Conserved Protein Domain Family
STKc_MRCK_beta

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cd05624: STKc_MRCK_beta (this model, PSSM-Id:173713 is obsolete and has been replaced by 270774)
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase beta
Serine/Threonine Kinases (STKs), DMPK-like subfamily, DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK) beta isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCKbeta is expressed ubiquitously in many tissues.
Statistics
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PSSM-Id: 173713
View PSSM: cd05624
Aligned: 4 rows
Threshold Bit Score: 730.266
Threshold Setting Gi: 27469638
Created: 5-Sep-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of peptide substrates to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #####   #            # #                               #               #
gi 5006445     74 EDFEIIKVIGRGAFGEVAVVKMknteRIYAMKILNKWEMLKraETACFREERDVLVNGdCQWITALHYAFQDenHLYLVM 153
gi 118092038   75 DDFEIIKVIGRGAFGEVAVVKMkcteRIYAMKILNKWEMLKraETACFREERNVLVNGdCQWITTLHYAFQDenYLYLVM 154
gi 27469638    74 DDFEIIKVIGRGAFGEVAVVRLksteRIYAMKILNKWEMLKraETACFREERNVLVNGdCQWITTLHYAFQDenYLYLVM 153
gi 113676998   74 DDFEMLKVIGRGAFGEVAVVKMkhteRVYAMKILNKWEMLKraETACFREERNVLVNGdCQWITTLHYAFQDdnYLYLVM 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #   # #                                     # # ## #         ##  #            
gi 5006445    154 DYYvGGDLLTLLSKfedKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDvnGHIRLADFGSCLKMNDDGTVQS 233
gi 118092038  155 DYYvGGDLLTLLSKfedKLPEDMARFYIGEMVLAIHSIHELHYVHRDIKPDNVLLDmnGHIRLADFGSCLKMSEDGTVQS 234
gi 27469638   154 DYYvGGDLLTLLSKfedRLPEDMSRFYLAEMVLAIHSIHQLHYVHRDIKPDNILLDmnGHIRLADFGSCLKMNKDGTVQS 233
gi 113676998  154 DYYvGGDLLTLLSKfedRLPEDMAKFYVAEMVLAIHSIHQQRYVHRDIKPDNVLLDmnGHIRLADFGSCLKMMQDGTVQS 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ######                               #     #  #                               
gi 5006445    234 SVAVGTPDYISPEILQAmedgmgkYGPECDWWSLGVCMYEMLYGETPFYAEsLVETYGKIMnhEERFQFPSHvtdvsEEA 313
gi 118092038  235 SVAVGTPDYISPEILQAmedgmgkYGPECDWWSLGVCMYEMLYGETPFYAEsLVETYGKIMnhEERFQFPSHvtdvsEEA 314
gi 27469638   234 SVAVGTPDYISPEILQAmedgmgkYGPECDWWSLGVCMYEMLYGETPFYAEsLVETYGKIMnhEERFQFPSHigdvsESA 313
gi 113676998  234 SVAVGTPDYISPEILQAmedgmgkYGPECDWWSLGVCMYEMLYGETPFYAEsLVETYGKIMnhEERFQFPSHitdvsEDA 313
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 5006445    314 KDLIQRLICSRERRLGqngIEDFKKHAFFEGLNWENIRnlEAPYIPDVSSPSDTSNFDVDDDvlrnteilppgshtgFSG 393
gi 118092038  315 KDLIQRLICSRERRLGqngIEDFKSHAFFEGLNWDNIRnlEAPYIPDVSSPSDTSNFDVDDDvlrnpevvppsshtgFSG 394
gi 27469638   314 KDLIQRLICSRERRLGqngIDDFKAHPFFEGIDWDNIRnlEAPYIPDVSSPSDTSNFDVDDDilrnpevipssthsgFSG 393
gi 113676998  314 KDLIQRLICSRERRLGqhgIEEFRKHAFFSGIDWENIRnmEAPYIPDVSSPSDTSNFDVDDDvlknpdiappvshtgFTG 393
                         330
                  ....*....|.
Feature 1                    
gi 5006445    394 LHLPFIGFTFT 404
gi 118092038  395 LHLPFVGFTYT 405
gi 27469638   394 FHLPFVGFTYT 404
gi 113676998  394 QHLPFVGFTYT 404

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