1QMZ,1W98,1PW2,1JST,2QKR,1V0O,3GBZ,1V0P,1UNL,2W96,2PK9,1UA2,3BLH


Conserved Protein Domain Family
STKc_CDK_like

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cd07829: STKc_CDK_like (this model, PSSM-Id:173733 is obsolete and has been replaced by 270823)
Click on image for an interactive view with Cn3D
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase (CDK)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH.
Statistics
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PSSM-Id: 173733
View PSSM: cd07829
Aligned: 64 rows
Threshold Bit Score: 346.394
Threshold Setting Gi: 12580757
Created: 16-Jul-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Structure:1QMZ_A; Human CDK2 binds MgATP and substrate p107 peptide; defined at 4A contacts.
    View structure with Cn3D
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ####    #            # #                   #              #               
1QMZ_A         5 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdt---etEGVPSTAIREISLLKELn-HPNIVKLLDVIHte------ 74  human
CAK93530      19 FERLDkLGEGTYGTVYAAKDKkknQVVAIKKVKIhd---snEGFPITCLREIKILQRLsaHPNVVNLLEVAVgpi----- 90  Paramecium tetr...
XP_001712540  35 YRRLGlIDEGTYGKVFRARKInnaRIYACKKILIey---klNENFSTSLREVNLLLSIn-HPNIIFVKEVRFsrs----- 105 Hemiselmis ande...
Q15131        39 FEKLNrIGEGTYGIVYRARDTqtdEIVALKKVRMdk---ekDGIPISSLREITLLLRLr-HPNIVELKEVVVgnh----- 109 human
P21127       438 FQCLNrIEEGTYGVVYRAKDKktdEIVALKRLKMek---ekEGFPITSLREINTILKAq-HPNIVTVREIVVgsn----- 508 human
EEE27716      71 FEIKEvIGEGTYGRVWRAYDKrhnVVVAVKQMRLaqqqsshEGFPRTAVREIGLLKQLq-HPHIVELMEVACgpdltlks 149 Toxoplasma gond...
3BLH_A        20 YEKLAkIGQGTFGEVFKARHRktgQKVALKKVLMen---ekEGFPITALREIKILQLLk-HENVVNLIEICRtkaspy-- 93  human
XP_001329778  21 FTFVEnIGKGTYATVSKCIDKatnKPVALKAIKKvt---deDGFTKTTLREIRLLQKLn-HENIVKLQKVLIck------ 90  Trichomonas vag...
EAY21859      18 FTKVEkIGLGTYGKVYKCLDIrkkQTVALKKIKIlk---pnDGFPVNTVREIKCLKELk-HDNIIRLRNVITlykp---- 89  Trichomonas vag...
CAC27075      10 YIKKKlIDYGTYGKVFEMMKMk-iKKCACKEIEIyy---snNSLKKEYISEVRFLSYIf-HPNLIFLQNFLYskn----- 79  Guillardia theta
Feature 1                           ####  # ##                                       # # ## #    
1QMZ_A        75 -------------nKLYLVFEFLHQDLKKFMdasa--ltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINte 139 human
CAK93530      91 ------------kdSIHLVFEYCAIDLAILVdnmfidnysfRENEIKCIVLQLLNGLAYINSNFILHRDIKLSNLLLTnd 158 Paramecium tetr...
XP_001712540 106 ------------inNIFIIMEYCEYDLKSILnsk----vnfSIPQIKFIMKQLIRGLKILHENWIIHRDLKTSNILLNnr 169 Hemiselmis ande...
Q15131       110 ------------leSIFLVMGYCEQDLASLLenmp---tpfSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTdk 174 human
P21127       509 ------------mdKIYIVMNYVEHDLKSLMetmk---qpfLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSha 573 human
EEE27716     150 kakknndqpysgsnSVYLVFEHCERDLGVLLdtrt---qpfSASEIKLIMRQLLLALHHLHSNFVIHRDVKLSNILISsn 226 Toxoplasma gond...
3BLH_A        94 ---------nrckgSIYLVFDFCEHDLAGLLsnvl---vkfTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITrd 161 human
XP_001329778  91 -------------gTIYLVLEYCQYDLSALLhrkn--aphlSERFIKCIQFQLMVCLRYLDTQRVIHRDLKPANLFITen 155 Trichomonas vag...
EAY21859      90 ----------nkpsTVWLSFDYCEFDLFGLLhktd--fpqlSTKQVLCYSRQLILAMLQCKQAEILHRDLKPANLFITrd 157 Trichomonas vag...
CAC27075      80 ------------edKISLIMDFCELNLRNLIenk----ikiSTNQILFIGLQLLNSIVYLHLNKIIHRDLKSSNILINrl 143 Guillardia theta
Feature 1              #  #               # #### #                                      ##       
1QMZ_A       140 GAIKLADFGLARAFGVPvr----tYXHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTr-RALFPGDs---EID 211 human
CAK93530     159 GIVKIADFGLAREYEIPqk----kYTNPVVTLWYRAPELLCQmnnYNTAIDIWSVGCVFAELINrgFPILQGKs---EIH 231 Paramecium tetr...
XP_001712540 170 GIIKICDFGLARIHSFKtn----nFTQGVVTLWYRAPEILLGqlfYKTAVDVWSVGCIFGELILn-DVLFPGKt---ELD 241 Hemiselmis ande...
Q15131       175 GCVKTADFGLARAYGVPvk----pMTPKVVTLWYRAPELLLGtttQTTSIDMWAVGCILAELLAh-RPLLPGTs---EIH 246 human
P21127       574 GILKVGDFGLAREYGSPlk----aYTPVVVTLWYRAPELLLGakeYSTAVDMWSVGCIFGELLTq-KPLFPGKs---EID 645 human
EEE27716     227 GSIKLADFGLTRTFTEPgh----aMTDGVVTLWYRAPELLFGastYSEKIDMWAVGCIFGELLLn-NPFLPGKt---EQE 298 Toxoplasma gond...
3BLH_A       162 GVLKLADFGLARAFSLAknsqpnrYXNRVVTLWYRPPELLLGerdYGPPIDLWGAGCIMAEMWTr-SPIMQGNt---EQH 237 human
XP_001329778 156 NVLKLGDFGLARDIMLNk-----rFTSKVITQWYRPPELLFGcseYGIEVDIWSAACIFYEIITk-KPLFYTQdtnnELA 229 Trichomonas vag...
EAY21859     158 NVLKIGDFGLARKFKSDdi----kYTYNVITLYYRAPELILGcqnYQYEVDVWSVGCILYELCTn-KYFFKAPig-kEID 231 Trichomonas vag...
CAC27075     144 GIVKICDFGMGTFLCSKki----cLSDKIVTLWYRAPEILLGqhfYDYSVDMWSFGCVIGELITg-EILFQGKs---ELD 215 Guillardia theta
Feature 1                                                                                        
1QMZ_A       212 QLFRIFRTLGTPDEVVWPgvtsmp--dykpsfPKWARQDf-----sKVVPpl--dEDGRSLLSQMLHYDPNKRISAKAAL 282 human
CAK93530     232 QLQLMCEMLGYPNASVWPdlhkngnkqilkelEKFQHCRpn---lqNVIKda--sPQALELISRMLTWDPEKRIGVMESL 306 Paramecium tetr...
XP_001712540 242 QLSKIFSLLGTPTTEIWIglhllpa-fkkikfPIQPFNNl-----gKKFSsv-ldFNGIDLLQRFLTYDPGKRITLEFAL 314 Hemiselmis ande...
Q15131       247 QIDLIVQLLGTPSENIWPgfsklpl-vgqyslRKQPYNNl-----kHKFPwl--sEAGLRLLHFLFMYDPKKRATAGDCL 318 human
P21127       646 QINKVFKDLGTPSEKIWPgyselpa-vkkmtfSEHPYNNl-----rKRFGal-lsDQGFDLMNKFLTYFPGRRISAEDGL 718 human
EEE27716     299 QVNLMCELLGVPEPKSWPemealpg-ysqlrlPASPKTSsl----rELFKke--tPNCVDLLSRLLIYNPANRISARDAL 371 Toxoplasma gond...
3BLH_A       238 QLALISQLCGSITPEVWPnvdnyelyeklelvKGQKRKVk------DRLKayvrdPYALDLIDKLLVLDPAQRIDSDDAL 311 human
XP_001329778 230 QLIRIFKICGMSEESRFMgydlwr--miqphlSQFPPPSnlkiyleKTIPkn--yHEIINLLLAMLRFNPKKRPTPSAIL 305 Trichomonas vag...
EAY21859     232 QLTAIFKITGTPDNEEWPefkeld--kgglftQKIEGNLley--leKTIPpe--fEGAADLISKMCRLTPSKRISMQEAF 305 Trichomonas vag...
CAC27075     216 QLNKIFQTIGTPTTEIWLnlhtlkf-tknivfPIQPYNKl-----nLKLEsk-tnKNLIFLLQKILVYDPKKRLKSTEAL 288 Guillardia theta
Feature 1             
1QMZ_A       283 AHPFF 287 human
CAK93530     307 LHEYF 311 Paramecium tetraurelia
XP_001712540 315 KHPFL 319 Hemiselmis andersenii
Q15131       319 ESSYF 323 human
P21127       719 KHEYF 723 human
EEE27716     372 LHPYF 376 Toxoplasma gondii VEG
3BLH_A       312 NHDFF 316 human
XP_001329778 306 DQYFT 310 Trichomonas vaginalis G3
EAY21859     306 MHPFI 310 Trichomonas vaginalis G3
CAC27075     289 KFFYS 293 Guillardia theta

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