Conserved Protein Domain Family
STKc_MAK_like

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cd07830: STKc_MAK_like (this model, PSSM-Id:173734 is obsolete and has been replaced by 270824)
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Male germ cell-Associated Kinase (MAK)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia (ECO), suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I.
Statistics
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Aligned: 43 rows
Threshold Bit Score: 407.305
Threshold Setting Gi: 238029172
Created: 18-Jul-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ####    #                                             # #               # 
P20794          4 YTTMRqLGDGTYGSVLMGKSNes---------------------------------gELVAIKRMKRKFyswDECMNLRE 50   human
417780         38 YQLIEkLGAGSFGCVTLAKAQfplsnilgkqhdirgtl---mdqpknghqnyitktqGVVAIKTMMTKLhtlQDYTRVRE 114  baker's yeast
XP_956947      26 FEVLKeIGDGSFGSVVLARVRsagat--------------------------varrgTVIAIKTMKKTFesvGPCMELRE 79   Neurospora cr...
AAM21640       56 FTVIKdVGDGSFGTVCLADWKsplpsgtmlspm------------qhpttrpeyigkRLVAIKKMKKPFpswQECMKLKE 123  Ustilago maydis
XP_504933      31 YVLLKnIGKGSFGHVSLARVRskaamen-----------------------edmragSMVAIKTMKKKLaaiDDYNLLRE 87   Yarrowia lipo...
EDK35947       72 YKMISrLGDGGFGIVRLAKYRhdksnllqsakrgt---------ltdvgdgsnvnlsPLVAIKTMNARLpklEHYTRVKE 142  Pichia guilli...
XP_001730549   17 FVPIKrLGTGSFGTVFVADWHsplpsgtmvpam------------qhsyarpeyvgkRIVAIKRMIRPYstlEDCLSLNE 84   Malassezia gl...
CAY67092       44 YKTVSsLGSGSFGSVVLAKIKdeyvsklaldltnpvhkntlryvnpsvpcnksysglHVVAIKTMTKRLthlRDYTKVKE 123  Pichia pastor...
XP_001704281    4 YTVITeLGSGNYGTVYKARENkk---------------------------------gTLVAIKHMKQKYkswSECVTLKE 50   Giardia lambl...
EEQ35892       69 YYMISrLGYGSFGYALLAKYKkninnfldqgkfsvgt----mmepirngnltnvrstGLVAVKVMKTQLknpSDYLRVNE 144  Clavispora lu...
Feature 1                      #                 ####   # ##                                      
P20794         51 VKSLKKLn-HANVIKLKEVIRe--nDHLYFIFEYM-KENLYQLMKdrn---klFPESVIRNIMYQILQGLAFIHKHGFFH 123  human
417780        115 IKFILAIpaNDHLIQIFEVFIdsenYQLHIVMECM-EQNLYQMMKhrr--rrvFSIPSLKSILSQILAGLKHIHEHNFFH 191  baker's yeast
XP_956947      80 VVFLRTLpaHPHLVPALDIFLdpftKKLHIAMEYM-EGNLYQLMKard--hkcLDNSSVKSILFQIMKGLEHIHAHHFFH 156  Neurospora cr...
AAM21640      124 LKSLLTIppHPNIIPLYDAFLmpttKELHFVFECM-EGNLYQLTKsrk--grpLAAGLVASIYEQIVLGLDHIHQHGYFH 200  Ustilago maydis
XP_504933      88 VEFIREVrpHRFLVNVHDMFVdsvnHHFHMSMEVM-EMNLYNLMKaqe--kvpFQPHAVRSMLWQIICGIDHIHRHNFFH 164  Yarrowia lipo...
EDK35947      143 VQFIQAMpaHINLLHIYEVFIdtsqYCLHFSMECM-DQTLYGLMRsrg--gkrFTASTVRSILWQLLSAISHIHDHGYFH 219  Pichia guilli...
XP_001730549   85 LHALIALppHENIIALYDVFRkpisQELYLVFECM-EGNLFQLMKsrk--grpMAPGLIASIIQQSIAGIEHVHSQGFFH 161  Malassezia gl...
CAY67092      124 VRFILSVpsHPNLVQIYDLLIdsttFQLQIVMESM-DQNLYQLMRark--sslFSPNTLRSILVQLLAGISHIHKHNFFH 200  Pichia pastor...
XP_001704281   51 VKSLIRMkeHPNIVKLMEVVRq--kEDLYFVFEYInSGNLFDFVVqqrsagikISELVAKDLVRQILEGLEHIHRNNYMH 128  Giardia lambl...
EEQ35892      145 VKFILSIpsHPNLLQIYNLFIdetsGKLNIVMEPM-NQNLYQFIQkhv--grpLSSKIVKGMLYQLLSAIRHIHSHGYFH 221  Clavispora lu...
Feature 1          # # ## #                                  #  #          # #### #               
P20794        124 RDMKPENLLCMg------------------------pELVKIADFGLARELRSqpPYTDYVSTRWYRAPEVLLRssvYSS 179  human
417780        192 RDLKPENILITpstqyfekey-------mnqigyqdnYVIKLADFGLARHVENknPYTAYVSTRWYRSPEILLRsgyYSK 264  baker's yeast
XP_956947     157 RDIKPENILVStsshmdatnsfrrysalmnppptpptYTVKIADFGLARETHSklPYTTYVSTRWYRAPEVLLRageYSA 236  Neurospora cr...
AAM21640      201 RDMKPENLLITttgladypnlq-----palaaerdvlVIVKLADFGLARETLSkpPYTEYVSTRWYRAPEVLLRsrdYSN 275  Ustilago maydis
XP_504933     165 RDIKPENILVSrylpyhne----------nsssphsgFRIKIADFGLSRHIEDrdPYTAYVSTRWYRAPEILLRceyYSA 234  Yarrowia lipo...
EDK35947      220 RDIKPQNILISsmsqyyggid------svppgsrdqkYMVKLADYGLARHVENckDFTTYISTRWYRAPEMLLRrkwHST 293  Pichia guilli...
XP_001730549  162 RDLKPENLLITttglgeyplsk----sqidgtkqdvlVVVKVADFGLARKMEEnaTFTTYVSTRWYRAPEILLEsqkYSS 237  Malassezia gl...
CAY67092      201 RDVKPENILVVsntayygske------sippsrrkdaYIIKLADYGLARHVDNvkPYTAYVSTRWYRSPEILLRqkfYSC 274  Pichia pastor...
XP_001704281  129 RDLKCENILVSddg--------------------tgtRCVKIADLGCAKSLLErpPHTVYVGTRWYRAVELFLKdssYSA 188  Giardia lambl...
EEQ35892      222 RDVKPENILVTstqqyygakh------dippemakdaFVLKLCDYGLAKSVKNkrVLTPYVSTRWYRAPEILLRhanYSR 295  Clavispora lu...
Feature 1                               #                                                         
P20794        180 PIDVWAVGSIMAELYMlRPLFPGtsEVDEIFKICQVLGTPKKs----------------------dWPEGYQLASSMNF- 236  human
417780        265 PLDIWAFGCVAVEVTVfRALFPGanEIDQIWKILEVLGTPIKrsdfvntnh------itapppggfWDDASNLVHKLNL- 337  baker's yeast
XP_956947     237 PVDIWAIGAMAVEIATlKPLFPGgnEVDQVWRVCEIMGSPGNwynkaga-----------rvgggeWREGTRLAGKLGF- 304  Neurospora cr...
AAM21640      276 PVDMWALGTILAELVNlKPLFPGhsEVDQVLQICDILGDPSHsyghdsrn---------rrngggpWDRGIRMARAVGF- 345  Ustilago maydis
XP_504933     235 PVDIWAFGAMAAEVANlKPLFPGtnELDQFSLQVALLGTPGQnsl------------------ggrWSRHPELCSKLNI- 295  Yarrowia lipo...
EDK35947      294 PVDIWAFGTVAAEVAKvTPLFPGanEIDQIWRIFKVLGNPAPpkniqar----------pfpvggyWVEGQLLAGKCGY- 362  Pichia guilli...
XP_001730549  238 AVDLWALGAIIAEMVRlEPLFPGnnAMDQLQCICSVLGAPTNdmhlpl-------------sngslWPAWLDVMQQWERs 304  Malassezia gl...
CAY67092      275 PVDMWAFATVAVEVTSfRPLFPGsnELDQLWKILEVLGSPEPssnaysaefepdsfassavplggyWPKAQSLAGDLGF- 353  Pichia pastor...
XP_001704281  189 KNDIWACACILCEILLmKPLFPGanDIDMLNLITSTLGSPTRe----------------------dWPAGYALAERIGY- 245  Giardia lambl...
EEQ35892      296 PIDIWAFASVAVELVNfRPIFCGrnETDQLWQVLKVLGHPGNshrnd---------------iggkWLEAIELSQNLGF- 359  Clavispora lu...
Feature 1                                                                  
P20794        237 RFPQCVPINL---KTLIPNa------sNEAIQLMTEMLNWDPKKRPTaSQALKHPYF 284  human
417780        338 KLPYVEGSSL---DHLLSSsq-----lSDLSEVVKKCLRWDPNERATaQELCEMPFF 386  baker's yeast
XP_956947     305 SFPKMAPHSM---DTILQTpq----wpASLAHFVTWCLMWDPKNRPTsTQALAHDYF 354  Neurospora crassa OR74A
AAM21640      346 TFPIRKPAKF---SRFFSDrv-----pQNLIDCIEDLLRYDPQARLTsKDCLQHDYM 394  Ustilago maydis
XP_504933     296 NIDAQTGQSS---NSIMCNpe-----hASLTDVVLMCLTWDPDARCSaRDIMYHRYF 344  Yarrowia lipolytica CLIB122
EDK35947      363 SFPEGTGIPI---DEFIPHs------yPFLCDMIRICLRWNPETRPIaSELYDQSYF 410  Pichia guilliermondii ATCC 6260
XP_001730549  305 VQPLSPVSLEr--YFPFPTs-------DVLLDFIFHILRYDPADRLTaRQCLQHPFL 352  Malassezia globosa CBS 7966
CAY67092      354 SLPEVAGISM---YQLIPRtdlptndlLDLLKVVKACLVWDPEKRASaTDLQQMSYF 407  Pichia pastoris GS115
XP_001704281  246 KFPRATQSRQeklRYLFPNv------tEDCINLLSRMFEFDQNKRLSaQDCLRHPWF 296  Giardia lamblia ATCC 50803
EEQ35892      360 TMPYAIGNSI---HHILPSs------yHELAETIKYCFLWDPDSRPTaEELFRSTYF 407  Clavispora lusitaniae ATCC 42720

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