Conserved Protein Domain Family
STKc_CCRK

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cd07832: STKc_CCRK (this model, PSSM-Id:173736 is obsolete and has been replaced by 270826)
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
Serine/Threonine Kinases (STKs), Cell Cycle-Related Kinase (CCRK) p42 subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed, this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure.
Statistics
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PSSM-Id: 173736
View PSSM: cd07832
Aligned: 16 rows
Threshold Bit Score: 402.821
Threshold Setting Gi: 86438640
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ####    #              # #                #              #               
gi 74759739    3 QYCILGRIGEGAHGIVFKAKHVET--GEIVALKKVALRRleDGFPNQALREIKALQEMedNQYVVQLKAVFPhgGGFVLA 80
gi 115660790  11 QYSILDRIGEGAHGIVFKAKHIET--GEIVALKKVPLRKldDGIPNTALREIKALQEIeeNQYVVKLKDVFPhgTGFVLV 88
gi 156546300   3 RYTISGRIGEGAHGLVLKAYDNASpvPKPVALKRILLKRieDGIPTSVVREVKTLQRLk-HPYIVELLDAFPagLDFVMV 81
gi 117380776  11 TYRIIRRLGQGAFGEVSLAGVLET--GEVVALKRIHIRNt-GGIPDVVVREIKALQSVs-HPNVVALLDVFPkgQAIYLV 86
gi 91085559    3 NYKLLGKVGKGAHGLVFKALDLQN--NKTVALKQIAVVNvtNGIPKNTMREICVLRALq-SKHIVKLVDIFNvdSSIIIA 79
gi 24648801    8 RYKMLEKIGEGVHGCVFKAIDLQR--NKEVAIKKVALKNkfGNIALNTLREIKTLQLCk-SEYILDIIDIYPdlTGLSLV 84
gi 68127079    3 KYALGPVIGEGQFGSVRMATVKAT--GQTVAVKLLHVPRltEGIPHPVARELLIASRVd-SPFLVKTIEITPcgSHMAVV 79
gi 70802350    3 KYLLGPSMGEGRFGSVRSAVIRGS--GVPVAIKLINVTRveEGIPHMVARELLVSMRLq-HPYIIRTYEVFPygSSVALV 79
gi 170045207   8 RYQMLGRIGEGVHGVVVKARDLSNd-DKIVAIKKLTLRTkhGWIAPCAIREIKVLQNSq-CENILSLLDMYPdlSGMSLV 85
gi 242013331   6 EYKVIGRIGEGAHGIVLKAKNRKT--GKLVALKRMLNNKgnEKVQLSLLREIESLKHVn-STYVIKLLEVLTvgSSVVLV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ####  # ##                                      # # ## #           #  #         
gi 74759739   81 FEFMLSDLAEVVRHaq--rpLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISa-sGQLKIADFGLARVFSPDgs 157
gi 115660790  89 FEFMLSDLSEVIRNsd--qpLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISe-tGHLKIADFGLARVFSNDeg 165
gi 156546300  82 FEYMPSGLWELLKDyd--kaLTDSQIKTYTRMLLEGVAYMHANNIMHRDLKPANLLIRe-dGVLTIADFGLGRLMWEDis 158
gi 117380776  87 QEYCTTDLAALLRRlp--apPPERIAKGLMLQLCRGLEALHAEGIMHRDVKPSNTLLSaasGTAKLADCGLARPLDGGer 164
gi 91085559   80 MEYLQRSLSDVLKDie--rpLTTPQIKLYTKMILMGVETMHSNRIMHRDLKPANLLIDd-hGVLKIADFGLSRIYNKEkd 156
gi 24648801   85 LEYQPDTLYNRLKSev--npLSRQQVRKFAHQMFKGIAYLHEAGLMHRDIKPANLLISd-tDMLKIADFGLARLYFPEde 161
gi 68127079   80 MERCMEDLACVLRKcspahpLPLLLTQSYLRMLLTALHALHSSGILHRDVKPSNCFVSv-dGCLKLGDFGLSRPLGSD-- 156
gi 70802350   80 MERCATDLSAVLCErspanpLSPQSAKSLFRMLLGALAYMHKEGILHRDVKPSNCFLAr-dGTLRLGDFGLSRMQDTEe- 157
gi 170045207  86 FEYMPHTLYSRMKDee--hpLSRGETRRFMAMLLNGLQYLHGLRIMHRDIKPANLLIDs-kDVLKIADFGLARLFNDQdp 162
gi 242013331  83 LELMAGGLSSVIGDvd--dpIQIPQVKAYSRMILEGCSHLHKLKIMHRDLKPANLLIGf-dGILKIADLGQARLNKGRp- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            # #### #                                       #                            
gi 74759739  158 -rlYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNg--SPLFPGknDIEQLCYVLRILGTPNPqVWPELTEL 234
gi 115660790 166 -rqYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIFGELLNn--SPIFPGenDIEQLCCVLRILGTPTEkTWPGMKDL 242
gi 156546300 159 -rpYSHQVATRWYRAPELLYGARFYTAAIDMWAVGCIFGEMLNn--SPLFPGesDIEQLAIVLGHLGSPTAeSWPELSSL 235
gi 117380776 165 -paYTHAVATRWYRAPELLYGARAYGPAVDVWALGLVFAELLGl--SPLVPGdnDIDQLGRVIATFGSMEP-VWLGVRAL 240
gi 91085559  157 -rqYTHQVGTRWYRAPELLYGSQKYTPAVDIWAVGCILAEMINk--QPLFPGetDIAQLAIVIATLGTPNEeIWPGLTSL 233
gi 24648801  162 srlYSPQVSTRWYRAPEILFGSQKYGTGVDMWAAGCVVAEMLRg--VPLFAGttDIEQLAIIIRTLGSPRLnQWPELTSL 239
gi 68127079  157 ---MSHEVVSRWYRAPELLFGQRRYGGEVDMWAAGCVFAELLRghgRPFFTGdgDISQIAKIFDVFGTPTGaTCSFYRQL 233
gi 70802350  158 --sMTHEVVSRWYRPPELLLGQRHYGPEVDMWSAGCVFVELLRgytGAFFASdgDVMQLSRIFDVLGTPTQeSWPTAELL 235
gi 170045207 163 tkvYSPQVATRWYRAPEILWGCQTYGPSIDLWAAGCVFAEMLRg--VPLFSGatDIEQLALVVRTLGTPNLkDWPEVRSL 240
gi 242013331 159 ---YSHQIGSRWYRAPELLYGSRKYSLSIDVWSIGCIIAEMINc--SPLFAGesDIEQLAIVIKSLGSPSEeTWPGVHTL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                
gi 74759739  235 PdynKISFKEQVPMPLEEVLPDVS-PQALDLLGQFLLYPPHQRIAaSKALLHQYFF 289
gi 115660790 243 PdynKITFPENPPIPLEQIVPDAS-PEALDLLKKFLVYPSRQRISaSEALLHPYFF 297
gi 156546300 236 PdynKITFPYHKGVLWERIVPDAQ-QEAVDLLRNILIYDSSKRLTaEEALRHVYFN 290
gi 117380776 241 PdwgKIAFPHCEPLPLGDLLPGAP-AAALEFLAAFLRYDPAKRITaACAVRSTYLT 295
gi 91085559  234 PdynKIAFTHSDGQTWNSKFPDCD-EATVDLIQQFLHYDQSKRIGaKKALNHRFFF 288
gi 24648801  240 PdysKIRFPNSVGIHWDNLFPSCThAVEINLVSNLVVYNPKNRLKaSEVGSASSLT 295
gi 68127079  234 PdweKVYFEEKKGTGLRVLLPFVP-PEALDLLTKMLALDPASRCSaAEALTHSFFA 288
gi 70802350  236 PdwgKVHFEPKNPCPLGEFFPEAS-GSAVDLLRGLLCLDPSRRLSaADALCHTYFN 290
gi 170045207 241 PdynKIRFPNAKGERWEDIFPSCTtKCEIGLVDGLVRYNPSRRFTaEELLKMRRKY 296
gi 242013331 234 PdygKITFPKSKGKLWKTLIPNSP-PGAIDLLKSLLLYNPKERLScEQALNHSFFY 288

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