Conserved Protein Domain Family
STKc_myosinIII_like

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cd06608: STKc_myosinIII_like (this model, PSSM-Id:173725 is obsolete and has been replaced by 270785)
Catalytic domain of Class III myosin-like Protein Serine/Threonine Kinases
Serine/threonine kinases (STKs), Class III myosin-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), mitogen-activated protein kinase (MAPK) kinase kinase kinase 4 (MAPKKKK4 or MAP4K4) and MAPKKKK6 (or MAP4K6). MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase (MAPKKK or MAP3K or MKKK). Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. MAPK signaling cascades are important in mediating cellular responses to extracellular signals.
Statistics
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PSSM-Id: 173725
Aligned: 17 rows
Threshold Bit Score: 468.68
Created: 2-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #####   #             # #                                          
Q8WXR4         20 LPDPTDTWEIIETIGKGTYGKVYKVTNKRd-GSLAAVKILDPvsd------------------------mdEEIEAEYNI 74   human
P10676          9 LPDPTDKFEIYEEIAQGVNAKVFRAKELDn-DRIVALKIQHYdee------------------------hqVSIEEEYRT 63   fruit fly
EAT48353        9 LPEPGNRYQLGEVIGTGVCAKVYKAVDTKasNKNVAIKIQKYeae------------------------lkTAIQEEYRI 64   yellow fever ...
XP_001660540   15 LSNPTERFELLDLIGEGTYGEVYSAKDKHt-GRKYAVKILESiad------------------------niEEIEEEYLV 69   yellow fever ...
XP_001635694   10 SLDPPVDWQLVESIGEGTYGEVYKVRNVKt-GEIAAAKVIDSile------------------------kiEEVLPELEI 64   starlet sea a...
Q8NEV4         14 FPDPSDTWEITETIGKGTYGKVFKVLNKKn-GQKAAVKILDPihd------------------------idEEIEAEYNI 68   human
XP_002111001   12 FPNPVGTWTLLDLIGDGLYSEVYTAKHNKk-NMMVAMKITDNiwd------------------------rkERLLHEIDI 66   Trichoplax ad...
Q9R0G8         18 LPDPTGIFSLDKAIGLGTYGRIFLGIHEKt-GSLVAVKVMSArktplpeigrrvrvnkyqksvgwrysdeeEDLRTELNL 96   house mouse
XP_002108826   16 LKDPANTFELMEIVGRGTYGLVYKGRHRKa-GKLAAIKIMGIkkd------------------------eeKEIKLEINM 70   Trichoplax ad...
XP_001750456   44 LPPPNDLFQLMEVIGTGTYGEVYRAKHAKt-QQIAAIKVMDLied------------------------eeDEIKVEVNI 98   Monosiga brev...
Feature 1                   #                          ####  ##  #                                
Q8WXR4         75 LQFLPNHPNVVKFYGMFYkadh------cvggQLWLVLELCnGGSVTELVKgllrcgqrLDEAMISYILYGALLGLQHLH 148  human
P10676         64 LRDYCDHPNLPEFYGVYKlskp------ngpdEIWFVMEYCaGGTAVDMVNkllkldrrMREEHIAYIIRETCRAAIELN 137  fruit fly
EAT48353       65 LRDYSNHGNLLDFYGVYRkkvp------gdadEIWFILEYCdHGPVIDVVKkihasnrrVSEEQIAYILRETAKAVVYLH 138  yellow fever ...
XP_001660540   70 LRDLSKHPNIPDFAGLFLkrgat-----veddQLWFVLELCtGGSVTDLVQglrnrgsrLTNNQIAYILRETVHALVFLH 144  yellow fever ...
XP_001635694   65 LKKFSDHPNIAGFHGAFIqrdp------nrqdQLWLVMELCrGGSVTNLVKnlikkgksLEEDLVAYILHETLKGVEYLH 138  starlet sea a...
Q8NEV4         69 LKALSDHPNVVRFYGIYFkkdk------vngdKLWLVLELCsGGSVTDLVKgflkrgerMSEPLIAYILHEALMGLQHLH 142  human
XP_002111001   67 LRHHSQHPNIIKFQGCFLkrrhlt---ltaedQLWFALEYCqGGSVSELARrvrdkgnrIRENIIAYIIRETMNALAFLH 143  Trichoplax ad...
Q9R0G8         97 LRKYSFHKNIVTFYGAFFklnpp-----ghqhQLWMVMELCaAGSVTDVVRmtr--nqsLKEDWIAYICREILQGLAHLH 169  house mouse
XP_002108826   71 LRRFSNQKNIATYYGAFIkqgsp-----gcesQLWLVMEFCgAGSVTDLVKgsd--kqlLKENWLAYICQEVLQGLSYLH 143  Trichoplax ad...
XP_001750456   99 LRKFGSHENITTFYGAFLappdtnsneriphpKLWLCMELCeGGSVIDLAQsvl--pkqLPEPLLAYFLHETTTALRYLH 176  Monosiga brev...
Feature 1                # #### #          #  #             #### #                                
Q8WXR4        149 NNRIIHRDVKGNNILLTteGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEqqy-----dssYDARCDVWSLG 223  human
P10676        138 RNHVLHRDIRGDNILLTknGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMesr-----epdITVRADVWALG 212  fruit fly
EAT48353      139 EHHVIHRDIRGSNILLNkeGEVKLCDFGLSRDSKSTLGKRGTCIGSPNWMAPEVISSSknd-----devYDNRSDVWALG 213  yellow fever ...
XP_001660540  145 ENHCMHRDIKGHNILLTenGHVKLVDFGVSSHLAATMARRNTSVGTPYWMAPEVIACEqql-----dqsYDSRCDVWSIG 219  yellow fever ...
XP_001635694  139 RKNVMHRDIKGANVMLTneADIRLIDFGVSSELTNALMKKNSSVGTPFWMAPEVIACEqql-----dysYDMRCDVWSIG 213  starlet sea a...
Q8NEV4        143 NNKTIHRDVKGNNILLTteGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEqql-----dttYDARCDTWSLG 217  human
XP_002111001  144 ERNIIHRDIKGGNILLTseAHVKLIDFDVSAMLKTSQQRRQSCTGTSYWVAPEVIACKsyanqqfeersYDSRCDTWSLG 223  Trichoplax ad...
Q9R0G8        170 AHQVIHRDIKGQNVLLThdAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDedp-----rcsYDYRSDVWSVG 244  house mouse
XP_002108826  144 SHKVIHRDIKGQNILLTenADVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACNdkp-----aysYDHRSDVWSLG 218  Trichoplax ad...
XP_001750456  177 KNLVIHRDVKGQNILIThdGGIKLVDFGVSAEMKSKNEARHTYIGTPYWMAPEVIACDqqm-----datYDQRSDIWSLG 251  Monosiga brev...
Feature 1             #        #                                                        
Q8WXR4        224 ITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPekWCEEFNHFISQCLIKDFERRPSVTHLLDHPFI 293  human
P10676        213 ITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPtnWSQQINDFISESLEKNAENRPMMVEMVEHPFL 282  fruit fly
EAT48353      214 ITAIELGDGKPPFGDMHPTRTMFQIVRNPPPTLYRPanWTQNYNDFITECLEKNPDHRPFMMEIMEHPFL 283  yellow fever mosquito
XP_001660540  220 ITAIELAEGDPPLCELHPMRALFQIPRNPPPRLTHPenYSAMLSDFISECLVKDLEQRPFSKELITHPFL 289  yellow fever mosquito
XP_001635694  214 ITGIELADGVAPLSDEHPMRALFKIPRNKPPTMKHPekWSHEYRDFIAHCLIKDFEERPFVSQLLQHPFL 283  starlet sea anemone
Q8NEV4        218 ITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPelWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287  human
XP_002111001  224 ITAIELADGKPPFAEQHPDRAMYKILRSVPSTVKEPtlWRADFNDFIKWCLAKNADKRPFIQDLFAHPLI 293  Trichoplax adhaerens
Q9R0G8        245 ITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSg-WSRKFQNFMENCMIKNFLFRPTSGNMLLHPFV 313  house mouse
XP_002108826  219 ITAIEMAERQPPLCDVHPMRALFLILRGPSPKLKSPrrWSRSFVNFVGSCLIKNYTRRPTTDHMLQHDFI 288  Trichoplax adhaerens
XP_001750456  252 ITAIEMAETEPPLSDLHPMRALFLIPRNPSPTLKPAa-WSDAFQDFVATCLIKDYEQRPTSKRLLEHAWL 320  Monosiga brevicollis MX1

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