2CLQ


Conserved Protein Domain Family
STKc_ASK

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cd06624: STKc_ASK (this model, PSSM-Id:173730 is obsolete and has been replaced by 270794)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinase, Apoptosis signal-regulating kinase
Serine/threonine kinases (STKs), Apoptosis signal-regulating kinase (ASK) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Subfamily members are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs or MAP3Ks) and include ASK1, ASK2, and MAPKKK15. MAPKKKs phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species (ROS)-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown.
Statistics
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PSSM-Id: 173730
Aligned: 7 rows
Threshold Bit Score: 556.753
Created: 21-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #####   #            # #                            #            
2CLQ_B         15 LEYDYEYDENGDRVVLGKGTYGIVYAGRDlsnQVRIAIKEIPErdsRYSQPLHEEIALHKHLkHKNIVQYLGSFSEn--- 91   human
AAC37267       77 IEYEYDYDEQNRKMVLGKGTYGTVYAARDkqtQVRIAIKEVPEknsQDVQPLHEEIKLHSQLrHRNIVRYLGSCSEn--- 153  fruit fly
T16511        655 IRFEYELSNSNERVVLGKGTYGTVYAARDmdtQRQIVVKEIEVkydEEVQPLMEEISLHSTLcHANIVQYLGCDLVgkdg 734  nematode
XP_001202919  579 NEIEYEFTESKDRVMLGRGTFGVVYAARDcrtQVTIAVKEIPItdmREVQPLHEEILLHSRLsHKNIVKYLGSDIVg--- 655  purple urchin
XP_419725     557 LEYDYEYDENGERVVLGKGTYGIVYAGRDlsnQVRIAIKEIPErdsRYSQPLHEEIALHKHLkHKNIVQYLGSLSEn--- 633  chicken
CAG05453      705 LEYEYDTNETGDRVVLGRGTYGVVYAGRDlsnQVRIAIKEIPErdsRYSQPLHEEIALHKYLkHRNIVQYLGSVSEn--- 781  Tetraodon nig...
Q6ZN16        643 LEYEYDHDANGERVVLGKGTYGIVYAGRDlsnQVRIAIKEIPErdsRYSQPLHEEIALHKYLkHRNIVQYLGSVSEn--- 719  human
Feature 1                 #### ###  #                                      # #### #          ### #
2CLQ_B         92 --gFIKIFMEQVPGGSLSALLRSKWGPlkdNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGT 169  human
AAC37267      154 --gFFKIFMEQVPGGSLSDLLETKWGPlkdNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGT 231  fruit fly
T16511        735 sndHFLIFMEHVPGGSLSSLLRSKWGPm--NENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGT 812  nematode
XP_001202919  656 --nTFKIYMEQVPGGSLSALLRSKWGPlkdHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGT 733  purple urchin
XP_419725     634 --gFIKIFMEQVPGGSLSALLRSKWGPlknNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGT 711  chicken
CAG05453      782 --gYIKIFMEQVPGGSLSALLRSKWGPl--KEATIIFYTRQILEGLRYLHDNQIVHRDIKGDNVLVNTYSGVLKISDFGT 857  Tetraodon nig...
Q6ZN16        720 --gYIKIFMEQVPGGSLSALLRSKWGPm--KEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGT 795  human
Feature 1                      #### #                            #        #                       
2CLQ_B        170 SKRLAGINPCTETFTGTLQYMAPEIIDKGpRGYGKAADIWSLGCTIIEMAtGKPPFYELGEPQAAMFKVGMFkVHPEIPE 249  human
AAC37267      232 SKRLARINPMTETFTGTLQYMAPEVIDQGvRGYGPAADIWSFGCTNVEMAtGKPPFIELGSAHAAMFKVGFYkKHPNIPE 311  fruit fly
T16511        813 CKRLAGLNPVTETFTGTLQYMAPEVIDHGqRGYGAPADIWSFGCTMVEMAtGRPPFVEMQNPQAAMFRVGMFkTHPPIPT 892  nematode
XP_001202919  734 SKRLAGLNPAASSFKGTLQYMAPEVIDKGlRGHGAPADIWSLGCTIVEMAtGKPPFIELGSPQAAMFKVGFYkDHPEIPE 813  purple urchin
XP_419725     712 SKRLAGINPCTETFTGTLQYMAPEIIDKGpRGYGKAADIWSLGCTIIEMAtGKPPFYELGEPQAAMFKVGMFkIHPEIPE 791  chicken
CAG05453      858 SKRLAGVNPCTETFTGTLQYMAPEIIDKGpRGYGAPADIWSLGCTIIEMAtGKPPFHELGEPQAAMFKVGMFkIHPEIPE 937  Tetraodon nig...
Q6ZN16        796 SKRLAGVNPCTETFTGTLQYMAPEIIDQGpRGYGAPADIWSLGCTIIEMAtSKPPFHELGEPQAAMFKVGMFkIHPEIPE 875  human
Feature 1                                          
2CLQ_B        250 SmsAEAKAFILKCFEPDPDKRACANDLLVDEFL 282  human
AAC37267      312 ElsANAKNFILRCFAISVMDRPSASQLLEDPFL 344  fruit fly
T16511        893 EitEKCRNFIKSCFLPEACDRPSAKDLLQDPFI 925  nematode
XP_001202919  814 SlsNAAKEFILRCFEPDPEKRATAHDLLQDPFL 846  purple urchin
XP_419725     792 SmsAEAKSFILRCFEPDPDKRAFAHELLVDEFL 824  chicken
CAG05453      938 SlsLEAKSFILRCFEPDPLKRAIATDLLRDTFV 970  Tetraodon nigroviridis
Q6ZN16        876 AlsAEARAFILSCFEPDPHKRATTAELLREGFL 908  human

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