Conserved Protein Domain Family
STKc_nPKC_delta

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cd05620: STKc_nPKC_delta 
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173710
View PSSM: cd05620
Aligned: 4 rows
Threshold Bit Score: 694.766
Threshold Setting Gi: 57524924
Created: 31-Aug-2007
Updated: 2-Mar-2014
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #####   #            # #                                #               ## #  
gi 57524924  361 KVLGKGSFGKVLLAELKGknEFFAIKALKKDVVLIDDDVECTMVEKRVLALAWENPFLTHLYCTFQTKDHLFFVMEFLNG 440
gi 47550719  361 KVLGKGSFGKVLLAELKGtgEWFAVKALKKDVVLMDDDVECTMVEKRVLALAWDNPFLTHLYSTFQTKEHLFFVMEYLNG 440
gi 50415318  360 KVLGKGSFGKVLLAELKGkgEYFAVKALKKDVVLIDDDVECTMVEKRVLALAWENPFLTHVHCTFQTKEHLFFVMEFLNG 439
gi 205371776 353 KVLGKGSFGKVLLGELKGrgEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG 432
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #                                                   # # ## #         ##  #   
gi 57524924  441 GDLMFHIQDKGRFDLYRATFYGAEILCGLQFLHSkgiiyrkftsitsepNWSSFRDLKLDNVMLDKEGRIKIADFGMCKE 520
gi 47550719  441 GDLMFHIQEKGRFDLYRATFYAAEIVCGLQFLHS---------------KGIIYRDLKLDNVMLDGDGHIKIADFGMCKE 505
gi 50415318  440 GDLMFHIQDKGRFDLYRATFYASEIICGLQFLHS---------------KGIIYRDLKLDNVMLDRDGHIKIADFGMCKE 504
gi 205371776 433 GDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS---------------KGIIYRDLKLDNVLLDRDGHIKIADFGMCKE 497
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  ######                          #     #  #                            
gi 57524924  521 NVVGENKASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWItKESKD 600
gi 47550719  506 NVFGDNRATTFCGTPDYIAPEILLGQQYSFSVDWWSFGVLVYEMLIGQSPFHGDDEDELFESIRMDTPHYPRWIlLDTRD 585
gi 50415318  505 NVYGDNKASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRQDTPHYPRWItKESKD 584
gi 205371776 498 NIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWItKESKD 577
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 57524924  601 LLEKLFERDPTRRLGvtGNIRDHPFFKTINWTTLEKREIDPPFKPKVKsasDYNNFDREFLNEKPKLSYSDKNLIDSMDQ 680
gi 47550719  586 MLERLFERDPSRRLGivGNIRGHSFFKTVNWAALEGREVDPPFKPKVKapnDCSNFDREFLSEKPRLSHCEKGLIDSMDQ 665
gi 50415318  585 ILEKFFERDPFKRLGvvGNIKLHPFFKTINWTALERRELDPPFKPKVKspsDYSNFDREFLSEKPRLSFSDKNLIDSMDQ 664
gi 205371776 578 ILEKLFEREPTKRLGvtGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKsprDYSNFDQEFLNEKARLSYSDKNLIDSMDQ 657
                        330
                 ....*....|.
Feature 1                   
gi 57524924  681 SAFAGFSFTNP 691
gi 47550719  666 CAFAGFSFINP 676
gi 50415318  665 SAFHGFSFINP 675
gi 205371776 658 SAFAGFSFVNP 668

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