Conserved Protein Domain Family
STKc_MOK

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cd07831: STKc_MOK (this model, PSSM-Id:173735 is obsolete and has been replaced by 270825)
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
Serine/Threonine Kinases (STKs), MAPK/MAK/MRK Overlapping Kinase (MOK) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation.
Statistics
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PSSM-Id: 173735
Aligned: 19 rows
Threshold Bit Score: 476.379
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ####    #            # #               #              #                 ##
Q9UQ07         4 YKAIGkIGEGTFSEVMKMQSLrdgNYYACKQMKQRFesiEQVNNLREIQALRRLnpHPNILMLHEVVFDrksGSLALICE 83  human
CAK84722      35 YKLVGkKGEGTFSEVIKSQSFktgNYVAIKCMKNKFtsiEQVNHLREIQALRKLspHEHIIKLIEVLYDeptGRLALVFE 114 Paramecium tetr...
XP_001315347  11 WRIINkLGEGSFSEVFKVKSMknqQFYAIKMLKKRFrsvEEVTRLPEIMCLRALegNPNIIRLEEVLFDskhNCLALVFE 90  Trichomonas vag...
ABG91274       4 YQILGkKGEGTFSEVLRAQDIktqQFVAIKCMKKAFkskEQVNRLREIQAVRRLqpHPNIVDLVEVLFDrstGRLALVLE 83  Leishmania mexi...
XP_001603934   4 YKVLDkIGEGTFSEVLRCQDRqtgALYATKRLKKIYqsvSEILESPELLAMRSVthHPNVLCATECHYDalpGRLSLVFE 83  jewel wasp
ACO63469      38 YRLVAkKGEGTFSEVLKAQCIkngKYVAIKCMKNHFdslDQVNNLREIQALRRLspHGNIIKLLEVLYDqptGRLALVFE 117 Micromonas sp. ...
XP_002427989   9 YKVLSqIGEGSFSEVLKCQERetgNLFAAKRLKKDYhslAEVTESPEVIAMRKLshHPNILHIIEFHVDpipGKVTFIFE 88  human body louse
XP_001704340  19 YKFVSkKGAGAFSDVIKAQCVkteEYVAIKRMKATFksiEQITSLREIQSLRRLadQPFIIRLIEILFDrttGRLALVFE 98  Giardia lamblia...
XP_002295735   4 YRLISkRGEGSFSEVIKAQNTktgTFHAIKCMKSSYksaDQVNNLREIQAIKRLtpHPHIVKMDEVLFDpptGRLALVFE 83  Thalassiosira p...
EER06225       4 YRLLGkKGEGTFSEVLLGRHVrsnQEVAIKYLKNKFhsiDAVNSFNEIRALRMLrdHPNIVRLLDVLYDittGSLALVLE 83  Perkinsus marin...
Feature 1        ##  # ##                                     # # ## #           #  #          # 
Q9UQ07        84 LMDMNIYELIRgrr-ypLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKq--DVLKLGDFGSCRSVYSKQPYTE 160 human
CAK84722     115 LMEQNLYEHIKgrr-qpLNPQKVKSFMYQLLKSIDHMHRNGIFHRDIKPENILLNs--DHLKLADFGSCKGIYSKHPYTE 191 Paramecium tetr...
XP_001315347  91 LLDENLFELMRdhk-qpFDEKTSLLIIYQLLKALSIMHAKNLFHRDIKPENCMINkdtYELKLADFGSARTTSDTGPFTE 169 Trichomonas vag...
ABG91274      84 LMDMSLYELIKgrk-qyLGEEKVRSYMYQLLKGLDHAHRIGVFHRDIKPENLLIDa-eGRLKIADFGSCKGVYSKLPLTE 161 Leishmania mexi...
XP_001603934  84 LMDMSLYDFTEnqkgrlLPEMRVKNYVYQLLRGLDHLHRHGVFHRDVKPENILLKg--NLLKLGDLGSVRAICVQPPYTE 161 jewel wasp
ACO63469     118 LMDMNIYELIRgrr-hyLAEDRVKTYMYQLIKSMDHMHRNGIFHRDIKPENILIMd--DCLKLADFGSCRGIYSKQPYTE 194 Micromonas sp. ...
XP_002427989  89 LMEMSLYDMMKnrk-rpLPELRVKRYLYQLLKGLDHLHHHGIFHRDIKPENILIKn--EIIKLADLGSIRGAYSRPPYTE 165 human body louse
XP_001704340  99 LMEMNLYELIKnrk-yhLPESSIKWYMWQLLHAVRIAHASGTFHRDIKPENILLDd-kDNLKLSDFGSCRGIHTQLPYTE 176 Giardia lamblia...
XP_002295735  84 LLEGNLYELMKdrh-ehFGEATVKSFMRQIFTALDHMHGKGVFHRDIKPENILVDkagKHLKLADFGSCRGINGKPPFTE 162 Thalassiosira p...
EER06225      84 LMDMNVYEAIKgrk-yyFPELRVGRWMTQLLCAVEFLHGKGLFHRDIKPENLLLHq-yETLKLADLGSCKGIDCKQPFTE 161 Perkinsus marin...
Feature 1        #### #                                     #                                    
Q9UQ07       161 YISTRWYRAPECLLTdGFYTYKMDLWSAGCVFYEIASlQPLFPGvnELDQISKIHDVIGTPAQki--ltKFKQSRAMNF- 237 human
CAK84722     192 YISTRWYRAPECLLTdGYYDQKMDLWGVGCVMFEIIAlFPLFPGtnELDQVNKIHNILGTPNPkvf-drFRKQATHMEI- 269 Paramecium tetr...
XP_001315347 170 YVATRWYRAPECILTsGSYGPAVDIWAVGCILYEILTtRPLFPGkhQLDQIARIHNILGTPGRevlsqfKQNPNSQINY- 248 Trichomonas vag...
ABG91274     162 YISTRWYRAPECLLTdGYYNYKMDLWSAGCVFFEIIAlFPLFPGsnELDQVHRIHNVLGTPPTeil-drLKKFGTHMDY- 239 Leishmania mexi...
XP_001603934 162 YISTRWYRSPECLLTgGFYGPKMDVWAAGCVFFELLAlEPLFPGenEVDQIARIHNVLGTPHArl--laKFRRSSRSSIg 239 jewel wasp
ACO63469     195 YISTRWYRAPECLLTdGYYNYKMDMWGVGCVFFEIVSlFPLFPGtnELDQIQKIHNIIGTPSAell-gkMKQRSAHMDF- 272 Micromonas sp. ...
XP_002427989 166 YISTRWYRSPECLLTtGYYGPKMDVWACGCVFYELLTtKPLFPGtnEVDQITKIHDVLGTPNTrllakfYRHKSRNCEY- 244 human body louse
XP_001704340 177 YISTRWYRSPECLLTdGVYGPEMDLFGVGCVMFEITAlFPLFPGkdELDQITRIHAILGTPPKel--iqRIRKGAKNNPi 254 Giardia lamblia...
XP_002295735 163 YISTRWYRPPECLLTcGRYGPEMDVWGVGCILFELTTlYPLFPGtdEADQIKRIHRVLGTPDPsvlvklKKHASTQANF- 241 Thalassiosira p...
EER06225     162 YISTRWYRAPECLLTdGYYSAGMDIWAIGCVYFEVLSlVPLFPGknEVDQVNKIHKVMGLPAE------DLLKYFKRSS- 234 Perkinsus marin...
Feature 1                                                               
Q9UQ07       238 --DFPFKKGSGI-PLLTTNl----sPQCLSLLHAMVAYDPDERIAaHQALQHPYF 285 human
CAK84722     270 --NFPNKHGTGI-ERLLQGq----tKECIDLIKMLLVYDPEERITaQSALRHEYF 317 Paramecium tetraurelia
XP_001315347 249 --AFPHRVPQGF-RSLLPNa----sEGIIDLLSKLLVYDPNGRISaNEALQHPVF 296 Trichomonas vaginalis G3
ABG91274     240 --DFPKKQGTGL-TKLLPHv----sAEALDLMKKLLTYDEEQRCTaKEALRHPYF 287 Leishmania mexicana
XP_001603934 240 elYFPSREGRGLlSCLLQKragrfsIRGLELLGLMLRYDPDSRAPaRKLLEHPYF 294 jewel wasp
ACO63469     273 --NFPQKSGTGI-EKLIPHa----pPECVDLINKLLAYNPDDRLSaRQALRHPYF 320 Micromonas sp. RCC299
XP_002427989 245 --FFQAKTGSGL-SCLLTNl----tDNGRDILKQMLTYDPEHRINvRRLLEHRYF 292 human body louse
XP_001704340 255 kgDFPPQKGSGL-AKLIPHa----sSTAIDLMLKLMEYDPQKRITaEEALRHPFF 304 Giardia lamblia ATCC 50803
XP_002295735 242 --AFPSQRGIGL-AKLLPDa----vANFLDLLTQSLAYEASTRITsRKAMKHSYF 289 Thalassiosira pseudonana CCMP1335
EER06225     235 --KSNSEIDLWL-RKCKVS------DEAIEIIKVLLTYDAEQRPTaTEALRLPYF 280 Perkinsus marinus ATCC 50983

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