Conserved Protein Domain Family
STKc_MAK_like

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cd07830: STKc_MAK_like (this model, PSSM-Id:173734 is obsolete and has been replaced by 270824)
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Male germ cell-Associated Kinase (MAK)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia (ECO), suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I.
Statistics
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PSSM-Id: 173734
View PSSM: cd07830
Aligned: 43 rows
Threshold Bit Score: 407.305
Threshold Setting Gi: 238029172
Created: 18-Jul-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ####    #                                             # #               # 
gi 13432166     4 YTTMRqLGDGTYGSVLMGKSNes---------------------------------gELVAIKRMKRKFyswDECMNLRE 50
gi 417780      38 YQLIEkLGAGSFGCVTLAKAQfplsnilgkqhdirgtl---mdqpknghqnyitktqGVVAIKTMMTKLhtlQDYTRVRE 114
gi 85082617    26 FEVLKeIGDGSFGSVVLARVRsagat--------------------------varrgTVIAIKTMKKTFesvGPCMELRE 79
gi 53850972    56 FTVIKdVGDGSFGTVCLADWKsplpsgtmlspm------------qhpttrpeyigkRLVAIKKMKKPFpswQECMKLKE 123
gi 50555049    31 YVLLKnIGKGSFGHVSLARVRskaamen-----------------------edmragSMVAIKTMKKKLaaiDDYNLLRE 87
gi 190344297   72 YKMISrLGDGGFGIVRLAKYRhdksnllqsakrgt---------ltdvgdgsnvnlsPLVAIKTMNARLpklEHYTRVKE 142
gi 164658848   17 FVPIKrLGTGSFGTVFVADWHsplpsgtmvpam------------qhsyarpeyvgkRIVAIKRMIRPYstlEDCLSLNE 84
gi 238029172   44 YKTVSsLGSGSFGSVVLAKIKdeyvsklaldltnpvhkntlryvnpsvpcnksysglHVVAIKTMTKRLthlRDYTKVKE 123
gi 159108014    4 YTVITeLGSGNYGTVYKARENkk---------------------------------gTLVAIKHMKQKYkswSECVTLKE 50
gi 238846428   69 YYMISrLGYGSFGYALLAKYKkninnfldqgkfsvgt----mmepirngnltnvrstGLVAVKVMKTQLknpSDYLRVNE 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                 ####   # ##                                      
gi 13432166    51 VKSLKKLn-HANVIKLKEVIRe--nDHLYFIFEYM-KENLYQLMKdrn---klFPESVIRNIMYQILQGLAFIHKHGFFH 123
gi 417780     115 IKFILAIpaNDHLIQIFEVFIdsenYQLHIVMECM-EQNLYQMMKhrr--rrvFSIPSLKSILSQILAGLKHIHEHNFFH 191
gi 85082617    80 VVFLRTLpaHPHLVPALDIFLdpftKKLHIAMEYM-EGNLYQLMKard--hkcLDNSSVKSILFQIMKGLEHIHAHHFFH 156
gi 53850972   124 LKSLLTIppHPNIIPLYDAFLmpttKELHFVFECM-EGNLYQLTKsrk--grpLAAGLVASIYEQIVLGLDHIHQHGYFH 200
gi 50555049    88 VEFIREVrpHRFLVNVHDMFVdsvnHHFHMSMEVM-EMNLYNLMKaqe--kvpFQPHAVRSMLWQIICGIDHIHRHNFFH 164
gi 190344297  143 VQFIQAMpaHINLLHIYEVFIdtsqYCLHFSMECM-DQTLYGLMRsrg--gkrFTASTVRSILWQLLSAISHIHDHGYFH 219
gi 164658848   85 LHALIALppHENIIALYDVFRkpisQELYLVFECM-EGNLFQLMKsrk--grpMAPGLIASIIQQSIAGIEHVHSQGFFH 161
gi 238029172  124 VRFILSVpsHPNLVQIYDLLIdsttFQLQIVMESM-DQNLYQLMRark--sslFSPNTLRSILVQLLAGISHIHKHNFFH 200
gi 159108014   51 VKSLIRMkeHPNIVKLMEVVRq--kEDLYFVFEYInSGNLFDFVVqqrsagikISELVAKDLVRQILEGLEHIHRNNYMH 128
gi 238846428  145 VKFILSIpsHPNLLQIYNLFIdetsGKLNIVMEPM-NQNLYQFIQkhv--grpLSSKIVKGMLYQLLSAIRHIHSHGYFH 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # # ## #                                  #  #          # #### #               
gi 13432166   124 RDMKPENLLCMg------------------------pELVKIADFGLARELRSqpPYTDYVSTRWYRAPEVLLRssvYSS 179
gi 417780     192 RDLKPENILITpstqyfekey-------mnqigyqdnYVIKLADFGLARHVENknPYTAYVSTRWYRSPEILLRsgyYSK 264
gi 85082617   157 RDIKPENILVStsshmdatnsfrrysalmnppptpptYTVKIADFGLARETHSklPYTTYVSTRWYRAPEVLLRageYSA 236
gi 53850972   201 RDMKPENLLITttgladypnlq-----palaaerdvlVIVKLADFGLARETLSkpPYTEYVSTRWYRAPEVLLRsrdYSN 275
gi 50555049   165 RDIKPENILVSrylpyhne----------nsssphsgFRIKIADFGLSRHIEDrdPYTAYVSTRWYRAPEILLRceyYSA 234
gi 190344297  220 RDIKPQNILISsmsqyyggid------svppgsrdqkYMVKLADYGLARHVENckDFTTYISTRWYRAPEMLLRrkwHST 293
gi 164658848  162 RDLKPENLLITttglgeyplsk----sqidgtkqdvlVVVKVADFGLARKMEEnaTFTTYVSTRWYRAPEILLEsqkYSS 237
gi 238029172  201 RDVKPENILVVsntayygske------sippsrrkdaYIIKLADYGLARHVDNvkPYTAYVSTRWYRSPEILLRqkfYSC 274
gi 159108014  129 RDLKCENILVSddg--------------------tgtRCVKIADLGCAKSLLErpPHTVYVGTRWYRAVELFLKdssYSA 188
gi 238846428  222 RDVKPENILVTstqqyygakh------dippemakdaFVLKLCDYGLAKSVKNkrVLTPYVSTRWYRAPEILLRhanYSR 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #                                                         
gi 13432166   180 PIDVWAVGSIMAELYMlRPLFPGtsEVDEIFKICQVLGTPKKs----------------------dWPEGYQLASSMNF- 236
gi 417780     265 PLDIWAFGCVAVEVTVfRALFPGanEIDQIWKILEVLGTPIKrsdfvntnh------itapppggfWDDASNLVHKLNL- 337
gi 85082617   237 PVDIWAIGAMAVEIATlKPLFPGgnEVDQVWRVCEIMGSPGNwynkaga-----------rvgggeWREGTRLAGKLGF- 304
gi 53850972   276 PVDMWALGTILAELVNlKPLFPGhsEVDQVLQICDILGDPSHsyghdsrn---------rrngggpWDRGIRMARAVGF- 345
gi 50555049   235 PVDIWAFGAMAAEVANlKPLFPGtnELDQFSLQVALLGTPGQnsl------------------ggrWSRHPELCSKLNI- 295
gi 190344297  294 PVDIWAFGTVAAEVAKvTPLFPGanEIDQIWRIFKVLGNPAPpkniqar----------pfpvggyWVEGQLLAGKCGY- 362
gi 164658848  238 AVDLWALGAIIAEMVRlEPLFPGnnAMDQLQCICSVLGAPTNdmhlpl-------------sngslWPAWLDVMQQWERs 304
gi 238029172  275 PVDMWAFATVAVEVTSfRPLFPGsnELDQLWKILEVLGSPEPssnaysaefepdsfassavplggyWPKAQSLAGDLGF- 353
gi 159108014  189 KNDIWACACILCEILLmKPLFPGanDIDMLNLITSTLGSPTRe----------------------dWPAGYALAERIGY- 245
gi 238846428  296 PIDIWAFASVAVELVNfRPIFCGrnETDQLWQVLKVLGHPGNshrnd---------------iggkWLEAIELSQNLGF- 359
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                  
gi 13432166   237 RFPQCVPINL---KTLIPNa------sNEAIQLMTEMLNWDPKKRPTaSQALKHPYF 284
gi 417780     338 KLPYVEGSSL---DHLLSSsq-----lSDLSEVVKKCLRWDPNERATaQELCEMPFF 386
gi 85082617   305 SFPKMAPHSM---DTILQTpq----wpASLAHFVTWCLMWDPKNRPTsTQALAHDYF 354
gi 53850972   346 TFPIRKPAKF---SRFFSDrv-----pQNLIDCIEDLLRYDPQARLTsKDCLQHDYM 394
gi 50555049   296 NIDAQTGQSS---NSIMCNpe-----hASLTDVVLMCLTWDPDARCSaRDIMYHRYF 344
gi 190344297  363 SFPEGTGIPI---DEFIPHs------yPFLCDMIRICLRWNPETRPIaSELYDQSYF 410
gi 164658848  305 VQPLSPVSLEr--YFPFPTs-------DVLLDFIFHILRYDPADRLTaRQCLQHPFL 352
gi 238029172  354 SLPEVAGISM---YQLIPRtdlptndlLDLLKVVKACLVWDPEKRASaTDLQQMSYF 407
gi 159108014  246 KFPRATQSRQeklRYLFPNv------tEDCINLLSRMFEFDQNKRLSaQDCLRHPWF 296
gi 238846428  360 TMPYAIGNSI---HHILPSs------yHELAETIKYCFLWDPDSRPTaEELFRSTYF 407

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