threshold Bit Score: 472.922
Threshold Setting Gi: 167525918
Created: 31-Jul-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ####    #                                                               
gi 60391917   19 LFEYEGckVGRGTYGHVYKARRKdg------------------------------------------------------- 43
gi 167525918  20 IFANAGc-VGQGTYGIVHKVYRLegtrqlnrgca---------------------------------------------- 52
gi 66828493   43 KYTFSYe-IGSGTYGMVYKADDKkr------------------------------------------------------- 66
gi 116499710  43 KYAILGf-ISSGTYGRVYKAQSIn-------------------------------------------------------- 65
gi 57230589   31 TYKILGf-ISSGTYGRVYKAVLLpppktasaksalpsstraalslpkdklp--------------------------sps 83
gi 14195032    4 GYKIIGf-ISSGTYGKVYKAVSSns------------------------------------------------------- 27
gi 6325215    74 KYEVIGy-IAAGTYGKVYKAKRQinsgtnsangsslngtnakipqfdstqpkssssmdmqantnalrrnllkdegvtpgr 152
gi 218511840  58 KYQIIGy-IAAGTYGKVYKAKSKtngnsnsnsalmndnvisig------------------------------------- 99
gi 166222397  39 RYHIVGf-ISSGTYGRVYKAIGKng------------------------------------------------------- 62
gi 168058775  18 QYDLVGk-IGEGTYGLVYLAKSKepahrlmtl------------------------------------------------ 48
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    # #                               #             #   
gi 60391917   44 ----------------------kdEKEYALKQIEG-------------------TGISMSACREIALLRELkHPNVIALQ 82
gi 167525918  53 -------------lrqegddlddtTKPYALKGMVTsvs--------------rtEGFSTANLRELALLRELhHDNVISLR 105
gi 66828493   67 -----------------------pNNKVAVKKFRStk---------------egEGLSLTAYREIGLLKELsNENIVKLL 108
gi 116499710  66 -----------------------gGELLAIKKFKPdkegd----------vvtyTGISQSAIREIALNREInHENVVALR 112
gi 57230589   84 ftedsdplnnpemcmrpgdrpakrGDVFAIKKFKPdkegd----------vltyAGISQSGAREIMLNRELhHRNLVSLR 153
gi 14195032   28 ----------------------ndKRLFAIKKFKAeskqvs--------snaqqTGVSQSAIREMMLCREIqHENIVSLV 77
gi 6325215   153 irttredvsphynsqkqtlikkplTVFYAIKKFKTekdgv---------eqlhyTGISQSACREMALCRELhNKHLTTLV 223
gi 218511840 100 -----ngqkeaglqktnnesmedkNQLFAIKKFKSdnhsnknnhdingnevihyTGISQSAIREMSLCRELsNKNITKVV 174
gi 166222397  63 -----------------------qKGEFAIKKFKPdkege----------iiqyTGLSQSAIREMALCSELdHPNVVQLA 109
gi 168058775  49 ----------------lslgaysrGTKIAIKKFKQsk---------------egDGVSPTAIREIMLLRECiHENIVKLV 97
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      ####  # ##                                            # # ## #    
gi 60391917   83 KVFLshsdrKVWLLFDYAEHDLWHIIKFHRASkankkpmqLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMge 162
gi 167525918 106 EAFIhsmtkEVWLLFDYAEYDLWWLCNDHRSAnl-----rLQEPMLKSIMFQLLQGVHYLHEQWVLHRDLKPANVFLTr- 179
gi 66828493  109 DVCLnpkdkLLYLIFDYAEFDLFGIIKYHRENgs-----hFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMge 183
gi 116499710 113 EVILed--kSIYMVFEYAEHDFLQVIHHYYQTir----tsIPTAVLKSLIYQLFNGLIYLHASHILHRDLKPANILITs- 185
gi 57230589  154 EVILed--kSIYMVFEYAEHDFLQIIHYHSQTar----asIPPSTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVTs- 226
gi 14195032   78 QVLLkd--gTISMVFEYAEHDLLQIIHFHSRSrt----rqIPPSILKSILWQIINGVAYLHENWIMHRDLKPANIMITa- 150
gi 6325215   224 EIFLer--kCVHMVYEYAEHDLLQIIHFHSHPek----rmIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTi- 296
gi 218511840 175 DILLen--kSIYMVFEYCEHDLLQIIQYHSHPdv----kpIPDFTIKSITWQILNGVTFLHKNWIFHRDLKPANIMVSs- 247
gi 166222397 110 EIILed--kCIFMVFEYTEHDLLQIIHHHTQPqr----haIPALMVRSILFQLLNGLLYLHTNWVLHRDLKPANILVTs- 182
gi 168058775  98 NVHInhgdmSLYLAFDYAEHDLYEIIRHHREKin----csINAYTVKSLLWQILNGLNYLHSNWIIHRDLKPSNILVMge 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  #                # #### #                                     ##   
gi 60391917  163 gperGRVKIADMGFARLFNSPLKp--LADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTsEPIFHCRqed 240
gi 167525918 180 ---gGSIKIGDLGMARVFVAPPKa--FSDVDPVVVTYWYRAPEIMLGAKHYTKAIDIWSIGCIFAELINlVPIFHVKndq 254
gi 66828493  184 gkecGTVKIGDFGLARIFQSPLK---PLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAIGCIFAELITtKPLFPGKekd 260
gi 116499710 186 ---qGVVKIGDLGLARLCYEPLQp--LFAGDKVVVTIWYRAPELLMGAKHYNKAIDCWAVGCVMAELASlRPIFKGEeak 260
gi 57230589  227 ---qGVVKIGDLGLARLWHKPLAqqgLYGGDKVVVTIWYRAPELILGAKHYTAAVDIWAVGCIYAELLSlRPIFKGDeak 303
gi 14195032  151 ---tGKVKIGDLGLGRLIRDPILp--FYSSDRVVVTIWYRAPELLLGAHDYTPAIDVWAIGCIYGEMLAlSPLFKGDeik 225
gi 6325215   297 ---dGCVKIGDLGLARKFHNMLQt--LYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGlQPIFKGEeak 371
gi 218511840 248 ---sGVVKIGDLGLARKFNNPLQs--LYTGDKVVVTIWYRAPELLLGARHYTPSIDLWAVGCILAELLSlRPIFKGEeak 322
gi 166222397 183 ---sGAIRIGDLGLARLFYKPLNs--LFSGDKVVVTIWYRAPELLMGSRHYTPAVDLWAVGCIFAELLSlRPIFKGEeak 257
gi 168058775 174 gdeqGLVKIGDFGLARIFQAPLR---SLSENGVVVTIWYRAPELLLGSRHYTSAVDMWAVGCIFAELLTlKPLFQGIedk 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 60391917  241 i----ktsnPFHHDQLDRIFSVMGFPADKDWEdIRKMPEYPtl---qkDFRRTTYan-sSLIKYMekhk----------- 301
gi 167525918 255 n-----srdPYYAAQLEAIFKVLGMPDEQKWSlLKHMPRYPdl---krDFKTKASkfddVLSKRMne------------- 313
gi 66828493  261 p----kipsLFQDDQVEKIIRVLGKPTLDMWPdIKHLPEWKr------LSSMEAFp--nSLAKCVgi------------- 315
gi 116499710 261 ld--skknvPFQRDQLIKIFEVLGTPDERDWPgVVDMPEYRn------MKLLDHFs--nRLSDWChtr------------ 318
gi 57230589  304 md--gkkslPFQRDQMGKICEVLGPVKPEQWPgIVHMPEYRt------YQATGPYphsnPLAPWYhar------------ 363
gi 14195032  226 me--dkkvvPFQSTQMLRIMELLGTPTEERWPgLKNYPEYYq-----lSSFEVRYwn-nLLPQWYqtv------------ 285
gi 6325215   372 ld--skktvPFQVNQLQRILEVLGTPDQKIWPyLEKYPEYDq------ITKFPKYr--dNLATWYhsa------------ 429
gi 218511840 323 idmnnkksvPFQKNQLQKIVEVLGTPTTKNWPtITKYPEYSaf----qQHFSNTYp--pNLISWYkli------------ 384
gi 166222397 258 md--skktvPFQRNQMMKIIEIMGLPTKEIWPgIVSMPEYSqlqslamSRAPGHFnrssNLEGWYqsclknngysanssa 335
gi 168058775 251 s-----spnPFQLDQLDKIFKVLGNPTADKWPtLLTLPHWAsn---rqNIQTRKYdn-pGLYSIVql------------- 308
                        410       420       430
                 ....*....|....*....|....*....|....
Feature 1                                          
gi 60391917  302 vkpDSKVFLLLQKLLTMDPTKRITSEQALQDPYF 335
gi 167525918 314 -peSSTRLSLMRRMFHYDPEKRISADEALTAPWF 346
gi 66828493  316 -deNSQAYDLLSKMILYDPSKRITASEALDHPYF 348
gi 116499710 319 -irSPQGYDLLRQLFAYDPDNRLTAEQAIQHKWF 351
gi 57230589  364 -snSSEGYDILVKMFEWDPARRITARDALRHPWF 396
gi 14195032  286 knrDPQGLDLLMKMLQYDPKSRITAKQALEHVFF 319
gi 6325215   430 ggrDKHALSLLYHLLNYDPIKRIDAFNALEHKYF 463
gi 218511840 385 grtSKQCLNLLRCLLEYDPTIRITADDALTHAFF 418
gi 166222397 336 gtpGADGFDLLSRLLEYDPTKRITAQEALEHPYF 369
gi 168058775 309 -ppKSPGFDLLSKMLEYDPIKRITASQALEHDYF 341

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