Conserved Protein Domain Family
STKc_cPKC_alpha

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cd05615: STKc_cPKC_alpha (this model, PSSM-Id:173706 is obsolete and has been replaced by 270766)
Catalytic domain of the Protein Serine/Threonine Kinase, Classical Protein Kinase C alpha
Serine/Threonine Kinases (STKs), Classical Protein Kinase C (cPKC) subfamily, alpha isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion.
Statistics
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PSSM-Id: 173706
Aligned: 6 rows
Threshold Bit Score: 703.679
Created: 31-Aug-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #####   #            # #                                #               #
P20444       338 DFNFLMVLGKGSFGKVMLADRkgteELYAIKILKKDvviqdDDVECTMVEKRVLALLdkPPFLTQLHSCFQTvdRLYFVM 417 house mouse
AAH78065     343 DFCFLMVLGKGSFGKVMLAERkgsdELYAIKILKKDvviqdDDVECTMVEKRVLALQekPPFLTQLHSCFQTvdRLYFVM 422 African clawed ...
NP_001012822 340 DFNFLMVLGKGSFGKVMLADRknteELYAIKILKKDvviqdDDVECTMVEKRVLALQdkPPFLTQLHSCFQTvdRLYFVM 419 chicken
1704381A     342 DFSFLMVLGKGSFGKVMVGRRkgsdELYAVKILKKDvviqdDDVECTMIEKRVLALQdkPPFLTQLQSCFQTvdRLYFVM 421 African clawed ...
CAD30698     336 DFNFLALLGKGSFGKVMLAEMkstdELYAIKILKKDvviqdDDVECTMVEKRVLAQRdkPPFLTQLHSCFQTvdRLYFVM 415 torafugu
CAG06123     314 TDGPSSLMPSNIMDQVMLVEMkatgELYAVKILKKDvviqdDDVECTMVEKRVLALQdkPPFLTQLHSCFQTvdRLYFVM 393 Tetraodon nigro...
Feature 1        # #   # #                                    # # ## #         ##  #             
P20444       418 EYVnGGDLMYHIQQvgkFKEPQAVFYAAEISIGLFFLHkRGIIYRDLKLNNVMLNseGHIKIADFGMCKEHMMDGVTTRT 497 house mouse
AAH78065     423 EYVsGGDLMYHIQQvgkFKEPQAVFYAAEISVGLFFLHrKGICYRDLKLDNVMLDfeGHIKIADFGMCKEHMVEGVTTRT 502 African clawed ...
NP_001012822 420 EYVnGGDLMYHIQQvgkFKEPQAVFYAAEISVGLFFLHnRGIVYRDLKLDNVMLDseGHIKIADFGMCKEHMLDGVTTRT 499 chicken
1704381A     422 EYVsGGDLMYHIQQvgkFKEPQAVFYAAEISVGLFFLHkKGIVYRDLKLDNVMLDseGHIKIADFGMCKEHVVEGVTTRT 501 African clawed ...
CAD30698     416 EYInGGDLMYHIQRmgkFKEPQAVFYAAEIAVGLFFLHrKGIIYRDLKLDNVMLDseGHIKIADFGMCKESMYEGMTTRT 495 torafugu
CAG06123     394 EYVnGGDLMYHIQQvgkFKEPQAVFYAAEIAVGLFFLHeRGIIYRDLKLDNVMLDseGHIKIADFGMCKENMVDGVCTRT 473 Tetraodon nigro...
Feature 1        ######                          #     #  #                                      
P20444       498 FCGTPDYIAPEIIAYqpyGKSVDWWAYGVLLYEMLAGQPPFDGEdeDELFQSIMEHNVSYPKSlsKEAVSICKGLMTkqP 577 house mouse
AAH78065     503 FCGTPDYIAPEIIAYqpyGRSVDWWAYGVLLYEMLAGQPPFDGEdeDELFQSIMEHNVSYPKSmsKEAVSICKGLMTkhP 582 African clawed ...
NP_001012822 500 FCGTPDYIAPEIIAYqpyGKSVDWWAYGVLLYEMLAGQPPFDGEdeDELFQSIMEHNVSYPKSlsKEAVSICKGLMTkhP 579 chicken
1704381A     502 FCGTPDYIAPEIIAYqpyGRSVDWWAIGVLLYEMLAGQPPFDGEdeDELFQSIMEHNVAYPKSmsKEAVSICKPLMTkhP 581 African clawed ...
CAD30698     496 FCGTPDYIAPEIIAYqpyGKSVDWWAYGVLLYEMLAGQPPFDGEdeDELFQSIMEHNVSYPKSmsKEAVSICKGLMTkhP 575 torafugu
CAG06123     474 FCGTPDYIAPEIIAYqpyGLSVDWWAYGVLLYEMLAGQPPFDGEdeDELFQSIMEHNVSYPKSlsKEAVSICKGLMAklP 553 Tetraodon nigro...
Feature 1                                                                                        
P20444       578 AKRLGCgpegERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKgaENFDKFFTRGQPVLTPPDqlviaNIDQSDFEGFS 657 house mouse
AAH78065     583 VKRLGCgpegERDIREHTFFRRIDWDKLENREIQPPFKPKVCGKgaENFDKFFTRGQPVLTPPDqlviaNIDQADFEGFS 662 African clawed ...
NP_001012822 580 AKRLGCglegERDIREHAFFRRIDWEKLENREIQPPFKPKVCGKgaENFDKFFTRGQPVLTPPDqlviaNIDQSDFEGFS 659 chicken
1704381A     582 VKRLGCgpegERDVREHTFFRRIDWDKLENREIQPPFKPKVCGKgaENFDKFFTRGQPVLTPPDqlviaNIDQADFEGFT 661 African clawed ...
CAD30698     576 SKRLGCgpegEMDIREQAFFRRIDWDRLANREIQPPFKPKVGGKgaENFDKFFTRTQPVLTPPDhlviaNIDQSEFAGFS 655 torafugu
CAG06123     554 SKRLGCgqegERDIRDHVFFRRIDWKRLENREIQPPFKPKVCGKaaENFDKFFTRTQPQLTPPDelviaNIDQAEFANFS 633 Tetraodon nigro...
Feature 1           
P20444       658 YVN 660 house mouse
AAH78065     663 YIN 665 African clawed frog
NP_001012822 660 YVN 662 chicken
1704381A     662 YVN 664 African clawed frog
CAD30698     656 YVN 658 torafugu
CAG06123     634 FIN 636 Tetraodon nigroviridis

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