Conserved Protein Domain Family
STKc_CCRK

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cd07832: STKc_CCRK (this model, PSSM-Id:173736 is obsolete and has been replaced by 270826)
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
Serine/Threonine Kinases (STKs), Cell Cycle-Related Kinase (CCRK) p42 subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed, this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure.
Statistics
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PSSM-Id: 173736
Aligned: 16 rows
Threshold Bit Score: 402.821
Threshold Setting Gi: 86438640
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ####    #              # #                #              #               
Q8IZL9         3 QYCILGRIGEGAHGIVFKAKHVET--GEIVALKKVALRRleDGFPNQALREIKALQEMedNQYVVQLKAVFPhgGGFVLA 80  human
XP_799108     11 QYSILDRIGEGAHGIVFKAKHIET--GEIVALKKVPLRKldDGIPNTALREIKALQEIeeNQYVVKLKDVFPhgTGFVLV 88  purple urchin
XP_001606120   3 RYTISGRIGEGAHGLVLKAYDNASpvPKPVALKRILLKRieDGIPTSVVREVKTLQRLk-HPYIVELLDAFPagLDFVMV 81  jewel wasp
ABK34486      11 TYRIIRRLGQGAFGEVSLAGVLET--GEVVALKRIHIRNt-GGIPDVVVREIKALQSVs-HPNVVALLDVFPkgQAIYLV 86  Chlamydomonas r...
XP_966910      3 NYKLLGKVGKGAHGLVFKALDLQN--NKTVALKQIAVVNvtNGIPKNTMREICVLRALq-SKHIVKLVDIFNvdSSIIIA 79  red flour beetle
NP_650984      8 RYKMLEKIGEGVHGCVFKAIDLQR--NKEVAIKKVALKNkfGNIALNTLREIKTLQLCk-SEYILDIIDIYPdlTGLSLV 84  fruit fly
CAJ04458       3 KYALGPVIGEGQFGSVRMATVKAT--GQTVAVKLLHVPRltEGIPHPVARELLIASRVd-SPFLVKTIEITPcgSHMAVV 79  Leishmania major
AAZ12255       3 KYLLGPSMGEGRFGSVRSAVIRGS--GVPVAIKLINVTRveEGIPHMVARELLVSMRLq-HPYIIRTYEVFPygSSVALV 79  Trypanosoma brucei
XP_001850208   8 RYQMLGRIGEGVHGVVVKARDLSNd-DKIVAIKKLTLRTkhGWIAPCAIREIKVLQNSq-CENILSLLDMYPdlSGMSLV 85  southern house ...
XP_002427364   6 EYKVIGRIGEGAHGIVLKAKNRKT--GKLVALKRMLNNKgnEKVQLSLLREIESLKHVn-STYVIKLLEVLTvgSSVVLV 82  human body louse
Feature 1        ####  # ##                                      # # ## #           #  #         
Q8IZL9        81 FEFMLSDLAEVVRHaq--rpLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISa-sGQLKIADFGLARVFSPDgs 157 human
XP_799108     89 FEFMLSDLSEVIRNsd--qpLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISe-tGHLKIADFGLARVFSNDeg 165 purple urchin
XP_001606120  82 FEYMPSGLWELLKDyd--kaLTDSQIKTYTRMLLEGVAYMHANNIMHRDLKPANLLIRe-dGVLTIADFGLGRLMWEDis 158 jewel wasp
ABK34486      87 QEYCTTDLAALLRRlp--apPPERIAKGLMLQLCRGLEALHAEGIMHRDVKPSNTLLSaasGTAKLADCGLARPLDGGer 164 Chlamydomonas r...
XP_966910     80 MEYLQRSLSDVLKDie--rpLTTPQIKLYTKMILMGVETMHSNRIMHRDLKPANLLIDd-hGVLKIADFGLSRIYNKEkd 156 red flour beetle
NP_650984     85 LEYQPDTLYNRLKSev--npLSRQQVRKFAHQMFKGIAYLHEAGLMHRDIKPANLLISd-tDMLKIADFGLARLYFPEde 161 fruit fly
CAJ04458      80 MERCMEDLACVLRKcspahpLPLLLTQSYLRMLLTALHALHSSGILHRDVKPSNCFVSv-dGCLKLGDFGLSRPLGSD-- 156 Leishmania major
AAZ12255      80 MERCATDLSAVLCErspanpLSPQSAKSLFRMLLGALAYMHKEGILHRDVKPSNCFLAr-dGTLRLGDFGLSRMQDTEe- 157 Trypanosoma brucei
XP_001850208  86 FEYMPHTLYSRMKDee--hpLSRGETRRFMAMLLNGLQYLHGLRIMHRDIKPANLLIDs-kDVLKIADFGLARLFNDQdp 162 southern house ...
XP_002427364  83 LELMAGGLSSVIGDvd--dpIQIPQVKAYSRMILEGCSHLHKLKIMHRDLKPANLLIGf-dGILKIADLGQARLNKGRp- 158 human body louse
Feature 1            # #### #                                       #                            
Q8IZL9       158 -rlYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNg--SPLFPGknDIEQLCYVLRILGTPNPqVWPELTEL 234 human
XP_799108    166 -rqYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIFGELLNn--SPIFPGenDIEQLCCVLRILGTPTEkTWPGMKDL 242 purple urchin
XP_001606120 159 -rpYSHQVATRWYRAPELLYGARFYTAAIDMWAVGCIFGEMLNn--SPLFPGesDIEQLAIVLGHLGSPTAeSWPELSSL 235 jewel wasp
ABK34486     165 -paYTHAVATRWYRAPELLYGARAYGPAVDVWALGLVFAELLGl--SPLVPGdnDIDQLGRVIATFGSMEP-VWLGVRAL 240 Chlamydomonas r...
XP_966910    157 -rqYTHQVGTRWYRAPELLYGSQKYTPAVDIWAVGCILAEMINk--QPLFPGetDIAQLAIVIATLGTPNEeIWPGLTSL 233 red flour beetle
NP_650984    162 srlYSPQVSTRWYRAPEILFGSQKYGTGVDMWAAGCVVAEMLRg--VPLFAGttDIEQLAIIIRTLGSPRLnQWPELTSL 239 fruit fly
CAJ04458     157 ---MSHEVVSRWYRAPELLFGQRRYGGEVDMWAAGCVFAELLRghgRPFFTGdgDISQIAKIFDVFGTPTGaTCSFYRQL 233 Leishmania major
AAZ12255     158 --sMTHEVVSRWYRPPELLLGQRHYGPEVDMWSAGCVFVELLRgytGAFFASdgDVMQLSRIFDVLGTPTQeSWPTAELL 235 Trypanosoma brucei
XP_001850208 163 tkvYSPQVATRWYRAPEILWGCQTYGPSIDLWAAGCVFAEMLRg--VPLFSGatDIEQLALVVRTLGTPNLkDWPEVRSL 240 southern house ...
XP_002427364 159 ---YSHQIGSRWYRAPELLYGSRKYSLSIDVWSIGCIIAEMINc--SPLFAGesDIEQLAIVIKSLGSPSEeTWPGVHTL 233 human body louse
Feature 1                                                                
Q8IZL9       235 PdynKISFKEQVPMPLEEVLPDVS-PQALDLLGQFLLYPPHQRIAaSKALLHQYFF 289 human
XP_799108    243 PdynKITFPENPPIPLEQIVPDAS-PEALDLLKKFLVYPSRQRISaSEALLHPYFF 297 purple urchin
XP_001606120 236 PdynKITFPYHKGVLWERIVPDAQ-QEAVDLLRNILIYDSSKRLTaEEALRHVYFN 290 jewel wasp
ABK34486     241 PdwgKIAFPHCEPLPLGDLLPGAP-AAALEFLAAFLRYDPAKRITaACAVRSTYLT 295 Chlamydomonas reinhardtii
XP_966910    234 PdynKIAFTHSDGQTWNSKFPDCD-EATVDLIQQFLHYDQSKRIGaKKALNHRFFF 288 red flour beetle
NP_650984    240 PdysKIRFPNSVGIHWDNLFPSCThAVEINLVSNLVVYNPKNRLKaSEVGSASSLT 295 fruit fly
CAJ04458     234 PdweKVYFEEKKGTGLRVLLPFVP-PEALDLLTKMLALDPASRCSaAEALTHSFFA 288 Leishmania major
AAZ12255     236 PdwgKVHFEPKNPCPLGEFFPEAS-GSAVDLLRGLLCLDPSRRLSaADALCHTYFN 290 Trypanosoma brucei
XP_001850208 241 PdynKIRFPNAKGERWEDIFPSCTtKCEIGLVDGLVRYNPSRRFTaEELLKMRRKY 296 southern house mosquito
XP_002427364 234 PdygKITFPKSKGKLWKTLIPNSP-PGAIDLLKSLLLYNPKERLScEQALNHSFFY 288 human body louse

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