Conserved Protein Domain Family
STKc_MSK2_N

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cd05614: STKc_MSK2_N (this model, PSSM-Id:173705 is obsolete and has been replaced by 270765)
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
Serine/Threonine Kinases (STKs), Mitogen and stress-activated kinase (MSK) subfamily, MSK2, N-terminal catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis.
Statistics
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Aligned: 3 rows
Threshold Bit Score: 701.708
Threshold Setting Gi: 3411161
Created: 8-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #####   #               # #                                 #            
AAC67395   16 NFELLKVLGTGAYGKVFLVRKAgghdagKLYAMKVLRKAALVQRAKtqEHTRTERSVLELVrqAPFLVTLHYAFQTdaKL 95  human
AAI24882   28 DFELLKILGTGAYGKVFLVRKVtgpdtnHLYAMKVLQKCALVKKEKtvEHTKTERNVLEHVreSPFLVTLHYAFQTeaKL 107 African clawed frog
CAM15832    3 NFELLKVLGTGAYGKVFLVRKIsghdkgKLYAMKVLKKAAIVQKAKtaEHTRTERQVLEHIrqSPFLVTLHYAFQTqtKL 82  zebrafish
Feature 1        ## #   # #                                    # # ## #         ##  #         
AAC67395   96 HLILDYVsGGEMFTHLYQrqyFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDseGHIVLTDFGLSKEFLTEEK 175 human
AAI24882  108 HLILDYVsGGELFTHLYQrdnFSEDAVRFYSGEVILALEHLHKLGVVYRDIKLENILLDseGHVVLTDFGLSKEFLSEEE 187 African clawed frog
CAM15832   83 HLILDYVsGGEMFTHLYQrdhFSEDEVRIYVGEIILALEHLHKLGIVYRDIKLENILLDsdGHVVLTDFGLSKEFLEEEK 162 zebrafish
Feature 1          ######                           #     #  #                                
AAC67395  176 ERTFSFCGTIEYMAPEIIRSktghGKAVDWWSLGILLFELLTGASPFTLEgerntQAEVSRRILKCSPPFPPRigPVAQD 255 human
AAI24882  188 ERTYSFCGTTEYMAPEIIRGqgghGKIVDWWSLGILIYELLTGASPFTLEgekntQSEVSRRILKMDPSLPSFlsFEARD 267 African clawed frog
CAM15832  163 ERTYSFCGTIEYMAPEIIRGksghGKAVDWWSLGILMFELLTGASPFTLEgernsQSEVSKRILRCEPPFPSIigPLAQD 242 zebrafish
Feature 1                                                                                     
AAC67395  256 LLQRLLCKdPKKRLGAgpqgAQEVRNHPFFQGLDWVALAARKIPAPFRPqirseldvgNFAEEFTRLEPVYSPPGSPppg 335 human
AAI24882  268 LLHKLLRKdPKKRLGAa--gASQIKEHPFYKDMDWEALSLRKVNPPFRPsirnetdvsNFAEEFTNLDPVYSPAGTPpsg 345 African clawed frog
CAM15832  243 LLRKLIVKdPHKRLGSgprgAEEIKGHPFFKGLNWSDLAEKKVQSPFRPelrdeldvgNFAEEFTGMEPVYSPASTPpst 322 zebrafish
Feature 1                  
AAC67395  336 dprIFQGYSFVAP 348 human
AAI24882  346 -apVFQGYSFIAP 357 African clawed frog
CAM15832  323 -drLFQGYSFVAP 334 zebrafish

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