Conserved Protein Domain Family
STKc_MAPKKK_Byr2_like

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cd06628: STKc_MAPKKK_Byr2_like (this model, PSSM-Id:173732 is obsolete and has been replaced by 270798)
Catalytic domain of fungal Byr2-like MAP Kinase Kinase Kinases
Serine/threonine kinases (STKs), mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) subfamily, fungal Byr2-like proteins, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses.
Statistics
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PSSM-Id: 173732
View PSSM: cd06628
Aligned: 4 rows
Threshold Bit Score: 537.504
Threshold Setting Gi: 2654103
Created: 16-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #####   #            # #                                       #         
gi 115195    393 KWIRGALIGSGSFGQVYLGMNAssGELMAVKQVILdsvses---kdrhakLLDALAGEIALLQELsHEHIVQYLGSNLns 469
gi 11119233  545 RWIKGALIGSGSFGSVFLGMNAlsGELMAVKQVEIpsidiqg--ckrkraMLDALQREISLLKELhHENIVQYLGSSMde 622
gi 25956302  935 KWIKGALIGAGSFGSVYLGMDAqsGLLMAVKQVELsagsakn--edrkrsMLSALEREIELLKELqHENIVQYLDSSVda 1012
gi 2654103   389 MWMKGSLIGQGSFGSVYLALHAitGELLAVKQVETpapgadskndarkksMIEALKREITLLRDLqHPNIVQYLGCSSsa 468
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #### ###  #                                   # #### #         ### #      
gi 115195    470 dhLNIFLEYVpGGSVAGLLTMYgsFEETLVKNFIKQTLKGLEYLHsRGIVHRDIKGANILVDnKGKIKISDFGISKKLEl 549
gi 11119233  623 thLTFFLEYVpGGSVTALLNNYgaFEEPLIRNFVRQILKGLNYLHnKKIIHRDIKGANILVDnKGGIKISDFGISKKVEa 702
gi 25956302 1013 nhLNIFLEYVpGGSVAALLNNYgaFEEALVRNFVRQILTGLNYLHmRGIVHRDIKGANILVDnKGGIKISDFGISKKVE- 1091
gi 2654103   469 eyLNIFLEYVpGGSVQTMLDQYgaLPESLVRSFVRQILQGLSYVHnRDIIHRDIKGANILVDnKGTIKISDFGISKKLEa 548
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #### #                          #        #                       
gi 115195    550 -NSTSTKtg-gaRPSFQGSSFWMAPEVVKQTmhTEKTDIWSLGCLVIEMLTsKHPYPNCdQMQAIFRIGe-nILPEFPSN 626
gi 11119233  703 -NLLSMTrn--qRPSLQGSVYWMAPEVVKQTlyTRKADIWSLGCLIVEMFTgKHPFPKMnQLQAIFKIGq-yVSPDIPEH 778
gi 25956302 1092 -NSLITGlr-tnRPSLQGSVFWMAPEVVKQTsySPKADIWSVGCLVVEMLTgTHPWADLtQMQAIFRIGs-lARPAPPSD 1168
gi 2654103   549 tNILNGAnnnkhRPSLQGSVFWMAPEVVKQTsyTRKADIWSLGCLVVEMMTgTHPFPDCtQLQAIFKIGgskASPTIPDN 628
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1                                        
gi 115195    627 isSSAIDFLEKTFAIDCNLRPTASELLSHPFV 658
gi 11119233  779 ctSEARHFLEKIFEPDYHARPTAADLLKYSFL 810
gi 25956302 1169 isVQADEFLRKTFEIEHAKRPTAAQLLKHPFI 1200
gi 2654103   629 asEEAKQFLAQTFEIDHNKRPSADELMLSPFL 660

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