Conserved Protein Domain Family
STKc_Cdc7_like

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cd06627: STKc_Cdc7_like (this model, PSSM-Id:173731 is obsolete and has been replaced by 270797)
Catalytic domain of Cell division control protein 7-like Protein Serine/Threonine Kinases
Serine/threonine kinases (STKs), (Cdc7)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane.
Statistics
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PSSM-Id: 173731
Aligned: 21 rows
Threshold Bit Score: 393.923
Threshold Setting Gi: 71746808
Created: 16-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #####   #            # #                                 #              
1168817         8 SITLG-DCLGKGAFGAVYRGLNiknGETVAVKKVKLskml---ksdlSVIKMEIDLLKNLDHPNIVKYRGSYQtndsLCI 83   fission yeast
399197         24 QYHLK-QVIGRGSYGVVYKAINkhtDQVVAIKEVVYend-----eelNDIMAEISLLKNLNHNNIVKYHGFIRksyeLYI 97   baker's yeast
XP_654672     419 VFSIA-NSIGRGAYGEVFQGMNadsGEFVAIKQMKVnkk-----svmKEVMEEIRLLKKLKHKHIVRYIASTEshgfLYI 492  Entamoeba his...
XP_647809      21 DYLLI-DIIGKGGFGVVYKGLHktkGYFSAIKKIKImkkkklqsesqISLMAEINLLKVLSHHNIVRYYEHIPssshSYI 99   Dictyostelium...
XP_646575      75 AFVISdIAIGKGAFATVFKGLNtlsGDFVAIKRFEKskis---neqhSSVSTEFDILQRLNHENIVRILGREEnenyIYI 151  Dictyostelium...
XP_638675      35 EYTLG-EKIGRGAFGQVFKGLNgktGEFVAIKQIDSnkid---esslQSVKGEVEILHKLRHNNIVKVLGVVEvqaqLNF 110  Dictyostelium...
XP_457906     262 NFQFS-TLVGRGASANVFKGINlktNQIVAIKQIILekn-----qnvMELMGEIDLLKILKHPNIVKYHGFVKtstsLNV 335  Debaryomyces ...
XP_638889      12 KYQIG-EAVGKGAFGKVFKALNaetGDFCAIKQIEKtiis---ekqlPSIIQEIKLLQTLQHPNIVKFIESYEtsryLYF 87   Dictyostelium...
XP_822459      13 TYQLQ-DLIGKGGNAVVYSAVDrntGLMVAVKKMEVhdd-----aamATCRNEVAILSHLKHPYVIRYIDHAHsgksFLI 86   Trypanosoma b...
XP_001312579   39 EFQLG-PKLGRGAFGCVYQGLNkdtGDYVAIKTISLtrfp----dalDSVQQEIDLMAPLEHPNVVKYITSHQtkdfLYI 113  Trichomonas v...
399197         24 QYHLK-QVIGRGSYGVVYKAINkhtDQVVAIKEVVYend-----eelNDIMAEISLLKNLNHNNIVKYHGFIRksyeLYI 97   baker's yeast
XP_654672     419 VFSIA-NSIGRGAYGEVFQGMNadsGEFVAIKQMKVnkk-----svmKEVMEEIRLLKKLKHKHIVRYIASTEshgfLYI 492  Entamoeba his...
XP_647809      21 DYLLI-DIIGKGGFGVVYKGLHktkGYFSAIKKIKImkkkklqsesqISLMAEINLLKVLSHHNIVRYYEHIPssshSYI 99   Dictyostelium...
XP_646575      75 AFVISdIAIGKGAFATVFKGLNtlsGDFVAIKRFEKskis---neqhSSVSTEFDILQRLNHENIVRILGREEnenyIYI 151  Dictyostelium...
XP_638675      35 EYTLG-EKIGRGAFGQVFKGLNgktGEFVAIKQIDSnkid---esslQSVKGEVEILHKLRHNNIVKVLGVVEvqaqLNF 110  Dictyostelium...
XP_457906     262 NFQFS-TLVGRGASANVFKGINlktNQIVAIKQIILekn-----qnvMELMGEIDLLKILKHPNIVKYHGFVKtstsLNV 335  Debaryomyces ...
XP_638889      12 KYQIG-EAVGKGAFGKVFKALNaetGDFCAIKQIEKtiis---ekqlPSIIQEIKLLQTLQHPNIVKFIESYEtsryLYF 87   Dictyostelium...
XP_822459      13 TYQLQ-DLIGKGGNAVVYSAVDrntGLMVAVKKMEVhdd-----aamATCRNEVAILSHLKHPYVIRYIDHAHsgksFLI 86   Trypanosoma b...
XP_001312579   39 EFQLG-PKLGRGAFGCVYQGLNkdtGDYVAIKTISLtrfp----dalDSVQQEIDLMAPLEHPNVVKYITSHQtkdfLYI 113  Trichomonas v...
Feature 1          #### ###  #                                    # #### #         ### #          
1168817        84 ILEYCeNGSLRSICKnf-gkIPENLVALYTFQVLQGLLYLHnQGVIHRDIKGANILTTkdGTIKLADFGVATKINALEd- 161  fission yeast
399197         98 LLEYCaNGSLRRLISrsstgLSENESKTYVTQTLLGLKYLHgEGVIHRDIKAANILLSadNTVKLADFGVSTIVNSSAl- 176  baker's yeast
XP_654672     493 IMEYMeSGSLLNIVKkf-nhLNESLSAKYIHQVLDGLAFIHdQGIVHRDIKAANILVAkdGSVKIADFGVSVQMNGNEkq 571  Entamoeba his...
XP_647809     100 VMEFIeNGSLEKIIKrh-glLPESLVTVYIAQVLNGLEYLHrQGVIHRDIKAANLLIStdGSIKLADFGVATKVSDLSsd 178  Dictyostelium...
XP_646575     152 FLEYMeNGSLSTILNnf-gtFPESLICNYVENVLKGLVYLHqEGVIHRDIKAANILINkaGEAKLSDFGTAGEIIKESdk 230  Dictyostelium...
XP_638675     111 ILEYVeNGSLRDVIEkf-gpLSEELCIIYLYQMLQGLAYLHsNKVIHRDIKASNILITkeGVIKLADFGVASQIDSESql 189  Dictyostelium...
XP_457906     336 FLEFCsKGSLRQLYQhtnhgLPEDQIIDFVRQILQGLHYLHeQGVVHRDVKAANVLITedGFIKLADFGVATKVSSQHe- 414  Debaryomyces ...
XP_638889      88 ALEFIeGGSLAKIAKry-gcFQEPLLSRYFSQVLKGLAYLHeKGVIHRDIKSDNILITkeGVIKLADFGSCTYSAIDRk- 165  Dictyostelium...
XP_822459      87 VTEFAlERSLLQRLKrh-grCGELEVARFMFQITSALAYLHkEKIVHRDIKCANVLLGaaEVVKLSDFGLAVNLGAVHgd 165  Trypanosoma b...
XP_001312579  114 VMEFAeGGSLQNVQKkf-enFNEHLASKYLYEVLLGLKYLHeQSIIHRDIKAANILLTk-GHCKLSDFGISVKLTDNKnp 191  Trichomonas v...
399197         98 LLEYCaNGSLRRLISrsstgLSENESKTYVTQTLLGLKYLHgEGVIHRDIKAANILLSadNTVKLADFGVSTIVNSSAl- 176  baker's yeast
XP_654672     493 IMEYMeSGSLLNIVKkf-nhLNESLSAKYIHQVLDGLAFIHdQGIVHRDIKAANILVAkdGSVKIADFGVSVQMNGNEkq 571  Entamoeba his...
XP_647809     100 VMEFIeNGSLEKIIKrh-glLPESLVTVYIAQVLNGLEYLHrQGVIHRDIKAANLLIStdGSIKLADFGVATKVSDLSsd 178  Dictyostelium...
XP_646575     152 FLEYMeNGSLSTILNnf-gtFPESLICNYVENVLKGLVYLHqEGVIHRDIKAANILINkaGEAKLSDFGTAGEIIKESdk 230  Dictyostelium...
XP_638675     111 ILEYVeNGSLRDVIEkf-gpLSEELCIIYLYQMLQGLAYLHsNKVIHRDIKASNILITkeGVIKLADFGVASQIDSESql 189  Dictyostelium...
XP_457906     336 FLEFCsKGSLRQLYQhtnhgLPEDQIIDFVRQILQGLHYLHeQGVVHRDVKAANVLITedGFIKLADFGVATKVSSQHe- 414  Debaryomyces ...
XP_638889      88 ALEFIeGGSLAKIAKry-gcFQEPLLSRYFSQVLKGLAYLHeKGVIHRDIKSDNILITkeGVIKLADFGSCTYSAIDRk- 165  Dictyostelium...
XP_822459      87 VTEFAlERSLLQRLKrh-grCGELEVARFMFQITSALAYLHkEKIVHRDIKCANVLLGaaEVVKLSDFGLAVNLGAVHgd 165  Trypanosoma b...
XP_001312579  114 VMEFAeGGSLQNVQKkf-enFNEHLASKYLYEVLLGLKYLHeQSIIHRDIKAANILLTk-GHCKLSDFGISVKLTDNKnp 191  Trichomonas v...
Feature 1                                   #### #                            #        #          
1168817       162 ------------------------hSVVGSPYWMAPEVIELvg--aTTASDIWSVGCTVIELLdgNPPYYDLdpTSALFR 215  fission yeast
399197        177 -------------------------TLAGTLNWMAPEILGNrg--aSTLSDIWSLGATVVEMLtkNPPYHNLtdANIYYA 229  baker's yeast
XP_654672     572 eg-------------------gsdeDPIGTPNWMAPEVIQMqg--tTVKADIWALGCTIIELItgNPPYYDLnpTAALYK 630  Entamoeba his...
XP_647809     179 n---------------------pddTFAGTPYWMAPEVIQMqg--iSTACDVWSLGCTIIELLtgTPPYFGLapAAALYK 235  Dictyostelium...
XP_646575     231 -----------------------rySVVGTPYWMAPEVIEIsg--hCQVSDIWSLGCTIIELFtsYPPYFDLnpLGAMYR 285  Dictyostelium...
XP_638675     190 -----------------------rfSVVGTPYWMAPESIEIsg--cSSASDIWSLGSTMIELLtgNPPYYTLqpMAAMFR 244  Dictyostelium...
XP_457906     415 -------------------------TVVGTPNWMAPETVLGge-glCTASDIWSLGATIIELFttNPPYHDLnpMATLHA 468  Debaryomyces ...
XP_638889     166 ------------------------lTVVGTPFWMAPEVIQMdmnarSTACDIWSLGCTLLEMLtgNPPYWDLgtMPAMFA 221  Dictyostelium...
XP_822459     166 tndeedgllsssavcdgdgksvaeeGIVGSVYWMAPEAVRGep--pAESCDIWSLGCLCIELLtgNPPFFDRkpANALYC 243  Trypanosoma b...
XP_001312579  192 -----------------------daLSQCSPFWAAPEVISMep--iTEKCDIWSLGITAIELFagQPPYFELnaVRAMFQ 246  Trichomonas v...
399197        177 -------------------------TLAGTLNWMAPEILGNrg--aSTLSDIWSLGATVVEMLtkNPPYHNLtdANIYYA 229  baker's yeast
XP_654672     572 eg-------------------gsdeDPIGTPNWMAPEVIQMqg--tTVKADIWALGCTIIELItgNPPYYDLnpTAALYK 630  Entamoeba his...
XP_647809     179 n---------------------pddTFAGTPYWMAPEVIQMqg--iSTACDVWSLGCTIIELLtgTPPYFGLapAAALYK 235  Dictyostelium...
XP_646575     231 -----------------------rySVVGTPYWMAPEVIEIsg--hCQVSDIWSLGCTIIELFtsYPPYFDLnpLGAMYR 285  Dictyostelium...
XP_638675     190 -----------------------rfSVVGTPYWMAPESIEIsg--cSSASDIWSLGSTMIELLtgNPPYYTLqpMAAMFR 244  Dictyostelium...
XP_457906     415 -------------------------TVVGTPNWMAPETVLGge-glCTASDIWSLGATIIELFttNPPYHDLnpMATLHA 468  Debaryomyces ...
XP_638889     166 ------------------------lTVVGTPFWMAPEVIQMdmnarSTACDIWSLGCTLLEMLtgNPPYWDLgtMPAMFA 221  Dictyostelium...
XP_822459     166 tndeedgllsssavcdgdgksvaeeGIVGSVYWMAPEAVRGep--pAESCDIWSLGCLCIELLtgNPPFFDRkpANALYC 243  Trypanosoma b...
XP_001312579  192 -----------------------daLSQCSPFWAAPEVISMep--iTEKCDIWSLGITAIELFagQPPYFELnaVRAMFQ 246  Trichomonas v...
Feature 1                                                      
1168817       216 MvkDEHPPLPSNi-SSAAKSFLMQCFQKdPNLRIKTRKLLKHPWV 259  fission yeast
399197        230 Ve-NDTYYPPSSf-SEPLKDFLSKCFVKnMYKRPTADQLLKHVWI 272  baker's yeast
XP_654672     631 IvnDDYPPFPSTv-SVQLKDFLFSCFKRnPNQRASSRELLKHKWF 674  Entamoeba histolytica HM-1:IMSS
XP_647809     236 IvqEDHPPIPPGi-SAALKDFLLNCFKKdENIRSSAKQLLHHPWV 279  Dictyostelium discoideum AX4
XP_646575     286 IcqDDRPPLPDDi-SSELANFLERCFCKsTEERATAKELLSHPWI 329  Dictyostelium discoideum AX4
XP_638675     245 IvsDQHPPFPTDi-SKEFLDYFQQSFKKdPTQRPTAQELLQHPIF 288  Dictyostelium discoideum AX4
XP_457906     469 IgtDDHPPLPKNi-SPLAKDFLLECFQKqPNLRISAKSLLRHKWV 512  Debaryomyces hansenii CBS767
XP_638889     222 MvnNPHPPIPNNi-SADLKHFLLACFVRdINKRPTASQLLEHPWI 265  Dictyostelium discoideum AX4
XP_822459     244 IseTDETPIPTMdvSEECRNFLTQCLDRdASKRPTAAALLKHGWF 288  Trypanosoma brucei TREU927
XP_001312579  247 IvqNPEPPLPKDi-SANFKDFLTSCLTKnVTFRKNTEQLLKHPFI 290  Trichomonas vaginalis G3
399197        230 Ve-NDTYYPPSSf-SEPLKDFLSKCFVKnMYKRPTADQLLKHVWI 272  baker's yeast
XP_654672     631 IvnDDYPPFPSTv-SVQLKDFLFSCFKRnPNQRASSRELLKHKWF 674  Entamoeba histolytica HM-1:IMSS
XP_647809     236 IvqEDHPPIPPGi-SAALKDFLLNCFKKdENIRSSAKQLLHHPWV 279  Dictyostelium discoideum AX4
XP_646575     286 IcqDDRPPLPDDi-SSELANFLERCFCKsTEERATAKELLSHPWI 329  Dictyostelium discoideum AX4
XP_638675     245 IvsDQHPPFPTDi-SKEFLDYFQQSFKKdPTQRPTAQELLQHPIF 288  Dictyostelium discoideum AX4
XP_457906     469 IgtDDHPPLPKNi-SPLAKDFLLECFQKqPNLRISAKSLLRHKWV 512  Debaryomyces hansenii CBS767
XP_638889     222 MvnNPHPPIPNNi-SADLKHFLLACFVRdINKRPTASQLLEHPWI 265  Dictyostelium discoideum AX4
XP_822459     244 IseTDETPIPTMdvSEECRNFLTQCLDRdASKRPTAAALLKHGWF 288  Trypanosoma brucei TREU927
XP_001312579  247 IvqNPEPPLPKDi-SANFKDFLTSCLTKnVTFRKNTEQLLKHPFI 290  Trichomonas vaginalis G3

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